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Items: 1 to 50 of 113

1.

How to develop therapeutic and translational research collaborations with industry.

Kleiman RJ, Ehlers MD.

Mol Biol Cell. 2019 Oct 15;30(22):2741-2743. doi: 10.1091/mbc.E19-05-0261.

PMID:
31609671
2.

The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.

Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM, Corrêa SAL.

Neuron. 2018 Jun 27;98(6):1124-1132.e7. doi: 10.1016/j.neuron.2018.05.012. Epub 2018 May 31.

3.

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.

Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ.

Nature. 2018 May;557(7704):177-182. doi: 10.1038/s41586-018-0090-6. Epub 2018 May 2.

4.

Neuroscience is the Next Oncology.

Ehlers MD.

Innov Clin Neurosci. 2018 Apr 1;15(3-4):15-16. No abstract available.

5.

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

Gray DL, Allen JA, Mente S, O'Connor RE, DeMarco GJ, Efremov I, Tierney P, Volfson D, Davoren J, Guilmette E, Salafia M, Kozak R, Ehlers MD.

Nat Commun. 2018 Feb 14;9(1):674. doi: 10.1038/s41467-017-02776-7.

6.

Peripheral Activity and Central Substrates of BACE1: Therapeutic Implications for Alzheimer's Disease.

Ehlers MD.

Biol Psychiatry. 2018 Mar 1;83(5):393-394. doi: 10.1016/j.biopsych.2017.12.005. No abstract available.

PMID:
29420953
7.

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.

Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD.

Nat Commun. 2017 Dec 4;8(1):1908. doi: 10.1038/s41467-017-02044-8.

8.

Arc ubiquitination in synaptic plasticity.

Mabb AM, Ehlers MD.

Semin Cell Dev Biol. 2018 May;77:10-16. doi: 10.1016/j.semcdb.2017.09.009. Epub 2017 Sep 7. Review.

PMID:
28890418
9.

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons.

Chung CG, Kwon MJ, Jeon KH, Hyeon DY, Han MH, Park JH, Cha IJ, Cho JH, Kim K, Rho S, Kim GR, Jeong H, Lee JW, Kim T, Kim K, Kim KP, Ehlers MD, Hwang D, Lee SB.

Cell Rep. 2017 Jul 11;20(2):356-369. doi: 10.1016/j.celrep.2017.06.059.

10.

The Mind Bending Quest for Cognitive Enhancers.

Arce E, Ehlers MD.

Clin Pharmacol Ther. 2017 Feb;101(2):179-181. doi: 10.1002/cpt.524. Epub 2016 Nov 24.

11.

Lessons from a Recovering Academic.

Ehlers MD.

Cell. 2016 May 19;165(5):1043-1048. doi: 10.1016/j.cell.2016.05.005.

12.

Specialization of biosynthetic membrane trafficking for neuronal form and function.

Hanus C, Ehlers MD.

Curr Opin Neurobiol. 2016 Aug;39:8-16. doi: 10.1016/j.conb.2016.03.004. Epub 2016 Mar 22. Review.

PMID:
27010827
13.

Data gaps limit the translational potential of preclinical research.

Kleiman RJ, Ehlers MD.

Sci Transl Med. 2016 Jan 6;8(320):320ps1. doi: 10.1126/scitranslmed.aac9888. Review.

PMID:
26738793
14.

Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.

Wang Q, Amato SP, Rubitski DM, Hayward MM, Kormos BL, Verhoest PR, Xu L, Brandon NJ, Ehlers MD.

J Pharmacol Exp Ther. 2016 Feb;356(2):410-23. doi: 10.1124/jpet.115.229880. Epub 2015 Dec 8.

PMID:
26645429
15.

Opportunities for New Drug Development in Psychiatry: A Glass Half-Full.

O'Donnell P, Ehlers MD.

JAMA Psychiatry. 2015 Nov;72(11):1067-8. doi: 10.1001/jamapsychiatry.2015.1735. No abstract available.

PMID:
26421731
16.

Digital technologies for cognitive assessment to accelerate drug development in Alzheimer's disease.

Leurent C, Ehlers MD.

Clin Pharmacol Ther. 2015 Nov;98(5):475-6. doi: 10.1002/cpt.212. Epub 2015 Sep 8. Review.

17.

Translating Neurogenomics Into New Medicines.

Wendland JR, Ehlers MD.

Biol Psychiatry. 2016 Apr 15;79(8):650-6. doi: 10.1016/j.biopsych.2015.04.027. Epub 2015 May 27. Review.

18.

Visual impairment in an optineurin mouse model of primary open-angle glaucoma.

Tseng HC, Riday TT, McKee C, Braine CE, Bomze H, Barak I, Marean-Reardon C, John SW, Philpot BD, Ehlers MD.

Neurobiol Aging. 2015 Jun;36(6):2201-12. doi: 10.1016/j.neurobiolaging.2015.02.012. Epub 2015 Feb 27.

19.

Organization of TNIK in dendritic spines.

Burette AC, Phend KD, Burette S, Lin Q, Liang M, Foltz G, Taylor N, Wang Q, Brandon NJ, Bates B, Ehlers MD, Weinberg RJ.

J Comp Neurol. 2015 Sep 1;523(13):1913-24. doi: 10.1002/cne.23770. Epub 2015 Jul 1.

20.

Triad3A regulates synaptic strength by ubiquitination of Arc.

Mabb AM, Je HS, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, Ehlers MD.

Neuron. 2014 Jun 18;82(6):1299-316. doi: 10.1016/j.neuron.2014.05.016.

21.

Synaptic control of secretory trafficking in dendrites.

Hanus C, Kochen L, Tom Dieck S, Racine V, Sibarita JB, Schuman EM, Ehlers MD.

Cell Rep. 2014 Jun 26;7(6):1771-8. doi: 10.1016/j.celrep.2014.05.028. Epub 2014 Jun 12.

22.

Age-related homeostatic midchannel proteolysis of neuronal L-type voltage-gated Ca²⁺ channels.

Michailidis IE, Abele-Henckels K, Zhang WK, Lin B, Yu Y, Geyman LS, Ehlers MD, Pnevmatikakis EA, Yang J.

Neuron. 2014 Jun 4;82(5):1045-57. doi: 10.1016/j.neuron.2014.04.017.

23.

Breaching the blood-brain barrier for drug delivery.

Bell RD, Ehlers MD.

Neuron. 2014 Jan 8;81(1):1-3. doi: 10.1016/j.neuron.2013.12.023.

24.

Dendritic trafficking for neuronal growth and plasticity.

Ehlers MD.

Biochem Soc Trans. 2013 Dec;41(6):1365-82. doi: 10.1042/BST20130081. Review.

PMID:
24256224
25.

Modeling autism by SHANK gene mutations in mice.

Jiang YH, Ehlers MD.

Neuron. 2013 Apr 10;78(1):8-27. doi: 10.1016/j.neuron.2013.03.016. Review.

26.

The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation.

Condon KH, Ho J, Robinson CG, Hanus C, Ehlers MD.

J Neurosci. 2013 Feb 27;33(9):3799-814. doi: 10.1523/JNEUROSCI.1930-11.2013.

27.

New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking.

Takatoh J, Nelson A, Zhou X, Bolton MM, Ehlers MD, Arenkiel BR, Mooney R, Wang F.

Neuron. 2013 Jan 23;77(2):346-60. doi: 10.1016/j.neuron.2012.11.010.

28.

Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.

Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD.

Neuron. 2012 Oct 18;76(2):396-409. doi: 10.1016/j.neuron.2012.07.006. Epub 2012 Oct 17. Erratum in: Neuron. 2012 Nov 8;76(3):667.

29.

Mining and modeling human genetics for autism therapeutics.

Smith DG, Ehlers MD.

Curr Opin Neurobiol. 2012 Oct;22(5):902-10. doi: 10.1016/j.conb.2012.03.004. Epub 2012 Apr 4. Review.

PMID:
22483267
30.

Transient activation of specific neurons in mice by selective expression of the capsaicin receptor.

Güler AD, Rainwater A, Parker JG, Jones GL, Argilli E, Arenkiel BR, Ehlers MD, Bonci A, Zweifel LS, Palmiter RD.

Nat Commun. 2012 Mar 20;3:746. doi: 10.1038/ncomms1749.

31.

Hijacking hebb: noninvasive methods to probe plasticity in psychiatric disease.

Ehlers MD.

Biol Psychiatry. 2012 Mar 15;71(6):484-6. doi: 10.1016/j.biopsych.2012.01.001. No abstract available.

PMID:
22364737
32.

Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites.

Cui-Wang T, Hanus C, Cui T, Helton T, Bourne J, Watson D, Harris KM, Ehlers MD.

Cell. 2012 Jan 20;148(1-2):309-21. doi: 10.1016/j.cell.2011.11.056.

33.

Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing.

Arenkiel BR, Hasegawa H, Yi JJ, Larsen RS, Wallace ML, Philpot BD, Wang F, Ehlers MD.

PLoS One. 2011;6(12):e29423. doi: 10.1371/journal.pone.0029423. Epub 2011 Dec 28.

34.

Membrane trafficking and cytoskeletal dynamics in neuronal function.

Blanpied TA, Ehlers MD.

Mol Cell Neurosci. 2011 Dec;48(4):267-8. doi: 10.1016/j.mcn.2011.09.006. No abstract available.

PMID:
22035734
35.

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.

Wang X, McCoy PA, Rodriguiz RM, Pan Y, Je HS, Roberts AC, Kim CJ, Berrios J, Colvin JS, Bousquet-Moore D, Lorenzo I, Wu G, Weinberg RJ, Ehlers MD, Philpot BD, Beaudet AL, Wetsel WC, Jiang YH.

Hum Mol Genet. 2011 Aug 1;20(15):3093-108. doi: 10.1093/hmg/ddr212. Epub 2011 May 10.

36.

Neural circuit mechanisms for pattern detection and feature combination in olfactory cortex.

Davison IG, Ehlers MD.

Neuron. 2011 Apr 14;70(1):82-94. doi: 10.1016/j.neuron.2011.02.047.

37.

Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors.

Gray SJ, Foti SB, Schwartz JW, Bachaboina L, Taylor-Blake B, Coleman J, Ehlers MD, Zylka MJ, McCown TJ, Samulski RJ.

Hum Gene Ther. 2011 Sep;22(9):1143-53. doi: 10.1089/hum.2010.245. Epub 2011 Jun 1.

38.

Mechanisms and function of dendritic exocytosis.

Kennedy MJ, Ehlers MD.

Neuron. 2011 Mar 10;69(5):856-75. doi: 10.1016/j.neuron.2011.02.032. Review.

39.

Rapid blue-light-mediated induction of protein interactions in living cells.

Kennedy MJ, Hughes RM, Peteya LA, Schwartz JW, Ehlers MD, Tucker CL.

Nat Methods. 2010 Dec;7(12):973-5. doi: 10.1038/nmeth.1524. Epub 2010 Oct 31.

40.

Neuronal and glial cell biology.

Ehlers MD, Polleux F.

Curr Opin Neurobiol. 2010 Oct;20(5):529-30. doi: 10.1016/j.conb.2010.06.004. Epub 2010 Aug 2. No abstract available.

PMID:
20678922
41.

Metaplasticity at single glutamatergic synapses.

Lee MC, Yasuda R, Ehlers MD.

Neuron. 2010 Jun 24;66(6):859-70. doi: 10.1016/j.neuron.2010.05.015.

42.

Ubiquitination in postsynaptic function and plasticity.

Mabb AM, Ehlers MD.

Annu Rev Cell Dev Biol. 2010;26:179-210. doi: 10.1146/annurev-cellbio-100109-104129. Review.

43.

TGF-beta signaling specifies axons during brain development.

Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD.

Cell. 2010 Jul 9;142(1):144-57. doi: 10.1016/j.cell.2010.06.010.

44.

Parallel on-axis holographic phase microscopy of biological cells and unicellular microorganism dynamics.

Shaked NT, Newpher TM, Ehlers MD, Wax A.

Appl Opt. 2010 May 20;49(15):2872-8. doi: 10.1364/AO.49.002872.

PMID:
20490249
45.

Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines.

Kennedy MJ, Davison IG, Robinson CG, Ehlers MD.

Cell. 2010 Apr 30;141(3):524-35. doi: 10.1016/j.cell.2010.02.042.

46.

Molecular genetics and imaging technologies for circuit-based neuroanatomy.

Arenkiel BR, Ehlers MD.

Nature. 2009 Oct 15;461(7266):900-7. doi: 10.1038/nature08536. Review.

47.

Signalling mechanisms.

Ehlers MD, Turrigiano G.

Curr Opin Neurobiol. 2009 Jun;19(3):235-6. doi: 10.1016/j.conb.2009.07.004. Epub 2009 Aug 7. No abstract available.

48.

Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation.

Petrini EM, Lu J, Cognet L, Lounis B, Ehlers MD, Choquet D.

Neuron. 2009 Jul 16;63(1):92-105. doi: 10.1016/j.neuron.2009.05.025.

49.

Ube3a is required for experience-dependent maturation of the neocortex.

Yashiro K, Riday TT, Condon KH, Roberts AC, Bernardo DR, Prakash R, Weinberg RJ, Ehlers MD, Philpot BD.

Nat Neurosci. 2009 Jun;12(6):777-83. doi: 10.1038/nn.2327. Epub 2009 May 10.

50.

Spine microdomains for postsynaptic signaling and plasticity.

Newpher TM, Ehlers MD.

Trends Cell Biol. 2009 May;19(5):218-27. doi: 10.1016/j.tcb.2009.02.004. Epub 2009 Mar 28. Review.

PMID:
19328694

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