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Items: 1 to 50 of 163


Effects of treadmill training on microvascular remodeling in the rat following spinal cord injury.

Kissane RWP, Wright O, Al'Joboori YD, Marczak P, Ichiyama RM, Egginton S.

Muscle Nerve. 2018 Nov 10. doi: 10.1002/mus.26379. [Epub ahead of print]


A solution to nature's haemoglobin knockout: a plasma-accessible carbonic anhydrase catalyses CO2 excretion in Antarctic icefish gills.

Harter TS, Sackville M, Wilson JM, Metzger DCH, Egginton S, Esbaugh AJ, Farrell AP, Brauner CJ.

J Exp Biol. 2018 Oct 5. pii: jeb.190918. doi: 10.1242/jeb.190918. [Epub ahead of print]


Exploring nature's natural knockouts: in vivo cardiorespiratory performance of Antarctic fishes during acute warming.

Joyce W, Egginton S, Farrell AP, Crockett EL, O'Brien KM, Axelsson M.

J Exp Biol. 2018 Aug 13;221(Pt 15). pii: jeb183160. doi: 10.1242/jeb.183160.


Cardiac mitochondrial metabolism may contribute to differences in thermal tolerance of red- and white-blooded Antarctic notothenioid fishes.

O'Brien KM, Rix AS, Egginton S, Farrell AP, Crockett EL, Schlauch K, Woolsey R, Hoffman M, Merriman S.

J Exp Biol. 2018 Aug 13;221(Pt 15). pii: jeb177816. doi: 10.1242/jeb.177816.


Efficacy and safety of intravenous belimumab in Japanese patients with systemic lupus erythematosus: A subgroup analysis of a phase 3 randomized placebo-controlled trial.

Tanaka Y, Bass D, Chu M, Egginton S, Ji B, Struemper H, Roth D.

Mod Rheumatol. 2018 Jul 20:1-9. doi: 10.1080/14397595.2018.1480915. [Epub ahead of print]


A pivotal phase III, randomised, placebo-controlled study of belimumab in patients with systemic lupus erythematosus located in China, Japan and South Korea.

Zhang F, Bae SC, Bass D, Chu M, Egginton S, Gordon D, Roth DA, Zheng J, Tanaka Y.

Ann Rheum Dis. 2018 Mar;77(3):355-363. doi: 10.1136/annrheumdis-2017-211631. Epub 2018 Jan 2.


The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F.

Cell Rep. 2017 Nov 7;21(6):1507-1520. doi: 10.1016/j.celrep.2017.10.040.


Regional variation in the mechanical properties and fibre-type composition of the rat extensor digitorum longus muscle.

Kissane RWP, Egginton S, Askew GN.

Exp Physiol. 2018 Jan 1;103(1):111-124. doi: 10.1113/EP086483. Epub 2017 Nov 26.


Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow.

Rogers NJ, Jeffery HC, Claire S, Lewis DJ, Zikeli G, Hodges NJ, Egginton S, Nash GB, Pikramenou Z.

Nanomedicine (Lond). 2017 Nov;12(22):2725-2740. doi: 10.2217/nnm-2017-0211. Epub 2017 Sep 29.


Alpha adrenergic receptor blockade increases capillarization and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle.

Mortensen SP, Egginton S, Madsen M, Hansen JB, Munch GDW, Iepsen UW, Åkerström T, Pedersen BK, Hellsten Y.

Acta Physiol (Oxf). 2017 Sep;221(1):32-43. doi: 10.1111/apha.12857. Epub 2017 Apr 11.


Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes.

Fujisawa T, Wang K, Niu XL, Egginton S, Ahmad S, Hewett P, Kontos CD, Ahmed A.

Cardiovasc Res. 2017 Jan;113(1):81-89. doi: 10.1093/cvr/cvw223.


Effects of prolonged anoxia on electrical activity of the heart in crucian carp (Carassius carassius).

Tikkanen E, Haverinen J, Egginton S, Hassinen M, Vornanen M.

J Exp Biol. 2017 Feb 1;220(Pt 3):445-454. doi: 10.1242/jeb.145177. Epub 2016 Nov 21.


3D Finite Element Electrical Model of Larval Zebrafish ECG Signals.

Crowcombe J, Dhillon SS, Hurst RM, Egginton S, Müller F, Sík A, Tarte E.

PLoS One. 2016 Nov 8;11(11):e0165655. doi: 10.1371/journal.pone.0165655. eCollection 2016.


Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.

Egginton S, Hussain A, Hall-Jones J, Chaudhry B, Syeda F, Glen KE.

Acta Physiol (Oxf). 2016 Nov;218(3):153-166. doi: 10.1111/apha.12728. Epub 2016 Jul 1.


In Vivo Models of Muscle Angiogenesis.

Egginton S.

Methods Mol Biol. 2016;1430:355-73. doi: 10.1007/978-1-4939-3628-1_25.


Cardiorespiratory responses in an Antarctic fish suggest limited capacity for thermal acclimation.

Egginton S, Campbell HA.

J Exp Biol. 2016 May 1;219(Pt 9):1283-6. doi: 10.1242/jeb.130963. Epub 2016 Mar 4.


Advances and challenges in skeletal muscle angiogenesis.

Olfert IM, Baum O, Hellsten Y, Egginton S.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H326-36. doi: 10.1152/ajpheart.00635.2015. Epub 2015 Nov 25. Review.


Multilevel functional genomics data integration as a tool for understanding physiology: a network biology perspective.

Davidsen PK, Turan N, Egginton S, Falciani F.

J Appl Physiol (1985). 2016 Feb 1;120(3):297-309. doi: 10.1152/japplphysiol.01110.2014. Epub 2015 Nov 5. Review.


Local capillary supply in muscle is not determined by local oxidative capacity.

Bosutti A, Egginton S, Barnouin Y, Ganse B, Rittweger J, Degens H.

J Exp Biol. 2015 Nov;218(Pt 21):3377-80. doi: 10.1242/jeb.126664. Epub 2015 Sep 18.


Maternal hypoxia decreases capillary supply and increases metabolic inefficiency leading to divergence in myocardial oxygen supply and demand.

Hauton D, Al-Shammari A, Gaffney EA, Egginton S.

PLoS One. 2015 Jun 1;10(6):e0127424. doi: 10.1371/journal.pone.0127424. eCollection 2015.


Changes to both cardiac metabolism and performance accompany acute reductions in functional capillary supply.

Hauton D, Winter J, Al-Shammari AA, Gaffney EA, Evans RD, Egginton S.

Biochim Biophys Acta. 2015 Apr;1850(4):681-90. doi: 10.1016/j.bbagen.2014.12.014. Epub 2014 Dec 18.


Electrical excitation of the heart in a basal vertebrate, the European river lamprey (Lampetra fluviatilis).

Haverinen J, Egginton S, Vornanen M.

Physiol Biochem Zool. 2014 Nov-Dec;87(6):817-28. doi: 10.1086/678954. Epub 2014 Nov 10.


A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis.

Naylor AJ, McGettrick HM, Maynard WD, May P, Barone F, Croft AP, Egginton S, Buckley CD.

PLoS One. 2014 Sep 22;9(9):e107146. doi: 10.1371/journal.pone.0107146. eCollection 2014.


In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanism.

Packham IM, Watson SP, Bicknell R, Egginton S.

PLoS One. 2014 Sep 19;9(9):e107503. doi: 10.1371/journal.pone.0107503. eCollection 2014.


A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD.

Davidsen PK, Herbert JM, Antczak P, Clarke K, Ferrer E, Peinado VI, Gonzalez C, Roca J, Egginton S, Barberá JA, Falciani F.

Genome Med. 2014 Aug 9;6(8):59. doi: 10.1186/s13073-014-0059-5. eCollection 2014.


In Memoriam: Olga Hudlická (11.07.26-03.05.14).

Egginton S, Brown MD.

Microcirculation. 2014 Jun 11. doi: 10.1111/micc.12151. [Epub ahead of print]


Modelling capillary oxygen supply capacity in mixed muscles: capillary domains revisited.

Al-Shammari AA, Gaffney EA, Egginton S.

J Theor Biol. 2014 Sep 7;356:47-61. doi: 10.1016/j.jtbi.2014.04.016. Epub 2014 Apr 24.


Angiogenesis: growth points.

Egginton S, Birot O.

Microcirculation. 2014 May;21(4):276-7. doi: 10.1111/micc.12131.


Shear stress regulated gene expression and angiogenesis in vascular endothelium.

Wragg JW, Durant S, McGettrick HM, Sample KM, Egginton S, Bicknell R.

Microcirculation. 2014 May;21(4):290-300. doi: 10.1111/micc.12119. Review.


Acute heat tolerance of cardiac excitation in the brown trout (Salmo trutta fario).

Vornanen M, Haverinen J, Egginton S.

J Exp Biol. 2014 Jan 15;217(Pt 2):299-309. doi: 10.1242/jeb.091272. Epub 2013 Sep 26.


How ubiquitous is endothelial NOS?

Syeda F, Hauton D, Young S, Egginton S.

Comp Biochem Physiol A Mol Integr Physiol. 2013 Sep;166(1):207-14. doi: 10.1016/j.cbpa.2013.05.027. Epub 2013 May 30.


TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb.

Patel AS, Smith A, Nucera S, Biziato D, Saha P, Attia RQ, Humphries J, Mattock K, Grover SP, Lyons OT, Guidotti LG, Siow R, Ivetic A, Egginton S, Waltham M, Naldini L, De Palma M, Modarai B.

EMBO Mol Med. 2013 Jun;5(6):858-69. doi: 10.1002/emmm.201302752. Epub 2013 May 7.


Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs.

Dhillon SS, Dóró E, Magyary I, Egginton S, Sík A, Müller F.

PLoS One. 2013 Apr 8;8(4):e60552. doi: 10.1371/journal.pone.0060552. Print 2013.


Is cold acclimation of benefit to hibernating rodents?

Egginton S, May S, Deveci D, Hauton D.

J Exp Biol. 2013 Jun 1;216(Pt 11):2140-9. doi: 10.1242/jeb.079160. Epub 2013 Feb 21.


G6f-like is an ITAM-containing collagen receptor in thrombocytes.

Hughes CE, Radhakrishnan UP, Lordkipanidzé M, Egginton S, Dijkstra JM, Jagadeeswaran P, Watson SP.

PLoS One. 2012;7(12):e52622. doi: 10.1371/journal.pone.0052622. Epub 2012 Dec 21.


Integrin-substrate interactions underlying shear-induced inhibition of the inflammatory response of endothelial cells.

Luu NT, Glen KE, Egginton S, Rainger GE, Nash GB.

Thromb Haemost. 2013 Feb;109(2):298-308. doi: 10.1160/TH12-06-0400. Epub 2012 Dec 13.


Towards a more relevant hind limb model of muscle ischaemia.

Lotfi S, Patel AS, Mattock K, Egginton S, Smith A, Modarai B.

Atherosclerosis. 2013 Mar;227(1):1-8. doi: 10.1016/j.atherosclerosis.2012.10.060. Epub 2012 Nov 2. Review.


Re-evaluating the use of Voronoi Tessellations in the assessment of oxygen supply from capillaries in muscle.

Al-Shammari AA, Gaffney EA, Egginton S.

Bull Math Biol. 2012 Sep;74(9):2204-31. doi: 10.1007/s11538-012-9753-x. Epub 2012 Jul 25.


The vascular-disrupting agent combretastatin impairs splitting and sprouting forms of physiological angiogenesis.

Hussain A, Steimle M, Hoppeler H, Baum O, Egginton S.

Microcirculation. 2012 May;19(4):296-305. doi: 10.1111/j.1549-8719.2012.00160.x.


In vivo shear stress response.

Egginton S.

Biochem Soc Trans. 2011 Dec;39(6):1633-8. doi: 10.1042/BST20110715. Review.


Advances in the cellular and molecular biology of angiogenesis.

Egginton S, Bicknell R.

Biochem Soc Trans. 2011 Dec;39(6):1551-5. doi: 10.1042/BST20110749.


Comments on point: counterpoint: high altitude is/is not for the birds!

Casey DP, Imray CH, Wilson MH, Flouris AD, Carrillo AE, Tedjasaputra V, Hopkins SR, Birchard GF, Billat V, West JB, Vagula MC, Nelatury C, Bennet L, Gasier HG, Gunga HC, Egginton S, Kumar P.

J Appl Physiol (1985). 2011 Nov;111(5):1520-4. doi: 10.1152/japplphysiol.01117.2011. No abstract available.


A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease.

Turan N, Kalko S, Stincone A, Clarke K, Sabah A, Howlett K, Curnow SJ, Rodriguez DA, Cascante M, O'Neill L, Egginton S, Roca J, Falciani F.

PLoS Comput Biol. 2011 Sep;7(9):e1002129. doi: 10.1371/journal.pcbi.1002129. Epub 2011 Sep 1.


Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: differential effects of the mechanotransducer CD31.

Glen K, Luu NT, Ross E, Buckley CD, Rainger GE, Egginton S, Nash GB.

J Cell Physiol. 2012 Jun;227(6):2710-21. doi: 10.1002/jcp.23015.


Cold-impaired cardiac performance in rats is only partially overcome by cold acclimation.

Hauton D, May S, Sabharwal R, Deveci D, Egginton S.

J Exp Biol. 2011 Sep 15;214(Pt 18):3021-31. doi: 10.1242/jeb.053587.


Angiogenic potential of endothelial progenitor cells and embryonic stem cells.

Rae PC, Kelly RD, Egginton S, St John JC.

Vasc Cell. 2011 May 11;3:11. doi: 10.1186/2045-824X-3-11.


Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1.

Cudmore MJ, Ahmad S, Sissaoui S, Ramma W, Ma B, Fujisawa T, Al-Ani B, Wang K, Cai M, Crispi F, Hewett PW, Gratacós E, Egginton S, Ahmed A.

Eur Heart J. 2012 May;33(9):1150-8. doi: 10.1093/eurheartj/ehr065. Epub 2011 Mar 16.


Angiogenesis - may the force be with you!

Egginton S.

J Physiol. 2010 Dec 1;588(Pt 23):4615-6. doi: 10.1113/jphysiol.2010.201012. No abstract available.


Muscle capillary supply takes the load.

Egginton S.

J Physiol. 2010 Dec 1;588(Pt 23):4607-8. doi: 10.1113/jphysiol.2010.200378. No abstract available.


Physiological angiogenesis is a graded, not threshold, response.

Egginton S, Badr I, Williams J, Hauton D, Baan GC, Jaspers RT.

J Physiol. 2011 Jan 1;589(Pt 1):195-206. doi: 10.1113/jphysiol.2010.194951. Epub 2010 Nov 8.

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