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Items: 1 to 50 of 215

1.

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.

Spaulding CN, Schreiber HL 4th, Zheng W, Dodson KW, Hazen JE, Conover MS, Wang F, Svenmarker P, Luna-Rico A, Francetic O, Andersson M, Hultgren S, Egelman EH.

Elife. 2018 Jan 18;7. pii: e31662. doi: 10.7554/eLife.31662.

2.

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation.

Avery AW, Fealey ME, Wang F, Orlova A, Thompson AR, Thomas DD, Hays TS, Egelman EH.

Nat Commun. 2017 Nov 7;8(1):1350. doi: 10.1038/s41467-017-01367-w.

3.

A structural model of flagellar filament switching across multiple bacterial species.

Wang F, Burrage AM, Postel S, Clark RE, Orlova A, Sundberg EJ, Kearns DB, Egelman EH.

Nat Commun. 2017 Oct 16;8(1):960. doi: 10.1038/s41467-017-01075-5.

4.

Structure of the calcium-dependent type 2 secretion pseudopilus.

López-Castilla A, Thomassin JL, Bardiaux B, Zheng W, Nivaskumar M, Yu X, Nilges M, Egelman EH, Izadi-Pruneyre N, Francetic O.

Nat Microbiol. 2017 Dec;2(12):1686-1695. doi: 10.1038/s41564-017-0041-2. Epub 2017 Oct 9.

5.

Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution.

Wang F, Coureuil M, Osinski T, Orlova A, Altindal T, Gesbert G, Nassif X, Egelman EH, Craig L.

Structure. 2017 Sep 5;25(9):1423-1435.e4. doi: 10.1016/j.str.2017.07.016.

PMID:
28877506
6.

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B.

Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31.

PMID:
28759049
7.

Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.

Zheng W, Wang F, Taylor NMI, Guerrero-Ferreira RC, Leiman PG, Egelman EH.

Structure. 2017 Sep 5;25(9):1436-1441.e2. doi: 10.1016/j.str.2017.06.017. Epub 2017 Jul 27.

PMID:
28757144
8.

Model for a novel membrane envelope in a filamentous hyperthermophilic virus.

Kasson P, DiMaio F, Yu X, Lucas-Staat S, Krupovic M, Schouten S, Prangishvili D, Egelman EH.

Elife. 2017 Jun 22;6. pii: e26268. doi: 10.7554/eLife.26268.

9.

RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps.

Frenz B, Walls AC, Egelman EH, Veesler D, DiMaio F.

Nat Methods. 2017 Aug;14(8):797-800. doi: 10.1038/nmeth.4340. Epub 2017 Jun 19.

10.

Cryo-EM of bacterial pili and archaeal flagellar filaments.

Egelman EH.

Curr Opin Struct Biol. 2017 Oct;46:31-37. doi: 10.1016/j.sbi.2017.05.012. Epub 2017 Jun 10. Review.

PMID:
28609682
11.

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.

Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H.

Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13.

12.

Bacterial flagellar capping proteins adopt diverse oligomeric states.

Postel S, Deredge D, Bonsor DA, Yu X, Diederichs K, Helmsing S, Vromen A, Friedler A, Hust M, Egelman EH, Beckett D, Wintrode PL, Sundberg EJ.

Elife. 2016 Sep 24;5. pii: e18857. doi: 10.7554/eLife.18857.

13.

Structure of the Neisseria meningitidis Type IV pilus.

Kolappan S, Coureuil M, Yu X, Nassif X, Egelman EH, Craig L.

Nat Commun. 2016 Oct 4;7:13015. doi: 10.1038/ncomms13015.

14.

Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex.

Costa TRD, Ilangovan A, Ukleja M, Redzej A, Santini JM, Smith TK, Egelman EH, Waksman G.

Cell. 2016 Sep 8;166(6):1436-1444.e10. doi: 10.1016/j.cell.2016.08.025.

15.

Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain.

Braun T, Vos MR, Kalisman N, Sherman NE, Rachel R, Wirth R, Schröder GF, Egelman EH.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10352-7. doi: 10.1073/pnas.1607756113. Epub 2016 Aug 30.

16.

Resolution advances in cryo-EM enable application to drug discovery.

Subramaniam S, Earl LA, Falconieri V, Milne JL, Egelman EH.

Curr Opin Struct Biol. 2016 Dec;41:194-202. doi: 10.1016/j.sbi.2016.07.009. Epub 2016 Aug 20. Review.

17.

The Current Revolution in Cryo-EM.

Egelman EH.

Biophys J. 2016 Mar 8;110(5):1008-12. doi: 10.1016/j.bpj.2016.02.001. Review. No abstract available.

18.

Biophysical Journal Special Issue: Focus on Cryo-EM.

Egelman EH, Engel A.

Biophys J. 2016 Feb 23;110(4):E01. doi: 10.1016/j.bpj.2016.01.025. No abstract available.

19.

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.

Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G.

Cell. 2016 Jan 14;164(1-2):269-278. doi: 10.1016/j.cell.2015.11.049. Epub 2015 Dec 24.

20.

Actin polymerization is stimulated by actin cross-linking protein palladin.

Gurung R, Yadav R, Brungardt JG, Orlova A, Egelman EH, Beck MR.

Biochem J. 2016 Feb 15;473(4):383-96. doi: 10.1042/BJ20151050. Epub 2015 Nov 25.

21.

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

Sborgi L, Ravotti F, Dandey VP, Dick MS, Mazur A, Reckel S, Chami M, Scherer S, Huber M, Böckmann A, Egelman EH, Stahlberg H, Broz P, Meier BH, Hiller S.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13237-42. doi: 10.1073/pnas.1507579112. Epub 2015 Oct 13.

22.

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC.

Morrone SR, Matyszewski M, Yu X, Delannoy M, Egelman EH, Sohn J.

Nat Commun. 2015 Jul 22;6:7827. doi: 10.1038/ncomms8827.

23.

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.

Taylor MRG, Špírek M, Chaurasiya KR, Ward JD, Carzaniga R, Yu X, Egelman EH, Collinson LM, Rueda D, Krejci L, Boulton SJ.

Cell. 2015 Jul 16;162(2):271-286. doi: 10.1016/j.cell.2015.06.015.

24.

The molecular basis for flexibility in the flexible filamentous plant viruses.

DiMaio F, Chen CC, Yu X, Frenz B, Hsu YH, Lin NS, Egelman EH.

Nat Struct Mol Biol. 2015 Aug;22(8):642-4. doi: 10.1038/nsmb.3054. Epub 2015 Jul 13.

25.

Archaeal actin from a hyperthermophile forms a single-stranded filament.

Braun T, Orlova A, Valegård K, Lindås AC, Schröder GF, Egelman EH.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9340-5. doi: 10.1073/pnas.1509069112. Epub 2015 Jun 29.

26.

Virology. A virus that infects a hyperthermophile encapsidates A-form DNA.

DiMaio F, Yu X, Rensen E, Krupovic M, Prangishvili D, Egelman EH.

Science. 2015 May 22;348(6237):914-7. doi: 10.1126/science.aaa4181.

27.

Three-dimensional reconstruction of helical polymers.

Egelman EH.

Arch Biochem Biophys. 2015 Sep 1;581:54-8. doi: 10.1016/j.abb.2015.04.004. Epub 2015 Apr 22. Review.

28.

Reproducibility of research in biophysics.

Loew L, Beckett D, Egelman EH, Scarlata S.

Biophys J. 2015 Apr 7;108(7):E1. doi: 10.1016/j.bpj.2015.03.002. No abstract available.

29.

Structure of the type VI secretion system contractile sheath.

Kudryashev M, Wang RY, Brackmann M, Scherer S, Maier T, Baker D, DiMaio F, Stahlberg H, Egelman EH, Basler M.

Cell. 2015 Feb 26;160(5):952-962. doi: 10.1016/j.cell.2015.01.037.

30.

De novo protein structure determination from near-atomic-resolution cryo-EM maps.

Wang RY, Kudryashev M, Li X, Egelman EH, Basler M, Cheng Y, Baker D, DiMaio F.

Nat Methods. 2015 Apr;12(4):335-8. doi: 10.1038/nmeth.3287. Epub 2015 Feb 23.

31.

Structural plasticity of helical nanotubes based on coiled-coil assemblies.

Egelman EH, Xu C, DiMaio F, Magnotti E, Modlin C, Yu X, Wright E, Baker D, Conticello VP.

Structure. 2015 Feb 3;23(2):280-9. doi: 10.1016/j.str.2014.12.008. Epub 2015 Jan 22.

32.

Near-atomic resolution for one state of F-actin.

Galkin VE, Orlova A, Vos MR, Schröder GF, Egelman EH.

Structure. 2015 Jan 6;23(1):173-182. doi: 10.1016/j.str.2014.11.006. Epub 2014 Dec 18.

33.

Ambiguities in helical reconstruction.

Egelman EH.

Elife. 2014 Dec 8;3. doi: 10.7554/eLife.04969.

34.

A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature.

Pang X, Fan J, Zhang Y, Zhang K, Gao B, Ma J, Li J, Deng Y, Zhou Q, Egelman EH, Hsu VW, Sun F.

Dev Cell. 2014 Oct 13;31(1):73-86. doi: 10.1016/j.devcel.2014.08.020. Epub 2014 Oct 2.

35.

Direct interaction of actin filaments with F-BAR protein pacsin2.

Kostan J, Salzer U, Orlova A, Törö I, Hodnik V, Senju Y, Zou J, Schreiner C, Steiner J, Meriläinen J, Nikki M, Virtanen I, Carugo O, Rappsilber J, Lappalainen P, Lehto VP, Anderluh G, Egelman EH, Djinović-Carugo K.

EMBO Rep. 2014 Nov;15(11):1154-62. doi: 10.15252/embr.201439267. Epub 2014 Sep 12.

36.

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.

Mol Cell. 2014 Aug 21;55(4):511-23. doi: 10.1016/j.molcel.2014.06.010. Epub 2014 Jul 10.

37.

Distinct docking and stabilization steps of the Pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers.

Nivaskumar M, Bouvier G, Campos M, Nadeau N, Yu X, Egelman EH, Nilges M, Francetic O.

Structure. 2014 May 6;22(5):685-96. doi: 10.1016/j.str.2014.03.001. Epub 2014 Mar 27.

38.

Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties.

Thompson PM, Tolbert CE, Shen K, Kota P, Palmer SM, Plevock KM, Orlova A, Galkin VE, Burridge K, Egelman EH, Dokholyan NV, Superfine R, Campbell SL.

Structure. 2014 May 6;22(5):697-706. doi: 10.1016/j.str.2014.03.002. Epub 2014 Mar 27.

39.

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH.

Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008.

40.

Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.

Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H.

Mol Cell. 2013 Sep 26;51(6):766-79. doi: 10.1016/j.molcel.2013.08.032.

41.

Organization of F-actin by Fesselin (avian smooth muscle synaptopodin 2).

Schroeter MM, Orlova A, Egelman EH, Beall B, Chalovich JM.

Biochemistry. 2013 Jul 23;52(29):4955-61. doi: 10.1021/bi4005254. Epub 2013 Jul 9.

42.

The structure of the CS1 pilus of enterotoxigenic Escherichia coli reveals structural polymorphism.

Galkin VE, Kolappan S, Ng D, Zong Z, Li J, Yu X, Egelman EH, Craig L.

J Bacteriol. 2013 Apr;195(7):1360-70. doi: 10.1128/JB.01989-12. Epub 2012 Nov 21.

43.

MDA5 assembles into a polar helical filament on dsRNA.

Berke IC, Yu X, Modis Y, Egelman EH.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18437-41. doi: 10.1073/pnas.1212186109. Epub 2012 Oct 22.

44.

Are ParM filaments polar or bipolar?

Galkin VE, Orlova A, Egelman EH.

J Mol Biol. 2012 Nov 2;423(4):482-5. doi: 10.1016/j.jmb.2012.08.006. Epub 2012 Aug 21.

45.

Filaments from Ignicoccus hospitalis show diversity of packing in proteins containing N-terminal type IV pilin helices.

Yu X, Goforth C, Meyer C, Rachel R, Wirth R, Schröder GF, Egelman EH.

J Mol Biol. 2012 Sep 14;422(2):274-81. doi: 10.1016/j.jmb.2012.05.031. Epub 2012 May 30.

46.

Stepwise molecular display utilizing icosahedral and helical complexes of phage coat and decoration proteins in the development of robust nanoscale display vehicles.

Parent KN, Deedas CT, Egelman EH, Casjens SR, Baker TS, Teschke CM.

Biomaterials. 2012 Aug;33(22):5628-37. doi: 10.1016/j.biomaterials.2012.04.026. Epub 2012 May 8.

47.

Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus.

Li J, Egelman EH, Craig L.

J Mol Biol. 2012 Apr 20;418(1-2):47-64. doi: 10.1016/j.jmb.2012.02.017. Epub 2012 Feb 21.

48.

Outcome of the first electron microscopy validation task force meeting.

Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL.

Structure. 2012 Feb 8;20(2):205-14. doi: 10.1016/j.str.2011.12.014.

49.

Actin filaments as tension sensors.

Galkin VE, Orlova A, Egelman EH.

Curr Biol. 2012 Feb 7;22(3):R96-101. doi: 10.1016/j.cub.2011.12.010. Review.

50.

Real-space processing of helical filaments in SPARX.

Behrmann E, Tao G, Stokes DL, Egelman EH, Raunser S, Penczek PA.

J Struct Biol. 2012 Feb;177(2):302-13. doi: 10.1016/j.jsb.2011.12.020. Epub 2012 Jan 11.

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