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Items: 1 to 50 of 224

1.

The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.

Demircioglu FE, Zheng W, McQuown AJ, Maier NK, Watson N, Cheeseman IM, Denic V, Egelman EH, Schwartz TU.

Nat Commun. 2019 Jul 22;10(1):3262. doi: 10.1038/s41467-019-11194-w.

2.

Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs.

Hughes SA, Wang F, Wang S, Kreutzberger MAB, Osinski T, Orlova A, Wall JS, Zuo X, Egelman EH, Conticello VP.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14456-14464. doi: 10.1073/pnas.1903910116. Epub 2019 Jul 1.

PMID:
31262809
3.

An extensively glycosylated archaeal pilus survives extreme conditions.

Wang F, Cvirkaite-Krupovic V, Kreutzberger MAB, Su Z, de Oliveira GAP, Osinski T, Sherman N, DiMaio F, Wall JS, Prangishvili D, Krupovic M, Egelman EH.

Nat Microbiol. 2019 Aug;4(8):1401-1410. doi: 10.1038/s41564-019-0458-x. Epub 2019 May 20.

PMID:
31110358
4.

Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.

Bardiaux B, de Amorim GC, Luna Rico A, Zheng W, Guilvout I, Jollivet C, Nilges M, Egelman EH, Izadi-Pruneyre N, Francetic O.

Structure. 2019 Jul 2;27(7):1082-1093.e5. doi: 10.1016/j.str.2019.03.021. Epub 2019 May 2.

PMID:
31056419
5.

Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers.

Wang F, Gu Y, O'Brien JP, Yi SM, Yalcin SE, Srikanth V, Shen C, Vu D, Ing NL, Hochbaum AI, Egelman EH, Malvankar NS.

Cell. 2019 Apr 4;177(2):361-369.e10. doi: 10.1016/j.cell.2019.03.029.

6.

Molecular mechanism for NLRP6 inflammasome assembly and activation.

Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057. doi: 10.1073/pnas.1817221116. Epub 2019 Jan 23.

7.

Functional reconstitution of the type IVa pilus assembly system from enterohaemorrhagic Escherichia coli.

Luna Rico A, Zheng W, Petiot N, Egelman EH, Francetic O.

Mol Microbiol. 2019 Mar;111(3):732-749. doi: 10.1111/mmi.14188. Epub 2019 Jan 21.

PMID:
30561149
8.

Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.

Matyszewski M, Zheng W, Lueck J, Antiochos B, Egelman EH, Sohn J.

J Biol Chem. 2018 Dec 28;293(52):20240-20248. doi: 10.1074/jbc.RA118.006050. Epub 2018 Nov 1.

PMID:
30385506
9.

Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile.

Liu Y, Osinski T, Wang F, Krupovic M, Schouten S, Kasson P, Prangishvili D, Egelman EH.

Nat Commun. 2018 Aug 22;9(1):3360. doi: 10.1038/s41467-018-05684-6.

10.

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.

Spaulding CN, Schreiber HL 4th, Zheng W, Dodson KW, Hazen JE, Conover MS, Wang F, Svenmarker P, Luna-Rico A, Francetic O, Andersson M, Hultgren S, Egelman EH.

Elife. 2018 Jan 18;7. pii: e31662. doi: 10.7554/eLife.31662.

11.

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation.

Avery AW, Fealey ME, Wang F, Orlova A, Thompson AR, Thomas DD, Hays TS, Egelman EH.

Nat Commun. 2017 Nov 7;8(1):1350. doi: 10.1038/s41467-017-01367-w.

12.

A structural model of flagellar filament switching across multiple bacterial species.

Wang F, Burrage AM, Postel S, Clark RE, Orlova A, Sundberg EJ, Kearns DB, Egelman EH.

Nat Commun. 2017 Oct 16;8(1):960. doi: 10.1038/s41467-017-01075-5.

13.

Structure of the calcium-dependent type 2 secretion pseudopilus.

López-Castilla A, Thomassin JL, Bardiaux B, Zheng W, Nivaskumar M, Yu X, Nilges M, Egelman EH, Izadi-Pruneyre N, Francetic O.

Nat Microbiol. 2017 Dec;2(12):1686-1695. doi: 10.1038/s41564-017-0041-2. Epub 2017 Oct 9.

14.

Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution.

Wang F, Coureuil M, Osinski T, Orlova A, Altindal T, Gesbert G, Nassif X, Egelman EH, Craig L.

Structure. 2017 Sep 5;25(9):1423-1435.e4. doi: 10.1016/j.str.2017.07.016.

15.

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B.

Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31.

PMID:
28759049
16.

Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.

Zheng W, Wang F, Taylor NMI, Guerrero-Ferreira RC, Leiman PG, Egelman EH.

Structure. 2017 Sep 5;25(9):1436-1441.e2. doi: 10.1016/j.str.2017.06.017. Epub 2017 Jul 27.

17.

Model for a novel membrane envelope in a filamentous hyperthermophilic virus.

Kasson P, DiMaio F, Yu X, Lucas-Staat S, Krupovic M, Schouten S, Prangishvili D, Egelman EH.

Elife. 2017 Jun 22;6. pii: e26268. doi: 10.7554/eLife.26268.

18.

RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps.

Frenz B, Walls AC, Egelman EH, Veesler D, DiMaio F.

Nat Methods. 2017 Aug;14(8):797-800. doi: 10.1038/nmeth.4340. Epub 2017 Jun 19.

19.

Cryo-EM of bacterial pili and archaeal flagellar filaments.

Egelman EH.

Curr Opin Struct Biol. 2017 Oct;46:31-37. doi: 10.1016/j.sbi.2017.05.012. Epub 2017 Jun 10. Review.

20.

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.

Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H.

Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13.

21.

Bacterial flagellar capping proteins adopt diverse oligomeric states.

Postel S, Deredge D, Bonsor DA, Yu X, Diederichs K, Helmsing S, Vromen A, Friedler A, Hust M, Egelman EH, Beckett D, Wintrode PL, Sundberg EJ.

Elife. 2016 Sep 24;5. pii: e18857. doi: 10.7554/eLife.18857.

22.

Structure of the Neisseria meningitidis Type IV pilus.

Kolappan S, Coureuil M, Yu X, Nassif X, Egelman EH, Craig L.

Nat Commun. 2016 Oct 4;7:13015. doi: 10.1038/ncomms13015.

23.

Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex.

Costa TRD, Ilangovan A, Ukleja M, Redzej A, Santini JM, Smith TK, Egelman EH, Waksman G.

Cell. 2016 Sep 8;166(6):1436-1444.e10. doi: 10.1016/j.cell.2016.08.025.

24.

Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain.

Braun T, Vos MR, Kalisman N, Sherman NE, Rachel R, Wirth R, Schröder GF, Egelman EH.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10352-7. doi: 10.1073/pnas.1607756113. Epub 2016 Aug 30.

25.

Resolution advances in cryo-EM enable application to drug discovery.

Subramaniam S, Earl LA, Falconieri V, Milne JL, Egelman EH.

Curr Opin Struct Biol. 2016 Dec;41:194-202. doi: 10.1016/j.sbi.2016.07.009. Epub 2016 Aug 20. Review.

26.

The Current Revolution in Cryo-EM.

Egelman EH.

Biophys J. 2016 Mar 8;110(5):1008-12. doi: 10.1016/j.bpj.2016.02.001. Review. No abstract available.

27.

Biophysical Journal Special Issue: Focus on Cryo-EM.

Egelman EH, Engel A.

Biophys J. 2016 Feb 23;110(4):E01. doi: 10.1016/j.bpj.2016.01.025. No abstract available.

28.

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.

Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G.

Cell. 2016 Jan 14;164(1-2):269-278. doi: 10.1016/j.cell.2015.11.049. Epub 2015 Dec 24.

29.

Actin polymerization is stimulated by actin cross-linking protein palladin.

Gurung R, Yadav R, Brungardt JG, Orlova A, Egelman EH, Beck MR.

Biochem J. 2016 Feb 15;473(4):383-96. doi: 10.1042/BJ20151050. Epub 2015 Nov 25.

30.

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

Sborgi L, Ravotti F, Dandey VP, Dick MS, Mazur A, Reckel S, Chami M, Scherer S, Huber M, Böckmann A, Egelman EH, Stahlberg H, Broz P, Meier BH, Hiller S.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13237-42. doi: 10.1073/pnas.1507579112. Epub 2015 Oct 13.

31.

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC.

Morrone SR, Matyszewski M, Yu X, Delannoy M, Egelman EH, Sohn J.

Nat Commun. 2015 Jul 22;6:7827. doi: 10.1038/ncomms8827.

32.

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.

Taylor MRG, Špírek M, Chaurasiya KR, Ward JD, Carzaniga R, Yu X, Egelman EH, Collinson LM, Rueda D, Krejci L, Boulton SJ.

Cell. 2015 Jul 16;162(2):271-286. doi: 10.1016/j.cell.2015.06.015.

33.

The molecular basis for flexibility in the flexible filamentous plant viruses.

DiMaio F, Chen CC, Yu X, Frenz B, Hsu YH, Lin NS, Egelman EH.

Nat Struct Mol Biol. 2015 Aug;22(8):642-4. doi: 10.1038/nsmb.3054. Epub 2015 Jul 13.

34.

Archaeal actin from a hyperthermophile forms a single-stranded filament.

Braun T, Orlova A, Valegård K, Lindås AC, Schröder GF, Egelman EH.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9340-5. doi: 10.1073/pnas.1509069112. Epub 2015 Jun 29.

35.

Virology. A virus that infects a hyperthermophile encapsidates A-form DNA.

DiMaio F, Yu X, Rensen E, Krupovic M, Prangishvili D, Egelman EH.

Science. 2015 May 22;348(6237):914-7. doi: 10.1126/science.aaa4181.

36.

Three-dimensional reconstruction of helical polymers.

Egelman EH.

Arch Biochem Biophys. 2015 Sep 1;581:54-8. doi: 10.1016/j.abb.2015.04.004. Epub 2015 Apr 22. Review.

37.

Reproducibility of research in biophysics.

Loew L, Beckett D, Egelman EH, Scarlata S.

Biophys J. 2015 Apr 7;108(7):E1. doi: 10.1016/j.bpj.2015.03.002. No abstract available.

38.

Structure of the type VI secretion system contractile sheath.

Kudryashev M, Wang RY, Brackmann M, Scherer S, Maier T, Baker D, DiMaio F, Stahlberg H, Egelman EH, Basler M.

Cell. 2015 Feb 26;160(5):952-962. doi: 10.1016/j.cell.2015.01.037.

39.

De novo protein structure determination from near-atomic-resolution cryo-EM maps.

Wang RY, Kudryashev M, Li X, Egelman EH, Basler M, Cheng Y, Baker D, DiMaio F.

Nat Methods. 2015 Apr;12(4):335-8. doi: 10.1038/nmeth.3287. Epub 2015 Feb 23.

40.

Structural plasticity of helical nanotubes based on coiled-coil assemblies.

Egelman EH, Xu C, DiMaio F, Magnotti E, Modlin C, Yu X, Wright E, Baker D, Conticello VP.

Structure. 2015 Feb 3;23(2):280-9. doi: 10.1016/j.str.2014.12.008. Epub 2015 Jan 22.

41.

Near-atomic resolution for one state of F-actin.

Galkin VE, Orlova A, Vos MR, Schröder GF, Egelman EH.

Structure. 2015 Jan 6;23(1):173-182. doi: 10.1016/j.str.2014.11.006. Epub 2014 Dec 18.

42.

Ambiguities in helical reconstruction.

Egelman EH.

Elife. 2014 Dec 8;3. doi: 10.7554/eLife.04969.

43.

A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature.

Pang X, Fan J, Zhang Y, Zhang K, Gao B, Ma J, Li J, Deng Y, Zhou Q, Egelman EH, Hsu VW, Sun F.

Dev Cell. 2014 Oct 13;31(1):73-86. doi: 10.1016/j.devcel.2014.08.020. Epub 2014 Oct 2.

44.

Direct interaction of actin filaments with F-BAR protein pacsin2.

Kostan J, Salzer U, Orlova A, Törö I, Hodnik V, Senju Y, Zou J, Schreiner C, Steiner J, Meriläinen J, Nikki M, Virtanen I, Carugo O, Rappsilber J, Lappalainen P, Lehto VP, Anderluh G, Egelman EH, Djinović-Carugo K.

EMBO Rep. 2014 Nov;15(11):1154-62. doi: 10.15252/embr.201439267. Epub 2014 Sep 12.

45.

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.

Mol Cell. 2014 Aug 21;55(4):511-23. doi: 10.1016/j.molcel.2014.06.010. Epub 2014 Jul 10.

46.

Distinct docking and stabilization steps of the Pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers.

Nivaskumar M, Bouvier G, Campos M, Nadeau N, Yu X, Egelman EH, Nilges M, Francetic O.

Structure. 2014 May 6;22(5):685-96. doi: 10.1016/j.str.2014.03.001. Epub 2014 Mar 27.

47.

Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties.

Thompson PM, Tolbert CE, Shen K, Kota P, Palmer SM, Plevock KM, Orlova A, Galkin VE, Burridge K, Egelman EH, Dokholyan NV, Superfine R, Campbell SL.

Structure. 2014 May 6;22(5):697-706. doi: 10.1016/j.str.2014.03.002. Epub 2014 Mar 27.

48.

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH.

Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008.

49.

Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.

Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H.

Mol Cell. 2013 Sep 26;51(6):766-79. doi: 10.1016/j.molcel.2013.08.032.

50.

Organization of F-actin by Fesselin (avian smooth muscle synaptopodin 2).

Schroeter MM, Orlova A, Egelman EH, Beall B, Chalovich JM.

Biochemistry. 2013 Jul 23;52(29):4955-61. doi: 10.1021/bi4005254. Epub 2013 Jul 9.

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