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Predicting and Experimentally Validating Hot-Spot Residues at Protein-Protein Interfaces.

Ibarra AA, Bartlett GJ, Hegedüs Z, Dutt S, Hobor F, Horner KA, Hetherington K, Spence K, Nelson A, Edwards TA, Woolfson DN, Sessions RB, Wilson AJ.

ACS Chem Biol. 2019 Oct 18;14(10):2252-2263. doi: 10.1021/acschembio.9b00560. Epub 2019 Sep 27.


Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis.

Davies K, Afrough B, Mankouri J, Hewson R, Edwards TA, Barr JN.

J Gen Virol. 2019 Aug;100(8):1208-1221. doi: 10.1099/jgv.0.001291. Epub 2019 Jul 3.


Reply to Rameix-Welti, "No Incongruity in Respiratory Syncytial Virus M2-1 Protein Remaining Bound to Viral mRNAs during Their Entire Life Time".

Edwards TA, Barr JN.

mBio. 2019 May 7;10(3). pii: e00629-19. doi: 10.1128/mBio.00629-19. No abstract available.


Hazara nairovirus elicits differential induction of apoptosis and nucleocapsid protein cleavage in mammalian and tick cells.

Fuller J, Surtees RA, Shaw AB, Álvarez-Rodríguez B, Slack GS, Bell-Sakyi L, Mankouri J, Edwards TA, Hewson R, Barr JN.

J Gen Virol. 2019 Mar;100(3):392-402. doi: 10.1099/jgv.0.001211. Epub 2019 Feb 5.


The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.

Selvaraj M, Yegambaram K, Todd EJAA, Richard CA, Dods RL, Pangratiou GM, Trinh CH, Moul SL, Murphy JC, Mankouri J, Éléouët JF, Barr JN, Edwards TA.

mBio. 2018 Nov 13;9(6). pii: e01554-18. doi: 10.1128/mBio.01554-18.


Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2018 Feb 2;9(7):2010-2011. doi: 10.1039/c8sc90024h. eCollection 2018 Feb 21.


Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2018 Feb 1;9(7):2008-2009. doi: 10.1039/c8sc90023j. eCollection 2018 Feb 21.


Predictors affecting outcome after single-event multilevel surgery in children with cerebral palsy: a systematic review.

Edwards TA, Theologis T, Wright J.

Dev Med Child Neurol. 2018 Dec;60(12):1201-1208. doi: 10.1111/dmcn.13981. Epub 2018 Aug 2.


Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein.

Muniyandi S, Pangratiou G, Edwards TA, Barr JN.

Subcell Biochem. 2018;88:245-260. doi: 10.1007/978-981-10-8456-0_11. Review.


Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening.

Easton V, McPhillie M, Garcia-Dorival I, Barr JN, Edwards TA, Foster R, Fishwick C, Harris M.

Antiviral Res. 2018 Aug;156:46-54. doi: 10.1016/j.antiviral.2018.06.003. Epub 2018 Jun 2.


The challenges of a comprehensive surgical approach to Blount's disease.

Edwards TA, Hughes R, Monsell F.

J Child Orthop. 2017 Dec 1;11(6):479-487. doi: 10.1302/1863-2548.11.170082.


Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.

Hughes DJ, Tiede C, Penswick N, Tang AA, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A.

Sci Signal. 2017 Nov 14;10(505). pii: eaaj2005. doi: 10.1126/scisignal.aaj2005.


Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2017 Jun 1;8(6):4188-4202. doi: 10.1039/c7sc00388a. Epub 2017 Apr 26. Erratum in: Chem Sci. 2018 Feb 1;9(7):2008-2009. Chem Sci. 2017 Jul 1;8(7):5214-5215.


Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2017 Jul 1;8(7):5214-5215. doi: 10.1039/c7sc90030a. Epub 2017 Jun 6. Erratum in: Chem Sci. 2018 Feb 2;9(7):2010-2011.


Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle.

Surtees R, Dowall SD, Shaw A, Armstrong S, Hewson R, Carroll MW, Mankouri J, Edwards TA, Hiscox JA, Barr JN.

J Virol. 2016 Sep 29;90(20):9305-16. doi: 10.1128/JVI.00661-16. Print 2016 Oct 15.


Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation.

Haywood NJ, Wolny M, Rogers B, Trinh CH, Shuping Y, Edwards TA, Peckham M.

Biochem J. 2016 Aug 15;473(16):2485-93. doi: 10.1042/BCJ20160421. Epub 2016 Jun 10.


Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.

Miles JA, Yeo DJ, Rowell P, Rodriguez-Marin S, Pask CM, Warriner SL, Edwards TA, Wilson AJ.

Chem Sci. 2016 Jun 1;7(6):3694-3702. doi: 10.1039/c5sc04048e. Epub 2016 Feb 29.


Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance.

Stevenson SR, Kamisugi Y, Trinh CH, Schmutz J, Jenkins JW, Grimwood J, Muchero W, Tuskan GA, Rensing SA, Lang D, Reski R, Melkonian M, Rothfels CJ, Li FW, Larsson A, Wong GK, Edwards TA, Cuming AC.

Plant Cell. 2016 Jun;28(6):1310-27. doi: 10.1105/tpc.16.00091. Epub 2016 May 18.


Rationale and design of a randomized controlled clinical trial of functional electrical stimulation cycling in persons with severe multiple sclerosis.

Pilutti LA, Motl RW, Edwards TA, Wilund KR.

Contemp Clin Trials Commun. 2016 May 15;3:147-152. doi: 10.1016/j.conctc.2016.05.005. eCollection 2016 Aug 15.


Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ.

Chem Commun (Camb). 2016 Apr 7;52(31):5421-4. doi: 10.1039/c6cc01812b.


ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection.

Sharkey LK, Edwards TA, O'Neill AJ.

mBio. 2016 Mar 22;7(2):e01975. doi: 10.1128/mBio.01975-15.


Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups.

Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ.

Org Biomol Chem. 2016 Apr 12;14(15):3782-6. doi: 10.1039/c6ob00078a.


Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions.

Barnard A, Long K, Martin HL, Miles JA, Edwards TA, Tomlinson DC, Macdonald A, Wilson AJ.

Angew Chem Weinheim Bergstr Ger. 2015 Mar 2;127(10):3003-3008. Epub 2015 Jan 30.


The crystal structure of the Hazara virus nucleocapsid protein.

Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN, Edwards TA.

BMC Struct Biol. 2015 Dec 29;15:24. doi: 10.1186/s12900-015-0051-3.


Probing Protein Surfaces: QSAR Analysis with Helix Mimetics.

Azzarito V, Rowell P, Barnard A, Edwards TA, Macdonald A, Warriner SL, Wilson AJ.

Chembiochem. 2016 Apr 15;17(8):768-73. doi: 10.1002/cbic.201500504. Epub 2016 Jan 21.


Bespoke RNA recognition by Pumilios.

Edwards TA.

Biochem Soc Trans. 2015 Oct;43(5):801-6. doi: 10.1042/BST20150072. Review.


Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA.

Mol Biosyst. 2015 Oct;11(10):2738-49. doi: 10.1039/c5mb00284b.


Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers.

Azzarito V, Miles JA, Fisher J, Edwards TA, Warriner SL, Wilson AJ.

Chem Sci. 2015 Apr 1;6(4):2434-2443. doi: 10.1039/c4sc03559c. Epub 2015 Jan 30.


Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions.

Barnard A, Long K, Martin HL, Miles JA, Edwards TA, Tomlinson DC, Macdonald A, Wilson AJ.

Angew Chem Int Ed Engl. 2015 Mar 2;54(10):2960-5. doi: 10.1002/anie.201410810. Epub 2015 Feb 4.


Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ.

Chembiochem. 2014 May 26;15(8):1083-7. doi: 10.1002/cbic.201400009. Epub 2014 Apr 29.


Probing bunyavirus N protein oligomerisation using mass spectrometry.

Shepherd DA, Ariza A, Edwards TA, Barr JN, Stonehouse NJ, Ashcroft AE.

Rapid Commun Mass Spectrom. 2014 Apr 15;28(7):793-800. doi: 10.1002/rcm.6841.


Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation.

Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët JF, Edwards TA, Barr JN.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1580-5. doi: 10.1073/pnas.1317262111. Epub 2014 Jan 13.


Mutagenesis mapping of the protein-protein interaction underlying FusB-type fusidic acid resistance.

Cox G, Edwards TA, O'Neill AJ.

Antimicrob Agents Chemother. 2013 Oct;57(10):4640-4. doi: 10.1128/AAC.00198-13. Epub 2013 Jul 8.


Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.

Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.

Nucleic Acids Res. 2013 Jun;41(11):5912-26. doi: 10.1093/nar/gkt268. Epub 2013 Apr 17.


Cultivation and characterization of thermophilic Nitrospira species from geothermal springs in the US Great Basin, China, and Armenia.

Edwards TA, Calica NA, Huang DA, Manoharan N, Hou W, Huang L, Panosyan H, Dong H, Hedlund BP.

FEMS Microbiol Ecol. 2013 Aug;85(2):283-92. doi: 10.1111/1574-6941.12117. Epub 2013 Apr 11.


Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics.

Long K, Edwards TA, Wilson AJ.

Bioorg Med Chem. 2013 Jul 15;21(14):4034-40. doi: 10.1016/j.bmc.2012.09.053. Epub 2012 Oct 3.


Cancer care in East and Central Harlem: community partnership needs assessment.

Edwards TA, Jandorf L, Freemantle H, Sly J, Ellison J, Wong CR, Villagra C, Hong J, Kaleya S, Poultney M, Villegas C, Brenner B, Bickell N.

J Cancer Educ. 2013 Mar;28(1):171-8. doi: 10.1007/s13187-012-0430-4.


Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.

Fuller JC, Jackson RM, Edwards TA, Wilson AJ, Shirts MR.

PLoS One. 2012;7(8):e43253. doi: 10.1371/journal.pone.0043253. Epub 2012 Aug 20.


Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein.

Carter SD, Surtees R, Walter CT, Ariza A, Bergeron É, Nichol ST, Hiscox JA, Edwards TA, Barr JN.

J Virol. 2012 Oct;86(20):10914-23. Epub 2012 Aug 8.


ATP-driven remodeling of the linker domain in the dynein motor.

Roberts AJ, Malkova B, Walker ML, Sakakibara H, Numata N, Kon T, Ohkura R, Edwards TA, Knight PJ, Sutoh K, Oiwa K, Burgess SA.

Structure. 2012 Oct 10;20(10):1670-80. doi: 10.1016/j.str.2012.07.003. Epub 2012 Aug 2.


2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature.

Azzarito V, Prabhakaran P, Bartlett AI, Murphy NS, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ.

Org Biomol Chem. 2012 Aug 28;10(32):6469-72. doi: 10.1039/c2ob26262b. Epub 2012 Jul 11.


Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein.

Carter SD, Barr JN, Edwards TA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):569-73. doi: 10.1107/S1744309112009736. Epub 2012 Apr 21.


Visualizing hydrophobic domains in silicone hydrogel lenses with Sudan IV.

Jacob JT, Levet J Jr, Edwards TA, Dassanayake N, Ketelson H.

Invest Ophthalmol Vis Sci. 2012 Jun 8;53(7):3473-80. doi: 10.1167/iovs.11-9104.


Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.

Cox G, Thompson GS, Jenkins HT, Peske F, Savelsbergh A, Rodnina MV, Wintermeyer W, Homans SW, Edwards TA, O'Neill AJ.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2102-7. doi: 10.1073/pnas.1117275109. Epub 2012 Jan 20.


Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

Jenkins HT, Malkova B, Edwards TA.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18266-71. doi: 10.1073/pnas.1105211108. Epub 2011 Oct 20.


Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution.

Walden M, Jenkins HT, Edwards TA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):744-8. doi: 10.1107/S1744309111017453. Epub 2011 Jun 23.


Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.

East DA, Sousa D, Martin SR, Edwards TA, Lehman W, Mulvihill DP.

Biochem J. 2011 Sep 1;438(2):265-73. doi: 10.1042/BJ20101316.


Ethnic, racial and cultural identity and perceived benefits and barriers related to genetic testing for breast cancer among at-risk women of African descent in New York City.

Sussner KM, Edwards TA, Thompson HS, Jandorf L, Kwate NO, Forman A, Brown K, Kapil-Pair N, Bovbjerg DH, Schwartz MD, Valdimarsdottir HB.

Public Health Genomics. 2011;14(6):356-70. doi: 10.1159/000325263. Epub 2011 May 3.


Helix-mediated protein--protein interactions as targets for intervention using foldamers.

Edwards TA, Wilson AJ.

Amino Acids. 2011 Aug;41(3):743-54. doi: 10.1007/s00726-011-0880-8. Epub 2011 Mar 17. Review.


Control methods for bovine respiratory disease for feedlot cattle.

Edwards TA.

Vet Clin North Am Food Anim Pract. 2010 Jul;26(2):273-84. doi: 10.1016/j.cvfa.2010.03.005. Epub 2010 May 14. Review.


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