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Medieval Climate Variability in the eastern Amazon-Cerrado regions and its archeological implications.

Azevedo V, Stríkis NM, Santos RA, de Souza JG, Ampuero A, Cruz FW, de Oliveira P, Iriarte J, Stumpf CF, Vuille M, Mendes VR, Cheng H, Edwards RL.

Sci Rep. 2019 Dec 30;9(1):20306. doi: 10.1038/s41598-019-56852-7.


Role of climate in the rise and fall of the Neo-Assyrian Empire.

Sinha A, Kathayat G, Weiss H, Li H, Cheng H, Reuter J, Schneider AW, Berkelhammer M, Adalı SF, Stott LD, Edwards RL.

Sci Adv. 2019 Nov 13;5(11):eaax6656. doi: 10.1126/sciadv.aax6656. eCollection 2019 Nov.


Rainfall variations in central Indo-Pacific over the past 2,700 y.

Tan L, Shen CC, Löwemark L, Chawchai S, Edwards RL, Cai Y, Breitenbach SFM, Cheng H, Chou YC, Duerrast H, Partin JW, Cai W, Chabangborn A, Gao Y, Kwiecien O, Wu CC, Shi Z, Hsu HH, Wohlfarth B.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17201-17206. doi: 10.1073/pnas.1903167116. Epub 2019 Aug 12.


Securing a Network for a Research-Intensive, Referral Academic Medical Center: University of Kentucky HealthCare as a Case Study.

Edwards RL, Birdwhistell MD, Zembrodt JW, Newman MF, Karpf M.

Acad Med. 2019 Dec;94(12):1895-1902. doi: 10.1097/ACM.0000000000002878.


Central Europe temperature constrained by speleothem fluid inclusion water isotopes over the past 14,000 years.

Affolter S, Häuselmann A, Fleitmann D, Edwards RL, Cheng H, Leuenberger M.

Sci Adv. 2019 Jun 5;5(6):eaav3809. doi: 10.1126/sciadv.aav3809. eCollection 2019 Jun.


Millennial-scale glacial climate variability in Southeastern Alaska follows Dansgaard-Oeschger cyclicity.

Wilcox PS, Dorale JA, Baichtal JF, Spötl C, Fowell SJ, Edwards RL, Kovarik JL.

Sci Rep. 2019 May 27;9(1):7880. doi: 10.1038/s41598-019-44231-1.


Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.

Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MXG, Odom John AR, Hruz PW.

PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019.


Archaic human remains from Hualongdong, China, and Middle Pleistocene human continuity and variation.

Wu XJ, Pei SW, Cai YJ, Tong HW, Li Q, Dong Z, Sheng JC, Jin ZT, Ma DD, Xing S, Li XL, Cheng X, Cheng H, de la Torre I, Edwards RL, Gong XC, An ZS, Trinkaus E, Liu W.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):9820-9824. doi: 10.1073/pnas.1902396116. Epub 2019 Apr 29.


Shallow particulate organic carbon regeneration in the South Pacific Ocean.

Pavia FJ, Anderson RF, Lam PJ, Cael BB, Vivancos SM, Fleisher MQ, Lu Y, Zhang P, Cheng H, Edwards RL.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):9753-9758. doi: 10.1073/pnas.1901863116. Epub 2019 Apr 29.


Millennial and orbital scale variability of the South American Monsoon during the penultimate glacial period.

Burns SJ, Welsh LK, Scroxton N, Cheng H, Edwards RL.

Sci Rep. 2019 Feb 4;9(1):1234. doi: 10.1038/s41598-018-37854-3.


Atmospheric 14C/12C changes during the last glacial period from Hulu Cave.

Cheng H, Edwards RL, Southon J, Matsumoto K, Feinberg JM, Sinha A, Zhou W, Li H, Li X, Xu Y, Chen S, Tan M, Wang Q, Wang Y, Ning Y.

Science. 2018 Dec 14;362(6420):1293-1297. doi: 10.1126/science.aau0747.


Speleothem record of geomagnetic South Atlantic Anomaly recurrence.

Trindade RIF, Jaqueto P, Terra-Nova F, Brandt D, Hartmann GA, Feinberg JM, Strauss BE, Novello VF, Cruz FW, Karmann I, Cheng H, Edwards RL.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13198-13203. doi: 10.1073/pnas.1809197115. Epub 2018 Dec 10.


Multi-decadal to centennial hydro-climate variability and linkage to solar forcing in the Western Mediterranean during the last 1000 years.

Ait Brahim Y, Wassenburg JA, Cruz FW, Sifeddine A, Scholz D, Bouchaou L, Dassié EP, Jochum KP, Edwards RL, Cheng H.

Sci Rep. 2018 Nov 28;8(1):17446. doi: 10.1038/s41598-018-35498-x.


Moisture availability in the southwest United States over the last three glacial-interglacial cycles.

Wendt KA, Dublyansky YV, Moseley GE, Edwards RL, Cheng H, Spötl C.

Sci Adv. 2018 Oct 24;4(10):eaau1375. doi: 10.1126/sciadv.aau1375. eCollection 2018 Oct.


Afatinib Therapy: Practical Management of Adverse Events With an Oral Agent for Non-Small Cell Lung Cancer Treatment.

Edwards RL, Andan C, Lalla RV, Lacouture ME, O'Brien D, Sequist LV.

Clin J Oncol Nurs. 2018 Oct 1;22(5):542-548. doi: 10.1188/18.CJON.542-548. Review.


MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.

Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS.

J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24.


A 200-year annually laminated stalagmite record of precipitation seasonality in southeastern China and its linkages to ENSO and PDO.

Zhang H, Cheng H, Spötl C, Cai Y, Sinha A, Tan L, Yi L, Yan H, Kathayat G, Ning Y, Li X, Zhang F, Zhao J, Edwards RL.

Sci Rep. 2018 Aug 17;8(1):12344. doi: 10.1038/s41598-018-30112-6.


Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin.

Joseph AI, Edwards RL, Luis PB, Presley SH, Porter NA, Schneider C.

Org Biomol Chem. 2018 May 2;16(17):3273-3281. doi: 10.1039/c8ob00639c.


South American monsoon response to iceberg discharge in the North Atlantic.

Stríkis NM, Cruz FW, Barreto EAS, Naughton F, Vuille M, Cheng H, Voelker AHL, Zhang H, Karmann I, Edwards RL, Auler AS, Santos RV, Sales HR.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3788-3793. doi: 10.1073/pnas.1717784115. Epub 2018 Mar 26.


Evidence of thermophilisation and elevation-dependent warming during the Last Interglacial in the Italian Alps.

Johnston VE, Borsato A, Frisia S, Spötl C, Dublyansky Y, Töchterle P, Hellstrom JC, Bajo P, Edwards RL, Cheng H.

Sci Rep. 2018 Feb 8;8(1):2680. doi: 10.1038/s41598-018-21027-3.


The Indian monsoon variability and civilization changes in the Indian subcontinent.

Kathayat G, Cheng H, Sinha A, Yi L, Li X, Zhang H, Li H, Ning Y, Edwards RL.

Sci Adv. 2017 Dec 13;3(12):e1701296. doi: 10.1126/sciadv.1701296. eCollection 2017 Dec.


The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites.

Edwards RL, Luis PB, Varuzza PV, Joseph AI, Presley SH, Chaturvedi R, Schneider C.

J Biol Chem. 2017 Dec 29;292(52):21243-21252. doi: 10.1074/jbc.RA117.000123. Epub 2017 Nov 2.


How well can we quantify dust deposition to the ocean?

Anderson RF, Cheng H, Edwards RL, Fleisher MQ, Hayes CT, Huang KF, Kadko D, Lam PJ, Landing WM, Lao Y, Lu Y, Measures CI, Moran SB, Morton PL, Ohnemus DC, Robinson LF, Shelley RU.

Philos Trans A Math Phys Eng Sci. 2016 Nov 28;374(2081). pii: 20150285. doi: 10.1098/rsta.2015.0285.


Abrupt climate changes during Termination III in Southern Europe.

Pérez-Mejías C, Moreno A, Sancho C, Bartolomé M, Stoll H, Cacho I, Cheng H, Edwards RL.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10047-10052. doi: 10.1073/pnas.1619615114. Epub 2017 Sep 5.


Estimating the upper limit of prehistoric peak ground acceleration using an in situ, intact and vulnerable stalagmite from Plavecká priepast cave (Detrekői-zsomboly), Little Carpathians, Slovakia-first results.

Gribovszki K, Kovács K, Mónus P, Bokelmann G, Konecny P, Lednická M, Moseley G, Spötl C, Edwards RL, Bednárik M, Brimich L, Tóth L.

J Seismol. 2017;21(5):1111-1130. doi: 10.1007/s10950-017-9655-3. Epub 2017 Mar 25.


MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.

Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, John ARO.

Sci Rep. 2017 Aug 21;7(1):8400. doi: 10.1038/s41598-017-07159-y.


The East Asian summer monsoon variability over the last 145 years inferred from the Shihua Cave record, North China.

Li X, Cheng H, Tan L, Ban F, Sinha A, Duan W, Li H, Zhang H, Ning Y, Kathayat G, Edwards RL.

Sci Rep. 2017 Aug 1;7(1):7078. doi: 10.1038/s41598-017-07251-3.


Cancer and Palliative Care in the United States, Turkey, and Malawi: Developing Global Collaborations.

Walker DK, Edwards RL, Bagcivan G, Bakitas MA.

Asia Pac J Oncol Nurs. 2017 Jul-Sep;4(3):209-219. doi: 10.4103/apjon.apjon_31_17. Review.


Diagnosing and Resolving Conflict Created by Strategic Plans: Where Outreach Strategies and Execution Meet at an Academic Health Center.

Edwards RL, Wollner SB, Weddle J, Zembrodt JW, Birdwhistell MD.

Hosp Top. 2017 Jul-Sep;95(3):72-78. doi: 10.1080/00185868.2017.1301172. Epub 2017 Apr 13.


A high-resolution history of the South American Monsoon from Last Glacial Maximum to the Holocene.

Novello VF, Cruz FW, Vuille M, Stríkis NM, Edwards RL, Cheng H, Emerick S, de Paula MS, Li X, Barreto ES, Karmann I, Santos RV.

Sci Rep. 2017 Mar 10;7:44267. doi: 10.1038/srep44267.


Hydroclimate changes across the Amazon lowlands over the past 45,000 years.

Wang X, Edwards RL, Auler AS, Cheng H, Kong X, Wang Y, Cruz FW, Dorale JA, Chiang HW.

Nature. 2017 Jan 11;541(7636):204-207. doi: 10.1038/nature20787.


Corrigendum: The Asian monsoon over the past 640,000 years and ice age terminations.

Cheng H, Edwards RL, Sinha A, Spötl C, Yi L, Chen S, Kelly M, Kathayat G, Wang X, Li X, Kong X, Wang Y, Ning Y, Zhang H.

Nature. 2017 Jan 5;541(7635):122. doi: 10.1038/nature20585. Epub 2016 Nov 23. No abstract available.


Response to Comments on "Reconciliation of the Devils Hole climate record with orbital forcing".

Moseley GE, Dublyansky YV, Edwards RL, Wendt KA, Pythoud M, Zhang P, Cheng H, Lu Y, Boch R, Spötl C.

Science. 2016 Oct 21;354(6310):296.


Climate variations of Central Asia on orbital to millennial timescales.

Cheng H, Spötl C, Breitenbach SF, Sinha A, Wassenburg JA, Jochum KP, Scholz D, Li X, Yi L, Peng Y, Lv Y, Zhang P, Votintseva A, Loginov V, Ning Y, Kathayat G, Edwards RL.

Sci Rep. 2016 Nov 11;5:36975. doi: 10.1038/srep36975.


Muddled mechanisms: recent progress towards antimalarial target identification.

Edwards RL, Odom John AR.

F1000Res. 2016 Oct 13;5:2514. eCollection 2016. Review.


A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.

Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec.


Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.

San Jose G, Jackson ER, Haymond A, Johny C, Edwards RL, Wang X, Brothers RC, Edelstein EK, Odom AR, Boshoff HI, Couch RD, Dowd CS.

ACS Infect Dis. 2016 Dec 9;2(12):923-935. Epub 2016 Oct 12.


Strong coupling of Asian Monsoon and Antarctic climates on sub-orbital timescales.

Chen S, Wang Y, Cheng H, Edwards RL, Wang X, Kong X, Liu D.

Sci Rep. 2016 Sep 8;6:32995. doi: 10.1038/srep32995.


The Asian monsoon over the past 640,000 years and ice age terminations.

Cheng H, Edwards RL, Sinha A, Spötl C, Yi L, Chen S, Kelly M, Kathayat G, Wang X, Li X, Kong X, Wang Y, Ning Y, Zhang H.

Nature. 2016 Jun 30;534(7609):640-6. doi: 10.1038/nature18591. Erratum in: Nature. 2017 Jan 5;541(7635):122.


Early Neanderthal constructions deep in Bruniquel Cave in southwestern France.

Jaubert J, Verheyden S, Genty D, Soulier M, Cheng H, Blamart D, Burlet C, Camus H, Delaby S, Deldicque D, Edwards RL, Ferrier C, Lacrampe-Cuyaubère F, Lévêque F, Maksud F, Mora P, Muth X, Régnier É, Rouzaud JN, Santos F.

Nature. 2016 Jun 2;534(7605):111-4. doi: 10.1038/nature18291. Epub 2016 May 25.


Centennial-scale solar forcing of the South American Monsoon System recorded in stalagmites.

Novello VF, Vuille M, Cruz FW, Stríkis NM, de Paula MS, Edwards RL, Cheng H, Karmann I, Jaqueto PF, Trindade RI, Hartmann GA, Moquet JS.

Sci Rep. 2016 Apr 21;6:24762. doi: 10.1038/srep24762.


Indian monsoon variability on millennial-orbital timescales.

Kathayat G, Cheng H, Sinha A, Spötl C, Edwards RL, Zhang H, Li X, Yi L, Ning Y, Cai Y, Lui WL, Breitenbach SF.

Sci Rep. 2016 Apr 13;6:24374. doi: 10.1038/srep24374.


Observation of Wakefield Suppression in a Photonic-Band-Gap Accelerator Structure.

Simakov EI, Arsenyev SA, Buechler CE, Edwards RL, Romero WP, Conde M, Ha G, Power JG, Wisniewski EE, Jing C.

Phys Rev Lett. 2016 Feb 12;116(6):064801. doi: 10.1103/PhysRevLett.116.064801. Epub 2016 Feb 10.


Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.

Imlay LS, Armstrong CM, Masters MC, Li T, Price KE, Edwards RL, Mann KM, Li LX, Stallings CL, Berry NG, O'Neill PM, Odom AR.

ACS Infect Dis. 2015 Apr 10;1(4):157-167. Epub 2015 Mar 2.


Reconciliation of the Devils Hole climate record with orbital forcing.

Moseley GE, Edwards RL, Wendt KA, Cheng H, Dublyansky Y, Lu Y, Boch R, Spötl C.

Science. 2016 Jan 8;351(6269):165-8. doi: 10.1126/science.aad4132.


The earliest unequivocally modern humans in southern China.

Liu W, Martinón-Torres M, Cai YJ, Xing S, Tong HW, Pei SW, Sier MJ, Wu XH, Edwards RL, Cheng H, Li YY, Yang XX, de Castro JM, Wu XJ.

Nature. 2015 Oct 29;526(7575):696-9. doi: 10.1038/nature15696. Epub 2015 Oct 14.


Woo et al. reply.

Jo KN, Woo KS, Yi S, Yang DY, Lim HS, Wang Y, Cheng H, Edwards RL.

Nature. 2015 Oct 1;526(7571):E2-3. doi: 10.1038/nature14977. No abstract available.


A Chinese cave links climate change, social impacts, and human adaptation over the last 500 years.

Tan L, Cai Y, An Z, Cheng H, Shen CC, Breitenbach SF, Gao Y, Edwards RL, Zhang H, Du Y.

Sci Rep. 2015 Aug 13;5:12284. doi: 10.1038/srep12284.


Native Liquid Extraction Surface Analysis Mass Spectrometry: Analysis of Noncovalent Protein Complexes Directly from Dried Substrates.

Martin NJ, Griffiths RL, Edwards RL, Cooper HJ.

J Am Soc Mass Spectrom. 2015 Aug;26(8):1320-7. doi: 10.1007/s13361-015-1152-8. Epub 2015 May 20.

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