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Items: 1 to 50 of 212

1.

Multiparametric slice culture platform for the investigation of human cardiac tissue physiology.

Qiao Y, Dong Q, Li B, Obaid S, Miccile C, Yin RT, Talapatra T, Lin Z, Li S, Li Z, Efimov IR.

Prog Biophys Mol Biol. 2018 Jun 27. pii: S0079-6107(18)30012-9. doi: 10.1016/j.pbiomolbio.2018.06.001. [Epub ahead of print]

PMID:
29960680
2.

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

Tsutsui K, Monfredi OJ, Sirenko-Tagirova SG, Maltseva LA, Bychkov R, Kim MS, Ziman BD, Tarasov KV, Tarasova YS, Zhang J, Wang M, Maltsev AV, Brennan JA, Efimov IR, Stern MD, Maltsev VA, Lakatta EG.

Sci Signal. 2018 Jun 12;11(534). pii: eaap7608. doi: 10.1126/scisignal.aap7608.

PMID:
29895616
3.

Cardiac connexin genotyping for identification of the circuit of atrioventricular nodal re-entrant tachycardia.

Katritsis DG, Efimov IR.

Europace. 2018 May 31. doi: 10.1093/europace/euy099. [Epub ahead of print] No abstract available.

PMID:
29860485
4.

Authors' Reply: Unravelling the Mysteries of the Human AV Node.

Efimov IR, George S.

Arrhythm Electrophysiol Rev. 2018 Mar;7(1):63-64. doi: 10.15420/aer.2018.7.1.L1.R1. No abstract available.

5.

Specialized impulse conduction pathway in the alligator heart.

Jensen B, Boukens BJ, Crossley DA 2nd, Conner J, Mohan RA, van Duijvenboden K, Postma AV, Gloschat CR, Elsey RM, Sedmera D, Efimov IR, Christoffels VM.

Elife. 2018 Mar 22;7. pii: e32120. doi: 10.7554/eLife.32120.

6.

Left Septal Slow Pathway Ablation for Atrioventricular Nodal Reentrant Tachycardia.

Katritsis DG, John RM, Latchamsetty R, Muthalaly RG, Zografos T, Katritsis GD, Stevenson WG, Efimov IR, Morady F.

Circ Arrhythm Electrophysiol. 2018 Mar;11(3):e005907. doi: 10.1161/CIRCEP.117.005907.

PMID:
29540373
7.

RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping.

Gloschat C, Aras K, Gupta S, Faye NR, Zhang H, Syunyaev RA, Pryamonosov RA, Rogers J, Kay MW, Efimov IR.

Sci Rep. 2018 Feb 13;8(1):2921. doi: 10.1038/s41598-018-21333-w.

8.

At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities.

George SA, Faye NR, Murillo-Berlioz A, Lee KB, Trachiotis GD, Efimov IR.

Arrhythm Electrophysiol Rev. 2017 Dec;6(4):179-185. doi: 10.15420/aer.2017.30.1.

9.

Ventricular Fibrillation: Rotors or Foci? Both!

Aras KK, Kay MW, Efimov IR.

Circ Arrhythm Electrophysiol. 2017 Dec;10(12). pii: e006011. doi: 10.1161/CIRCEP.117.006011. No abstract available.

PMID:
29247034
10.

Fractionated electrograms with ST-segment elevation recorded from the human right ventricular outflow tract.

Vigmond EJ, Efimov IR, Rentschler SL, Coronel R, Boukens BJ.

HeartRhythm Case Rep. 2017 Sep 28;3(11):546-550. doi: 10.1016/j.hrcr.2017.08.010. eCollection 2017 Nov. No abstract available.

11.

β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle.

Kang C, Badiceanu A, Brennan JA, Gloschat C, Qiao Y, Trayanova NA, Efimov IR.

Sci Rep. 2017 Nov 21;7(1):15922. doi: 10.1038/s41598-017-16218-3.

12.

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.

Kharche SR, Vigmond E, Efimov IR, Dobrzynski H.

PLoS One. 2017 Sep 5;12(9):e0183727. doi: 10.1371/journal.pone.0183727. eCollection 2017.

13.

Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.

Fang H, Yu KJ, Gloschat C, Yang Z, Chiang CH, Zhao J, Won SM, Xu S, Trumpis M, Zhong Y, Song E, Han SW, Xue Y, Xu D, Cauwenberghs G, Kay M, Huang Y, Viventi J, Efimov IR, Rogers JA.

Nat Biomed Eng. 2017;1. pii: 0038. doi: 10.1038/s41551-017-0038. Epub 2017 Mar 1.

14.

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease.

Hsueh B, Burns VM, Pauerstein P, Holzem K, Ye L, Engberg K, Wang AC, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, Efimov IR, Kim S, Deisseroth K.

Sci Rep. 2017 Jul 19;7(1):5899. doi: 10.1038/s41598-017-05614-4.

15.

Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.

Qiao Y, Lipovsky C, Hicks S, Bhatnagar S, Li G, Khandekar A, Guzy R, Woo KV, Nichols CG, Efimov IR, Rentschler S.

Circ Res. 2017 Aug 18;121(5):549-563. doi: 10.1161/CIRCRESAHA.116.310396. Epub 2017 Jul 3.

PMID:
28674041
16.

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H221-H223. doi: 10.1152/ajpheart.00329.2017. Epub 2017 Jun 16. No abstract available.

PMID:
28626081
17.

Local transmural action potential gradients are absent in the isolated, intact dog heart but present in the corresponding coronary-perfused wedge.

Boukens BJ, Meijborg VMF, Belterman CN, Opthof T, Janse MJ, Schuessler RB, Coronel R, Efimov IR.

Physiol Rep. 2017 May;5(10). pii: e13251. doi: 10.14814/phy2.13251.

18.

Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL.

Crit Care Med. 2017 Mar;45(3):407-414. doi: 10.1097/CCM.0000000000002207.

19.
20.

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.

Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP.

Sci Transl Med. 2016 Aug 31;8(354):354ra115. doi: 10.1126/scitranslmed.aaf4891.

21.

Optical Mapping of Cardiac Electromechanics.

Kay MW, Efimov IR.

Biophys J. 2016 Jul 26;111(2):269-270. doi: 10.1016/j.bpj.2016.04.052. No abstract available.

22.

Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials.

Kang C, Qiao Y, Li G, Baechle K, Camelliti P, Rentschler S, Efimov IR.

Sci Rep. 2016 Jun 30;6:28798. doi: 10.1038/srep28798.

23.

Technical advances in studying cardiac electrophysiology - Role of rabbit models.

Kang C, Brennan JA, Kuzmiak-Glancy S, Garrott KE, Kay MW, Efimov IR.

Prog Biophys Mol Biol. 2016 Jul;121(2):97-109. doi: 10.1016/j.pbiomolbio.2016.05.006. Epub 2016 May 19. Review.

PMID:
27210306
24.

Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts.

Holzem KM, Vinnakota KC, Ravikumar VK, Madden EJ, Ewald GA, Dikranian K, Beard DA, Efimov IR.

FASEB J. 2016 Aug;30(8):2698-707. doi: 10.1096/fj.201500118R. Epub 2016 Apr 13.

25.

Arrhythmogenic and metabolic remodelling of failing human heart.

Gloschat CR, Koppel AC, Aras KK, Brennan JA, Holzem KM, Efimov IR.

J Physiol. 2016 Jul 15;594(14):3963-80. doi: 10.1113/JP271992. Epub 2016 Jun 12. Review.

26.

A technical review of optical mapping of intracellular calcium within myocardial tissue.

Jaimes R 3rd, Walton RD, Pasdois P, Bernus O, Efimov IR, Kay MW.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1388-401. doi: 10.1152/ajpheart.00665.2015. Epub 2016 Mar 25. Review.

27.

Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring.

Koh A, Gutbrod SR, Meyers JD, Lu C, Webb RC, Shin G, Li Y, Kang SK, Huang Y, Efimov IR, Rogers JA.

Adv Healthc Mater. 2016 Feb 4;5(3):373-81. doi: 10.1002/adhm.201500451. Epub 2015 Dec 9.

28.

Diet-induced obesity promotes altered remodeling and exacerbated cardiac hypertrophy following pressure overload.

Holzem KM, Marmerstein JT, Madden EJ, Efimov IR.

Physiol Rep. 2015 Aug;3(8). pii: e12489. doi: 10.14814/phy2.12489.

29.

Imaging of Ventricular Fibrillation and Defibrillation: The Virtual Electrode Hypothesis.

Boukens BJ, Gutbrod SR, Efimov IR.

Adv Exp Med Biol. 2015;859:343-65. doi: 10.1007/978-3-319-17641-3_14. Review.

30.

Transmural APD gradient synchronizes repolarization in the human left ventricular wall.

Boukens BJ, Sulkin MS, Gloschat CR, Ng FS, Vigmond EJ, Efimov IR.

Cardiovasc Res. 2015 Oct 1;108(1):188-96. doi: 10.1093/cvr/cvv202. Epub 2015 Jul 24.

31.

Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure.

Holzem KM, Gomez JF, Glukhov AV, Madden EJ, Koppel AC, Ewald GA, Trenor B, Efimov IR.

J Mol Cell Cardiol. 2016 Jul;96:82-92. doi: 10.1016/j.yjmcc.2015.06.008. Epub 2015 Jun 17.

32.

Dual Vm/Ca imaging of premature ventricular contractions: bridging the gap of anatomical scales.

Ripplinger CM, Efimov IR.

Circ Arrhythm Electrophysiol. 2015 Jun;8(3):529-30. doi: 10.1161/CIRCEP.115.002916. No abstract available.

33.

Feasibility of a semi-automated method for cardiac conduction velocity analysis of high-resolution activation maps.

Doshi AN, Walton RD, Krul SP, de Groot JR, Bernus O, Efimov IR, Boukens BJ, Coronel R.

Comput Biol Med. 2015 Oct 1;65:177-83. doi: 10.1016/j.compbiomed.2015.05.008. Epub 2015 May 21.

PMID:
26045101
34.

An activation-repolarization time metric to predict localized regions of high susceptibility to reentry.

Child N, Bishop MJ, Hanson B, Coronel R, Opthof T, Boukens BJ, Walton RD, Efimov IR, Bostock J, Hill Y, Rinaldi CA, Razavi R, Gill J, Taggart P.

Heart Rhythm. 2015 Jul;12(7):1644-53. doi: 10.1016/j.hrthm.2015.04.013. Epub 2015 Apr 9.

35.

Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model.

Gutbrod SR, Walton R, Gilbert S, Meillet V, Jaïs P, Hocini M, Haïssaguerre M, Dubois R, Bernus O, Efimov IR.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):456-65. doi: 10.1161/CIRCEP.114.002545. Epub 2015 Feb 24.

36.

Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.

Lang D, Holzem K, Kang C, Xiao M, Hwang HJ, Ewald GA, Yamada KA, Efimov IR.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):409-19. doi: 10.1161/CIRCEP.114.002065. Epub 2015 Feb 11.

37.

Materials and fractal designs for 3D multifunctional integumentary membranes with capabilities in cardiac electrotherapy.

Xu L, Gutbrod SR, Ma Y, Petrossians A, Liu Y, Webb RC, Fan JA, Yang Z, Xu R, Whalen JJ 3rd, Weiland JD, Huang Y, Efimov IR, Rogers JA.

Adv Mater. 2015 Mar 11;27(10):1731-7. doi: 10.1002/adma.201405017. Epub 2015 Jan 12.

38.

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

Gillers BS, Chiplunkar A, Aly H, Valenta T, Basler K, Christoffels VM, Efimov IR, Boukens BJ, Rentschler S.

Circ Res. 2015 Jan 30;116(3):398-406. doi: 10.1161/CIRCRESAHA.116.304731. Epub 2014 Nov 6.

39.

Electrophysiological changes correlated with temperature increases induced by high-intensity focused ultrasound ablation.

Wu Z, Kumon RE, Laughner JI, Efimov IR, Deng CX.

Ultrasound Med Biol. 2015 Feb;41(2):432-48. doi: 10.1016/j.ultrasmedbio.2014.09.009. Epub 2014 Dec 13.

40.

Human cardiac systems electrophysiology and arrhythmogenesis: iteration of experiment and computation.

Holzem KM, Madden EJ, Efimov IR.

Europace. 2014 Nov;16 Suppl 4:iv77-iv85. doi: 10.1093/europace/euu264. Review.

41.

Nanoscale three-dimensional imaging of the human myocyte.

Sulkin MS, Yang F, Holzem KM, Van Leer B, Bugge C, Laughner JI, Green K, Efimov IR.

J Struct Biol. 2014 Oct;188(1):55-60. doi: 10.1016/j.jsb.2014.08.005. Epub 2014 Aug 23.

42.

Mitochondrial depolarization and electrophysiological changes during ischemia in the rabbit and human heart.

Sulkin MS, Boukens BJ, Tetlow M, Gutbrod SR, Ng FS, Efimov IR.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1178-86. doi: 10.1152/ajpheart.00437.2014. Epub 2014 Aug 15.

43.

Adverse remodeling of the electrophysiological response to ischemia-reperfusion in human heart failure is associated with remodeling of metabolic gene expression.

Ng FS, Holzem KM, Koppel AC, Janks D, Gordon F, Wit AL, Peters NS, Efimov IR.

Circ Arrhythm Electrophysiol. 2014 Oct;7(5):875-82. doi: 10.1161/CIRCEP.113.001477. Epub 2014 Aug 11.

44.

Patient-specific flexible and stretchable devices for cardiac diagnostics and therapy.

Gutbrod SR, Sulkin MS, Rogers JA, Efimov IR.

Prog Biophys Mol Biol. 2014 Aug;115(2-3):244-51. doi: 10.1016/j.pbiomolbio.2014.07.011. Epub 2014 Aug 5. Review.

45.

A shocking past: a walk through generations of defibrillation development.

Gutbrod SR, Efimov IR.

IEEE Trans Biomed Eng. 2014 May;61(5):1466-73. doi: 10.1109/TBME.2014.2301035. Review.

PMID:
24759279
46.

Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes.

Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B.

J Cell Sci. 2014 May 1;127(Pt 9):2106-19. doi: 10.1242/jcs.141440. Epub 2014 Feb 25.

47.

3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium.

Xu L, Gutbrod SR, Bonifas AP, Su Y, Sulkin MS, Lu N, Chung HJ, Jang KI, Liu Z, Ying M, Lu C, Webb RC, Kim JS, Laughner JI, Cheng H, Liu Y, Ameen A, Jeong JW, Kim GT, Huang Y, Efimov IR, Rogers JA.

Nat Commun. 2014 Feb 25;5:3329. doi: 10.1038/ncomms4329.

48.

c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction.

Rutledge CA, Ng FS, Sulkin MS, Greener ID, Sergeyenko AM, Liu H, Gemel J, Beyer EC, Sovari AA, Efimov IR, Dudley SC.

J Am Coll Cardiol. 2014 Mar 11;63(9):928-34. doi: 10.1016/j.jacc.2013.10.081. Epub 2014 Jan 8.

49.

A fully implantable pacemaker for the mouse: from battery to wireless power.

Laughner JI, Marrus SB, Zellmer ER, Weinheimer CJ, MacEwan MR, Cui SX, Nerbonne JM, Efimov IR.

PLoS One. 2013 Oct 23;8(10):e76291. doi: 10.1371/journal.pone.0076291. eCollection 2013.

50.

A century of optocardiography.

Boukens BJ, Efimov IR.

IEEE Rev Biomed Eng. 2014;7:115-25. doi: 10.1109/RBME.2013.2286296. Epub 2013 Oct 23. Review.

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