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CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.

Argiriadi MA, Benatuil L, Dubrovska I, Egan DA, Gao L, Greischar A, Hardman J, Harlan J, Iyer RB, Judge RA, Lake M, Perron DC, Sadhukhan R, Sielaff B, Sousa S, Wang R, McRae BL.

BMC Mol Cell Biol. 2019 Aug 5;20(1):29. doi: 10.1186/s12860-019-0213-4.


The Standardized Video Interview: How Does It Affect the Likelihood to Invite for a Residency Interview?

Husain A, Li I, Ardolic B, Bond MC, Shoenberger J, Shah KH, Chung AS, Dermark JV, Bronner JM, White M, Taylor T, Cygan L, Caputo W, Silver M, Krauss WC, Egan DJ, Weizberg M.

AEM Educ Train. 2019 Mar 14;3(3):226-232. doi: 10.1002/aet2.10331. eCollection 2019 Jul.


T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.

Chapuis AG, Egan DN, Bar M, Schmitt TM, McAfee MS, Paulson KG, Voillet V, Gottardo R, Ragnarsson GB, Bleakley M, Yeung CC, Muhlhauser P, Nguyen HN, Kropp LA, Castelli L, Wagener F, Hunter D, Lindberg M, Cohen K, Seese A, McElrath MJ, Duerkopp N, Gooley TA, Greenberg PD.

Nat Med. 2019 Jul;25(7):1064-1072. doi: 10.1038/s41591-019-0472-9. Epub 2019 Jun 24.


A Multiple Dose Phase 1 Assessment of Rilpivirine Long Acting in a Model of Preexposure Prophylaxis Against HIV.

Cranston RD, Dezzutti CS, Siegel A, Engstrom J, Shetler C, Richardson-Harman N, Abebe KZ, Back D, Else L, Egan D, Khoo S, Egan JE, Stall R, Williams P, Brand RM, Parikh UM, McGowan I.

AIDS Res Hum Retroviruses. 2019 Sep;35(9):794-804. doi: 10.1089/AID.2018.0265. Epub 2019 Jul 16.


An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM.

Cell Metab. 2019 Jul 2;30(1):190-200.e6. doi: 10.1016/j.cmet.2019.04.013. Epub 2019 May 16.


Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.

Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW.

Thyroid. 2019 Jun;29(6):760-777. doi: 10.1089/thy.2018.0416. Epub 2019 May 13.


Thyroid and Cardiovascular Disease Research Agenda for Enhancing Knowledge, Prevention, and Treatment.

Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW.

Circulation. 2019 May 13. doi: 10.1161/CIRCULATIONAHA.118.036859. [Epub ahead of print]


Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.

Wiggers CRM, Govers AMAP, Lelieveld D, Egan DA, Zwaan CM, Sonneveld E, Coffer PJ, Bartels M.

Pediatr Blood Cancer. 2019 Aug;66(8):e27785. doi: 10.1002/pbc.27785. Epub 2019 May 1.


An Emergency Medicine Remediation Consult Service: Access to Expert Remediation Advice and Resources.

Egan DJ, Gentges J, Regan L, Smith JL, Williamson K, Murano T.

AEM Educ Train. 2019 Mar 14;3(2):193-196. doi: 10.1002/aet2.10330. eCollection 2019 Apr.


A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine.

Francis J, Zvada SP, Denti P, Hatherill M, Charalambous S, Mungofa S, Dawson R, Dorman S, Gupte N, Wiesner L, Jindani A, Harrison TS, Olagunju A, Egan D, Owen A, McIlleron HM.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01964-18. doi: 10.1128/AAC.01964-18. Print 2019 Apr.


Standardized Video Interviews Do Not Correlate to United States Medical Licensing Examination Step 1 and Step 2 Scores.

Egan DJ, Husain A, Bond MC, Caputo W, Cygan L, Van Dermark J, Shoenberger JM, Li I, Krauss W, Bronner J, White M, Chung AS, Shah KH, Taylor T, Silver M, Ardolic B, Weizberg M.

West J Emerg Med. 2019 Jan;20(1):87-91. doi: 10.5811/westjem.2018.11.39730. Epub 2018 Dec 12.


Optical Rehabilitation of a Patient with Keratoconus and Nystagmus.

Tsang DK, Spors F, Shen J, McNaughton LE, Egan DJ.

Med Hypothesis Discov Innov Ophthalmol. 2018 Winter;7(4):183-189.


Widespread use of herbal medicines by people living with human immunodeficiency virus and contamination of herbal medicines with antiretrovirals in Nigeria.

Gini J, Amara A, Penchala SD, Back DJ, Else L, Egan D, Chiong J, Harri BI, Kabilis ED, Pama PP, Stephen M, Khoo SH.

Int J STD AIDS. 2019 Mar;30(4):371-377. doi: 10.1177/0956462418809749. Epub 2018 Nov 30.


Validation and clinical application of a novel LC-MS method for quantification of dolutegravir in breast milk.

Gini J, Penchala SD, Amara A, Challenger E, Egan D, Waitt C, Lamorde M, Orrell C, Myer L, Khoo S, Else LJ.

Bioanalysis. 2018 Nov 19. doi: 10.4155/bio-2018-0085. [Epub ahead of print]


In-Vivo Evaluation of Peripheral Refraction Changes with Single Vision and Multifocal Soft Contact Lenses.

Shen J, Spors F, Tsang D, McNaughton LE, Egan DJ.

Med Hypothesis Discov Innov Ophthalmol. 2018 Fall;7(3):112-118.


Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.

Hobson AD, Judge RA, Aguirre AL, Brown BS, Cui Y, Ding P, Dominguez E, DiGiammarino E, Egan DA, Freiberg GM, Gopalakrishnan SM, Harris CM, Honore MP, Kage KL, Kapecki NJ, Ling C, Ma J, Mack H, Mamo M, Maurus S, McRae B, Moore NS, Mueller BK, Mueller R, Namovic MT, Patel K, Pratt SD, Putman CB, Queeney KL, Sarris KK, Schaffter LM, Stoll V, Vasudevan A, Wang L, Wang L, Wirthl W, Yach K.

J Med Chem. 2018 Dec 27;61(24):11074-11100. doi: 10.1021/acs.jmedchem.8b01098. Epub 2018 Dec 12.


Designing an education programme to improve quality of life for cancer survivors: a systematic review.

Aubin M, Egan D.

Br J Nurs. 2018 Sep 20;27(17):S18-S23. doi: 10.12968/bjon.2018.27.17.S18.


Is Your Color My Color? Dividing the Labor of the Stroop Task Between Co-actors.

Yamaguchi M, Clarke EL, Egan DL.

Front Psychol. 2018 Aug 6;9:1407. doi: 10.3389/fpsyg.2018.01407. eCollection 2018.


Polymorphisms of tenofovir disoproxil fumarate transporters and risk of kidney tubular dysfunction in HIV-positive patients: genetics of tenofovir transporters.

Danjuma MI, Egan D, Abubeker IY, Post F, Khoo S.

Int J STD AIDS. 2018 Aug 2:956462418786562. doi: 10.1177/0956462418786562. [Epub ahead of print]


Recognizing and managing emerging infectious diseases in the emergency department [digest].

Millán R, Thomas-Paulose D, Egan DJ, Nusbaum J, Gupta N.

Emerg Med Pract. 2018 May 1;20(Suppl 5):1-2.


Recognizing and managing emerging infectious diseases in the emergency department.

Millán R, Thomas-Paulose D, Egan DJ.

Emerg Med Pract. 2018 May;20(5):1-20. Epub 2018 May 1.


Intra-tumour diversification in colorectal cancer at the single-cell level.

Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble SJ, Alder C, van de Wetering M, Campbell PJ, Stratton MR, Clevers H.

Nature. 2018 Apr;556(7702):457-462. doi: 10.1038/s41586-018-0024-3. Epub 2018 Apr 11.


TMEM59 potentiates Wnt signaling by promoting signalosome formation.

Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9.


Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardiac Arrest Among Children and Adults.

Hansen M, Schmicker RH, Newgard CD, Grunau B, Scheuermeyer F, Cheskes S, Vithalani V, Alnaji F, Rea T, Idris AH, Herren H, Hutchison J, Austin M, Egan D, Daya M; Resuscitation Outcomes Consortium Investigators.

Circulation. 2018 May 8;137(19):2032-2040. doi: 10.1161/CIRCULATIONAHA.117.033067. Epub 2018 Mar 6.


Peripheral refraction and image blur in four meridians in emmetropes and myopes.

Shen J, Spors F, Egan D, Liu C.

Clin Ophthalmol. 2018 Feb 19;12:345-358. doi: 10.2147/OPTH.S151288. eCollection 2018.


Transplant Conditioning with Treosulfan/Fludarabine with or without Total Body Irradiation: A Randomized Phase II Trial in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Deeg HJ, Stevens EA, Salit RB, Ermoian RP, Fang M, Gyurkocza B, Sorror ML, Fatobene G, Baumgart J, Burroughs LM, Delaney C, Doney K, Egan DN, Flowers MED, Milano F, Radich JP, Scott BL, Sickle EJ, Wood BL, Yeung C, Storer BE.

Biol Blood Marrow Transplant. 2018 May;24(5):956-963. doi: 10.1016/j.bbmt.2017.12.785. Epub 2017 Dec 20.


When a Mass Casualty Is Your Own.

Egan DJ.

J Grad Med Educ. 2017 Dec;9(6):775-776. doi: 10.4300/JGME-D-17-00429.1. No abstract available.


A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H.

Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7.


An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4.

van Battum EY, Verhagen MG, Vangoor VR, Fujita Y, Derijck AAHA, O'Duibhir E, Giuliani G, de Gunst T, Adolfs Y, Lelieveld D, Egan D, Schaapveld RQJ, Yamashita T, Pasterkamp RJ.

J Neurosci. 2018 Jan 17;38(3):613-630. doi: 10.1523/JNEUROSCI.0662-17.2017. Epub 2017 Dec 1.


DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells.

Kruitwagen HS, Westendorp B, Viebahn CS, Post K, van Wolferen ME, Oosterhoff LA, Egan DA, Delabar JM, Toussaint MJ, Schotanus BA, de Bruin A, Rothuizen J, Penning LC, Spee B.

Stem Cells Dev. 2018 Jan 15;27(2):133-146. doi: 10.1089/scd.2017.0139. Epub 2018 Jan 3.


Antiarrhythmic Drugs for Nonshockable-Turned-Shockable Out-of-Hospital Cardiac Arrest: The ALPS Study (Amiodarone, Lidocaine, or Placebo).

Kudenchuk PJ, Leroux BG, Daya M, Rea T, Vaillancourt C, Morrison LJ, Callaway CW, Christenson J, Ornato JP, Dunford JV, Wittwer L, Weisfeldt ML, Aufderheide TP, Vilke GM, Idris AH, Stiell IG, Colella MR, Kayea T, Egan D, Desvigne-Nickens P, Gray P, Gray R, Straight R, Dorian P; Resuscitation Outcomes Consortium Investigators.

Circulation. 2017 Nov 28;136(22):2119-2131. doi: 10.1161/CIRCULATIONAHA.117.028624. Epub 2017 Sep 13.


Improving Comprehension Efficiency of High Content Screening Data Through Interactive Visualizations.

Omta WA, Nobel J, Klumperman J, Egan DA, Spruit MR, Brinkhuis MJS.

Assay Drug Dev Technol. 2017 Aug/Sep;15(6):247-256. doi: 10.1089/adt.2017.794.


UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.

Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19.


Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.

Sloan DJ, McCallum AD, Schipani A, Egan D, Mwandumba HC, Ward SA, Waterhouse D, Banda G, Allain TJ, Owen A, Khoo SH, Davies GR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00210-17. doi: 10.1128/AAC.00210-17. Print 2017 Jul.


Impact of patient race and primary language on ED triage in a system that relies on chief complaint and general appearance.

Davey K, Olivieri P, Saul T, Atmar S, Rabrich JS, Egan DJ.

Am J Emerg Med. 2017 Jul;35(7):1013-1015. doi: 10.1016/j.ajem.2017.01.039. Epub 2017 Jan 27. No abstract available.


Multicenter study of cigarette smoking among adults with asthma exacerbations in the emergency department, 2011-2012.

Silverman RA, Hasegawa K, Egan DJ, Stiffler KA, Sullivan AF, Camargo CA Jr.

Respir Med. 2017 Apr;125:89-91. doi: 10.1016/j.rmed.2017.02.004. Epub 2017 Feb 7.


Publish or perish: can a 'Write Club' help junior faculty be more productive?

Lee SJ, Cheng GS, Hyun TS, Salit RB, Loggers ET, Egan D, Shadman M, Connelly-Smith L, Krakow EF, Flowers ME.

Bone Marrow Transplant. 2017 Mar;52(3):489-490. doi: 10.1038/bmt.2016.314. Epub 2016 Dec 12. No abstract available.


Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

Verissimo CS, Overmeer RM, Ponsioen B, Drost J, Mertens S, Verlaan-Klink I, Gerwen BV, van der Ven M, Wetering MV, Egan DA, Bernards R, Clevers H, Bos JL, Snippert HJ.

Elife. 2016 Nov 15;5. pii: e18489. doi: 10.7554/eLife.18489.


Making the diagnosis, the tools, and risk stratification: More than just BCR-ABL.

Egan D, Radich J.

Best Pract Res Clin Haematol. 2016 Sep;29(3):252-263. doi: 10.1016/j.beha.2016.10.015. Epub 2016 Oct 20. Review.


Goal-directed Focused Ultrasound Milestones Revised: A Multiorganizational Consensus.

Nelson M, Abdi A, Adhikari S, Boniface M, Bramante RM, Egan DJ, Matthew Fields J, Leo MM, Liteplo AS, Liu R, Nomura JT, Pigott DC, Raio CC, Ruskis J, Strony R, Thom C, Lewiss RE.

Acad Emerg Med. 2016 Nov;23(11):1274-1279. doi: 10.1111/acem.13069. Epub 2016 Oct 31.


Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform.

Pagliero RJ, D'Astolfo DS, Lelieveld D, Pratiwi RD, Aits S, Jaattela M, Martin NI, Klumperman J, Egan DA.

Assay Drug Dev Technol. 2016 Oct;14(8):489-510. Epub 2016 Sep 22.


Brief Report: Pharmacokinetic/Pharmacodynamic Investigation of Single-Dose Oral Maraviroc in the Context of HIV-1 Pre-exposure Prophylaxis.

Fox J, Tiraboschi JM, Herrera C, Else L, Egan D, Dickinson L, Jackson A, Olejniczak N, Back D, Khoo S, Shattock R, Boffito M.

J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):252-257.


Long-acting rilpivirine as potential pre-exposure prophylaxis for HIV-1 prevention (the MWRI-01 study): an open-label, phase 1, compartmental, pharmacokinetic and pharmacodynamic assessment.

McGowan I, Dezzutti CS, Siegel A, Engstrom J, Nikiforov A, Duffill K, Shetler C, Richardson-Harman N, Abebe K, Back D, Else L, Egan D, Khoo S, Egan JE, Stall R, Williams PE, Rehman KK, Adler A, Brand RM, Chen B, Achilles S, Cranston RD.

Lancet HIV. 2016 Dec;3(12):e569-e578. doi: 10.1016/S2352-3018(16)30113-8. Epub 2016 Sep 16.


HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets.

Omta WA, van Heesbeen RG, Pagliero RJ, van der Velden LM, Lelieveld D, Nellen M, Kramer M, Yeong M, Saeidi AM, Medema RH, Spruit M, Brinkkemper S, Klumperman J, Egan DA.

Assay Drug Dev Technol. 2016 Oct;14(8):439-452. Epub 2016 Sep 16.


An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.

Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F.

J Cell Biol. 2016 Aug 29;214(5):619-35. doi: 10.1083/jcb.201602046.


Molecular monitoring of chronic myeloid leukemia: present and future.

Yeung CC, Egan D, Radich JP.

Expert Rev Mol Diagn. 2016 Oct;16(10):1083-1091. Epub 2016 Sep 6. Review.


Cytotoxic chemotherapy and the evolution of cellular and viral resistance to antiretroviral therapy in HIV- infected individuals with lymphoma.

McFaul K, Liptrott N, Cox A, Martin P, Egan D, Owen A, Kelly S, Karolia Z, Shaw K, Bower M, Boffito M.

HIV Clin Trials. 2016 Sep;17(5):197-203. doi: 10.1080/15284336.2016.1210719. Epub 2016 Jul 25.


Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.

van Heesbeen RGHP, Raaijmakers JA, Tanenbaum ME, Halim VA, Lelieveld D, Lieftink C, Heck AJR, Egan DA, Medema RH.

Chromosoma. 2017 Aug;126(4):473-486. doi: 10.1007/s00412-016-0607-4. Epub 2016 Jun 29.


The development and application of a novel LC-MS/MS method for the measurement of Dolutegravir, Elvitegravir and Cobicistat in human plasma.

Penchala SD, Fawcett S, Else L, Egan D, Amara A, Elliot E, Challenger E, Back D, Boffito M, Khoo S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 1;1027:174-80. doi: 10.1016/j.jchromb.2016.05.040. Epub 2016 May 27.


Monitoring disease burden in chronic myeloid leukemia: Past, present, and future.

Egan D, Radich J.

Am J Hematol. 2016 Jul;91(7):742-6. doi: 10.1002/ajh.24381. Epub 2016 May 24. Review.

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