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Targeted metabolome analysis of the dog brain exposed to PCBs suggests inhibition of oxidative phosphorylation by hydroxylated PCBs.

Nomiyama K, Eguchi A, Takaguchi K, Yoo J, Mizukawa H, Oshihoi T, Tanabe S, Iwata H.

Toxicol Appl Pharmacol. 2019 Jun 10:114620. doi: 10.1016/j.taap.2019.114620. [Epub ahead of print]


Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis.

Povero D, Pinatel EM, Leszczynska A, Goyal NP, Nishio T, Kim J, Kneiber D, de Araujo Horcel L, Eguchi A, Ordonez PM, Kisseleva T, Feldstein AE.

JCI Insight. 2019 Jun 11;5. pii: 125652. doi: 10.1172/jci.insight.125652.


Serum Liver-Type Fatty Acid-Binding Protein Is a Possible Prognostic Factor in Human Chronic Liver Diseases From Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma.

Eguchi A, Hasegawa H, Iwasa M, Tamai Y, Ohata K, Oikawa T, Sugaya T, Takei Y.

Hepatol Commun. 2019 Apr 2;3(6):825-837. doi: 10.1002/hep4.1350. eCollection 2019 Jun.


Ionic Liquid Chelate Extraction Behavior of Trivalent Group 13 Metals into 1-Alkyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)imides Using 8-Quinolinol as Chelating Extractant.

Eguchi A, Morita K, Hirayama N.

Anal Sci. 2019 May 24. doi: 10.2116/analsci.19P132. [Epub ahead of print] No abstract available.


Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study.

Kimura N, Aso Y, Yabuuchi K, Ishibashi M, Hori D, Sasaki Y, Nakamichi A, Uesugi S, Fujioka H, Iwao S, Jikumaru M, Katayama T, Sumi K, Eguchi A, Nonaka S, Kakumu M, Matsubara E.

Front Neurol. 2019 Apr 24;10:401. doi: 10.3389/fneur.2019.00401. eCollection 2019.


Extracellular vesicles, the liquid biopsy of the future.

Eguchi A, Kostallari E, Feldstein AE, Shah VH.

J Hepatol. 2019 Jun;70(6):1292-1294. doi: 10.1016/j.jhep.2019.01.030. Epub 2019 Apr 12. No abstract available.


The relationship of maternal PCB, toxic, and essential trace element exposure levels with birth weight and head circumference in Chiba, Japan.

Eguchi A, Yanase K, Yamamoto M, Sakurai K, Watanabe M, Todaka E, Mori C.

Environ Sci Pollut Res Int. 2019 May;26(15):15677-15684. doi: 10.1007/s11356-019-05009-0. Epub 2019 Apr 4.


An epitope-directed antibody affinity maturation system utilizing mammalian cell survival as readout.

Eguchi A, Nakakido M, Nagatoishi S, Kuroda D, Tsumoto K, Nagamune T, Kawahara M.

Biotechnol Bioeng. 2019 Jul;116(7):1742-1751. doi: 10.1002/bit.26965. Epub 2019 Mar 29.


Circulating Extracellular Vesicles and Their miR "Barcode" Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients.

Eguchi A, Franz N, Kobayashi Y, Iwasa M, Wagner N, Hildebrand F, Takei Y, Marzi I, Relja B.

Front Med (Lausanne). 2019 Feb 25;6:30. doi: 10.3389/fmed.2019.00030. eCollection 2019.


Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS).

Yamamoto M, Sakurai K, Eguchi A, Yamazaki S, Nakayama SF, Isobe T, Takeuchi A, Sato T, Hata A, Mori C, Nitta H; Japan Environment and Children's Study Group:.

Environ Res. 2019 May;172:117-126. doi: 10.1016/j.envres.2019.02.007. Epub 2019 Feb 8.


Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour.

Tanoue R, Margiotta-Casaluci L, Huerta B, Runnalls TJ, Eguchi A, Nomiyama K, Kunisue T, Tanabe S, Sumpter JP.

Sci Total Environ. 2019 May 10;664:915-926. doi: 10.1016/j.scitotenv.2019.02.090. Epub 2019 Feb 6.


Risk Factors for Severe Dry Eye Disease: Crowdsourced Research Using DryEyeRhythm.

Inomata T, Nakamura M, Iwagami M, Shiang T, Yoshimura Y, Fujimoto K, Okumura Y, Eguchi A, Iwata N, Miura M, Hori S, Hiratsuka Y, Uchino M, Tsubota K, Dana R, Murakami A.

Ophthalmology. 2019 May;126(5):766-768. doi: 10.1016/j.ophtha.2018.12.013. Epub 2018 Dec 11. No abstract available.


Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases.

Eguchi A, Feldstein AE.

Liver Res. 2018 Mar;2(1):30-34. doi: 10.1016/j.livres.2018.01.001. Epub 2018 Feb 28.


Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis.

Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson CD, Dasgupta S, Hernandez CD, Nguyen PS, Swafford AD, Knight R, Feldstein AE, Loomba R, Kumar V.

J Immunol. 2018 Nov 15;201(10):3017-3035. doi: 10.4049/jimmunol.1800614. Epub 2018 Oct 15.


Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis.

Dissanayake E, Inoue Y, Ochiai S, Eguchi A, Nakano T, Yamaide F, Hasegawa S, Kojima H, Suzuki H, Mori C, Kohno Y, Taniguchi M, Shimojo N.

J Allergy Clin Immunol. 2019 Jan;143(1):447-450.e11. doi: 10.1016/j.jaci.2018.09.024. Epub 2018 Oct 9. No abstract available.


Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats.

Nakamura M, Eguchi A, Inohana M, Nagahara R, Murayama H, Kawashima M, Mizukami S, Koyanagi M, Hayashi SM, Maronpot RR, Shibutani M, Yoshida T.

J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.


Recent Progress on Cyclic Nitrenoid Precursors in Transition-Metal-Catalyzed Nitrene-Transfer Reactions.

Shimbayashi T, Sasakura K, Eguchi A, Okamoto K, Ohe K.

Chemistry. 2019 Mar 1;25(13):3156-3180. doi: 10.1002/chem.201803716. Epub 2018 Dec 14. Review.


New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging.

de Lucia C, Eguchi A, Koch WJ.

Front Pharmacol. 2018 Aug 10;9:904. doi: 10.3389/fphar.2018.00904. eCollection 2018. Review.


A case of rapid recurrence of apocrine ductal carcinoma originating from the oral scent gland of a Richardson's ground squirrel (Urocitellus richardsonii).

Eguchi A, Inohana M, Nakamura M, Nagahara R, Itahashi M, Nakajima K, Yoshida T, Shibutani M.

J Toxicol Pathol. 2018 Jul;31(3):189-193. doi: 10.1293/tox.2017-0071. Epub 2018 Mar 29.


Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice.

Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE.

J Lipid Res. 2018 Sep;59(9):1597-1609. doi: 10.1194/jlr.M083741. Epub 2018 Jul 3.


Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis.

Kawamoto E, Masui-Ito A, Eguchi A, Soe ZY, Prajuabjinda O, Darkwah S, Park EJ, Imai H, Shimaoka M.

Shock. 2019 Jul;52(1):13-22. doi: 10.1097/SHK.0000000000001228.


Ratio between estimated glomerular filtration rates of creatinine and cystatin C predicts overall survival in patients with hepatocellular carcinoma.

Tamai Y, Iwasa M, Kawasaki Y, Yoshizawa N, Ogura S, Sugimoto R, Eguchi A, Yamamoto N, Sugimoto K, Hasegawa H, Takei Y.

Hepatol Res. 2019 Feb;49(2):153-163. doi: 10.1111/hepr.13230. Epub 2018 Aug 12.


Alterations in urinary metabolomic profiles due to lead exposure from a lead-acid battery recycling site.

Eguchi A, Nomiyama K, Sakurai K, Kim Trang PT, Viet PH, Takahashi S, Iwata H, Tanabe S, Todaka E, Mori C.

Environ Pollut. 2018 Nov;242(Pt A):98-105. doi: 10.1016/j.envpol.2018.06.071. Epub 2018 Jun 26.


Exploration of predictive metabolic factors for gestational diabetes mellitus in Japanese women using metabolomic analysis.

Sakurai K, Eguchi A, Watanabe M, Yamamoto M, Ishikawa K, Mori C.

J Diabetes Investig. 2019 Mar;10(2):513-520. doi: 10.1111/jdi.12887. Epub 2018 Aug 31.


A new approach to solving the feature-binding problem in primate vision.

Isbister JB, Eguchi A, Ahmad N, Galeazzi JM, Buckley MJ, Stringer S.

Interface Focus. 2018 Aug 6;8(4):20180021. doi: 10.1098/rsfs.2018.0021. Epub 2018 Jun 15.


Circulating extracellular vesicles are associated with lipid and insulin metabolism.

Kobayashi Y, Eguchi A, Tempaku M, Honda T, Togashi K, Iwasa M, Hasegawa H, Takei Y, Sumida Y, Taguchi O.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E574-E582. doi: 10.1152/ajpendo.00160.2018. Epub 2018 Jun 26.


The emergence of polychronization and feature binding in a spiking neural network model of the primate ventral visual system.

Eguchi A, Isbister JB, Ahmad N, Stringer S.

Psychol Rev. 2018 Jul;125(4):545-571. doi: 10.1037/rev0000103. Epub 2018 Jun 4.


Spironolactone in Combination with α-glycosyl Isoquercitrin Prevents Steatosis-related Early Hepatocarcinogenesis in Rats through the Observed NADPH Oxidase Modulation.

Murayama H, Eguchi A, Nakamura M, Kawashima M, Nagahara R, Mizukami S, Kimura M, Makino E, Takahashi N, Ohtsuka R, Koyanagi M, Hayashi SM, Maronpot RR, Shibutani M, Yoshida T.

Toxicol Pathol. 2018 Jul;46(5):530-539. doi: 10.1177/0192623318778508. Epub 2018 May 29.


Extraction Ability of 4-Benzoyl-3-phenyl-5-isoxazolone towards 4f-Ions into Ionic and Molecular Media.

Atanassova M, Okamura H, Eguchi A, Ueda Y, Sugita T, Shimojo K.

Anal Sci. 2018 Aug 10;34(8):973-978. doi: 10.2116/analsci.18P166. Epub 2018 May 18.


Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation.

Eguchi A, Koyama Y, Wree A, Johnson CD, Nakamura R, Povero D, Kneiber D, Tameda M, Contreras P, Spada A, Feldstein AE.

J Mol Med (Berl). 2018 Jun;96(6):575-583. doi: 10.1007/s00109-018-1642-9. Epub 2018 May 5.


Developmental Exposure to Aluminum Chloride Irreversibly Affects Postnatal Hippocampal Neurogenesis Involving Multiple Functions in Mice.

Inohana M, Eguchi A, Nakamura M, Nagahara R, Onda N, Nakajima K, Saegusa Y, Yoshida T, Shibutani M.

Toxicol Sci. 2018 Jul 1;164(1):264-277. doi: 10.1093/toxsci/kfy081.


Fluorescence tumor imaging by i.v. administered indocyanine green in a mouse model of colitis-associated colon cancer.

Nagahara R, Onda N, Yamashita S, Kojima M, Inohana M, Eguchi A, Nakamura M, Matsumoto S, Yoshida T, Shibutani M.

Cancer Sci. 2018 May;109(5):1638-1647. doi: 10.1111/cas.13564. Epub 2018 Apr 19.


Choroid plexus carcinoma with neuronal and glial differentiation in a 7-week-old male Sprague-Dawley rat.

Inohana M, Eguchi A, Nakamura M, Nagahara R, Watanabe Y, Yoshida T, Shibutani M.

J Vet Med Sci. 2018 Apr 18;80(4):611-615. doi: 10.1292/jvms.17-0644. Epub 2018 Feb 16.


Fetal exposure markers of dioxins and dioxin-like PCBs.

Lampa E, Eguchi A, Todaka E, Mori C.

Environ Sci Pollut Res Int. 2018 Apr;25(12):11940-11947. doi: 10.1007/s11356-018-1447-y. Epub 2018 Feb 15.


Neutrophil gelatinase-associated lipocalin level is a prognostic factor for survival in rat and human chronic liver diseases.

Yoshikawa K, Iwasa M, Eguchi A, Kojima S, Yoshizawa N, Tempaku M, Sugimoto R, Yamamoto N, Sugimoto K, Kobayashi Y, Hasegawa H, Takei Y.

Hepatol Commun. 2017 Oct 16;1(9):946-956. doi: 10.1002/hep4.1109. eCollection 2017 Nov.


Reprogramming cell fate with artificial transcription factors.

Heiderscheit EA, Eguchi A, Spurgat MC, Ansari AZ.

FEBS Lett. 2018 Mar;592(6):888-900. doi: 10.1002/1873-3468.12993. Epub 2018 Feb 11. Review.


In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells.

Tamura Y, Takata K, Eguchi A, Kataoka Y.

Sci Rep. 2018 Jan 10;8(1):393. doi: 10.1038/s41598-017-18763-3.


Intermediate-grade mammary gland adenocarcinoma in an 18-year-old female black leopard (Panthera pardus) with acute pancreatic necrosis and chronic interstitial nephropathy.

Nakamura M, Yoshida T, Eguchi A, Inohana M, Nagahara R, Shiraki A, Ito N, Shibutani M.

J Vet Med Sci. 2018 Mar 2;80(2):337-340. doi: 10.1292/jvms.17-0570. Epub 2017 Dec 19.


Dietary Habits and Cooking Methods Could Reduce Avoidable Exposure to PCBs in Maternal and Cord Sera.

Jin W, Otake M, Eguchi A, Sakurai K, Nakaoka H, Watanabe M, Todaka E, Mori C.

Sci Rep. 2017 Dec 11;7(1):17357. doi: 10.1038/s41598-017-17656-9.


Synthetic transcription elongation factors license transcription across repressive chromatin.

Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ.

Science. 2017 Dec 22;358(6370):1617-1622. doi: 10.1126/science.aan6414. Epub 2017 Nov 30.


Asymmetric Synthesis of 2H-Azirines with a Tetrasubstituted Stereocenter by Enantioselective Ring Contraction of Isoxazoles.

Okamoto K, Nanya A, Eguchi A, Ohe K.

Angew Chem Int Ed Engl. 2018 Jan 22;57(4):1039-1043. doi: 10.1002/anie.201710920. Epub 2017 Dec 12.


Changes in liver function and body composition by direct-acting antiviral therapy for hepatitis C virus infection.

Sugimoto R, Iwasa M, Hara N, Tamai Y, Yoshikawa K, Ogura S, Tanaka H, Eguchi A, Yamamoto N, Kobayashi Y, Hasegawa H, Takei Y.

Hepatol Res. 2018 Apr;48(5):337-344. doi: 10.1111/hepr.12999. Epub 2017 Dec 6.


Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers.

Hagopian JC, Hamil AS, van den Berg A, Meade BR, Eguchi A, Palm-Apergi C, Dowdy SF.

Nucleic Acid Ther. 2017 Oct;27(5):260-271. doi: 10.1089/nat.2017.0686. Epub 2017 Sep 21.


NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice.

Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE.

Hepatology. 2017 Sep 13. doi: 10.1002/hep.29523. [Epub ahead of print]


Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance.

Miki T, Lee EY, Eguchi A, Sakurai K, Sawabe Y, Yoshida T, Saito K, Yokoh H, Ishikawa K, Yokote K, Kuzuya T, Miki E, Mori C, Nomura F.

J Diabetes Investig. 2017 Aug 2. doi: 10.1111/jdi.12719. [Epub ahead of print]


Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.

Naito Y, Sawada H, Oboshi M, Okuno K, Yasumura S, Okuhara Y, Eguchi A, Nishimura K, Soyama Y, Asakura M, Ishihara M, Tsujino T, Masuyama T.

Heart Vessels. 2017 Nov;32(11):1410-1414. doi: 10.1007/s00380-017-1013-4. Epub 2017 Jul 1.


Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity.

Okuhara Y, Yokoe S, Iwasaku T, Eguchi A, Nishimura K, Li W, Oboshi M, Naito Y, Mano T, Asahi M, Okamura H, Masuyama T, Hirotani S.

Int J Cardiol. 2017 Sep 15;243:396-403. doi: 10.1016/j.ijcard.2017.04.082. Epub 2017 May 4.


The methylation levels of the H19 differentially methylated region in human umbilical cords reflect newborn parameters and changes by maternal environmental factors during early pregnancy.

Miyaso H, Sakurai K, Takase S, Eguchi A, Watanabe M, Fukuoka H, Mori C.

Environ Res. 2017 Aug;157:1-8. doi: 10.1016/j.envres.2017.05.006. Epub 2017 May 10.

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