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Items: 44

1.

Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila.

Nie Y, Yu S, Li Q, Nirala NK, Amcheslavsky A, Edwards YJK, Shum PW, Jiang Z, Wang W, Zhang B, Gao N, Ip YT.

Genetics. 2019 Aug;212(4):1227-1239. doi: 10.1534/genetics.119.302137. Epub 2019 Jun 18.

PMID:
31213502
2.

Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.

Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA.

J Immunol. 2019 Feb 1;202(3):647-651. doi: 10.4049/jimmunol.1800278. Epub 2019 Jan 4.

PMID:
30610162
3.

CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.

Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP.

J Biol Chem. 2018 Nov 2;293(44):17291-17305. doi: 10.1074/jbc.RA118.004554. Epub 2018 Sep 6.

4.

The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation.

Girnius N, Edwards YJ, Garlick DS, Davis RJ.

Elife. 2018 Jun 1;7. pii: e36389. doi: 10.7554/eLife.36389.

5.

The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution.

Girnius N, Edwards YJK, Davis RJ.

Cell Death Differ. 2018 Sep;25(9):1702-1715. doi: 10.1038/s41418-018-0081-z. Epub 2018 Mar 6.

6.

Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma.

Venkatesan AM, Vyas R, Gramann AK, Dresser K, Gujja S, Bhatnagar S, Chhangawala S, Gomes CBF, Xi HS, Lian CG, Houvras Y, Edwards YJK, Deng A, Green M, Ceol CJ.

J Clin Invest. 2018 Jan 2;128(1):294-308. doi: 10.1172/JCI92513. Epub 2017 Dec 4.

7.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA.

Cell Metab. 2018 Jan 9;27(1):195-209.e6. doi: 10.1016/j.cmet.2017.10.008. Epub 2017 Nov 16.

8.

Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy.

Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF Jr, Zile MR, Aurigemma GP.

Front Cardiovasc Med. 2017 Aug 3;4:49. doi: 10.3389/fcvm.2017.00049. eCollection 2017.

9.

An alternative splicing program promotes adipose tissue thermogenesis.

Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ.

Elife. 2016 Sep 16;5. pii: e17672. doi: 10.7554/eLife.17672.

10.

Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior.

Mansur F, Ivshina M, Gu W, Schaevitz L, Stackpole E, Gujja S, Edwards YJ, Richter JD.

RNA. 2016 Oct;22(10):1492-9. doi: 10.1261/rna.056937.116. Epub 2016 Aug 5.

11.

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation.

Smulan LJ, Ding W, Freinkman E, Gujja S, Edwards YJK, Walker AK.

Cell Rep. 2016 Jun 28;16(1):9-18. doi: 10.1016/j.celrep.2016.05.086. Epub 2016 Jun 16.

12.

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.

Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP.

Mol Cell Biol. 2016 May 31;36(12):1740-9. doi: 10.1128/MCB.01121-15. Print 2016 Jun 15.

13.

Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss.

Diaz-Horta O, Duman D, Foster J 2nd, Sırmacı A, Gonzalez M, Mahdieh N, Fotouhi N, Bonyadi M, Cengiz FB, Menendez I, Ulloa RH, Edwards YJ, Züchner S, Blanton S, Tekin M.

PLoS One. 2012;7(11):e50628. doi: 10.1371/journal.pone.0050628. Epub 2012 Nov 30.

14.

Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.

Yariz KO, Duman D, Zazo Seco C, Dallman J, Huang M, Peters TA, Sirmaci A, Lu N, Schraders M, Skromne I, Oostrik J, Diaz-Horta O, Young JI, Tokgoz-Yilmaz S, Konukseven O, Shahin H, Hetterschijt L, Kanaan M, Oonk AM, Edwards YJ, Li H, Atalay S, Blanton S, Desmidt AA, Liu XZ, Pennings RJ, Lu Z, Chen ZY, Kremer H, Tekin M.

Am J Hum Genet. 2012 Nov 2;91(5):872-82. doi: 10.1016/j.ajhg.2012.09.011.

15.

Challenges in whole exome sequencing: an example from hereditary deafness.

Sirmaci A, Edwards YJ, Akay H, Tekin M.

PLoS One. 2012;7(2):e32000. doi: 10.1371/journal.pone.0032000. Epub 2012 Feb 21.

16.

Comparison of three targeted enrichment strategies on the SOLiD sequencing platform.

Hedges DJ, Guettouche T, Yang S, Bademci G, Diaz A, Andersen A, Hulme WF, Linker S, Mehta A, Edwards YJ, Beecham GW, Martin ER, Pericak-Vance MA, Zuchner S, Vance JM, Gilbert JR.

PLoS One. 2011 Apr 29;6(4):e18595. doi: 10.1371/journal.pone.0018595.

17.

Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach.

Edwards YJ, Beecham GW, Scott WK, Khuri S, Bademci G, Tekin D, Martin ER, Jiang Z, Mash DC, ffrench-Mullen J, Pericak-Vance MA, Tsinoremas N, Vance JM.

PLoS One. 2011 Feb 22;6(2):e16917. doi: 10.1371/journal.pone.0016917.

18.

Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa.

Züchner S, Dallman J, Wen R, Beecham G, Naj A, Farooq A, Kohli MA, Whitehead PL, Hulme W, Konidari I, Edwards YJ, Cai G, Peter I, Seo D, Buxbaum JD, Haines JL, Blanton S, Young J, Alfonso E, Vance JM, Lam BL, Peričak-Vance MA.

Am J Hum Genet. 2011 Feb 11;88(2):201-6. doi: 10.1016/j.ajhg.2011.01.001. Epub 2011 Feb 3.

19.

Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family.

Montenegro G, Powell E, Huang J, Speziani F, Edwards YJ, Beecham G, Hulme W, Siskind C, Vance J, Shy M, Züchner S.

Ann Neurol. 2011 Mar;69(3):464-70. doi: 10.1002/ana.22235. Epub 2011 Jan 20.

20.

The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.

Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Züchner S.

Cell Metab. 2010 Dec 1;12(6):675-82. doi: 10.1016/j.cmet.2010.11.012.

21.

Recurrent and private MYO15A mutations are associated with deafness in the Turkish population.

Cengiz FB, Duman D, Sirmaci A, Tokgöz-Yilmaz S, Erbek S, Oztürkmen-Akay H, Incesulu A, Edwards YJ, Ozdag H, Liu XZ, Tekin M.

Genet Test Mol Biomarkers. 2010 Aug;14(4):543-50. doi: 10.1089/gtmb.2010.0039.

PMID:
20642360
22.

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data.

Edwards YJ, Lobley AE, Pentony MM, Jones DT.

Genome Biol. 2009;10(5):R50. doi: 10.1186/gb-2009-10-5-r50. Epub 2009 May 11.

23.

A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness.

Edwards YJ, Bryson K, Jones DT.

PLoS One. 2008 Jul 16;3(7):e2712. doi: 10.1371/journal.pone.0002712.

24.

SAND, a new protein family: from nucleic acid to protein structure and function prediction.

Cottage A, Edwards YJ, Elgar G.

Comp Funct Genomics. 2001;2(4):226-35. doi: 10.1002/cfg.93.

25.

Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis.

Ikeda D, Ono Y, Snell P, Edwards YJ, Elgar G, Watabe S.

Physiol Genomics. 2007 Dec 19;32(1):1-15. Epub 2007 Oct 16.

PMID:
17940200
26.

Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies.

Edwards YJ, Walter K, McEwen G, Vavouri T, Kelly KA, Abnizova I, Woolfe A, Goode DK, Goodson M, North P, Snell P, Callaway H, Smith SF, Gilks WR, Cooke JE, Elgar G.

Comp Biochem Physiol Part D Genomics Proteomics. 2006 Mar;1(1):46-58. doi: 10.1016/j.cbd.2005.03.001. Epub 2005 Sep 15.

PMID:
20483234
27.

Molecular characterisation of the SAND protein family: a study based on comparative genomics, structural bioinformatics and phylogeny.

Cottage A, Mullan L, Portela MB, Hellen E, Carver T, Patel S, Vavouri T, Elgar G, Edwards YJ.

Cell Mol Biol Lett. 2004;9(4A):739-53.

28.

Highly conserved non-coding sequences are associated with vertebrate development.

Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T, Smith SF, North P, Callaway H, Kelly K, Walter K, Abnizova I, Gilks W, Edwards YJ, Cooke JE, Elgar G.

PLoS Biol. 2005 Jan;3(1):e7. Epub 2004 Nov 11.

29.

A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes.

Halling-Brown M, Sansom C, Moss DS, Elgar G, Edwards YJ.

Nucleic Acids Res. 2004 May 11;32(8):2618-22. Print 2004.

30.

Fugu ESTs: new resources for transcription analysis and genome annotation.

Clark MS, Edwards YJ, Peterson D, Clifton SW, Thompson AJ, Sasaki M, Suzuki Y, Kikuchi K, Watabe S, Kawakami K, Sugano S, Elgar G, Johnson SL.

Genome Res. 2003 Dec;13(12):2747-53. Epub 2003 Nov 12.

31.

AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals.

Cottage AJ, Edwards YJ, Elgar G.

Mamm Genome. 2003 Aug;14(8):514-25.

PMID:
12925884
32.

Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence.

Edwards YJ, Carver TJ, Vavouri T, Frith M, Bishop MJ, Elgar G.

Nucleic Acids Res. 2003 Jul 1;31(13):3510-7.

33.

Bioinformatics methods to predict protein structure and function. A practical approach.

Edwards YJ, Cottage A.

Mol Biotechnol. 2003 Feb;23(2):139-66. Review.

PMID:
12632698
34.

Fugu orthologues of human major histocompatibility complex genes: a genome survey.

Sambrook JG, Russell R, Umrania Y, Edwards YJ, Campbell RD, Elgar G, Clark MS.

Immunogenetics. 2002 Sep;54(6):367-80. Epub 2002 Jul 16.

PMID:
12242588
35.

Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes.

Aparicio S, Chapman J, Stupka E, Putnam N, Chia JM, Dehal P, Christoffels A, Rash S, Hoon S, Smit A, Gelpke MD, Roach J, Oh T, Ho IY, Wong M, Detter C, Verhoef F, Predki P, Tay A, Lucas S, Richardson P, Smith SF, Clark MS, Edwards YJ, Doggett N, Zharkikh A, Tavtigian SV, Pruss D, Barnstead M, Evans C, Baden H, Powell J, Glusman G, Rowen L, Hood L, Tan YH, Elgar G, Hawkins T, Venkatesh B, Rokhsar D, Brenner S.

Science. 2002 Aug 23;297(5585):1301-10. Epub 2002 Jul 25.

36.

Prediction of protein structure and function by using bioinformatics.

Edwards YJ, Cottage A.

Methods Mol Biol. 2001;175:341-75. Review. No abstract available.

PMID:
11462846
37.

Finding genes in genomic nucleotide sequences by using bioinformatics.

Edwards YJ, Brocklehurst SM.

Methods Mol Biol. 2001;175:235-47. Review. No abstract available.

PMID:
11462838
38.

Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation.

Perkins SJ, Hinshelwood J, Edwards YJ, Jenkins PV.

Biochem Soc Trans. 1999 Dec;27(6):815-20. Review. No abstract available.

PMID:
10830108
40.

Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning.

Elgar G, Clark MS, Meek S, Smith S, Warner S, Edwards YJ, Bouchireb N, Cottage A, Yeo GS, Umrania Y, Williams G, Brenner S.

Genome Res. 1999 Oct;9(10):960-71.

41.

Sequence scanning chicken cosmids: a methodology for genome screening.

Clark MS, Edwards YJ, McQueen HA, Meek SE, Smith S, Umrania Y, Warner S, Williams G, Elgar G.

Gene. 1999 Feb 18;227(2):223-30.

PMID:
10023066

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