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Items: 1 to 50 of 381

1.

The Contribution of GWAS Loci in Familial Dyslipidemias.

Ripatti P, Rämö JT, Söderlund S, Surakka I, Matikainen N, Pirinen M, Pajukanta P, Sarin AP, Service SK, Laurila PP, Ehnholm C, Salomaa V, Wilson RK, Palotie A, Freimer NB, Taskinen MR, Ripatti S.

PLoS Genet. 2016 May 26;12(5):e1006078. doi: 10.1371/journal.pgen.1006078. eCollection 2016 May.

2.

Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes: Analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Williams KH, Sullivan DR, Nicholson GC, George J, Jenkins AJ, Januszewski AS, Gebski VJ, Manning P, Tan YM, Donoghoe MW, Ehnholm C, Young S, O'Brien R, Buizen L, Twigg SM, Keech AC.

Metabolism. 2016 May;65(5):783-93. doi: 10.1016/j.metabol.2015.12.008. Epub 2015 Dec 21.

PMID:
27085785
3.

Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism.

Minicocci I, Tikka A, Poggiogalle E, Metso J, Montali A, Ceci F, Labbadia G, Fontana M, Di Costanzo A, Maranghi M, Rosano A, Ehnholm C, Donini LM, Jauhiainen M, Arca M.

J Lipid Res. 2016 Jun;57(6):1097-107. doi: 10.1194/jlr.P066183. Epub 2016 Apr 3.

4.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

PMID:
26819196
5.

Low alanine aminotransferase levels and higher number of cardiovascular events in people with Type 2 diabetes: analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Williams KH, Sullivan DR, Veillard AS, O'Brien R, George J, Jenkins AJ, Young S, Ehnholm C, Duffield A, Twigg SM, Keech AC.

Diabet Med. 2016 Mar;33(3):356-64. doi: 10.1111/dme.12972. Epub 2015 Dec 7.

PMID:
26433207
6.

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.

Nidhina Haridas PA, Soronen J, Sädevirta S, Mysore R, Quagliarini F, Pasternack A, Metso J, Perttilä J, Leivonen M, Smas CM, Fischer-Posovszky P, Wabitsch M, Ehnholm C, Ritvos O, Jauhiainen M, Olkkonen VM, Yki-Järvinen H.

J Clin Endocrinol Metab. 2015 Oct;100(10):E1299-307. doi: 10.1210/jc.2015-1254. Epub 2015 Jul 23.

PMID:
26204133
7.

HDL biogenesis, remodeling, and catabolism.

Zannis VI, Fotakis P, Koukos G, Kardassis D, Ehnholm C, Jauhiainen M, Chroni A.

Handb Exp Pharmacol. 2015;224:53-111. doi: 10.1007/978-3-319-09665-0_2. Review.

PMID:
25522986
8.
9.

Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study.

Tuuri AL, Jauhiainen MS, Ehnholm CP, Tikkanen MJ, Nicholls MG, Kaaja RJ.

Hypertens Pregnancy. 2013 Aug;32(3):203-13. doi: 10.3109/10641955.2013.784783.

PMID:
23905605
10.

Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids.

Robciuc MR, Maranghi M, Lahikainen A, Rader D, Bensadoun A, Öörni K, Metso J, Minicocci I, Ciociola E, Ceci F, Montali A, Arca M, Ehnholm C, Jauhiainen M.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1706-13. doi: 10.1161/ATVBAHA.113.301397. Epub 2013 May 9. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):e124. Oörni, Katariina [corrected to Öörni, Katariina].

PMID:
23661675
11.

Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.

Laurila PP, Surakka I, Sarin AP, Yetukuri L, Hyötyläinen T, Söderlund S, Naukkarinen J, Tang J, Kettunen J, Mirel DB, Soronen J, Lehtimäki T, Ruokonen A, Ehnholm C, Eriksson JG, Salomaa V, Jula A, Raitakari OT, Järvelin MR, Palotie A, Peltonen L, Oresic M, Jauhiainen M, Taskinen MR, Ripatti S.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):847-57. doi: 10.1161/ATVBAHA.112.300733. Epub 2013 Feb 14.

PMID:
23413431
12.

Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study.

Herrmann M, Whiting MJ, Veillard AS, Ehnholm C, Sullivan DR, Keech AC; FIELD study investigators.

Clin Chem Lab Med. 2012 Dec;50(12):2213-9.

PMID:
23093273
13.

Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.

Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C.

PLoS One. 2012;7(10):e46212. doi: 10.1371/journal.pone.0046212. Epub 2012 Oct 4.

14.

OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype.

Zhou Y, Robciuc MR, Wabitsch M, Juuti A, Leivonen M, Ehnholm C, Yki-Järvinen H, Olkkonen VM.

PLoS One. 2012;7(9):e45352. doi: 10.1371/journal.pone.0045352. Epub 2012 Sep 21.

15.

Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization.

Minicocci I, Montali A, Robciuc MR, Quagliarini F, Censi V, Labbadia G, Gabiati C, Pigna G, Sepe ML, Pannozzo F, Lütjohann D, Fazio S, Jauhiainen M, Ehnholm C, Arca M.

J Clin Endocrinol Metab. 2012 Jul;97(7):E1266-75. doi: 10.1210/jc.2012-1298. Epub 2012 Jun 1.

16.

Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins.

Robciuc MR, Naukkarinen J, Ortega-Alonso A, Tyynismaa H, Raivio T, Rissanen A, Kaprio J, Ehnholm C, Jauhiainen M, Pietiläinen KH.

J Lipid Res. 2011 Aug;52(8):1575-82. doi: 10.1194/jlr.P015867. Epub 2011 May 19.

17.

The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk.

Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2277-82. doi: 10.1161/ATVBAHA.110.212209. Epub 2010 Sep 9.

18.

Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Drury PL, Ting R, Zannino D, Ehnholm C, Flack J, Whiting M, Fassett R, Ansquer JC, Dixon P, Davis TM, Pardy C, Colman P, Keech A.

Diabetologia. 2011 Jan;54(1):32-43. doi: 10.1007/s00125-010-1854-1. Epub 2010 Jul 30.

PMID:
20668832
19.

Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass.

Robciuc MR, Metso J, Sima A, Ehnholm C, Jauhiainen M.

Lipids Health Dis. 2010 Jun 9;9:59. doi: 10.1186/1476-511X-9-59.

20.

Ability of traditional lipid ratios and apolipoprotein ratios to predict cardiovascular risk in people with type 2 diabetes.

Taskinen MR, Barter PJ, Ehnholm C, Sullivan DR, Mann K, Simes J, Best JD, Hamwood S, Keech AC; FIELD study investigators.

Diabetologia. 2010 Sep;53(9):1846-55. doi: 10.1007/s00125-010-1806-9. Epub 2010 Jun 6.

PMID:
20526762
21.

Increased apolipoprotein E level and reduced high-density lipoprotein mean particle size associate with low high-density lipoprotein cholesterol and features of metabolic syndrome.

Söderlund S, Watanabe H, Ehnholm C, Jauhiainen M, Taskinen MR.

Metabolism. 2010 Oct;59(10):1502-9. doi: 10.1016/j.metabol.2010.01.015. Epub 2010 Mar 6.

PMID:
20206948
22.

The role of phospholipid transfer protein in lipoprotein-mediated neutralization of the procoagulant effect of anionic liposomes.

Oslakovic C, Jauhiainen M, Ehnholm C, Dahlbäck B.

J Thromb Haemost. 2010 Apr;8(4):766-72. doi: 10.1111/j.1538-7836.2010.03744.x. Epub 2010 Jan 17.

23.

A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.

Simes J, Voysey M, O'Connell R, Glasziou P, Best JD, Scott R, Pardy C, Byth K, Sullivan DR, Ehnholm C, Keech A; FIELD Study Investigators.

PLoS One. 2010 Jan 8;5(1):e8580. doi: 10.1371/journal.pone.0008580. Erratum in: PLoS One. 2010;5(1). doi: 10.1371/annotation/54433693-04e0-4f30-9a99-38fe3c5bb16b.

24.

Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.

Laurila PP, Naukkarinen J, Kristiansson K, Ripatti S, Kauttu T, Silander K, Salomaa V, Perola M, Karhunen PJ, Barter PJ, Ehnholm C, Peltonen L.

Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):346-52. doi: 10.1161/ATVBAHA.109.188912. Epub 2009 Nov 12.

25.

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample.

Robciuc MR, Tahvanainen E, Jauhiainen M, Ehnholm C.

J Lipid Res. 2010 Apr;51(4):824-31. doi: 10.1194/jlr.M002618. Epub 2009 Oct 13.

26.

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.

Bailey D, Ruel I, Hafiane A, Cochrane H, Iatan I, Jauhiainen M, Ehnholm C, Krimbou L, Genest J.

J Lipid Res. 2010 Apr;51(4):785-97. doi: 10.1194/jlr.M001875. Epub 2009 Sep 29.

27.

Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate.

Taskinen MR, Sullivan DR, Ehnholm C, Whiting M, Zannino D, Simes RJ, Keech AC, Barter PJ; FIELD study investigators.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):950-5. doi: 10.1161/ATVBAHA.108.178228. Epub 2009 Mar 26.

PMID:
19325138
28.

Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins.

Oslakovic C, Krisinger MJ, Andersson A, Jauhiainen M, Ehnholm C, Dahlbäck B.

J Biol Chem. 2009 Feb 27;284(9):5896-904. doi: 10.1074/jbc.M807286200. Epub 2009 Jan 6.

29.

Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Scott R, O'Brien R, Fulcher G, Pardy C, D'Emden M, Tse D, Taskinen MR, Ehnholm C, Keech A; Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators.

Diabetes Care. 2009 Mar;32(3):493-8. doi: 10.2337/dc08-1543. Epub 2008 Nov 4.

30.

Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.

Nakanishi S, Vikstedt R, Söderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR.

J Lipid Res. 2009 Feb;50(2):183-92. doi: 10.1194/jlr.M800196-JLR200. Epub 2008 Sep 11.

31.

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies.

Ahnström J, Axler O, Jauhiainen M, Salomaa V, Havulinna AS, Ehnholm C, Frikke-Schmidt R, Tybjaerg-Hansen A, Dahlbäck B.

J Lipid Res. 2008 Sep;49(9):1912-7. doi: 10.1194/jlr.M700471-JLR200. Epub 2008 May 19.

32.

Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice.

Christoffersen C, Jauhiainen M, Moser M, Porse B, Ehnholm C, Boesl M, Dahlbäck B, Nielsen LB.

J Biol Chem. 2008 Jan 25;283(4):1839-47. Epub 2007 Nov 15.

33.

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.

Yan D, Mäyränpää MI, Wong J, Perttilä J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM.

J Biol Chem. 2008 Jan 4;283(1):332-40. Epub 2007 Nov 8.

34.

Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.

Vikstedt R, Metso J, Hakala J, Olkkonen VM, Ehnholm C, Jauhiainen M.

Biochemistry. 2007 Oct 23;46(42):11979-86. Epub 2007 Sep 27.

PMID:
17900150
35.

Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus.

Hiukka A, Leinonen E, Jauhiainen M, Sundvall J, Ehnholm C, Keech AC, Taskinen MR.

Diabetologia. 2007 Oct;50(10):2067-75. Epub 2007 Jul 26. Erratum in: Diabetologia. 2007 Dec;50(12):2611-3.

PMID:
17653691
36.

Low HDL-C predicts the onset of transplant vasculopathy in pediatric cardiac recipients on pravastatin therapy.

Hedman M, Pahlman R, Sundvall J, Ehnholm C, Syvänne M, Jokinen E, Jauhiainen M, Holmberg C, Antikainen M.

Pediatr Transplant. 2007 Aug;11(5):481-90.

PMID:
17631015
37.

Low phospholipid transfer protein (PLTP) is a risk factor for peripheral atherosclerosis.

Schgoer W, Mueller T, Jauhiainen M, Wehinger A, Gander R, Tancevski I, Salzmann K, Eller P, Ritsch A, Haltmayer M, Ehnholm C, Patsch JR, Foeger B.

Atherosclerosis. 2008 Jan;196(1):219-26. Epub 2007 Jun 5.

PMID:
17553507
38.

Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice.

Yan D, Jauhiainen M, Hildebrand RB, Willems van Dijk K, Van Berkel TJ, Ehnholm C, Van Eck M, Olkkonen VM.

Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1618-24. Epub 2007 May 3.

PMID:
17478758
39.

Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis.

Bykov I, Jauhiainen M, Olkkonen VM, Saarikoski ST, Ehnholm C, Junnikkala S, Väkevä A, Lindros KO, Meri S.

J Hepatol. 2007 May;46(5):907-14. Epub 2007 Jan 2.

PMID:
17321001
40.

Lipid transfer protein activities in subjects with impaired glucose tolerance.

Julius U, Jauhiainen M, Ehnholm C, Pietzsch J.

Clin Chem Lab Med. 2007;45(2):237-43.

PMID:
17311515
41.

Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.

Yan D, Lehto M, Rasilainen L, Metso J, Ehnholm C, Ylä-Herttuala S, Jauhiainen M, Olkkonen VM.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1108-14. Epub 2007 Feb 15.

PMID:
17303778
42.

Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice.

Van Eck M, Ye D, Hildebrand RB, Kar Kruijt J, de Haan W, Hoekstra M, Rensen PC, Ehnholm C, Jauhiainen M, Van Berkel TJ.

Circ Res. 2007 Mar 16;100(5):678-85. Epub 2007 Feb 9.

PMID:
17293475
43.

Interfacial and lipid transfer properties of human phospholipid transfer protein: implications for the transfer mechanism of phospholipids.

Setälä NL, Holopainen JM, Metso J, Wiedmer SK, Yohannes G, Kinnunen PK, Ehnholm C, Jauhiainen M.

Biochemistry. 2007 Feb 6;46(5):1312-9.

PMID:
17260960
44.

Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development.

Vikstedt R, Ye D, Metso J, Hildebrand RB, Van Berkel TJ, Ehnholm C, Jauhiainen M, Van Eck M.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):578-86. Epub 2006 Dec 14.

PMID:
17170377
45.

ApoE polymorphism is associated with C-reactive protein in low-HDL family members and in normolipidemic subjects.

Kahri J, Soro-Paavonen A, Ehnholm C, Taskinen MR.

Mediators Inflamm. 2006;2006(3):12587.

46.

Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL.

Soro-Paavonen A, Westerbacka J, Ehnholm C, Taskinen MR.

Ann Med. 2006;38(3):229-38.

PMID:
16720437
47.

The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?

Olkkonen VM, Johansson M, Suchanek M, Yan D, Hynynen R, Ehnholm C, Jauhiainen M, Thiele C, Lehto M.

Biochem Soc Trans. 2006 Jun;34(Pt 3):389-91. Review.

PMID:
16709169
48.

Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.

Lee-Rueckert M, Vikstedt R, Metso J, Ehnholm C, Kovanen PT, Jauhiainen M.

J Lipid Res. 2006 Aug;47(8):1725-32. Epub 2006 May 10.

49.

Genetics of familial combined hyperlipidemia.

Naukkarinen J, Ehnholm C, Peltonen L.

Curr Opin Lipidol. 2006 Jun;17(3):285-90. Review.

PMID:
16680034
50.

The unique role of apolipoprotein A-I in HDL remodeling and metabolism.

Pownall HJ, Ehnholm C.

Curr Opin Lipidol. 2006 Jun;17(3):209-13. Review.

PMID:
16680023

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