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Items: 37


Breaking self-tolerance during autoimmunity and cancer immunity: Myeloid cells and type I IFN response regulation.

Tarbell KV, Egen JG.

J Leukoc Biol. 2018 Feb 2. doi: 10.1002/JLB.3MIR1017-400R. [Epub ahead of print] Review.


αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis.

Lamb CA, Mansfield JC, Tew GW, Gibbons D, Long AK, Irving P, Diehl L, Eastham-Anderson J, Price MB, O'Boyle G, Jones DEJ, O'Byrne S, Hayday A, Keir ME, Egen JG, Kirby JA.

J Crohns Colitis. 2017 May 1;11(5):610-620. doi: 10.1093/ecco-jcc/jjw189.


Use of two-photon microscopy to study Leishmania major infection of the skin.

Carneiro MB, Hohman LS, Egen JG, Peters NC.

Methods. 2017 Aug 15;127:45-52. doi: 10.1016/j.ymeth.2017.04.012. Epub 2017 Apr 19. Review.


CXCL14 is a candidate biomarker for Hedgehog signalling in idiopathic pulmonary fibrosis.

Jia G, Chandriani S, Abbas AR, DePianto DJ, N'Diaye EN, Yaylaoglu MB, Moore HM, Peng I, DeVoss J, Collard HR, Wolters PJ, Egen JG, Arron JR.

Thorax. 2017 Sep;72(9):780-787. doi: 10.1136/thoraxjnl-2015-207682. Epub 2017 Mar 1.


Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.

Tew GW, Hackney JA, Gibbons D, Lamb CA, Luca D, Egen JG, Diehl L, Eastham Anderson J, Vermeire S, Mansfield JC, Feagan BG, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Kirby JA, Irving PM, De Hertogh G, Van Assche GA, Rutgeerts P, O'Byrne S, Hayday A, Keir ME.

Gastroenterology. 2016 Feb;150(2):477-87.e9. doi: 10.1053/j.gastro.2015.10.041. Epub 2015 Oct 30.


TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.


Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.

DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR.

Thorax. 2015 Jan;70(1):48-56. doi: 10.1136/thoraxjnl-2013-204596. Epub 2014 Sep 12.


Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.

Chandriani S, DePianto DJ, N'Diaye EN, Abbas AR, Jackman J, Bevers J 3rd, Ramirez-Carrozzi V, Pappu R, Kauder SE, Toy K, Ha C, Modrusan Z, Wu LC, Collard HR, Wolters PJ, Egen JG, Arron JR.

J Immunol. 2014 Jul 1;193(1):111-9. doi: 10.4049/jimmunol.1301761. Epub 2014 May 30.


Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial.

Vermeire S, O'Byrne S, Keir M, Williams M, Lu TT, Mansfield JC, Lamb CA, Feagan BG, Panes J, Salas A, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Tew GW, Luca D, Tang MT, Diehl L, Eastham-Anderson J, De Hertogh G, Perrier C, Egen JG, Kirby JA, van Assche G, Rutgeerts P.

Lancet. 2014 Jul 26;384(9940):309-18. doi: 10.1016/S0140-6736(14)60661-9. Epub 2014 May 9.


Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.

Honda T, Egen JG, Lämmermann T, Kastenmüller W, Torabi-Parizi P, Germain RN.

Immunity. 2014 Feb 20;40(2):235-247. doi: 10.1016/j.immuni.2013.11.017. Epub 2014 Jan 16.


Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.

Torabi-Parizi P, Vrisekoop N, Kastenmuller W, Gerner MY, Egen JG, Germain RN.

J Immunol. 2014 Feb 15;192(4):1651-1660. doi: 10.4049/jimmunol.1301743. Epub 2014 Jan 15.


Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

Kauder SE, Santell L, Mai E, Wright LY, Luis E, N'Diaye EN, Lutman J, Ratti N, Sa SM, Maun HR, Stefanich E, Gonzalez LC, Graham RR, Diehl L, Faubion WA Jr, Keir ME, Young J, Chaudhuri A, Lazarus RA, Egen JG.

PLoS One. 2013 Dec 23;8(12):e83958. doi: 10.1371/journal.pone.0083958. eCollection 2013.


Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway.

Talay O, Yan D, Brightbill HD, Straney EE, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC.

Nat Immunol. 2013 Dec;14(12):1302-4. doi: 10.1038/ni.2770. No abstract available.


Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node.

Kastenmüller W, Brandes M, Wang Z, Herz J, Egen JG, Germain RN.

Immunity. 2013 Mar 21;38(3):502-13. doi: 10.1016/j.immuni.2012.11.012. Epub 2013 Jan 24.


CRIg mediates early Kupffer cell responses to adenovirus.

He JQ, Katschke KJ Jr, Gribling P, Suto E, Lee WP, Diehl L, Eastham-Anderson J, Ponakala A, Komuves L, Egen JG, van Lookeren Campagne M.

J Leukoc Biol. 2013 Feb;93(2):301-6. doi: 10.1189/jlb.0612311. Epub 2012 Dec 5.


Three-dimensional imaging of solvent-cleared organs using 3DISCO.

Ertürk A, Becker K, Jährling N, Mauch CP, Hojer CD, Egen JG, Hellal F, Bradke F, Sheng M, Dodt HU.

Nat Protoc. 2012 Nov;7(11):1983-95. doi: 10.1038/nprot.2012.119. Epub 2012 Oct 11.


IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway.

Talay O, Yan D, Brightbill HD, Straney EE, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC.

Nat Immunol. 2012 Feb 26;13(4):396-404. doi: 10.1038/ni.2256.


Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas.

Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN.

Immunity. 2011 May 27;34(5):807-19. doi: 10.1016/j.immuni.2011.03.022. Epub 2011 May 19.


Trafficking of a dual-modality magnetic resonance and fluorescence imaging superparamagnetic iron oxide-based nanoprobe to lymph nodes.

Bumb A, Regino CA, Egen JG, Bernardo M, Dobson PJ, Germain RN, Choyke PL, Brechbiel MW.

Mol Imaging Biol. 2011 Dec;13(6):1163-72. doi: 10.1007/s11307-010-0424-8.


Even neurons are excited by Th17 cells.

Egen JG, Ouyang W.

Immunity. 2010 Sep 24;33(3):298-300. doi: 10.1016/j.immuni.2010.09.004.


Quantifying cellular interaction dynamics in 3D fluorescence microscopy data.

Klauschen F, Ishii M, Qi H, Bajénoff M, Egen JG, Germain RN, Meier-Schellersheim M.

Nat Protoc. 2009;4(9):1305-11. doi: 10.1038/nprot.2009.129. Epub 2009 Aug 20.


Computational reconstruction of cell and tissue surfaces for modeling and data analysis.

Klauschen F, Qi H, Egen JG, Germain RN, Meier-Schellersheim M.

Nat Protoc. 2009;4(7):1006-12. doi: 10.1038/nprot.2009.94. Epub 2009 Jun 4.


In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.

Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A.

J Immunol. 2009 Jun 1;182(11):6915-25. doi: 10.4049/jimmunol.0900074.


Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.

Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN.

Nature. 2009 Mar 26;458(7237):524-8. doi: 10.1038/nature07713. Epub 2009 Feb 8. Erratum in: Nature. 2010 Jun 17;465(7300):966.


In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies.

Peters NC, Egen JG, Secundino N, Debrabant A, Kimblin N, Kamhawi S, Lawyer P, Fay MP, Germain RN, Sacks D.

Science. 2008 Aug 15;321(5891):970-4. doi: 10.1126/science.1159194. Erratum in: Science. 2008 Dec 12;322(5908):1634.


Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging.

Germain RN, Bajénoff M, Castellino F, Chieppa M, Egen JG, Huang AY, Ishii M, Koo LY, Qi H.

Immunol Rev. 2008 Feb;221:163-81. doi: 10.1111/j.1600-065X.2008.00591.x.


Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas.

Egen JG, Rothfuchs AG, Feng CG, Winter N, Sher A, Germain RN.

Immunity. 2008 Feb;28(2):271-84. doi: 10.1016/j.immuni.2007.12.010. Epub 2008 Feb 7.


Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.

Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A.

J Immunol. 2007 Sep 15;179(6):3463-71.


Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node.

Bajénoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN.

Trends Immunol. 2007 Aug;28(8):346-52. Epub 2007 Jul 10. Review.


Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.

Bajénoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN.

Immunity. 2006 Dec;25(6):989-1001. Epub 2006 Nov 16.


Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells.

Qi H, Egen JG, Huang AY, Germain RN.

Science. 2006 Jun 16;312(5780):1672-6.


An extended vision for dynamic high-resolution intravital immune imaging.

Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H.

Semin Immunol. 2005 Dec;17(6):431-41. Epub 2005 Oct 10. Review.


B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.

Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP.

Immunity. 2004 Sep;21(3):401-13.


CTLA-4: new insights into its biological function and use in tumor immunotherapy.

Egen JG, Kuhns MS, Allison JP.

Nat Immunol. 2002 Jul;3(7):611-8. Review.


CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.

Chambers CA, Kuhns MS, Egen JG, Allison JP.

Annu Rev Immunol. 2001;19:565-94. Review.


Baculoviral expressed HLA class I heavy chains used to screen a synthetic peptide library for allele-specific peptide binding motifs.

Smith MH, Nuara AA, Egen JG, Sirjani DB, Lam KS, Grimes WJ.

Mol Immunol. 1998 Nov;35(16):1033-43.


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