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Items: 1 to 50 of 128

1.

Quantitating Ligand Bias Using the Competitive Model of Ligand Activity.

Stahl EL, Ehlert FJ, Bohn LM.

Methods Mol Biol. 2019;1957:235-247. doi: 10.1007/978-1-4939-9158-7_15.

PMID:
30919358
2.

Analysis of Biased Agonism.

Ehlert FJ.

Prog Mol Biol Transl Sci. 2018;160:63-104. doi: 10.1016/bs.pmbts.2018.08.001. Epub 2018 Oct 15.

PMID:
30470293
3.

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA Jr, Ostrom RS.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):530-541. doi: 10.1165/rcmb.2017-0294OC.

4.
5.

Cooperativity Has Empirical and Ultimate Levels of Explanation.

Ehlert FJ.

Trends Pharmacol Sci. 2016 Aug;37(8):620-623. doi: 10.1016/j.tips.2016.06.001. Epub 2016 Jun 27.

6.

Functional studies cast light on receptor states.

Ehlert FJ.

Trends Pharmacol Sci. 2015 Sep;36(9):596-604. doi: 10.1016/j.tips.2015.05.008. Epub 2015 Jun 26. Review.

7.

Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.

DiMattio KM, Ehlert FJ, Liu-Chen LY.

Eur J Pharmacol. 2015 Aug 15;761:235-44. doi: 10.1016/j.ejphar.2015.05.054. Epub 2015 Jun 6.

8.

A novel method for analyzing extremely biased agonism at G protein-coupled receptors.

Stahl EL, Zhou L, Ehlert FJ, Bohn LM.

Mol Pharmacol. 2015 May;87(5):866-77. doi: 10.1124/mol.114.096503. Epub 2015 Feb 13.

9.

A kinetic model of GPCRs: analysis of G protein activity, occupancy, coupling and receptor-state affinity constants.

Stein RS, Ehlert FJ.

J Recept Signal Transduct Res. 2015;35(4):269-83. doi: 10.3109/10799893.2014.975250. Epub 2014 Oct 29.

PMID:
25353707
10.

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ.

Pharmacol Rev. 2014 Oct;66(4):918-47. doi: 10.1124/pr.114.008862.

PMID:
25026896
11.

Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias.

Ehlert FJ, Griffin MT.

J Pharmacol Toxicol Methods. 2014 May-Jun;69(3):253-79. doi: 10.1016/j.vascn.2014.01.002. Epub 2014 Jan 13.

13.

What ligand-gated ion channels can tell us about the allosteric regulation of G protein-coupled receptors.

Ehlert FJ.

Prog Mol Biol Transl Sci. 2013;115:291-347. doi: 10.1016/B978-0-12-394587-7.00007-5. Review.

PMID:
23415097
14.

Quantifying agonist activity at G protein-coupled receptors.

Ehlert FJ, Suga H, Griffin MT.

J Vis Exp. 2011 Dec 26;(58):e3179. doi: 10.3791/3179.

15.

Muscarinic agonists and antagonists: effects on gastrointestinal function.

Ehlert FJ, Pak KJ, Griffin MT.

Handb Exp Pharmacol. 2012;(208):343-74. doi: 10.1007/978-3-642-23274-9_15. Review.

PMID:
22222706
16.

Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard.

Yoshida A, Seki M, Nasrin S, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Ehlert FJ, Yamada S.

Urology. 2011 Sep;78(3):721.e7-721.e12. doi: 10.1016/j.urology.2011.05.011. Epub 2011 Jul 20.

PMID:
21777958
17.

Analysis of functional responses at G protein-coupled receptors: estimation of relative affinity constants for the inactive receptor state.

Ehlert FJ, Griffin MT, Suga H.

J Pharmacol Exp Ther. 2011 Aug;338(2):658-70. doi: 10.1124/jpet.111.179291. Epub 2011 May 16.

18.
19.
20.

The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder.

Pak KJ, Ostrom RS, Matsui M, Ehlert FJ.

J Pharmacol Exp Ther. 2010 Oct;335(1):239-48. doi: 10.1124/jpet.110.169995. Epub 2010 Jul 12.

21.

Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard.

Figueroa KW, Suga H, Ehlert FJ.

Br J Pharmacol. 2010 Jul;160(6):1534-49. doi: 10.1111/j.1476-5381.2010.00810.x.

22.

Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.

Pak KJ, Ostrom RS, Matsui M, Ehlert FJ.

Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):441-54. doi: 10.1007/s00210-010-0509-6. Epub 2010 Mar 27.

23.

Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative.

Suga H, Ehlert FJ.

Biochem Pharmacol. 2010 Apr 1;79(7):1025-35. doi: 10.1016/j.bcp.2009.11.005. Epub 2009 Nov 12.

24.

A conserved motif in the membrane proximal C-terminal tail of human muscarinic m1 acetylcholine receptors affects plasma membrane expression.

Sawyer GW, Ehlert FJ, Shults CA.

J Pharmacol Exp Ther. 2010 Jan;332(1):76-86. doi: 10.1124/jpet.109.160986. Epub 2009 Oct 19.

25.

The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum.

Griffin MT, Matsui M, Ostrom RS, Ehlert FJ.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Oct;380(4):327-35. doi: 10.1007/s00210-009-0434-8. Epub 2009 Jul 7.

26.

Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptors.

Tran JA, Chang A, Matsui M, Ehlert FJ.

Mol Pharmacol. 2009 Feb;75(2):381-96. doi: 10.1124/mol.108.051276. Epub 2008 Nov 7.

27.

Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes.

Figueroa KW, Griffin MT, Ehlert FJ.

J Pharmacol Exp Ther. 2009 Jan;328(1):331-42. doi: 10.1124/jpet.108.145219. Epub 2008 Sep 29.

28.

Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor.

Suga H, Figueroa KW, Ehlert FJ.

J Pharmacol Exp Ther. 2008 Nov;327(2):518-28. doi: 10.1124/jpet.108.141234. Epub 2008 Aug 5.

29.

5th International Symposium on receptor mechanisms, signal transduction and drug effects.

Yamada S, Ehlert FJ, Hollenberg MD.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):267-8. doi: 10.1007/s00210-008-0273-z. No abstract available.

PMID:
18357439
30.

Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor.

Ehlert FJ, Griffin MT.

J Pharmacol Exp Ther. 2008 Jun;325(3):1039-60. doi: 10.1124/jpet.108.136960. Epub 2008 Feb 27.

PMID:
18305010
31.

On the analysis of ligand-directed signaling at G protein-coupled receptors.

Ehlert FJ.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):549-77. doi: 10.1007/s00210-008-0260-4. Epub 2008 Feb 6. Review.

PMID:
18253722
32.

Cysteine pairs in the third intracellular loop of the muscarinic m1 acetylcholine receptor play a role in agonist-induced internalization.

Sawyer GW, Ehlert FJ, Shults CA.

J Pharmacol Exp Ther. 2008 Jan;324(1):196-205. Epub 2007 May 31.

PMID:
17540859
33.

Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder.

Ehlert FJ, Ahn S, Pak KJ, Park GJ, Sangnil MS, Tran JA, Matsui M.

J Pharmacol Exp Ther. 2007 Aug;322(2):631-7. Epub 2007 May 1.

PMID:
17473176
34.

Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.

Griffin MT, Figueroa KW, Liller S, Ehlert FJ.

J Pharmacol Exp Ther. 2007 Jun;321(3):1193-207. Epub 2007 Mar 28.

PMID:
17392404
35.
36.

Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system.

Sawyer GW, Ehlert FJ, Hart JP.

J Pharmacol Toxicol Methods. 2006 May-Jun;53(3):219-33. Epub 2005 Oct 5.

PMID:
16213169
37.

Analysis of allosterism in functional assays.

Ehlert FJ.

J Pharmacol Exp Ther. 2005 Nov;315(2):740-54. Epub 2005 Jul 26.

PMID:
16046613
38.

The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder.

Ehlert FJ, Griffin MT, Abe DM, Vo TH, Taketo MM, Manabe T, Matsui M.

J Pharmacol Exp Ther. 2005 Apr;313(1):368-78. Epub 2004 Dec 17.

PMID:
15608083
39.

Functional analysis of muscarinic acetylcholine receptors using knockout mice.

Matsui M, Yamada S, Oki T, Manabe T, Taketo MM, Ehlert FJ.

Life Sci. 2004 Nov 5;75(25):2971-81. Review.

PMID:
15474550
40.

Comparison of the antimuscarinic action of p-fluorohexahydrosiladifenidol in ileal and tracheal smooth muscle.

Ehlert FJ, Hsu JC, Leung K, Lee AG, Shehnaz D, Griffin MT.

J Pharmacol Exp Ther. 2005 Feb;312(2):592-600. Epub 2004 Sep 29.

PMID:
15456838
41.
42.

Muscarinic agonist-mediated heterologous desensitization in isolated ileum requires activation of both muscarinic M2 and M3 receptors.

Griffin MT, Matsui M, Shehnaz D, Ansari KZ, Taketo MM, Manabe T, Ehlert FJ.

J Pharmacol Exp Ther. 2004 Jan;308(1):339-49. Epub 2003 Oct 16.

PMID:
14563784
43.
44.

Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination.

Griffin MT, Hsu JC, Shehnaz D, Ehlert FJ.

Biochem Pharmacol. 2003 Apr 15;65(8):1227-41.

PMID:
12694864
45.

Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice.

Matsui M, Griffin MT, Shehnaz D, Taketo MM, Ehlert FJ.

J Pharmacol Exp Ther. 2003 Apr;305(1):106-13.

PMID:
12649358
46.
47.

Acetylcholine-induced desensitization of muscarinic contractile response in Guinea pig ileum is inhibited by pertussis toxin treatment.

Ehlert FJ, Ansari KZ, Shehnaz D, Sawyer GW, Griffin MT.

J Pharmacol Exp Ther. 2001 Dec;299(3):1126-32.

PMID:
11714903
49.

Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.

Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY.

Mol Pharmacol. 2001 Apr;59(4):692-8.

PMID:
11259612
50.

Human urotensin II mediates vasoconstriction via an increase in inositol phosphates.

Saetrum Opgaard O, Nothacker H, Ehlert FJ, Krause DN.

Eur J Pharmacol. 2000 Oct 13;406(2):265-71.

PMID:
11020490

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