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Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.

Sandoz J, Nagy Z, Catez P, Caliskan G, Geny S, Renaud JB, Concordet JP, Poterszman A, Tora L, Egly JM, Le May N, Coin F.

Nat Commun. 2019 Mar 20;10(1):1288. doi: 10.1038/s41467-019-09270-2.


C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines.

Tomita T, Ieguchi K, Takita M, Tsukahara F, Yamada M, Egly JM, Maru Y.

J Biochem. 2018 Dec 1;164(6):415-426. doi: 10.1093/jb/mvy069.


XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.

Bidon B, Iltis I, Semer M, Nagy Z, Larnicol A, Cribier A, Benkirane M, Coin F, Egly JM, Le May N.

Nat Commun. 2018 Jul 4;9(1):2610. doi: 10.1038/s41467-018-05010-0.


Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.

Epanchintsev A, Costanzo F, Rauschendorf MA, Caputo M, Ye T, Donnio LM, Proietti-de-Santis L, Coin F, Laugel V, Egly JM.

Mol Cell. 2017 Dec 21;68(6):1054-1066.e6. doi: 10.1016/j.molcel.2017.11.009. Epub 2017 Dec 7.


Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro.

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E.

Stem Cell Res. 2017 Dec;25:72-82. doi: 10.1016/j.scr.2017.10.013. Epub 2017 Oct 26.


The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C.

Nucleic Acids Res. 2017 Oct 13;45(18):10872-10883. doi: 10.1093/nar/gkx743.


MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression.

Donnio LM, Bidon B, Hashimoto S, May M, Epanchintsev A, Ryan C, Allen W, Hackett A, Gecz J, Skinner C, Stevenson RE, de Brouwer APM, Coutton C, Francannet C, Jouk PS, Schwartz CE, Egly JM.

Hum Mol Genet. 2017 Jun 1;26(11):2062-2075. doi: 10.1093/hmg/ddx099.


Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression.

Alekseev S, Nagy Z, Sandoz J, Weiss A, Egly JM, Le May N, Coin F.

Mol Cell. 2017 Feb 2;65(3):504-514.e4. doi: 10.1016/j.molcel.2017.01.012.


Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE.

Biochim Biophys Acta. 2016 Nov;1859(11):1440-1448. doi: 10.1016/j.bbagrm.2016.09.005. Epub 2016 Sep 21.


Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.

Santamaría Nuñez G, Robles CM, Giraudon C, Martínez-Leal JF, Compe E, Coin F, Aviles P, Galmarini CM, Egly JM.

Mol Cancer Ther. 2016 Oct;15(10):2399-2412. Epub 2016 Sep 14.


Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.

Compe E, Egly JM.

Annu Rev Biochem. 2016 Jun 2;85:265-90. doi: 10.1146/annurev-biochem-060815-014857. Review.


[The DNA surgery honored with a Nobel prize].

Coin F, Egly JM.

Rev Prat. 2016 Feb;66(2):226-228. French. No abstract available.


Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor.

Coin F, Egly JM.

Mol Cell. 2015 Aug 20;59(4):513-4. doi: 10.1016/j.molcel.2015.08.006.


Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44.

Kim JS, Saint-André C, Lim HS, Hwang CS, Egly JM, Cho Y.

J Biol Chem. 2015 Mar 27;290(13):8321-30. doi: 10.1074/jbc.M115.636514. Epub 2015 Feb 13.


TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription.

Singh A, Compe E, Le May N, Egly JM.

Am J Hum Genet. 2015 Feb 5;96(2):194-207. doi: 10.1016/j.ajhg.2014.12.012. Epub 2015 Jan 22.


TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.

Arseni L, Lanzafame M, Compe E, Fortugno P, Afonso-Barroso A, Peverali FA, Lehmann AR, Zambruno G, Egly JM, Stefanini M, Orioli D.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1499-504. doi: 10.1073/pnas.1416181112. Epub 2015 Jan 20.


Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy.

Traboulsi H, Davoli S, Catez P, Egly JM, Compe E.

PLoS Genet. 2014 Oct 23;10(10):e1004732. doi: 10.1371/journal.pgen.1004732. eCollection 2014 Oct.


In TFIIH, XPD helicase is exclusively devoted to DNA repair.

Kuper J, Braun C, Elias A, Michels G, Sauer F, Schmitt DR, Poterszman A, Egly JM, Kisker C.

PLoS Biol. 2014 Sep 30;12(9):e1001954. doi: 10.1371/journal.pbio.1001954. eCollection 2014 Sep.


Design and development of a robotized system coupled to µCT imaging for intratumoral drug evaluation in a HCC mouse model.

Bour G, Martel F, Goffin L, Bayle B, Gangloff J, Aprahamian M, Marescaux J, Egly JM.

PLoS One. 2014 Sep 9;9(9):e106675. doi: 10.1371/journal.pone.0106675. eCollection 2014.


Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin.

Ziani S, Nagy Z, Alekseev S, Soutoglou E, Egly JM, Coin F.

J Cell Biol. 2014 Sep 1;206(5):589-98. doi: 10.1083/jcb.201403096. Epub 2014 Aug 25.


A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the chemosensitization of tumor cells to platinum.

Alekseev S, Ayadi M, Brino L, Egly JM, Larsen AK, Coin F.

Chem Biol. 2014 Mar 20;21(3):398-407. doi: 10.1016/j.chembiol.2013.12.014. Epub 2014 Feb 6.


Response to Emanuele.

Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P.

J Invest Dermatol. 2014 Jul;134(7):2053-2055. doi: 10.1038/jid.2014.67. Epub 2014 Feb 3. No abstract available.


Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation.

Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P.

J Invest Dermatol. 2014 May;134(5):1408-1417. doi: 10.1038/jid.2013.509. Epub 2013 Nov 27.


Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack.

Oksenych V, Zhovmer A, Ziani S, Mari PO, Eberova J, Nardo T, Stefanini M, Giglia-Mari G, Egly JM, Coin F.

PLoS Genet. 2013;9(7):e1003611. doi: 10.1371/journal.pgen.1003611. Epub 2013 Jul 4.


Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.

Kristensen U, Epanchintsev A, Rauschendorf MA, Laugel V, Stevnsner T, Bohr VA, Coin F, Egly JM.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2261-70. doi: 10.1073/pnas.1220071110. Epub 2013 Jun 3.


Cockayne syndrome group B (CSB) protein: at the crossroads of transcriptional networks.

Vélez-Cruz R, Egly JM.

Mech Ageing Dev. 2013 May-Jun;134(5-6):234-42. doi: 10.1016/j.mad.2013.03.004. Epub 2013 Apr 3. Review.


Design and in vivo evaluation of a robotized needle insertion system for small animals.

Goffin L, Bour G, Martel F, Nicolau S, Gangloff J, Egly JM, Bayle B.

IEEE Trans Biomed Eng. 2013 Aug;60(8):2193-204. doi: 10.1109/TBME.2013.2243728. Epub 2013 Mar 7.


ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.

Abdulrahman W, Iltis I, Radu L, Braun C, Maglott-Roth A, Giraudon C, Egly JM, Poterszman A.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E633-42. doi: 10.1073/pnas.1213981110. Epub 2013 Feb 4.


Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells.

Vélez-Cruz R, Zadorin AS, Coin F, Egly JM.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E212-20. doi: 10.1073/pnas.1213076110. Epub 2012 Dec 24.


Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum.

Zhou X, Khan SG, Tamura D, Ueda T, Boyle J, Compe E, Egly JM, DiGiovanna JJ, Kraemer KH.

Eur J Hum Genet. 2013 Aug;21(8):831-7. doi: 10.1038/ejhg.2012.246. Epub 2012 Dec 12.


XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.

Orioli D, Compe E, Nardo T, Mura M, Giraudon C, Botta E, Arrigoni L, Peverali FA, Egly JM, Stefanini M.

Hum Mol Genet. 2013 Mar 15;22(6):1061-73. doi: 10.1093/hmg/dds508. Epub 2012 Dec 5.


Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

Le May N, Iltis I, Amé JC, Zhovmer A, Biard D, Egly JM, Schreiber V, Coin F.

Mol Cell. 2012 Dec 14;48(5):785-98. doi: 10.1016/j.molcel.2012.09.021. Epub 2012 Oct 25.


[DNA repair mechanisms: from basic biology to genetic pathology].

Egly JM.

Bull Acad Natl Med. 2011 Oct;195(7):1689-90. French. No abstract available.


XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes.

Le May N, Fradin D, Iltis I, Bougnères P, Egly JM.

Mol Cell. 2012 Aug 24;47(4):622-32. doi: 10.1016/j.molcel.2012.05.050. Epub 2012 Jul 5.


TFIIH: when transcription met DNA repair.

Compe E, Egly JM.

Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54. doi: 10.1038/nrm3350. Review. Erratum in: Nat Rev Mol Cell Biol. 2012 Jul;13(7):476.


[Early gene expression dysregulation and intellectual disability].

Boissel S, Hashimoto S, Rio M, Zarhrate M, Munnich A, Colleaux L, Egly JM.

Med Sci (Paris). 2012 Feb;28(2):128-9. doi: 10.1051/medsci/2012282003. Epub 2012 Feb 27. French. No abstract available.


MED23 mutation links intellectual disability to dysregulation of immediate early gene expression.

Hashimoto S, Boissel S, Zarhrate M, Rio M, Munnich A, Egly JM, Colleaux L.

Science. 2011 Aug 26;333(6046):1161-3. doi: 10.1126/science.1206638.


XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.

Feuerhahn S, Giraudon C, Martínez-Díez M, Bueren-Calabuig JA, Galmarini CM, Gago F, Egly JM.

Chem Biol. 2011 Aug 26;18(8):988-99. doi: 10.1016/j.chembiol.2011.06.007.


Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations.

Bueren-Calabuig JA, Giraudon C, Galmarini CM, Egly JM, Gago F.

Nucleic Acids Res. 2011 Oct;39(18):8248-57. doi: 10.1093/nar/gkr512. Epub 2011 Jul 3.


A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.

Egly JM, Coin F.

DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17. Review.


Mechanics of the IL2RA gene activation revealed by modeling and atomic force microscopy.

Milani P, Marilley M, Sanchez-Sevilla A, Imbert J, Vaillant C, Argoul F, Egly JM, Rocca-Serra J, Arneodo A.

PLoS One. 2011 Apr 13;6(4):e18811. doi: 10.1371/journal.pone.0018811.


Myo-InositolTrisPyroPhosphate treatment leads to HIF-1α suppression and eradication of early hepatoma tumors in rats.

Aprahamian M, Bour G, Akladios CY, Fylaktakidou K, Greferath R, Soler L, Marescaux J, Egly JM, Lehn JM, Nicolau C.

Chembiochem. 2011 Mar 21;12(5):777-83. doi: 10.1002/cbic.201000619. Epub 2011 Mar 2.


The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process.

Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM.

EMBO J. 2011 Feb 2;30(3):468-79. doi: 10.1038/emboj.2010.337. Epub 2010 Dec 14.


Assessing the impact of prehospital intubation on survival in out-of-hospital cardiac arrest.

Egly J, Custodio D, Bishop N, Prescott M, Lucia V, Jackson RE, Swor RA.

Prehosp Emerg Care. 2011 Jan-Mar;15(1):44-9. doi: 10.3109/10903127.2010.514090. Epub 2010 Sep 21.


True lies: the double life of the nucleotide excision repair factors in transcription and DNA repair.

Le May N, Egly JM, Coin F.

J Nucleic Acids. 2010 Jul 25;2010. pii: 616342. doi: 10.4061/2010/616342.


A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.

Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ.

Mol Cell. 2010 Jun 11;38(5):637-48. doi: 10.1016/j.molcel.2010.04.017.


NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack.

Le May N, Mota-Fernandes D, Vélez-Cruz R, Iltis I, Biard D, Egly JM.

Mol Cell. 2010 Apr 9;38(1):54-66. doi: 10.1016/j.molcel.2010.03.004.


Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients.

Ueda T, Compe E, Catez P, Kraemer KH, Egly JM.

J Exp Med. 2009 Dec 21;206(13):3031-46. doi: 10.1084/jem.20091892. Epub 2009 Nov 23.


Interacting partners of the Tfb2 subunit from yeast TFIIH.

Kainov DE, Selth LA, Svejstrup JQ, Egly JM, Poterzsman A.

DNA Repair (Amst). 2010 Jan 2;9(1):33-9. doi: 10.1016/j.dnarep.2009.10.002. Epub 2009 Nov 7.


Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.

Laugel V, Dalloz C, Durand M, Sauvanaud F, Kristensen U, Vincent MC, Pasquier L, Odent S, Cormier-Daire V, Gener B, Tobias ES, Tolmie JL, Martin-Coignard D, Drouin-Garraud V, Heron D, Journel H, Raffo E, Vigneron J, Lyonnet S, Murday V, Gubser-Mercati D, Funalot B, Brueton L, Sanchez Del Pozo J, Muñoz E, Gennery AR, Salih M, Noruzinia M, Prescott K, Ramos L, Stark Z, Fieggen K, Chabrol B, Sarda P, Edery P, Bloch-Zupan A, Fawcett H, Pham D, Egly JM, Lehmann AR, Sarasin A, Dollfus H.

Hum Mutat. 2010 Feb;31(2):113-26. doi: 10.1002/humu.21154.


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