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Items: 1 to 50 of 155

1.

Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling.

Yampolsky P, Koenen M, Mosqueira M, Geschwill P, Nauck S, Witzenberger M, Seyler C, Fink T, Kruska M, Bruehl C, Schwoerer AP, Ehmke H, Fink RHA, Draguhn A, Thomas D, Katus HA, Schweizer PA.

Nat Commun. 2019 Jul 23;10(1):3295. doi: 10.1038/s41467-019-11261-2.

2.

Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model.

Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, Sehner S, Ehmke H, Reichenspurner H, Eschenhagen T, Schwoerer AP.

Sci Rep. 2019 Jul 8;9(1):9831. doi: 10.1038/s41598-019-46409-z.

3.

The heterotopic heart transplantation in mice as a small animal model to study mechanical unloading - Establishment of the procedure, perioperative management and postoperative scoring.

Westhofen S, Jelinek M, Dreher L, Biermann D, Martin J, Vitzhum H, Reichenspurner H, Ehmke H, Schwoerer AP.

PLoS One. 2019 Apr 12;14(4):e0214513. doi: 10.1371/journal.pone.0214513. eCollection 2019.

4.

Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation.

Schaefer A, Schneeberger Y, Schulz S, Krasemann S, Werner T, Piasecki A, Höppner G, Müller C, Morhenn K, Lorenz K, Wieczorek D, Schwoerer AP, Eschenhagen T, Ehmke H, Reichenspurner H, Stenzig J, Cuello F.

Sci Rep. 2019 Apr 5;9(1):5710. doi: 10.1038/s41598-019-42263-1.

5.

Novel Approach to Elucidate Human Baroreflex Regulation at the Brainstem Level: Pharmacological Testing During fMRI.

Gerlach DA, Manuel J, Hoff A, Kronsbein H, Hoffmann F, Heusser K, Ehmke H, Diedrich A, Jordan J, Tank J, Beissner F.

Front Neurosci. 2019 Mar 5;13:193. doi: 10.3389/fnins.2019.00193. eCollection 2019.

6.

The mechanotransduction of blood pressure.

Ehmke H.

Science. 2018 Oct 26;362(6413):398-399. doi: 10.1126/science.aav3495. No abstract available.

PMID:
30361358
7.

Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UO.

Br J Pharmacol. 2019 Jun;176(12):2002-2014. doi: 10.1111/bph.14509. Epub 2018 Dec 18.

PMID:
30270435
8.

The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II-induced hypertension.

Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust HJ, Huber TB, Stahl RAK, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UO.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1526-F1535. doi: 10.1152/ajprenal.00149.2018. Epub 2018 Sep 12.

PMID:
30207169
9.

Salt, inflammation, IL-17 and hypertension.

Wenzel UO, Bode M, Kurts C, Ehmke H.

Br J Pharmacol. 2019 Jun;176(12):1853-1863. doi: 10.1111/bph.14359. Epub 2018 Jun 15. Review.

PMID:
29767465
10.

Genetic background dominates the susceptibility to ventricular arrhythmias in a murine model of β-adrenergic stimulation.

Jelinek M, Wallach C, Ehmke H, Schwoerer AP.

Sci Rep. 2018 Feb 2;8(1):2312. doi: 10.1038/s41598-018-20792-5.

11.

A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.

Wenzel UO, Bode M, Köhl J, Ehmke H.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H349-H354. doi: 10.1152/ajpheart.00759.2016. Epub 2016 Dec 16. Review.

12.

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer.

Dyshlovoy SA, Otte K, Alsdorf WH, Hauschild J, Lange T, Venz S, Bauer CK, Bähring R, Amann K, Mandanchi R, Schumacher U, Schröder-Schwarz J, Makarieva TN, Guzii AG, Tabakmakher KM, Fedorov SN, Shubina LK, Kasheverov IE, Ehmke H, Steuber T, Stonik VA, Bokemeyer C, Honecker F, von Amsberg G.

Oncotarget. 2016 Oct 25;7(43):69703-69717. doi: 10.18632/oncotarget.11941.

13.

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension.

Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UO.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1356-65. doi: 10.1152/ajprenal.00040.2016. Epub 2016 Apr 6.

14.

A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation.

Schaefer A, Schneeberger Y, Stenzig J, Biermann D, Jelinek M, Reichenspurner H, Eschenhagen T, Ehmke H, Schwoerer AP.

PLoS One. 2016 Feb 3;11(2):e0148259. doi: 10.1371/journal.pone.0148259. eCollection 2016.

15.

Immune Mechanisms in Arterial Hypertension.

Wenzel U, Turner JE, Krebs C, Kurts C, Harrison DG, Ehmke H.

J Am Soc Nephrol. 2016 Mar;27(3):677-86. doi: 10.1681/ASN.2015050562. Epub 2015 Aug 28. Review.

16.

Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle.

Hübner CA, Schroeder BC, Ehmke H.

Pflugers Arch. 2015 Mar;467(3):605-14. doi: 10.1007/s00424-014-1684-y. Epub 2015 Jan 16. Review.

PMID:
25588975
17.

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.

Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.

Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664.

18.

Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice.

Lehners A, Lange S, Niemann G, Rosendahl A, Meyer-Schwesinger C, Oh J, Stahl R, Ehmke H, Benndorf R, Klinke A, Baldus S, Wenzel UO.

Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F407-17. doi: 10.1152/ajprenal.00262.2014. Epub 2014 Jul 2.

19.

Smooth muscle BK channel activity influences blood pressure independent of vascular tone in mice.

Sachse G, Faulhaber J, Seniuk A, Ehmke H, Pongs O.

J Physiol. 2014 Jun 15;592(12):2563-74. doi: 10.1113/jphysiol.2014.272880. Epub 2014 Mar 31.

20.

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.

Heinze C, Seniuk A, Sokolov MV, Huebner AK, Klementowicz AE, Szijártó IA, Schleifenbaum J, Vitzthum H, Gollasch M, Ehmke H, Schroeder BC, Hübner CA.

J Clin Invest. 2014 Feb;124(2):675-86. doi: 10.1172/JCI70025. Epub 2014 Jan 9.

21.

Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.

Vitzthum H, Seniuk A, Schulte LH, Müller ML, Hetz H, Ehmke H.

J Physiol. 2014 Mar 1;592(5):1139-57. doi: 10.1113/jphysiol.2013.266924. Epub 2014 Jan 6.

22.

Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension.

Krebs CF, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl RA, Benndorf RA, Velden J, Paust HJ, Panzer U, Ehmke H, Wenzel UO.

Hypertension. 2014 Mar;63(3):565-71. doi: 10.1161/HYPERTENSIONAHA.113.02620. Epub 2013 Dec 23.

PMID:
24366079
23.

Enhanced Ca²+ influx through cardiac L-type Ca²+ channels maintains the systolic Ca²+ transient in early cardiac atrophy induced by mechanical unloading.

Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, Biermann D, Didié M, Vettel C, Maier LS, Zimmermann WH, Carrier L, Eschenhagen T, Volk T, El-Armouche A, Ehmke H.

Pflugers Arch. 2013 Dec;465(12):1763-73. doi: 10.1007/s00424-013-1316-y. Epub 2013 Jul 11.

24.

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, Potter BV, Ehmke H, Guse AH.

J Biol Chem. 2013 May 31;288(22):16017-30. doi: 10.1074/jbc.M112.441246. Epub 2013 Apr 5.

25.

Parthenogenetic stem cells for tissue-engineered heart repair.

Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH.

J Clin Invest. 2013 Mar;123(3):1285-98. doi: 10.1172/JCI66854. Epub 2013 Feb 22.

26.

Baseline systolic left ventricular function determines hemodynamic adaptation following percutaneous mitral valve repair.

Rudolph V, Moenig C, Lubos E, Lubs D, Knap M, Schlüter M, Kuß O, Koschyk D, Schwoerer AP, Treede H, Schirmer J, Reichenspurner H, Ehmke H, Blankenberg S, Baldus S.

Int J Cardiol. 2013 Sep 10;167(6):3039-40. doi: 10.1016/j.ijcard.2012.11.093. Epub 2012 Dec 7. No abstract available.

PMID:
23219314
27.

Impact of AT2 receptor deficiency on postnatal cardiovascular development.

Biermann D, Heilmann A, Didié M, Schlossarek S, Wahab A, Grimm M, Römer M, Reichenspurner H, Sultan KR, Steenpass A, Ergün S, Donzelli S, Carrier L, Ehmke H, Zimmermann WH, Hein L, Böger RH, Benndorf RA.

PLoS One. 2012;7(10):e47916. doi: 10.1371/journal.pone.0047916. Epub 2012 Oct 29.

28.

Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.

Sydow K, Schmitz C, von Leitner EC, von Leitner R, Klinke A, Atzler D, Krebs C, Wieboldt H, Ehmke H, Schwedhelm E, Meinertz T, Blankenberg S, Böger RH, Magnus T, Baldus S, Wenzel U.

PLoS One. 2012;7(10):e48150. doi: 10.1371/journal.pone.0048150. Epub 2012 Oct 26.

29.

Compartment syndrome of the lower leg after punch biopsy.

Faulhaber J, Ehmke H, Koenen W, Weiss B, Goerdt S, Schneider SW.

Dermatol Surg. 2012 Feb;38(2):277-8. doi: 10.1111/j.1524-4725.2011.02244.x. Epub 2012 Jan 30. No abstract available.

PMID:
22288936
30.

The sigma-1 receptor: a molecular chaperone for the heart and the soul?

Ehmke H.

Cardiovasc Res. 2012 Jan 1;93(1):6-7. doi: 10.1093/cvr/cvr313. Epub 2011 Nov 23. No abstract available.

PMID:
22116620
31.

Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.

Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T, Boettger T.

Hum Mol Genet. 2012 Mar 1;21(5):1025-36. doi: 10.1093/hmg/ddr533. Epub 2011 Nov 14.

PMID:
22082831
32.

Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.

von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, Tsikas D, D'Alecy LG, Lau D, Willems S, Kubala L, Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku CA, Böger RH, Baldus S, Sydow K.

Circulation. 2011 Dec 13;124(24):2735-45. doi: 10.1161/CIRCULATIONAHA.111.060541. Epub 2011 Nov 14.

PMID:
22082678
33.

Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1.

Schwoerer AP, Zenouzi R, Ehmke H, Friederich P.

Anesth Analg. 2011 Dec;113(6):1365-73. doi: 10.1213/ANE.0b013e3182323245. Epub 2011 Oct 14.

PMID:
22003215
34.

Myeloperoxidase deficiency preserves vasomotor function in humans.

Rudolph TK, Wipper S, Reiter B, Rudolph V, Coym A, Detter C, Lau D, Klinke A, Friedrichs K, Rau T, Pekarova M, Russ D, Knöll K, Kolk M, Schroeder B, Wegscheider K, Andresen H, Schwedhelm E, Boeger R, Ehmke H, Baldus S.

Eur Heart J. 2012 Jul;33(13):1625-34. doi: 10.1093/eurheartj/ehr193. Epub 2011 Jun 30.

35.

Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.

Bott-Flügel L, Bernshausen A, Schneider H, Luppa P, Zimmermann K, Albrecht-Küpper B, Kast R, Laugwitz KL, Ehmke H, Knorr A, Seyfarth M.

PLoS One. 2011 Mar 28;6(3):e18048. doi: 10.1371/journal.pone.0018048.

36.

Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):251-61. Epub 2011 May 1.

37.

Pacemaker activity and ionic currents in mouse atrioventricular node cells.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):241-50. Epub 2011 May 1.

38.

Medicinal leeches for the treatment of venous congestion and hematoma after plastic reconstructive surgery.

Riede F, Koenen W, Goerdt S, Ehmke H, Faulhaber J.

J Dtsch Dermatol Ges. 2010 Nov;8(11):881-8. doi: 10.1111/j.1610-0387.2010.07473.x. English, German.

PMID:
21182735
39.

Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.

El-Armouche A, Schwoerer AP, Neuber C, Emons J, Biermann D, Christalla T, Grundhoff A, Eschenhagen T, Zimmermann WH, Ehmke H.

PLoS One. 2010 Dec 9;5(12):e14263. doi: 10.1371/journal.pone.0014263. Erratum in: PLoS One. 2011;6(7). doi: 10.1371/annotation/45ab2d79-0ce9-4832-a0d1-5274b5a1ddaa. Emmons, Julius [corrected to Emons, Julius].

40.

Myeloperoxidase attracts neutrophils by physical forces.

Klinke A, Nussbaum C, Kubala L, Friedrichs K, Rudolph TK, Rudolph V, Paust HJ, Schröder C, Benten D, Lau D, Szocs K, Furtmüller PG, Heeringa P, Sydow K, Duchstein HJ, Ehmke H, Schumacher U, Meinertz T, Sperandio M, Baldus S.

Blood. 2011 Jan 27;117(4):1350-8. doi: 10.1182/blood-2010-05-284513. Epub 2010 Oct 27.

41.

The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome.

Schwoerer AP, Kebernik J, Ehmke H, Friederich P.

Anesth Analg. 2010 Sep;111(3):638-46. doi: 10.1213/ANE.0b013e3181e41996. Epub 2010 Jul 2.

PMID:
20601449
42.

Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.

Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S.

Nat Med. 2010 Apr;16(4):470-4. doi: 10.1038/nm.2124. Epub 2010 Mar 21.

43.

Larger transient outward K(+) current and shorter action potential duration in Galpha(11) mutant mice.

Wagner M, Rudakova E, Schütz V, Frank M, Ehmke H, Volk T.

Pflugers Arch. 2010 Mar;459(4):607-18. doi: 10.1007/s00424-009-0762-z. Epub 2009 Dec 2.

PMID:
19953263
44.

Molecular and functional remodeling of I(to) by angiotensin II in the mouse left ventricle.

Tozakidou M, Goltz D, Hagenström T, Budack MK, Vitzthum H, Szlachta K, Bähring R, Ehmke H.

J Mol Cell Cardiol. 2010 Jan;48(1):140-51. doi: 10.1016/j.yjmcc.2009.08.027. Epub 2009 Sep 8.

PMID:
19744491
45.

Control of heart rate by cAMP sensitivity of HCN channels.

Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12189-94. doi: 10.1073/pnas.0810332106. Epub 2009 Jul 1.

46.

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.

Benndorf RA, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz OM, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl RA, Böger RH, Wenzel UO.

Kidney Int. 2009 May;75(10):1039-49. doi: 10.1038/ki.2009.2. Epub 2009 Feb 11.

47.

Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects.

Schmechel A, Grimm M, El-Armouche A, Höppner G, Schwoerer AP, Ehmke H, Eschenhagen T.

Cardiovasc Res. 2009 Apr 1;82(1):100-6. doi: 10.1093/cvr/cvp005. Epub 2009 Jan 9.

PMID:
19136528
48.

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.

Schirok H, Kast R, Figueroa-Pérez S, Bennabi S, Gnoth MJ, Feurer A, Heckroth H, Thutewohl M, Paulsen H, Knorr A, Hütter J, Lobell M, Münter K, Geiss V, Ehmke H, Lang D, Radtke M, Mittendorf J, Stasch JP.

ChemMedChem. 2008 Dec;3(12):1893-904. doi: 10.1002/cmdc.200800211.

PMID:
18973168
49.

Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance.

Schwoerer AP, Neuber C, Schmechel A, Melnychenko I, Mearini G, Boknik P, Kirchhefer U, Schmitz W, Ehmke H, Eschenhagen T, El-Armouche A.

J Mol Cell Cardiol. 2008 Dec;45(6):846-52. doi: 10.1016/j.yjmcc.2008.09.003. Epub 2008 Sep 20.

PMID:
18848565
50.

Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization.

Schwoerer AP, Melnychenko I, Goltz D, Hedinger N, Broichhausen I, El-Armouche A, Eschenhagen T, Volk T, Ehmke H.

J Mol Cell Cardiol. 2008 Nov;45(5):633-41. doi: 10.1016/j.yjmcc.2008.02.271. Epub 2008 Mar 10.

PMID:
18721926

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