Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 329

1.

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.

Mason B, Flach S, Teixeira FR, Manzano Garcia R, Rueda OM, Abraham JE, Caldas C, Edwards PAW, Laman H.

Cell Mol Life Sci. 2019 Sep 27. doi: 10.1007/s00018-019-03306-y. [Epub ahead of print]

PMID:
31560077
2.

The route and rate of thiamethoxam soil degradation in laboratory and outdoor incubated tests, and field studies following seed treatments or spray application.

Hilton MJ, Emburey SN, Edwards PA, Dougan C, Ricketts DC.

Pest Manag Sci. 2019 Jan;75(1):63-78. doi: 10.1002/ps.5168. Epub 2018 Oct 3.

3.

Complex multi-enhancer contacts captured by genome architecture mapping.

Beagrie RA, Scialdone A, Schueler M, Kraemer DC, Chotalia M, Xie SQ, Barbieri M, de Santiago I, Lavitas LM, Branco MR, Fraser J, Dostie J, Game L, Dillon N, Edwards PA, Nicodemi M, Pombo A.

Nature. 2017 Mar 23;543(7646):519-524. doi: 10.1038/nature21411. Epub 2017 Mar 8.

4.

Corrigendum: Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.

Secrier M, Li X, de Silva N, Eldridge MD, Contino G, Bornschein J, MacRae S, Grehan N, O'Donovan M, Miremadi A, Yang TP, Bower L, Chettouh H, Crawte J, Galeano-Dalmau N, Grabowska A, Saunders J, Underwood T, Waddell N, Barbour AP, Nutzinger B, Achilleos A, Edwards PA, Lynch AG, Tavaré S, Fitzgerald RC; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium.

Nat Genet. 2017 Jan 31;49(2):317. doi: 10.1038/ng0217-317a. No abstract available.

PMID:
28138154
5.

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.

Secrier M, Li X, de Silva N, Eldridge MD, Contino G, Bornschein J, MacRae S, Grehan N, O'Donovan M, Miremadi A, Yang TP, Bower L, Chettouh H, Crawte J, Galeano-Dalmau N, Grabowska A, Saunders J, Underwood T, Waddell N, Barbour AP, Nutzinger B, Achilleos A, Edwards PA, Lynch AG, Tavaré S, Fitzgerald RC; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium.

Nat Genet. 2016 Oct;48(10):1131-41. doi: 10.1038/ng.3659. Epub 2016 Sep 5. Erratum in: Nat Genet. 2017 Jan 31;49(2):317.

6.

Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.

Contino G, Eldridge MD, Secrier M, Bower L, Fels Elliott R, Weaver J, Lynch AG, Edwards PA, Fitzgerald RC.

F1000Res. 2016 Jun 10;5:1336. doi: 10.12688/f1000research.7033.1. eCollection 2016.

7.

Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report.

Tarling EJ, Edwards PA.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1323-7. doi: 10.1161/ATVBAHA.116.307414. Epub 2016 May 26.

8.

Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis.

Paterson AL, Weaver JM, Eldridge MD, Tavaré S, Fitzgerald RC, Edwards PA; OCCAMs Consortium.

BMC Genomics. 2015 Jul 10;16:473. doi: 10.1186/s12864-015-1685-z.

9.

Focal middle cerebral artery ischemia in rats via a transfemoral approach using a custom designed microwire.

Divani AA, Chow R, Sadeghi-Bazargani H, Murphy AJ, Nordberg JA, Tokarev JV, Hevesi M, Wang X, Zhu XH, Acompanado T, Edwards PA, Zhang Y, Chen W.

J Neurointerv Surg. 2016 Jun;8(6):608-14. doi: 10.1136/neurintsurg-2014-011607. Epub 2015 May 2.

PMID:
25935923
10.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism.

de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA.

Cell Metab. 2015 Feb 3;21(2):298-311. doi: 10.1016/j.cmet.2015.01.007. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.

11.

Reproducibility of Optovue RTVue Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Zeiss Stratus Metrics in Diabetic Macular Edema.

Bressler SB, Edwards AR, Andreoli CM, Edwards PA, Glassman AR, Jaffe GJ, Melia M, Sun JK; for the Diabetic Retinopathy Clinical Research Network/Writing Committee.

Transl Vis Sci Technol. 2015 Jan 22;4(1):5. eCollection 2015 Jan.

12.

The effect of suspended sediment on fertilization success in the urchin Evechinus chloroticus: analysis of experimental data using hierarchical Bayesian methods.

Miller SL, Richardson K, Edwards PA.

Mar Pollut Bull. 2014 Nov 15;88(1-2):28-33. doi: 10.1016/j.marpolbul.2014.09.033. Epub 2014 Oct 3.

PMID:
25287223
13.

Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.

Li Y, Liu X, Zhou T, Kelley MR, Edwards PA, Gao H, Qiao X.

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4461-9. doi: 10.1167/iovs.14-14451.

14.

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

Weaver JMJ, Ross-Innes CS, Shannon N, Lynch AG, Forshew T, Barbera M, Murtaza M, Ong CJ, Lao-Sirieix P, Dunning MJ, Smith L, Smith ML, Anderson CL, Carvalho B, O'Donovan M, Underwood TJ, May AP, Grehan N, Hardwick R, Davies J, Oloumi A, Aparicio S, Caldas C, Eldridge MD, Edwards PAW, Rosenfeld N, Tavaré S, Fitzgerald RC; OCCAMS consortium.

Nat Genet. 2014 Aug;46(8):837-843. doi: 10.1038/ng.3013. Epub 2014 Jun 22.

15.

Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells.

Das S, Edwards PA, Crockett JC, Rogers MJ.

Biochim Biophys Acta. 2014 Apr 4;1841(4):569-73. doi: 10.1016/j.bbalip.2013.12.010. Epub 2013 Dec 22.

PMID:
24369118
16.

Pilot study of individuals with diabetic macular edema undergoing cataract surgery.

Diabetic Retinopathy Clinical Research Network Authors/Writing Committee, Bressler SB, Baker CW, Almukhtar T, Bressler NM, Edwards PA, Glassman AR, Scott MH.

JAMA Ophthalmol. 2014 Feb;132(2):224-6. doi: 10.1001/jamaophthalmol.2013.6209. No abstract available.

17.

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.

Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P.

Cell Metab. 2013 Nov 5;18(5):685-97. doi: 10.1016/j.cmet.2013.10.002.

18.

The relative timing of mutations in a breast cancer genome.

Newman S, Howarth KD, Greenman CD, Bignell GR, Tavaré S, Edwards PA.

PLoS One. 2013 Jun 10;8(6):e64991. doi: 10.1371/journal.pone.0064991. Print 2013.

19.

Pleiotropic roles of bile acids in metabolism.

de Aguiar Vallim TQ, Tarling EJ, Edwards PA.

Cell Metab. 2013 May 7;17(5):657-69. doi: 10.1016/j.cmet.2013.03.013. Epub 2013 Apr 18. Review.

20.

Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS.

Cell Metab. 2013 Apr 2;17(4):549-61. doi: 10.1016/j.cmet.2013.03.009.

21.

MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.

de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA.

Circ Res. 2013 Jun 7;112(12):1602-12. doi: 10.1161/CIRCRESAHA.112.300648. Epub 2013 Mar 21.

22.

Role of ABC transporters in lipid transport and human disease.

Tarling EJ, de Aguiar Vallim TQ, Edwards PA.

Trends Endocrinol Metab. 2013 Jul;24(7):342-50. doi: 10.1016/j.tem.2013.01.006. Epub 2013 Feb 14. Review.

23.

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.

Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ.

Cell Metab. 2013 Jan 8;17(1):49-60. doi: 10.1016/j.cmet.2012.12.011.

24.

Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes.

Schulte I, Batty EM, Pole JC, Blood KA, Mo S, Cooke SL, Ng C, Howe KL, Chin SF, Brenton JD, Caldas C, Howarth KD, Edwards PA.

BMC Genomics. 2012 Dec 22;13:719. doi: 10.1186/1471-2164-13-719.

25.

Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.

Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nũnez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M.

Mol Cell. 2012 Jul 27;47(2):203-14. doi: 10.1016/j.molcel.2012.06.010. Epub 2012 Jul 12.

26.

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.

Kim J, Villadsen R, Sørlie T, Fogh L, Grønlund SZ, Fridriksdottir AJ, Kuhn I, Rank F, Wielenga VT, Solvang H, Edwards PA, Børresen-Dale AL, Rønnov-Jessen L, Bissell MJ, Petersen OW.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6124-9. doi: 10.1073/pnas.1203203109. Epub 2012 Mar 27.

27.

Are breast cancers driven by fusion genes?

Edwards PA, Howarth KD.

Breast Cancer Res. 2012 Mar 16;14(2):303.

28.

Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.

Zhang Y, Ge X, Heemstra LA, Chen WD, Xu J, Smith JL, Ma H, Kasim N, Edwards PA, Novak CM.

Mol Endocrinol. 2012 Feb;26(2):272-80. doi: 10.1210/me.2011-1157. Epub 2012 Jan 19.

29.

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.

Ng CK, Cooke SL, Howe K, Newman S, Xian J, Temple J, Batty EM, Pole JC, Langdon SP, Edwards PA, Brenton JD.

J Pathol. 2012 Apr;226(5):703-12. doi: 10.1002/path.3980. Epub 2012 Feb 9.

PMID:
22183581
30.

Evaluation of visual acuity measurements after autorefraction vs manual refraction in eyes with and without diabetic macular edema.

Sun JK, Qin H, Aiello LP, Melia M, Beck RW, Andreoli CM, Edwards PA, Glassman AR, Pavlica MR; Diabetic Retinopathy Clinical Research Network.

Arch Ophthalmol. 2012 Apr;130(4):470-9. doi: 10.1001/archophthalmol.2011.377. Epub 2011 Dec 12.

31.

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter.

Tarling EJ, Edwards PA.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19719-24. doi: 10.1073/pnas.1113021108. Epub 2011 Nov 17.

32.

Estimation of rearrangement phylogeny for cancer genomes.

Greenman CD, Pleasance ED, Newman S, Yang F, Fu B, Nik-Zainal S, Jones D, Lau KW, Carter N, Edwards PA, Futreal PA, Stratton MR, Campbell PJ.

Genome Res. 2012 Feb;22(2):346-61. doi: 10.1101/gr.118414.110. Epub 2011 Oct 12.

33.

Targeted next-generation sequencing for routine clinical screening of mutations.

Weaver JM, Edwards PA.

Genome Med. 2011 Sep 12;3(9):58. doi: 10.1186/gm274.

34.

Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis.

Tarling EJ, Edwards PA.

Biochim Biophys Acta. 2012 Mar;1821(3):386-95. doi: 10.1016/j.bbalip.2011.07.011. Epub 2011 Jul 28. Review.

PMID:
21824529
36.

The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood.

Guo AM, Janic B, Sheng J, Falck JR, Roman RJ, Edwards PA, Arbab AS, Scicli AG.

J Pharmacol Exp Ther. 2011 Aug;338(2):421-9. doi: 10.1124/jpet.111.179036. Epub 2011 Apr 28. Erratum in: J Pharmacol Exp Ther. 2012 Feb;340(2):490.

37.

Single-molecule analysis of genome rearrangements in cancer.

Pole JC, McCaughan F, Newman S, Howarth KD, Dear PH, Edwards PA.

Nucleic Acids Res. 2011 Jul;39(13):e85. doi: 10.1093/nar/gkr227. Epub 2011 Apr 27.

38.

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ.

Sci Signal. 2011 Mar 29;4(166):ra17. doi: 10.1126/scisignal.2001752. Erratum in: Sci Signal. 2011;4(170). doi:10.1126/scisignal.4170er2. Corrected and republished in: Sci Signal. 2011;4(170):er2.

39.

Large duplications at reciprocal translocation breakpoints that might be the counterpart of large deletions and could arise from stalled replication bubbles.

Howarth KD, Pole JC, Beavis JC, Batty EM, Newman S, Bignell GR, Edwards PA.

Genome Res. 2011 Apr;21(4):525-34. doi: 10.1101/gr.114116.110. Epub 2011 Jan 20.

40.

Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.

Yin L, Ma H, Ge X, Edwards PA, Zhang Y.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):328-36. doi: 10.1161/ATVBAHA.110.217828. Epub 2010 Nov 11.

41.

Regulation of ABCG1 expression in human keratinocytes and murine epidermis.

Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR.

J Lipid Res. 2010 Nov;51(11):3185-95. doi: 10.1194/jlr.M006445. Epub 2010 Aug 1.

42.

Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.

Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA.

Mol Endocrinol. 2010 Aug;24(8):1626-36. doi: 10.1210/me.2010-0117. Epub 2010 Jun 23.

43.

Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.

Chong HK, Infante AM, Seo YK, Jeon TI, Zhang Y, Edwards PA, Xie X, Osborne TF.

Nucleic Acids Res. 2010 Oct;38(18):6007-17. doi: 10.1093/nar/gkq397. Epub 2010 May 18.

44.

Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis.

Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, Bjorkhem I, Edwards PA.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1174-80. doi: 10.1161/ATVBAHA.110.205617. Epub 2010 Mar 18.

45.
46.

Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.

Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA.

J Biol Chem. 2010 Jan 29;285(5):3035-43. doi: 10.1074/jbc.M109.083899. Epub 2009 Dec 7.

47.

Fusion genes and chromosome translocations in the common epithelial cancers.

Edwards PA.

J Pathol. 2010 Jan;220(2):244-54. doi: 10.1002/path.2632. Review.

PMID:
19921709
48.

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

Chua YL, Ito Y, Pole JC, Newman S, Chin SF, Stein RC, Ellis IO, Caldas C, O'Hare MJ, Murrell A, Edwards PA.

Oncogene. 2009 Nov 19;28(46):4041-52. doi: 10.1038/onc.2009.259. Epub 2009 Oct 5.

49.

Bile acids have the gall to function as hormones.

Vallim TQ, Edwards PA.

Cell Metab. 2009 Sep;10(3):162-4. doi: 10.1016/j.cmet.2009.08.005.

50.

Differential expression and function of ABCG1 and ABCG4 during development and aging.

Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lövgren-Sandblom A, Björkhem I, Edwards PA.

J Lipid Res. 2010 Jan;51(1):169-81. doi: 10.1194/M900250-JLR200.

Supplemental Content

Loading ...
Support Center