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Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations.

Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, Toussaint M, Walton RP, Finney LJ, Aniscenko J, Zhu J, Trujillo-Torralbo MB, Calderazzo MA, Grainge C, Loo SL, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, James PL, Solari R, Wark PAB, Knight DA, Moffatt MF, Cookson WO, Edwards MR, Mallia P, Bartlett NW, Johnston SL.

Nat Commun. 2018 Jun 8;9(1):2229. doi: 10.1038/s41467-018-04574-1.


Non-operative management of an isolated lateral collateral ligament injury in an adolescent patient and review of the literature.

Davenport D, Arora A, Edwards MR.

BMJ Case Rep. 2018 May 15;2018. pii: bcr-2017-223478. doi: 10.1136/bcr-2017-223478.


Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations.

Zhu J, Message SD, Mallia P, Kebadze T, Contoli M, Ward CK, Barnathan ES, Mascelli MA, Kon OM, Papi A, Stanciu LA, Edwards MR, Jeffery PK, Johnston SL.

J Allergy Clin Immunol. 2018 Apr 24. pii: S0091-6749(18)30610-9. doi: 10.1016/j.jaci.2018.04.003. [Epub ahead of print]


Cytokine Responses to Rhinovirus and Development of Asthma, Allergic Sensitization, and Respiratory Infections during Childhood.

Custovic A, Belgrave D, Lin L, Bakhsoliani E, Telcian AG, Solari R, Murray CS, Walton RP, Curtin J, Edwards MR, Simpson A, Rattray M, Johnston SL.

Am J Respir Crit Care Med. 2018 May 15;197(10):1265-1274. doi: 10.1164/rccm.201708-1762OC.


Innate Immune Response to Viral Infections in Primary Bronchial Epithelial Cells is Modified by the Atopic Status of Asthmatic Patients.

Moskwa S, Piotrowski W, Marczak J, Pawełczyk M, Lewandowska-Polak A, Jarzębska M, Brauncajs M, Głobińska A, Górski P, Papadopoulos NG, Edwards MR, Johnston SL, Kowalski ML.

Allergy Asthma Immunol Res. 2018 Mar;10(2):144-154. doi: 10.4168/aair.2018.10.2.144.


A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication.

Luthra P, Liang J, Pietzsch CA, Khadka S, Edwards MR, Wei S, De S, Posner B, Bukreyev A, Ready JM, Basler CF.

Antiviral Res. 2018 Feb;150:193-201. doi: 10.1016/j.antiviral.2017.12.019. Epub 2017 Dec 30.


β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells.

Ritchie AI, Singanayagam A, Wiater E, Edwards MR, Montminy M, Johnston SL.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):128-132. doi: 10.1165/rcmb.2017-0315LE. No abstract available.


Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus.

Luo XM, Edwards MR, Mu Q, Yu Y, Vieson MD, Reilly CM, Ahmed SA, Bankole AA.

Appl Environ Microbiol. 2018 Jan 31;84(4). pii: e02288-17. doi: 10.1128/AEM.02288-17. Print 2018 Feb 15.


Immune response to vaccines is maintained in patients treated with dimethyl fumarate.

von Hehn C, Howard J, Liu S, Meka V, Pultz J, Mehta D, Prada C, Ray S, Edwards MR, Sheikh SI.

Neurol Neuroimmunol Neuroinflamm. 2017 Nov 15;5(1):e409. doi: 10.1212/NXI.0000000000000409. eCollection 2018 Jan.


Corrigendum: Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.

Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SL.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384a.


Blood on screwdriver tip to aid screw insertion at depth.

Chowdhury A, Nzeako O, Edwards MR.

Ann R Coll Surg Engl. 2018 Feb;100(2):159. doi: 10.1308/rcsann.2017.0131. Epub 2017 Oct 19. No abstract available.


Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness.

Edwards MR, Strong K, Cameron A, Walton RP, Jackson DJ, Johnston SL.

J Allergy Clin Immunol. 2017 Oct;140(4):909-920. doi: 10.1016/j.jaci.2017.07.025. Review.


Ethanol Stimulates Locomotion via a Gαs-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans.

Johnson JR, Edwards MR, Davies H, Newman D, Holden W, Jenkins RE, Burgoyne RD, Lucas RJ, Barclay JW.

Genetics. 2017 Nov;207(3):1023-1039. doi: 10.1534/genetics.117.300119. Epub 2017 Sep 26.


X-ray amplification by stimulated Brillouin scattering.

Edwards MR, Mikhailova JM, Fisch NJ.

Phys Rev E. 2017 Aug;96(2-1):023209. doi: 10.1103/PhysRevE.96.023209. Epub 2017 Aug 25.


Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways.

Reuschl AK, Edwards MR, Parker R, Connell DW, Hoang L, Halliday A, Jarvis H, Siddiqui N, Wright C, Bremang S, Newton SM, Beverley P, Shattock RJ, Kon OM, Lalvani A.

PLoS Pathog. 2017 Sep 1;13(9):e1006577. doi: 10.1371/journal.ppat.1006577. eCollection 2017 Sep.


Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma.

Upton N, Jackson DJ, Nikonova AA, Hingley-Wilson S, Khaitov M, Del Rosario A, Traub S, Trujillo-Torralbo MB, Habibi M, Elkin SL, Kon OM, Edwards MR, Mallia P, Footitt J, Macintyre J, Stanciu LA, Johnston SL, Sykes A.

PLoS One. 2017 Aug 31;12(8):e0183864. doi: 10.1371/journal.pone.0183864. eCollection 2017.


Hip Fractures in Centenarians: Has Care Improved in the National Hip Fracture Database Era?

Dick AG, Davenport D, Bansal M, Burch TS, Edwards MR.

Geriatr Orthop Surg Rehabil. 2017 Sep;8(3):161-165. doi: 10.1177/2151458517722104. Epub 2017 Aug 8.


The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations.

Edwards MR, Walton RP, Jackson DJ, Feleszko W, Skevaki C, Jartti T, Makrinoti H, Nikonova A, Shilovskiy IP, Schwarze J, Johnston SL, Khaitov MR; EAACI Anti-infectives in Asthma and Asthma Exacerbations Task Force.

Allergy. 2018 Jan;73(1):50-63. doi: 10.1111/all.13257. Epub 2017 Aug 10. Review.


Control of lupus nephritis by changes of gut microbiota.

Mu Q, Zhang H, Liao X, Lin K, Liu H, Edwards MR, Ahmed SA, Yuan R, Li L, Cecere TE, Branson DB, Kirby JL, Goswami P, Leeth CM, Read KA, Oestreich KJ, Vieson MD, Reilly CM, Luo XM.

Microbiome. 2017 Jul 11;5(1):73. doi: 10.1186/s40168-017-0300-8.


Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW.

Nat Microbiol. 2017 Jun 30;2:17101. doi: 10.1038/nmicrobiol.2017.101.


Vehicle emissions of short-lived and long-lived climate forcers: trends and tradeoffs.

Edwards MR, Klemun MM, Kim HC, Wallington TJ, Winkler SL, Tamor MA, Trancik JE.

Faraday Discuss. 2017 Aug 24;200:453-474. doi: 10.1039/c7fd00063d.


Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice.

Edwards MR, Dai R, Heid B, Cecere TE, Khan D, Mu Q, Cowan C, Luo XM, Ahmed SA.

Int Immunol. 2017 Jun 1;29(6):263-276. doi: 10.1093/intimm/dxx033.


Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators.

Edwards MR, Saglani S, Schwarze J, Skevaki C, Smith JA, Ainsworth B, Almond M, Andreakos E, Belvisi MG, Chung KF, Cookson W, Cullinan P, Hawrylowicz C, Lommatzsch M, Jackson D, Lutter R, Marsland B, Moffatt M, Thomas M, Virchow JC, Xanthou G, Edwards J, Walker S, Johnston SL; members of the EARIP WP2 working group.

Eur Respir J. 2017 May 1;49(5). pii: 1602448. doi: 10.1183/13993003.02448-2016. Print 2017 May. Review.


Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.

Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Bartlett NW, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SL.

Nat Med. 2017 Jun;23(6):681-691. doi: 10.1038/nm.4332. Epub 2017 May 1. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.


Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes.

Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB, Harwood JL, Sabroe I, Parker LC.

Mucosal Immunol. 2017 May;10(3):829. doi: 10.1038/mi.2017.40. No abstract available.


Efficacy of novel antibody-based drugs against rhinovirus infection: In vitro and in vivo results.

Petrova NV, Emelyanova AG, Gorbunov EA, Edwards MR, Walton RP, Bartlett NW, Aniscenko J, Gogsadze L, Bakhsoliani E, Khaitov MR, Johnston SL, Tarasov SA, Epstein OI.

Antiviral Res. 2017 Jun;142:185-192. doi: 10.1016/j.antiviral.2017.03.017. Epub 2017 Mar 27.


Comparative effectiveness of delayed-release dimethyl fumarate versus glatiramer acetate in multiple sclerosis patients: results of a matching-adjusted indirect comparison.

Chan A, Cutter G, Fox RJ, Xiao J, Lewin JB, Edwards MR.

J Comp Eff Res. 2017 Jun;6(4):313-323. doi: 10.2217/cer-2016-0085. Epub 2017 Mar 28.


Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.

McFarlane AJ, McSorley HJ, Davidson DJ, Fitch PM, Errington C, Mackenzie KJ, Gollwitzer ES, Johnston CJC, MacDonald AS, Edwards MR, Harris NL, Marsland BJ, Maizels RM, Schwarze J.

J Allergy Clin Immunol. 2017 Oct;140(4):1068-1078.e6. doi: 10.1016/j.jaci.2017.01.016. Epub 2017 Feb 11.


Quantifying the Benefits of Dimethyl Fumarate Over β Interferon and Glatiramer Acetate Therapies on Work Productivity Outcomes in MS Patients.

Lee A, Pike J, Edwards MR, Petrillo J, Waller J, Jones E.

Neurol Ther. 2017 Jun;6(1):79-90. doi: 10.1007/s40120-016-0061-5. Epub 2017 Jan 16.


Mucosal Type 2 Innate Lymphoid Cells Are a Key Component of the Allergic Response to Aeroallergens.

Dhariwal J, Cameron A, Trujillo-Torralbo MB, Del Rosario A, Bakhsoliani E, Paulsen M, Jackson DJ, Edwards MR, Rana BMJ, Cousins DJ, Hansel TT, Johnston SL, Walton RP; MRC-GSK Strategic Alliance Consortium.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1586-1596. doi: 10.1164/rccm.201609-1846OC.


VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2017 Jan 31;91(4). pii: e01715-16. doi: 10.1128/JVI.01715-16. Print 2017 Feb 15.


Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro.

Telcian AG, Zdrenghea MT, Edwards MR, Laza-Stanca V, Mallia P, Johnston SL, Stanciu LA.

Antiviral Res. 2017 Jan;137:93-101. doi: 10.1016/j.antiviral.2016.11.004. Epub 2016 Nov 10.


Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching.

Dejong CA, Chen GM, Li H, Johnston CW, Edwards MR, Rees PN, Skinnider MA, Webster AL, Magarvey NA.

Nat Chem Biol. 2016 Dec;12(12):1007-1014. doi: 10.1038/nchembio.2188. Epub 2016 Oct 3.


Comparative effectiveness using a matching-adjusted indirect comparison between delayed-release dimethyl fumarate and fingolimod for the treatment of multiple sclerosis.

Fox RJ, Chan A, Zhang A, Xiao J, Levison D, Lewin JB, Edwards MR, Marantz JL.

Curr Med Res Opin. 2017 Feb;33(2):175-183. doi: 10.1080/03007995.2016.1248380. Epub 2016 Nov 10.


Waveform-Controlled Relativistic High-Order-Harmonic Generation.

Edwards MR, Mikhailova JM.

Phys Rev Lett. 2016 Sep 16;117(12):125001. Epub 2016 Sep 16.


Raised interferon-β, type 3 interferon and interferon-stimulated genes - evidence of innate immune activation in neutrophilic asthma.

da Silva J, Hilzendeger C, Moermans C, Schleich F, Henket M, Kebadze T, Mallia P, Edwards MR, Johnston SL, Louis R.

Clin Exp Allergy. 2017 Mar;47(3):313-323. doi: 10.1111/cea.12809. Epub 2016 Oct 14.


Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses.

Johnson B, Li J, Adhikari J, Edwards MR, Zhang H, Schwarz T, Leung DW, Basler CF, Gross ML, Amarasinghe GK.

J Mol Biol. 2016 Aug 28;428(17):3483-94. doi: 10.1016/j.jmb.2016.07.020. Epub 2016 Aug 4.


Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium.

Porter JD, Watson J, Roberts LR, Gill SK, Groves H, Dhariwal J, Almond MH, Wong E, Walton RP, Jones LH, Tregoning J, Kilty I, Johnston SL, Edwards MR.

J Antimicrob Chemother. 2016 Oct;71(10):2767-81. doi: 10.1093/jac/dkw222. Epub 2016 Jul 25.


Reduced sputum expression of interferon-stimulated genes in severe COPD.

Hilzendeger C, da Silva J, Henket M, Schleich F, Corhay JL, Kebadze T, Edwards MR, Mallia P, Johnston SL, Louis R.

Int J Chron Obstruct Pulmon Dis. 2016 Jun 30;11:1485-94. doi: 10.2147/COPD.S105948. eCollection 2016.


Human rhinoviruses enter and induce proliferation of B lymphocytes.

Aab A, Wirz O, van de Veen W, Söllner S, Stanic B, Rückert B, Aniscenko J, Edwards MR, Johnston SL, Papadopoulos NG, Rebane A, Akdis CA, Akdis M.

Allergy. 2017 Feb;72(2):232-243. doi: 10.1111/all.12931. Epub 2016 Jun 8.


Airway Epithelial Orchestration of Innate Immune Function in Response to Virus Infection. A Focus on Asthma.

Ritchie AI, Jackson DJ, Edwards MR, Johnston SL.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S55-63. doi: 10.1513/AnnalsATS.201507-421MG. Review.


Anti-inflammatory effects of the novel inhaled phosphodiesterase type 4 inhibitor CHF6001 on virus-inducible cytokines.

Edwards MR, Facchinetti F, Civelli M, Villetti G, Johnston SL.

Pharmacol Res Perspect. 2016 Jan 15;4(1):e00202. doi: 10.1002/prp2.202. eCollection 2016 Feb.


Examination of the adult knee.

Davenport D, Colaco HB, Edwards MR.

Br J Hosp Med (Lond). 2016 Mar;77(3):C45-8. doi: 10.12968/hmed.2016.77.3.C45. Review. No abstract available.


Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes.

Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB, Harwood JL, Sabroe I, Parker LC.

Mucosal Immunol. 2016 Sep;9(5):1303-16. doi: 10.1038/mi.2015.137. Epub 2016 Feb 24.


Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.

Edwards MR, Liu G, Mire CE, Sureshchandra S, Luthra P, Yen B, Shabman RS, Leung DW, Messaoudi I, Geisbert TW, Amarasinghe GK, Basler CF.

Cell Rep. 2016 Feb 23;14(7):1632-1640. doi: 10.1016/j.celrep.2016.01.049. Epub 2016 Feb 11.


Strongly Enhanced Stimulated Brillouin Backscattering in an Electron-Positron Plasma.

Edwards MR, Fisch NJ, Mikhailova JM.

Phys Rev Lett. 2016 Jan 8;116(1):015004. doi: 10.1103/PhysRevLett.116.015004. Epub 2016 Jan 8.


Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection.

Schögler A, Stokes AB, Casaulta C, Regamey N, Edwards MR, Johnston SL, Jung A, Moeller A, Geiser T, Alves MP.

J Cyst Fibros. 2016 May;15(3):332-9. doi: 10.1016/j.jcf.2015.10.013. Epub 2015 Nov 21.


Comparative Effectiveness Using A Matching-Adjusted Indirect Comparison Between Delayed-Release Dimethyl Fumarate and Fingolimod for The Treatment of Relapsing-Remitting Multiple Sclerosis.

Fox RJ, Cutter G, Chan A, Xiao J, Okwuokenye M, Levison D, Lewin J, Edwards MR, Marantz JL.

Value Health. 2015 Nov;18(7):A750. doi: 10.1016/j.jval.2015.09.2902. Epub 2015 Oct 20. No abstract available.


Effect of doxycycline on contralateral canine cranial cruciate ligament rupture. A prospective randomized clinical trial in 69 dogs.

von Pfeil DJ, Sung J, Barry J, Hayashi K, Edwards MR.

Vet Comp Orthop Traumatol. 2015;28(6):371-8. doi: 10.3415/VCOT-15-02-0034. Epub 2015 Oct 1.


High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication.

Edwards MR, Pietzsch C, Vausselin T, Shaw ML, Bukreyev A, Basler CF.

ACS Infect Dis. 2015 Aug 14;1(8):380-7. doi: 10.1021/acsinfecdis.5b00053. Epub 2015 Jun 24.

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