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Items: 1 to 50 of 111

1.

Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer.

Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A.

J Natl Cancer Inst. 2014 Oct 11;106(12). pii: dju320. doi: 10.1093/jnci/dju320. Print 2014 Dec.

PMID:
25306215
2.

SDF-1 activates papillary label-retaining cells during kidney repair from injury.

Oliver JA, Maarouf O, Cheema FH, Liu C, Zhang QY, Kraus C, Zeeshan Afzal M, Firdous M, Klinakis A, Efstratiadis A, Al-Awqati Q.

Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1362-73. doi: 10.1152/ajprenal.00202.2011. Epub 2012 Mar 28.

3.

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I.

Nature. 2011 May 12;473(7346):230-3. doi: 10.1038/nature09999.

4.

Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma.

Abraham J, Prajapati SI, Nishijo K, Schaffer BS, Taniguchi E, Kilcoyne A, McCleish AT, Nelon LD, Giles FG, Efstratiadis A, LeGallo RD, Nowak BM, Rubin BP, Malempati S, Keller C.

Mol Cancer Ther. 2011 Apr;10(4):697-707. doi: 10.1158/1535-7163.MCT-10-0695. Epub 2011 Mar 29.

5.

Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.

Xuan S, Szabolcs M, Cinti F, Perincheri S, Accili D, Efstratiadis A.

J Biol Chem. 2010 Dec 24;285(52):41044-50. doi: 10.1074/jbc.M110.144790. Epub 2010 Oct 14.

6.

Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.

Pitetti JL, Torre D, Conne B, Papaioannou MD, Cederroth CR, Xuan S, Kahn R, Parada LF, Vassalli JD, Efstratiadis A, Nef S.

Sex Dev. 2009;3(5):264-72. doi: 10.1159/000252813. Epub 2009 Oct 23.

PMID:
19851056
7.

Proliferation and migration of label-retaining cells of the kidney papilla.

Oliver JA, Klinakis A, Cheema FH, Friedlander J, Sampogna RV, Martens TP, Liu C, Efstratiadis A, Al-Awqati Q.

J Am Soc Nephrol. 2009 Nov;20(11):2315-27. doi: 10.1681/ASN.2008111203. Epub 2009 Sep 17.

8.

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.

Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, Lipp M, Ibrahim S, Efstratiadis A, Zagzag D, Bromberg JS, Dustin ML, Aifantis I.

Nature. 2009 Jun 18;459(7249):1000-4. doi: 10.1038/nature08020.

9.

Igf1r as a therapeutic target in a mouse model of basal-like breast cancer.

Klinakis A, Szabolcs M, Chen G, Xuan S, Hibshoosh H, Efstratiadis A.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2359-64. doi: 10.1073/pnas.0810221106. Epub 2009 Jan 27.

10.

Irs2 inactivation suppresses tumor progression in Pten+/- mice.

Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R.

Am J Pathol. 2009 Jan;174(1):276-86. doi: 10.2353/ajpath.2009.080086. Epub 2008 Dec 18.

11.

The hormonal action of IGF1 in postnatal mouse growth.

Stratikopoulos E, Szabolcs M, Dragatsis I, Klinakis A, Efstratiadis A.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.

12.

Role of IGF signaling in olfactory sensory map formation and axon guidance.

Scolnick JA, Cui K, Duggan CD, Xuan S, Yuan XB, Efstratiadis A, Ngai J.

Neuron. 2008 Mar 27;57(6):847-57. doi: 10.1016/j.neuron.2008.01.027.

13.

Notch, Myc and breast cancer.

Efstratiadis A, Szabolcs M, Klinakis A.

Cell Cycle. 2007 Feb 15;6(4):418-29. Epub 2007 Feb 9. Review.

PMID:
17329972
14.

Independent regulation of skeletal growth by Ihh and IGF signaling.

Long F, Joeng KS, Xuan S, Efstratiadis A, McMahon AP.

Dev Biol. 2006 Oct 1;298(1):327-33. Epub 2006 Jun 30.

15.

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.

Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9262-7. Epub 2006 Jun 2.

16.

Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.

Li Z, Szabolcs M, Terwilliger JD, Efstratiadis A.

Carcinogenesis. 2006 May;27(5):1054-67. Epub 2006 Jan 9.

PMID:
16401639
17.

Role for Akt3/protein kinase Bgamma in attainment of normal brain size.

Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ.

Mol Cell Biol. 2005 Mar;25(5):1869-78.

18.

Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.

Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S.

Am J Pathol. 2004 Aug;165(2):695-705.

19.

Mosaic analysis of insulin receptor function.

Kitamura T, Kitamura Y, Nakae J, Giordano A, Cinti S, Kahn CR, Efstratiadis A, Accili D.

J Clin Invest. 2004 Jan;113(2):209-19.

20.

A mouse model of uterine leiomyosarcoma.

Politi K, Szabolcs M, Fisher P, Kljuic A, Ludwig T, Efstratiadis A.

Am J Pathol. 2004 Jan;164(1):325-36.

21.

'Designer' tumors in mice.

Politi K, Kljuic A, Szabolcs M, Fisher P, Ludwig T, Efstratiadis A.

Oncogene. 2004 Feb 26;23(8):1558-65.

PMID:
14661057
22.

Testis determination requires insulin receptor family function in mice.

Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF.

Nature. 2003 Nov 20;426(6964):291-5.

23.

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination.

Mason JL, Xuan S, Dragatsis I, Efstratiadis A, Goldman JE.

J Neurosci. 2003 Aug 20;23(20):7710-8.

24.

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A.

J Clin Invest. 2002 Oct;110(7):1011-9.

25.

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.

Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL.

J Biol Chem. 2002 Nov 15;277(46):44005-12. Epub 2002 Sep 4.

26.

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.

Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D.

J Biol Chem. 2002 Sep 27;277(39):36740-7. Epub 2002 Jul 5.

27.

Genomic imprinting: piece of cake.

Tycko B, Efstratiadis A.

Nature. 2002 Jun 27;417(6892):913-4. No abstract available.

PMID:
12087392
28.

Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling.

Chiao E, Fisher P, Crisponi L, Deiana M, Dragatsis I, Schlessinger D, Pilia G, Efstratiadis A.

Dev Biol. 2002 Mar 1;243(1):185-206.

29.

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.

Ludwig T, Fisher P, Murty V, Efstratiadis A.

Oncogene. 2001 Jul 5;20(30):3937-48.

30.

Tumorigenesis in mice carrying a truncating Brca1 mutation.

Ludwig T, Fisher P, Ganesan S, Efstratiadis A.

Genes Dev. 2001 May 15;15(10):1188-93.

31.

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.

Migliazza A, Bosch F, Komatsu H, Cayanis E, Martinotti S, Toniato E, Guccione E, Qu X, Chien M, Murty VV, Gaidano G, Inghirami G, Zhang P, Fischer S, Kalachikov SM, Russo J, Edelman I, Efstratiadis A, Dalla-Favera R.

Blood. 2001 Apr 1;97(7):2098-104.

32.

Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.

Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A.

Dev Biol. 2001 Jan 1;229(1):141-62.

33.

Molecular pathogenesis of B-cell chronic lymphocytic leukemia: analysis of 13q14 chromosomal deletions.

Migliazza A, Cayanis E, Bosch-Albareda F, Komatsu H, Martinotti S, Toniato E, Kalachikov S, Bonaldo MF, Jelene P, Ye X, Rzhetsky A, Qu X, Chien M, Inghirami G, Gaidano G, Vitolo U, Saglio G, Resegotti L, Zhang P, Soares MB, Russo J, Fischer SG, Edelman IS, Efstratiadis A, Dalla-Favera R.

Curr Top Microbiol Immunol. 2000;252:275-84. Review. No abstract available.

PMID:
11125485
34.

Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes.

Dietrich P, Dragatsis I, Xuan S, Zeitlin S, Efstratiadis A.

Mamm Genome. 2000 Mar;11(3):196-205.

PMID:
10723724
35.

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease.

Levine MS, Klapstein GJ, Koppel A, Gruen E, Cepeda C, Vargas ME, Jokel ES, Carpenter EM, Zanjani H, Hurst RS, Efstratiadis A, Zeitlin S, Chesselet MF.

J Neurosci Res. 1999 Nov 15;58(4):515-32.

PMID:
10533044
36.

Genetics of mouse growth.

Efstratiadis A.

Int J Dev Biol. 1998;42(7):955-76. Review.

37.

Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.

Dragatsis I, Efstratiadis A, Zeitlin S.

Development. 1998 Apr;125(8):1529-39.

38.

High-resolution YAC-cosmid-STS map of human chromosome 13.

Cayanis E, Russo JJ, Kalachikov S, Ye X, Park SH, Sunjevaric I, Bonaldo MF, Lawton L, Venkatraj VS, Schon E, Soares MB, Rothstein R, Warburton D, Edelman IS, Zhang P, Efstratiadis A, Fischer SG.

Genomics. 1998 Jan 1;47(1):26-43.

PMID:
9465293
39.

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.

Eggenschwiler J, Ludwig T, Fisher P, Leighton PA, Tilghman SM, Efstratiadis A.

Genes Dev. 1997 Dec 1;11(23):3128-42.

40.
41.

Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia.

Kalachikov S, Migliazza A, Cayanis E, Fracchiolla NS, Bonaldo MF, Lawton L, Jelenc P, Ye X, Qu X, Chien M, Hauptschein R, Gaidano G, Vitolo U, Saglio G, Resegotti L, Brodjansky V, Yankovsky N, Zhang P, Soares MB, Russo J, Edelman IS, Efstratiadis A, Dalla-Favera R, Fischer SG.

Genomics. 1997 Jun 15;42(3):369-77.

PMID:
9205107
43.

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor.

Morrione A, Valentinis B, Xu SQ, Yumet G, Louvi A, Efstratiadis A, Baserga R.

Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3777-82.

44.

Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.

Ludwig T, Eggenschwiler J, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A.

Dev Biol. 1996 Aug 1;177(2):517-35.

45.

Effects of an Igf1 gene null mutation on mouse reproduction.

Baker J, Hardy MP, Zhou J, Bondy C, Lupu F, Bellvé AR, Efstratiadis A.

Mol Endocrinol. 1996 Jul;10(7):903-18.

PMID:
8813730
46.

A high-resolution annotated physical map of the human chromosome 13q12-13 region containing the breast cancer susceptibility locus BRCA2.

Fischer SG, Cayanis E, de Fatima Bonaldo M, Bowcock AM, Deaven LL, Edelman IS, Gallardo T, Kalachikov S, Lawton L, Longmire JL, Lovett M, Osborne-Lawrence S, Rothstein R, Russo JJ, Soares MB, Sunjevaric I, Venkatraj VS, Warburton D, Zhang P, Efstratiadis A.

Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):690-4.

47.

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue.

Zeitlin S, Liu JP, Chapman DL, Papaioannou VE, Efstratiadis A.

Nat Genet. 1995 Oct;11(2):155-63.

PMID:
7550343
48.

Disruption of imprinting caused by deletion of the H19 gene region in mice.

Leighton PA, Ingram RS, Eggenschwiler J, Efstratiadis A, Tilghman SM.

Nature. 1995 May 4;375(6526):34-9.

PMID:
7536897
49.

Epigenetics. A new whiff of monoallelic expression.

Efstratiadis A.

Curr Biol. 1995 Jan 1;5(1):21-4. Review.

50.

Construction and characterization of a normalized cDNA library.

Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A.

Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9228-32.

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