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Alterations in cellular expression in EBV infected epithelial cell lines and tumors.

Edwards RH, Dekroon R, Raab-Traub N.

PLoS Pathog. 2019 Oct 4;15(10):e1008071. doi: 10.1371/journal.ppat.1008071. eCollection 2019 Oct.


The physiological role of α-synuclein and its relationship to Parkinson's Disease.

Sulzer D, Edwards RH.

J Neurochem. 2019 Sep;150(5):475-486. doi: 10.1111/jnc.14810. Epub 2019 Jul 28. Review.


Structures suggest a mechanism for energy coupling by a family of organic anion transporters.

Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH.

PLoS Biol. 2019 May 13;17(5):e3000260. doi: 10.1371/journal.pbio.3000260. eCollection 2019 May.


Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties.

Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH.

Neuron. 2019 May 22;102(4):786-800.e5. doi: 10.1016/j.neuron.2019.03.031. Epub 2019 Apr 16.


Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.

Mol Psychiatry. 2018 Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print]


The dual role of chloride in synaptic vesicle glutamate transport.

Chang R, Eriksen J, Edwards RH.

Elife. 2018 Jul 24;7. pii: e34896. doi: 10.7554/eLife.34896.


A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll RA, Edwards RH.

Nat Commun. 2018 Jan 23;9(1):330. doi: 10.1038/s41467-017-02716-5.


Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.

Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K.

eNeuro. 2017 Apr 28;4(2). pii: ENEURO.0216-16.2017. doi: 10.1523/ENEURO.0216-16.2017. eCollection 2017 Mar-Apr.


α-Synuclein promotes dilation of the exocytotic fusion pore.

Logan T, Bendor J, Toupin C, Thorn K, Edwards RH.

Nat Neurosci. 2017 May;20(5):681-689. doi: 10.1038/nn.4529. Epub 2017 Mar 13.


Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.

Maas JW, Yang J, Edwards RH.

Front Synaptic Neurosci. 2017 Feb 23;9:5. doi: 10.3389/fnsyn.2017.00005. eCollection 2017.


One Cycle Fuels Another: The Energetics of Neurotransmitter Release.

Silm K, Edwards RH.

Neuron. 2017 Feb 8;93(3):470-472. doi: 10.1016/j.neuron.2017.01.024.


A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons.

Sheng N, Yang J, Silm K, Edwards RH, Nicoll RA.

Neuropharmacology. 2017 Mar 15;115:4-9. doi: 10.1016/j.neuropharm.2016.08.028. Epub 2016 Aug 25.


Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord.

Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ, Kaltschmidt JA.

Neuron. 2016 Jun 15;90(6):1189-1202. doi: 10.1016/j.neuron.2016.05.008. Epub 2016 Jun 2.


Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism.

Eriksen J, Chang R, McGregor M, Silm K, Suzuki T, Edwards RH.

Neuron. 2016 May 18;90(4):768-80. doi: 10.1016/j.neuron.2016.03.026. Epub 2016 Apr 28.


Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.

Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA.

Mol Metab. 2015 Sep 11;4(11):857-66. doi: 10.1016/j.molmet.2015.09.001. eCollection 2015 Nov.


Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.

Divito CB, Steece-Collier K, Case DT, Williams SP, Stancati JA, Zhi L, Rubio ME, Sortwell CE, Collier TJ, Sulzer D, Edwards RH, Zhang H, Seal RP.

J Neurosci. 2015 Nov 11;35(45):14983-99. doi: 10.1523/JNEUROSCI.2124-15.2015.


Host Gene Expression Is Regulated by Two Types of Noncoding RNAs Transcribed from the Epstein-Barr Virus BamHI A Rightward Transcript Region.

Marquitz AR, Mathur A, Edwards RH, Raab-Traub N.

J Virol. 2015 Nov;89(22):11256-68. doi: 10.1128/JVI.01492-15. Epub 2015 Aug 26.


Is Aspartate an Excitatory Neurotransmitter?

Herring BE, Silm K, Edwards RH, Nicoll RA.

J Neurosci. 2015 Jul 15;35(28):10168-71. doi: 10.1523/JNEUROSCI.0524-15.2015.


The role of mitochondrially derived ATP in synaptic vesicle recycling.

Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K.

J Biol Chem. 2015 Sep 11;290(37):22325-36. doi: 10.1074/jbc.M115.656405. Epub 2015 Jun 30.


Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.

Edwards RH, Marquitz AR, Raab-Traub N.

mBio. 2015 Apr 14;6(2). pii: e00441-15. doi: 10.1128/mBio.00441-15.


A non-canonical pathway from cochlea to brain signals tissue-damaging noise.

Flores EN, Duggan A, Madathany T, Hogan AK, Márquez FG, Kumar G, Seal RP, Edwards RH, Liberman MC, García-Añoveros J.

Curr Biol. 2015 Mar 2;25(5):606-12. doi: 10.1016/j.cub.2015.01.009. Epub 2015 Jan 29.


Mobile binding sites regulate glutamate clearance.

Edwards RH.

Nat Neurosci. 2015 Feb;18(2):166-8. doi: 10.1038/nn.3931. No abstract available.


Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.

Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K.

J Neurosci. 2014 Oct 22;34(43):14304-17. doi: 10.1523/JNEUROSCI.0930-14.2014.


Efficient, complete deletion of synaptic proteins using CRISPR.

Incontro S, Asensio CS, Edwards RH, Nicoll RA.

Neuron. 2014 Sep 3;83(5):1051-7. doi: 10.1016/j.neuron.2014.07.043. Epub 2014 Aug 21. Erratum in: Neuron. 2015 Nov 4;88(3):617.


A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb.

Tatti R, Bhaukaurally K, Gschwend O, Seal RP, Edwards RH, Rodriguez I, Carleton A.

Nat Commun. 2014 May 7;5:3791. doi: 10.1038/ncomms4791.


Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.

Asensio CS, Sirkis DW, Maas JW Jr, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH.

Dev Cell. 2013 Nov 25;27(4):425-37. doi: 10.1016/j.devcel.2013.10.007. Epub 2013 Nov 7.


Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.

Sirkis DW, Edwards RH, Asensio CS.

PLoS Genet. 2013;9(9):e1003812. doi: 10.1371/journal.pgen.1003812. Epub 2013 Sep 26.


The function of α-synuclein.

Bendor JT, Logan TP, Edwards RH.

Neuron. 2013 Sep 18;79(6):1044-66. doi: 10.1016/j.neuron.2013.09.004.


Modulation of B-cell exosome proteins by gamma herpesvirus infection.

Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2925-33. doi: 10.1073/pnas.1303906110. Epub 2013 Jul 1.


Multiple dileucine-like motifs direct VGLUT1 trafficking.

Foss SM, Li H, Santos MS, Edwards RH, Voglmaier SM.

J Neurosci. 2013 Jun 26;33(26):10647-60. doi: 10.1523/JNEUROSCI.5662-12.2013.


Region-specific expression of vesicular glutamate and GABA transporters under various ischaemic conditions in mouse forebrain and retina.

Michalski D, Härtig W, Krügel K, Edwards RH, Böddener M, Böhme L, Pannicke T, Reichenbach A, Grosche A.

Neuroscience. 2013 Feb 12;231:328-44. doi: 10.1016/j.neuroscience.2012.11.046. Epub 2012 Dec 5.


Ventral tegmental area glutamate neurons: electrophysiological properties and projections.

Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH.

J Neurosci. 2012 Oct 24;32(43):15076-85. doi: 10.1523/JNEUROSCI.3128-12.2012.


Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.

Akil O, Seal RP, Burke K, Wang C, Alemi A, During M, Edwards RH, Lustig LR.

Neuron. 2012 Jul 26;75(2):283-93. doi: 10.1016/j.neuron.2012.05.019.


AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.

Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K.

Cell Metab. 2012 Jul 3;16(1):113-21. doi: 10.1016/j.cmet.2012.05.014.


Fabs enable single particle cryoEM studies of small proteins.

Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y.

Structure. 2012 Apr 4;20(4):582-92. doi: 10.1016/j.str.2012.02.017. Epub 2012 Apr 3.


Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model.

Shair KH, Bendt KM, Edwards RH, Nielsen JN, Moore DT, Raab-Traub N.

J Virol. 2012 May;86(9):5352-65. doi: 10.1128/JVI.07035-11. Epub 2012 Feb 22.


Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.

Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ.

J Clin Invest. 2012 Feb;122(2):507-18. doi: 10.1172/JCI58470. Epub 2012 Jan 3.


Vesicular and plasma membrane transporters for neurotransmitters.

Blakely RD, Edwards RH.

Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2). pii: a005595. doi: 10.1101/cshperspect.a005595. Review.


Neurotransmitter corelease: mechanism and physiological role.

Hnasko TS, Edwards RH.

Annu Rev Physiol. 2012;74:225-43. doi: 10.1146/annurev-physiol-020911-153315. Epub 2011 Oct 31. Review.


Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.

Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH.

Nat Neurosci. 2011 Aug 28;14(10):1285-92. doi: 10.1038/nn.2898.


Genetic targeting and physiological features of VGLUT3+ amacrine cells.

Grimes WN, Seal RP, Oesch N, Edwards RH, Diamond JS.

Vis Neurosci. 2011 Sep;28(5):381-92. doi: 10.1017/S0952523811000290. Epub 2011 Aug 25.


v-SNARE composition distinguishes synaptic vesicle pools.

Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH.

Neuron. 2011 Aug 11;71(3):474-87. doi: 10.1016/j.neuron.2011.06.010.


Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.

Brumovsky PR, Robinson DR, La JH, Seroogy KB, Lundgren KH, Albers KM, Kiyatkin ME, Seal RP, Edwards RH, Watanabe M, Hökfelt T, Gebhart GF.

J Comp Neurol. 2011 Nov 1;519(16):3346-66. doi: 10.1002/cne.22730.


Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement.

Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM.

Neuron. 2011 Jul 28;71(2):235-42. doi: 10.1016/j.neuron.2011.05.045.


Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.

Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL.

PLoS One. 2011 Apr 22;6(4):e19155. doi: 10.1371/journal.pone.0019155.


Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.

Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH.

J Biol Chem. 2011 Jun 10;286(23):20710-26. doi: 10.1074/jbc.M110.213538. Epub 2011 Apr 13.


RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway.

Asensio CS, Sirkis DW, Edwards RH.

J Cell Biol. 2010 Dec 13;191(6):1173-87. doi: 10.1083/jcb.201006131.


VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.

Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22296-301. doi: 10.1073/pnas.1013413108. Epub 2010 Dec 6.


Human tumor virus utilizes exosomes for intercellular communication.

Meckes DG Jr, Shair KH, Marquitz AR, Kung CP, Edwards RH, Raab-Traub N.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20370-5. doi: 10.1073/pnas.1014194107. Epub 2010 Nov 8.


Metabolic control of vesicular glutamate transport and release.

Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y.

Neuron. 2010 Oct 6;68(1):99-112. doi: 10.1016/j.neuron.2010.09.002.

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