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Items: 1 to 50 of 68

1.

Aflatoxin-guanine DNA Adducts and Oxidatively-induced DNA Damage in Aflatoxin-treated Mice in vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope-dilution.

Coskun E, Jaruga P, Vartanian V, Erdem O, Egner PA, Groopman JD, Lloyd RS, Dizdaroglu M.

Chem Res Toxicol. 2018 Dec 11. doi: 10.1021/acs.chemrestox.8b00202. [Epub ahead of print]

PMID:
30525498
2.

Aflatoxin exposure in children living in Mirpur, Dhaka: data from MAL-ED companion study.

Mahfuz M, Alam MA, Fahim SM, Gazi MA, Raihan MJ, Hossain M, Egner PA, Bessong PO, Petri WA, Groopman JD, Ahmed T.

J Expo Sci Environ Epidemiol. 2018 Sep 5. doi: 10.1038/s41370-018-0066-5. [Epub ahead of print]

PMID:
30185944
3.

The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.).

Fahey JW, Olson ME, Stephenson KK, Wade KL, Chodur GM, Odee D, Nouman W, Massiah M, Alt J, Egner PA, Hubbard WC.

Sci Rep. 2018 May 22;8(1):7994. doi: 10.1038/s41598-018-26058-4.

4.

Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania.

Chen C, Mitchell NJ, Gratz J, Houpt ER, Gong Y, Egner PA, Groopman JD, Riley RT, Showker JL, Svensen E, Mduma ER, Patil CL, Wu F.

Environ Int. 2018 Jun;115:29-37. doi: 10.1016/j.envint.2018.03.001. Epub 2018 Mar 13.

5.

Aflatoxin and viral hepatitis exposures in Guatemala: Molecular biomarkers reveal a unique profile of risk factors in a region of high liver cancer incidence.

Smith JW, Kroker-Lobos MF, Lazo M, Rivera-Andrade A, Egner PA, Wedemeyer H, Torres O, Freedman ND, McGlynn KA, Guallar E, Groopman JD, Ramirez-Zea M.

PLoS One. 2017 Dec 13;12(12):e0189255. doi: 10.1371/journal.pone.0189255. eCollection 2017.

6.

Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.

Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM.

Toxicol Sci. 2017 Nov 1;160(1):173-179. doi: 10.1093/toxsci/kfx171.

7.

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.

Vartanian V, Minko IG, Chawanthayatham S, Egner PA, Lin YC, Earley LF, Makar R, Eng JR, Camp MT, Li L, Stone MP, Lasarev MR, Groopman JD, Croy RG, Essigmann JM, McCullough AK, Lloyd RS.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4207-4212. doi: 10.1073/pnas.1620932114. Epub 2017 Apr 3.

8.

Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study.

Mitchell NJ, Hsu HH, Chandyo RK, Shrestha B, Bodhidatta L, Tu YK, Gong YY, Egner PA, Ulak M, Groopman JD, Wu F.

PLoS One. 2017 Feb 17;12(2):e0172124. doi: 10.1371/journal.pone.0172124. eCollection 2017.

9.

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.

Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE.

Cancer Prev Res (Phila). 2016 Jul;9(7):547-57. doi: 10.1158/1940-6207.CAPR-15-0290. Epub 2016 Jun 23.

10.

Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.

Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.

Toxicol Sci. 2016 Jul;152(1):40-52. doi: 10.1093/toxsci/kfw065. Epub 2016 Apr 12.

11.

Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study.

Mitchell NJ, Riley RT, Egner PA, Groopman JD, Wu F.

J Expo Sci Environ Epidemiol. 2017 Jan;27(1):106-111. doi: 10.1038/jes.2015.87. Epub 2016 Jan 6.

PMID:
26732375
12.

Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance.

Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA.

Pediatr Res. 2015 Aug;78(2):120-7. doi: 10.1038/pr.2015.84. Epub 2015 May 4.

13.

Aflatoxin exposure during the first 1000 days of life in rural South Asia assessed by aflatoxin B₁-lysine albumin biomarkers.

Groopman JD, Egner PA, Schulze KJ, Wu LS, Merrill R, Mehra S, Shamim AA, Ali H, Shaikh S, Gernand A, Khatry SK, LeClerq SC, West KP Jr, Christian P.

Food Chem Toxicol. 2014 Dec;74:184-9. doi: 10.1016/j.fct.2014.09.016. Epub 2014 Oct 13.

14.

Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.

Chawanthayatham S, Thiantanawat A, Egner PA, Groopman JD, Wogan GN, Croy RG, Essigmann JM.

Int J Cancer. 2015 Mar 15;136(6):1254-62. doi: 10.1002/ijc.29102. Epub 2014 Aug 7.

15.

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.

16.

Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice.

Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA.

Toxicol Sci. 2014 Jun;139(2):293-300. doi: 10.1093/toxsci/kfu056. Epub 2014 Mar 27.

17.

Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.

Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD.

Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. doi: 10.1158/1940-6207.CAPR-13-0430. Epub 2014 Mar 24.

18.

Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China.

Chen JG, Egner PA, Ng D, Jacobson LP, Muñoz A, Zhu YR, Qian GS, Wu F, Yuan JM, Groopman JD, Kensler TW.

Cancer Prev Res (Phila). 2013 Oct;6(10):1038-45. doi: 10.1158/1940-6207.CAPR-13-0168. Epub 2013 Aug 20.

19.

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.

Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P.

Top Curr Chem. 2013;329:163-77. doi: 10.1007/128_2012_339. Review.

20.

A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver.

Wattanawaraporn R, Woo LL, Belanger C, Chang SC, Adams JE, Trudel LJ, Bouhenguel JT, Egner PA, Groopman JD, Croy RG, Essigmann JM, Wogan GN.

Toxicol Sci. 2012 Aug;128(2):326-33. doi: 10.1093/toxsci/kfs151. Epub 2012 Apr 26.

21.

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P.

Cancer Prev Res (Phila). 2012 Apr;5(4):603-11. doi: 10.1158/1940-6207.CAPR-11-0538. Epub 2012 Feb 7.

22.

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS.

Carcinogenesis. 2012 Jan;33(1):101-7. doi: 10.1093/carcin/bgr229. Epub 2011 Nov 1. Erratum in: Carcinogenesis. 2012 Mar;33(3):722.

23.

Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.

Woo LL, Egner PA, Belanger CL, Wattanawaraporn R, Trudel LJ, Croy RG, Groopman JD, Essigmann JM, Wogan GN, Bouhenguel JT.

Toxicol Sci. 2011 Jul;122(1):38-44. doi: 10.1093/toxsci/kfr087. Epub 2011 Apr 19. Erratum in: Toxicol Sci. 2012 Jan;125(1):326. Bouhenguel, Jason T [added].

24.

Predictive power of hepatitis B 1762T/1764A mutations in plasma for hepatocellular carcinoma risk in Qidong, China.

Muñoz A, Chen JG, Egner PA, Marshall ML, Johnson JL, Schneider MF, Lu JH, Zhu YR, Wang JB, Chen TY, Kensler TW, Groopman JD.

Carcinogenesis. 2011 Jun;32(6):860-5. doi: 10.1093/carcin/bgr055. Epub 2011 Apr 7.

25.

Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.

Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, Chen TY, Botting NP, Zhang Q, Fahey JW, Talalay P, Groopman JD, Kensler TW.

Cancer Prev Res (Phila). 2011 Mar;4(3):384-95. doi: 10.1158/1940-6207.CAPR-10-0296.

26.

Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.

Fiala JL, Egner PA, Wiriyachan N, Ruchirawat M, Kensler KH, Wogan GN, Groopman JD, Croy RG, Essigmann JM.

Toxicol Sci. 2011 May;121(1):57-62. doi: 10.1093/toxsci/kfr026. Epub 2011 Jan 28.

27.

Aflatoxin B(1)-Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae.

Fasullo M, Chen Y, Bortcosh W, Sun M, Egner PA.

J Nucleic Acids. 2010 Dec 2;2010:456487. doi: 10.4061/2010/456487.

28.

Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1.

Ilic Z, Crawford D, Vakharia D, Egner PA, Sell S.

Toxicol Appl Pharmacol. 2010 Feb 1;242(3):241-6. doi: 10.1016/j.taap.2009.10.008. Epub 2009 Oct 20. Erratum in: Toxicol Appl Pharmacol. 2010 Jun 1;245(2):280. Vakharia, Dilip [added].

29.

Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.

Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR.

Toxicol Sci. 2009 May;109(1):41-9. doi: 10.1093/toxsci/kfp003. Epub 2009 Jan 23.

30.

Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.

Egner PA, Kensler TW, Chen JG, Gange SJ, Groopman JD, Friesen MD.

Chem Res Toxicol. 2008 Oct;21(10):1991-6. doi: 10.1021/tx800210k. Epub 2008 Aug 26.

31.

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.

Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB.

Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123.

32.

Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.

Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR.

Chem Res Toxicol. 2008 May;21(5):1134-42. doi: 10.1021/tx7004458. Epub 2008 Apr 15.

33.

Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry.

Johnson DN, Egner PA, Obrian G, Glassbrook N, Roebuck BD, Sutter TR, Payne GA, Kensler TW, Groopman JD.

Chem Res Toxicol. 2008 Mar;21(3):752-60. doi: 10.1021/tx700397n. Epub 2008 Feb 12.

PMID:
18266327
34.

Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry.

Chen JG, Kuang SY, Egner PA, Lu JH, Zhu YR, Wang JB, Zhang BC, Chen TY, Muñoz A, Kensler TW, Groopman JD.

Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1213-8.

35.

Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.

Simonich MT, Egner PA, Roebuck BD, Orner GA, Jubert C, Pereira C, Groopman JD, Kensler TW, Dashwood RH, Williams DE, Bailey GS.

Carcinogenesis. 2007 Jun;28(6):1294-302. Epub 2007 Feb 8.

PMID:
17290047
36.

Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry.

Egner PA, Groopman JD, Wang JS, Kensler TW, Friesen MD.

Chem Res Toxicol. 2006 Sep;19(9):1191-5.

PMID:
16978023
37.

DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice.

Skipper PL, Trudel LJ, Kensler TW, Groopman JD, Egner PA, Liberman RG, Wogan GN, Tannenbaum SR.

Chem Res Toxicol. 2006 Aug;19(8):1086-90.

PMID:
16918249
38.

Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase.

Yu X, Egner PA, Wakabayashi J, Wakabayashi N, Yamamoto M, Kensler TW.

J Biol Chem. 2006 Sep 8;281(36):26245-52. Epub 2006 Jul 20.

39.

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.

Cancer Res. 2006 Feb 15;66(4):2488-94.

40.

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.

Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, Carmella SG, Hecht SS, Benning L, Gange SJ, Groopman JD, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2605-13.

41.

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.

Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P.

Carcinogenesis. 2005 Jul;26(7):1247-55. Epub 2005 Mar 17.

PMID:
15774490
42.

Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas.

Kensler TW, Egner PA, Wang JB, Zhu YR, Zhang BC, Lu PX, Chen JG, Qian GS, Kuang SY, Jackson PE, Gange SJ, Jacobson LP, Muñoz A, Groopman JD.

Gastroenterology. 2004 Nov;127(5 Suppl 1):S310-8. Review.

PMID:
15508099
43.

Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1.

Egner PA, Yu X, Johnson JK, Nathasingh CK, Groopman JD, Kensler TW, Roebuck BD.

Chem Res Toxicol. 2003 Sep;16(9):1174-80.

PMID:
12971806
44.

Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin.

Egner PA, Muñoz A, Kensler TW.

Mutat Res. 2003 Feb-Mar;523-524:209-16.

PMID:
12628519
45.

Strategies for chemoprevention of liver cancer.

Kensler TW, Egner PA, Wang JB, Zhu YR, Zhang BC, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Muñoz A, Groopman JD.

Eur J Cancer Prev. 2002 Aug;11 Suppl 2:S58-64. Review.

PMID:
12570336
46.

Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.

Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y, Zhang QN, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Helzlsouer KJ, Bailey GS, Groopman JD, Kensler TW.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14601-6. Epub 2001 Nov 27.

47.

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.

Kwak MK, Egner PA, Dolan PM, Ramos-Gomez M, Groopman JD, Itoh K, Yamamoto M, Kensler TW.

Mutat Res. 2001 Sep 1;480-481:305-15. Review.

PMID:
11506823
48.

Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.

Camoirano A, Bagnasco M, Bennicelli C, Cartiglia C, Wang JB, Zhang BC, Zhu YR, Qian GS, Egner PA, Jacobson LP, Kensler TW, De Flora S.

Cancer Epidemiol Biomarkers Prev. 2001 Jul;10(7):775-83.

49.

Identification and characterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial.

Egner PA, Stansbury KH, Snyder EP, Rogers ME, Hintz PA, Kensler TW.

Chem Res Toxicol. 2000 Sep;13(9):900-6.

PMID:
10995263
50.

Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis).

Li Y, Su J, Qin L, Egner PA, Wang J, Groopman JD, Kensler TW, Roebuck BD.

Cancer Lett. 2000 Jun 1;154(1):79-83.

PMID:
10799742

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