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Items: 1 to 50 of 107


In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.

Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E.

Psychoneuroendocrinology. 2018 Oct;96:179-187. doi: 10.1016/j.psyneuen.2018.06.020. Epub 2018 Jun 26.


Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments.

Dock J, Ramirez CM, Hultin L, Hausner MA, Hultin P, Elliott J, Yang OO, Anton PA, Jamieson BD, Effros RB.

PLoS One. 2017 Aug 23;12(8):e0182498. doi: 10.1371/journal.pone.0182498. eCollection 2017.


Human immune compartment comparisons: Optimization of proliferative assays for blood and gut T lymphocytes.

Dock J, Hultin L, Hultin P, Elliot J, Yang OO, Anton PA, Jamieson BD, Effros RB.

J Immunol Methods. 2017 Jun;445:77-87. doi: 10.1016/j.jim.2017.03.014. Epub 2017 Mar 21.


Insomnia and Telomere Length in Older Adults.

Carroll JE, Esquivel S, Goldberg A, Seeman TE, Effros RB, Dock J, Olmstead R, Breen EC, Irwin MR.

Sleep. 2016 Mar 1;39(3):559-64. doi: 10.5665/sleep.5526.


The silent war of CMV in aging and HIV infection.

Effros RB.

Mech Ageing Dev. 2016 Sep;158:46-52. doi: 10.1016/j.mad.2015.09.003. Epub 2015 Sep 25. Review.


Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.

Chou JP, Ramirez CM, Ryba DM, Koduri MP, Effros RB.

PLoS One. 2014 Jun 11;9(6):e99432. doi: 10.1371/journal.pone.0099432. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e107600.


Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8+ T cells.

Chou JP, Ramirez CM, Wu JE, Effros RB.

PLoS One. 2013 May 22;8(5):e64702. doi: 10.1371/journal.pone.0064702. Print 2013.


Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated HIV infection.

Unemori P, Leslie KS, Hunt PW, Sinclair E, Epling L, Mitsuyasu R, Effros RB, Dock J, Dollard SG, Deeks SG, Martin JN, Maurer TA.

AIDS. 2013 Jul 17;27(11):1735-42. doi: 10.1097/QAD.0b013e3283601144.


Functional assessment of pharmacological telomerase activators in human T cells.

Molgora B, Bateman R, Sweeney G, Finger D, Dimler T, Effros RB, Valenzuela HF.

Cells. 2013 Jan 14;2(1):57-66. doi: 10.3390/cells2010057.


Preface: aging and oncogenesis.

Effros RB.

Crit Rev Oncog. 2013;18(6):485-7. No abstract available.


T cell replicative senescence in human aging.

Chou JP, Effros RB.

Curr Pharm Des. 2013;19(9):1680-98. Review.


HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group.

High KP, Brennan-Ing M, Clifford DB, Cohen MH, Currier J, Deeks SG, Deren S, Effros RB, Gebo K, Goronzy JJ, Justice AC, Landay A, Levin J, Miotti PG, Munk RJ, Nass H, Rinaldo CR Jr, Shlipak MG, Tracy R, Valcour V, Vance DE, Walston JD, Volberding P; OAR Working Group on HIV and Aging.

J Acquir Immune Defic Syndr. 2012 Jul 1;60 Suppl 1:S1-18. doi: 10.1097/QAI.0b013e31825a3668.


Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.

Watson MB, Richter F, Lee SK, Gabby L, Wu J, Masliah E, Effros RB, Chesselet MF.

Exp Neurol. 2012 Oct;237(2):318-34. doi: 10.1016/j.expneurol.2012.06.025. Epub 2012 Jun 27.


Editorial: T cell memory, bone marrow, and aging: the good news.

Effros RB.

J Leukoc Biol. 2012 Feb;91(2):185-7. doi: 10.1189/jlb.0811438. No abstract available.


Low physical function as a risk factor for incident diabetes mellitus and insulin resistance.

Longenberger A, Lim JY, Brown TT, Abraham A, Palella FJ, Effros RB, Orchard T, Brooks MM, Kingsley LA.

Future Virol. 2011 Apr;6(4):439-449.


The dual impact of HIV-1 infection and aging on naïve CD4 T-cells: additive and distinct patterns of impairment.

Rickabaugh TM, Kilpatrick RD, Hultin LE, Hultin PM, Hausner MA, Sugar CA, Althoff KN, Margolick JB, Rinaldo CR, Detels R, Phair J, Effros RB, Jamieson BD.

PLoS One. 2011 Jan 26;6(1):e16459. doi: 10.1371/journal.pone.0016459.


Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress.

Effros RB.

Exp Gerontol. 2011 Feb-Mar;46(2-3):135-40. doi: 10.1016/j.exger.2010.08.027. Epub 2010 Sep 15. Review.


Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes.

Parish ST, Wu JE, Effros RB.

J Clin Immunol. 2010 Nov;30(6):798-805. doi: 10.1007/s10875-010-9449-7. Epub 2010 Aug 19. Review.


PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.

Tseng W, Graham LS, Geng Y, Reddy A, Lu J, Effros RB, Demer L, Tintut Y.

J Biol Chem. 2010 Sep 24;285(39):29925-31. doi: 10.1074/jbc.M110.117366. Epub 2010 Jul 27.


Bone density and hyperlipidemia: the T-lymphocyte connection.

Graham LS, Tintut Y, Parhami F, Kitchen CM, Ivanov Y, Tetradis S, Effros RB.

J Bone Miner Res. 2010 Nov;25(11):2460-9. doi: 10.1002/jbmr.148.


Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes.

Parish ST, Kim S, Sekhon RK, Wu JE, Kawakatsu Y, Effros RB.

J Immunol. 2010 Mar 15;184(6):2847-54. doi: 10.4049/jimmunol.0903647. Epub 2010 Feb 10.


Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.

Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB.

Clin Immunol. 2009 Nov;133(2):265-75. doi: 10.1016/j.clim.2009.07.011. Epub 2009 Aug 22.


Immunosenescence: what does it mean to health outcomes in older adults?

McElhaney JE, Effros RB.

Curr Opin Immunol. 2009 Aug;21(4):418-24. doi: 10.1016/j.coi.2009.05.023. Epub 2009 Jun 29. Review.


Vaccination in the elderly: an immunological perspective.

Chen WH, Kozlovsky BF, Effros RB, Grubeck-Loebenstein B, Edelman R, Sztein MB.

Trends Immunol. 2009 Jul;30(7):351-9. doi: 10.1016/ Epub 2009 Jun 18. Review.


Modulation of T lymphocyte replicative senescence via TNF-{alpha} inhibition: role of caspase-3.

Parish ST, Wu JE, Effros RB.

J Immunol. 2009 Apr 1;182(7):4237-43. doi: 10.4049/jimmunol.0803449.


Kleemeier Award Lecture 2008--the canary in the coal mine: telomeres and human healthspan.

Effros RB.

J Gerontol A Biol Sci Med Sci. 2009 May;64(5):511-5. doi: 10.1093/gerona/glp001. Epub 2009 Feb 19. Review.


Premature aging of T cells is associated with faster HIV-1 disease progression.

Cao W, Jamieson BD, Hultin LE, Hultin PM, Effros RB, Detels R.

J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):137-47. doi: 10.1097/QAI.0b013e3181926c28.


Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

Fauce SR, Jamieson BD, Chin AC, Mitsuyasu RT, Parish ST, Ng HL, Kitchen CM, Yang OO, Harley CB, Effros RB.

J Immunol. 2008 Nov 15;181(10):7400-6.


Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.

Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, Huebner RE, Janoff EN, Justice AC, Kuritzkes D, Nayfield SG, Plaeger SF, Schmader KE, Ashworth JR, Campanelli C, Clayton CP, Rada B, Woolard NF, High KP.

Clin Infect Dis. 2008 Aug 15;47(4):542-53. doi: 10.1086/590150.


The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America.

Effros RB, Austad S, Blau H, Chesselet MF, Ingram D, Johnson TE, Kaeberlein M, Lundblad V, McCarter R, McElhaney J, Saag M.

J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):331-7.


Reduced telomerase activity in human T lymphocytes exposed to cortisol.

Choi J, Fauce SR, Effros RB.

Brain Behav Immun. 2008 May;22(4):600-5. doi: 10.1016/j.bbi.2007.12.004. Epub 2008 Jan 25.


Challenges for vaccination in the elderly.

Aspinall R, Del Giudice G, Effros RB, Grubeck-Loebenstein B, Sambhara S.

Immun Ageing. 2007 Dec 11;4:9.


Telomerase induction in T cells: a cure for aging and disease?

Effros RB.

Exp Gerontol. 2007 May;42(5):416-20. Epub 2006 Dec 19. Review.


Role of T lymphocyte replicative senescence in vaccine efficacy.

Effros RB.

Vaccine. 2007 Jan 8;25(4):599-604. Epub 2006 Sep 7. Review.


The role of CD8+ T-cell replicative senescence in human aging.

Effros RB, Dagarag M, Spaulding C, Man J.

Immunol Rev. 2005 Jun;205:147-57. Review.


Roy Walford and the immunologic theory of aging.

Effros RB.

Immun Ageing. 2005 Apr 25;2(1):7.


Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes.

Yang OO, Lin H, Dagarag M, Ng HL, Effros RB, Uittenbogaart CH.

Virology. 2005 Feb 5;332(1):16-9.


T cell replicative senescence: pleiotropic effects on human aging.

Effros RB.

Ann N Y Acad Sci. 2004 Jun;1019:123-6. Review.


Replicative senescence of CD8 T cells: potential effects on cancer immune surveillance and immunotherapy.

Effros RB.

Cancer Immunol Immunother. 2004 Oct;53(10):925-33. Epub 2004 Apr 6. Review.


Replicative senescence of CD8 T cells: effect on human ageing.

Effros RB.

Exp Gerontol. 2004 Apr;39(4):517-24. Review.


Age related microsatellite instability in T cells from healthy individuals.

Krichevsky S, Pawelec G, Gural A, Effros RB, Globerson A, Yehuda DB, Yehuda AB.

Exp Gerontol. 2004 Apr;39(4):507-15.


Replicative senescence: the final stage of memory T cell differentiation?

Effros RB.

Curr HIV Res. 2003 Apr;1(2):153-65. Review.


In vitro senescence of immune cells.

Effros RB, Dagarag M, Valenzuela HF.

Exp Gerontol. 2003 Nov-Dec;38(11-12):1243-9. Review.


CD8 T cells and aging.

Effros RB, Cai Z, Linton PJ.

Crit Rev Immunol. 2003;23(1-2):45-64. Review.


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