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Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes.

Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogested J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE.

Circ Res. 2020 Mar 27;126(7):889-906. doi: 10.1161/CIRCRESAHA.119.315641. Epub 2020 Feb 19.


Prognostic Risk Modelling for Patients Undergoing Major Lower Limb Amputation: An Analysis of the UK National Vascular Registry.

Ambler GK, Thomas-Jones E, Edwards AGK, Twine CP.

Eur J Vasc Endovasc Surg. 2019 Dec 26. pii: S1078-5884(19)32639-5. doi: 10.1016/j.ejvs.2019.12.006. [Epub ahead of print]


Arrhythmogenic Current Generation by Myofilament-Triggered Ca2+ Release and Sarcomere Heterogeneity.

Timmermann V, Edwards AG, Wall ST, Sundnes J, McCulloch AD.

Biophys J. 2019 Dec 17;117(12):2471-2485. doi: 10.1016/j.bpj.2019.11.009. Epub 2019 Nov 20.


General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG.

Clin Pharmacol Ther. 2020 Jan;107(1):102-111. doi: 10.1002/cpt.1647. Epub 2019 Nov 10.


Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.

Mäki-Marttunen T, Kaufmann T, Elvsåshagen T, Devor A, Djurovic S, Westlye LT, Linne ML, Rietschel M, Schubert D, Borgwardt S, Efrim-Budisteanu M, Bettella F, Halnes G, Hagen E, Næss S, Ness TV, Moberget T, Metzner C, Edwards AG, Fyhn M, Dale AM, Einevoll GT, Andreassen OA.

Front Psychiatry. 2019 Aug 6;10:534. doi: 10.3389/fpsyt.2019.00534. eCollection 2019. Review.


Properties of cardiac conduction in a cell-based computational model.

Jæger KH, Edwards AG, McCulloch A, Tveito A.

PLoS Comput Biol. 2019 May 31;15(5):e1007042. doi: 10.1371/journal.pcbi.1007042. eCollection 2019 May.


Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia.

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE.

Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007045. doi: 10.1161/CIRCEP.118.007045.


Mirroring preeclampsia: the molecular basis of Ballantyne syndrome.

Hobson SR, Wallace EM, Chan YF, Edwards AG, Teoh MWT, Khaw AP.

J Matern Fetal Neonatal Med. 2020 Mar;33(5):768-773. doi: 10.1080/14767058.2018.1500550. Epub 2019 Jan 6.


Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems.

Tveito A, Jæger KH, Huebsch N, Charrez B, Edwards AG, Wall S, Healy KE.

Sci Rep. 2018 Dec 4;8(1):17626. doi: 10.1038/s41598-018-35858-7.


Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations.

Mäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, Ness TV, Moberget T, Elvsåshagen T, Metzner C, Devor A, Edwards AG, Fyhn M, Djurovic S, Dale AM, Andreassen OA, Einevoll GT.

Cereb Cortex. 2019 Feb 1;29(2):875-891. doi: 10.1093/cercor/bhy291.


Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.

Mäki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA.

Transl Psychiatry. 2017 Nov 17;7(11):5. doi: 10.1038/s41398-017-0007-4.


3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes.

Shen X, van den Brink J, Hou Y, Colli D, Le C, Kolstad TR, MacQuaide N, Carlson CR, Kekenes-Huskey PM, Edwards AG, Soeller C, Louch WE.

J Physiol. 2019 Jan;597(2):399-418. doi: 10.1113/JP277360. Epub 2018 Nov 28.


Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation.

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK.

PLoS One. 2018 Nov 6;13(11):e0207100. doi: 10.1371/journal.pone.0207100. eCollection 2018.


Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes.

Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE.

Elife. 2018 Oct 30;7. pii: e39427. doi: 10.7554/eLife.39427.


Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges.

Vagos M, van Herck IGM, Sundnes J, Arevalo HJ, Edwards AG, Koivumäki JT.

Front Physiol. 2018 Sep 4;9:1221. doi: 10.3389/fphys.2018.01221. eCollection 2018. Review.


From 'Parent' to 'Expert': How Parents of Children with Autism Spectrum Disorder Make Decisions About Which Intervention Approaches to Access.

Edwards AG, Brebner CM, McCormack PF, MacDougall CJ.

J Autism Dev Disord. 2018 Jun;48(6):2122-2138. doi: 10.1007/s10803-018-3473-5.


An integrative appraisal of mechano-electric feedback mechanisms in the heart.

Timmermann V, Dejgaard LA, Haugaa KH, Edwards AG, Sundnes J, McCulloch AD, Wall ST.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):404-417. doi: 10.1016/j.pbiomolbio.2017.08.008. Epub 2017 Aug 26.


An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons.

Tveito A, Jæger KH, Lines GT, Paszkowski Ł, Sundnes J, Edwards AG, Māki-Marttunen T, Halnes G, Einevoll GT.

Front Comput Neurosci. 2017 Apr 24;11:27. doi: 10.3389/fncom.2017.00027. eCollection 2017.


Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling.

Maleckar MM, Edwards AG, Louch WE, Lines GT.

Clin Med Insights Cardiol. 2017 Apr 12;11:1179546817698602. doi: 10.1177/1179546817698602. eCollection 2017.


Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus.

Edwards AG, Louch WE.

Clin Med Insights Cardiol. 2017 Feb 2;11:1179546816686061. doi: 10.1177/1179546816686061. eCollection 2017. Review.


Discordant retinopathy of prematurity in twin anemia-polycythemia sequence.

Sheales MP, Sheth S, Edwards AG, Carden SM.

J AAPOS. 2017 Apr;21(2):173-174. doi: 10.1016/j.jaapos.2016.11.026. Epub 2017 Feb 24.


ϕX174 Procapsid Assembly: Effects of an Inhibitory External Scaffolding Protein and Resistant Coat Proteins In Vitro.

Cherwa JE Jr.,, Tyson J, Bedwell GJ, Brooke D, Edwards AG, Dokland T, Prevelige PE, Fane BA.

J Virol. 2016 Dec 16;91(1). pii: e01878-16. doi: 10.1128/JVI.01878-16. Print 2017 Jan 1.


Balancing Patient Access to Fetoscopic Laser Photocoagulation for Twin-to-Twin Transfusion Syndrome With Maintaining Procedural Competence: Are Collaborative Services Part of the Solution?

Edwards AG, Teoh M, Hodges RJ, Palma-Dias R, Cole SA, Fung AM, Walker SP.

Twin Res Hum Genet. 2016 Jun;19(3):276-84. doi: 10.1017/thg.2016.24. Epub 2016 Apr 18. Review.


Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease.

Squiers JJ, Edwards AG, Parra A, Hofmann SL.

J Investig Med High Impact Case Rep. 2016 Mar 16;4(1):2324709616638363. doi: 10.1177/2324709616638363. eCollection 2016 Jan-Mar.


Field-measured drag area is a key correlate of level cycling time trial performance.

Peterman JE, Lim AC, Ignatz RI, Edwards AG, Byrnes WC.

PeerJ. 2015 Aug 11;3:e1144. doi: 10.7717/peerj.1144. eCollection 2015.


Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes.

Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E.

J Mol Cell Cardiol. 2016 Jul;96:63-71. doi: 10.1016/j.yjmcc.2015.07.030. Epub 2015 Aug 1.


Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing.

Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth DM, Omens JH, McCulloch AD.

J Mol Cell Cardiol. 2014 Nov;76:265-74. doi: 10.1016/j.yjmcc.2014.09.014. Epub 2014 Sep 26.


Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.

Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1205-13. doi: 10.1161/CIRCEP.113.001666. Epub 2014 Sep 18.


CaMKII comes of age in cardiac health and disease.

Grandi E, Edwards AG, Herren AW, Bers DM.

Front Pharmacol. 2014 Jul 3;5:154. doi: 10.3389/fphar.2014.00154. eCollection 2014. No abstract available.


Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.

Vincent KP, McCulloch AD, Edwards AG.

Front Pharmacol. 2014 May 16;5:110. doi: 10.3389/fphar.2014.00110. eCollection 2014. Review.


A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.

Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E.

J Physiol. 2014 Mar 15;592(6):1181-97. doi: 10.1113/jphysiol.2013.266676. Epub 2014 Jan 13.


Randomized clinical trial of intraoperative superficial cervical plexus block versus incisional local anaesthesia in thyroid and parathyroid surgery.

Egan RJ, Hopkins JC, Beamish AJ, Shah R, Edwards AG, Morgan JD.

Br J Surg. 2013 Dec;100(13):1732-8. doi: 10.1002/bjs.9292.


Interventions to promote informed consent for patients undergoing surgical and other invasive healthcare procedures.

Kinnersley P, Phillips K, Savage K, Kelly MJ, Farrell E, Morgan B, Whistance R, Lewis V, Mann MK, Stephens BL, Blazeby J, Elwyn G, Edwards AG.

Cochrane Database Syst Rev. 2013 Jul 6;(7):CD009445. doi: 10.1002/14651858.CD009445.pub2. Review.


The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias.

Westenbrink BD, Edwards AG, McCulloch AD, Brown JH.

Expert Opin Ther Targets. 2013 Aug;17(8):889-903. doi: 10.1517/14728222.2013.809064. Epub 2013 Jun 24. Review.


Psychological interventions for women with metastatic breast cancer.

Mustafa M, Carson-Stevens A, Gillespie D, Edwards AG.

Cochrane Database Syst Rev. 2013 Jun 4;(6):CD004253. doi: 10.1002/14651858.CD004253.pub4. Review.


Conference report from the 2012 AHA scientific sessions in Los Angeles.

Westenbrink BD, Edwards AG, Miyamoto S.

Expert Opin Ther Targets. 2013 Jun;17(6):733-7. doi: 10.1517/14728222.2013.794791. Epub 2013 May 4.


Personalised risk communication for informed decision making about taking screening tests.

Edwards AG, Naik G, Ahmed H, Elwyn GJ, Pickles T, Hood K, Playle R.

Cochrane Database Syst Rev. 2013 Feb 28;(2):CD001865. doi: 10.1002/14651858.CD001865.pub3. Review.


"Many miles to go …": a systematic review of the implementation of patient decision support interventions into routine clinical practice.

Elwyn G, Scholl I, Tietbohl C, Mann M, Edwards AG, Clay C, Légaré F, van der Weijden T, Lewis CL, Wexler RM, Frosch DL.

BMC Med Inform Decis Mak. 2013;13 Suppl 2:S14. doi: 10.1186/1472-6947-13-S2-S14. Epub 2013 Nov 29. Review.


Slow Calcium-Depolarization-Calcium waves may initiate fast local depolarization waves in ventricular tissue.

Tveito A, Lines GT, Edwards AG, Maleckar MM, Michailova A, Hake J, McCulloch A.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):295-304. doi: 10.1016/j.pbiomolbio.2012.07.005. Epub 2012 Jul 24.


Communicating risk.

Ahmed H, Naik G, Willoughby H, Edwards AG.

BMJ. 2012 Jun 18;344:e3996. doi: 10.1136/bmj.e3996. No abstract available.


Communicating risk to patients and the public.

Naik G, Ahmed H, Edwards AG.

Br J Gen Pract. 2012 Apr;62(597):213-6. doi: 10.3399/bjgp12X636236. No abstract available.


Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit.

Hake J, Edwards AG, Yu Z, Kekenes-Huskey PM, Michailova AP, McCammon JA, Holst MJ, Hoshijima M, McCulloch AD.

J Physiol. 2012 Sep 15;590(18):4403-22. doi: 10.1113/jphysiol.2012.227926. Epub 2012 Apr 10.


Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes.

Tveito A, Lines GT, Hake J, Edwards AG.

Math Biosci. 2012 Apr;236(2):97-107. doi: 10.1016/j.mbs.2012.02.005. Epub 2012 Mar 3.


What for nature, and who to nurture?

Donato AJ, Edwards AG.

J Appl Physiol (1985). 2011 Jan;110(1):283; discussion 294. doi: 10.1152/japplphysiol.01259.2010. No abstract available.


Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK.

Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL.

Mech Ageing Dev. 2010 Nov-Dec;131(11-12):739-42. doi: 10.1016/j.mad.2010.09.007. Epub 2010 Oct 8.


Measuring changes in aerodynamic/rolling resistances by cycle-mounted power meters.

Lim AC, Homestead EP, Edwards AG, Carver TC, Kram R, Byrnes WC.

Med Sci Sports Exerc. 2011 May;43(5):853-60. doi: 10.1249/MSS.0b013e3181fcb140.


The RISAP-study: a complex intervention in risk communication and shared decision-making in general practice.

Kirkegaard P, Edwards AG, Hansen B, Hansen MD, Jensen MS, Lauritzen T, Risoer MB, Thomsen JL.

BMC Fam Pract. 2010 Sep 22;11:70. doi: 10.1186/1471-2296-11-70.


Paediatric non-heart-beating renal transplantation.

Edwards AG, McCarthy H, Morgan JD, Saleem MA.

Arch Dis Child. 2010 Oct;95(10):843-4. doi: 10.1136/adc.2009.166942. Epub 2010 Jul 6.


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