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Items: 32

1.

Computational and Experimental Studies of Inhibitor Design for Aldolase A.

Qi R, Walker B, Jing Z, Yu M, Stancu G, Edupuganti R, Dalby KN, Ren P.

J Phys Chem B. 2019 Jul 18;123(28):6034-6041. doi: 10.1021/acs.jpcb.9b04551. Epub 2019 Jul 3.

PMID:
31268712
2.

Computational insights into the binding of IN17 inhibitors to MELK.

Harger M, Lee JH, Walker B, Taliaferro JM, Edupuganti R, Dalby KN, Ren P.

J Mol Model. 2019 May 8;25(6):151. doi: 10.1007/s00894-019-4036-1.

PMID:
31069524
3.

NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells.

Kloet SL, Karemaker ID, van Voorthuijsen L, Lindeboom RGH, Baltissen MP, Edupuganti RR, Poramba-Liyanage DW, Jansen PWTC, Vermeulen M.

Nat Commun. 2018 Nov 2;9(1):4588. doi: 10.1038/s41467-018-07063-7.

4.

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.

Ebelt ND, Kaoud TS, Edupuganti R, Van Ravenstein S, Dalby KN, Van Den Berg CL.

Oncotarget. 2017 Aug 24;8(62):104894-104912. doi: 10.18632/oncotarget.20581. eCollection 2017 Dec 1.

5.

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.

Jose J, Tavares CDJ, Ebelt ND, Lodi A, Edupuganti R, Xie X, Devkota AK, Kaoud TS, Van Den Berg CL, Anslyn EV, Tiziani S, Bartholomeusz C, Dalby KN.

ACS Med Chem Lett. 2017 Sep 14;8(10):1072-1076. doi: 10.1021/acsmedchemlett.7b00282. eCollection 2017 Oct 12.

6.

An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells.

Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U, Meshorer E.

Stem Cell Reports. 2017 Oct 10;9(4):1304-1314. doi: 10.1016/j.stemcr.2017.08.022. Epub 2017 Sep 28.

7.

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation.

Edupuganti RR, Harikumar A, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MA, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R, Meshorer E.

Stem Cell Reports. 2017 Oct 10;9(4):1291-1303. doi: 10.1016/j.stemcr.2017.08.021. Epub 2017 Sep 28.

8.

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis.

Edupuganti RR, Geiger S, Lindeboom RGH, Shi H, Hsu PJ, Lu Z, Wang SY, Baltissen MPA, Jansen PWTC, Rossa M, Müller M, Stunnenberg HG, He C, Carell T, Vermeulen M.

Nat Struct Mol Biol. 2017 Oct;24(10):870-878. doi: 10.1038/nsmb.3462. Epub 2017 Sep 4.

9.

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth.

Edupuganti R, Taliaferro JM, Wang Q, Xie X, Cho EJ, Vidhu F, Ren P, Anslyn EV, Bartholomeusz C, Dalby KN.

Bioorg Med Chem. 2017 May 1;25(9):2609-2616. doi: 10.1016/j.bmc.2017.03.018. Epub 2017 Mar 10.

PMID:
28351607
10.

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.

Xie X, Kaoud TS, Edupuganti R, Zhang T, Kogawa T, Zhao Y, Chauhan GB, Giannoukos DN, Qi Y, Tripathy D, Wang J, Gray NS, Dalby KN, Bartholomeusz C, Ueno NT.

Oncogene. 2017 May 4;36(18):2599-2608. doi: 10.1038/onc.2016.417. Epub 2016 Dec 12.

11.

ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

Spruijt CG, Luijsterburg MS, Menafra R, Lindeboom RG, Jansen PW, Edupuganti RR, Baltissen MP, Wiegant WW, Voelker-Albert MC, Matarese F, Mensinga A, Poser I, Vos HR, Stunnenberg HG, van Attikum H, Vermeulen M.

Cell Rep. 2016 Oct 11;17(3):783-798. doi: 10.1016/j.celrep.2016.09.037.

12.

Synthesis and structural analyses of phenylethynyl-substituted tris(2-pyridylmethyl)amines and their copper(ii) complexes.

Lim J, Lynch VM, Edupuganti R, Ellington A, Anslyn EV.

Dalton Trans. 2016 Jun 28;45(26):10585-98. doi: 10.1039/c6dt00473c.

PMID:
27264275
13.

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

Grandjean G, de Jong PR, James B, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby K, Powis G.

Cancer Res. 2016 Jul 15;76(14):4259-4269. doi: 10.1158/0008-5472.CAN-16-0401. Epub 2016 Jun 3.

14.

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

Varier RA, Carrillo de Santa Pau E, van der Groep P, Lindeboom RG, Matarese F, Mensinga A, Smits AH, Edupuganti RR, Baltissen MP, Jansen PW, Ter Hoeve N, van Weely DR, Poser I, van Diest PJ, Stunnenberg HG, Vermeulen M.

J Biol Chem. 2016 Apr 1;291(14):7313-24. doi: 10.1074/jbc.M115.701227. Epub 2016 Feb 3.

15.

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.

Wang Q, Edupuganti R, Tavares CD, Dalby KN, Ren P.

Front Mol Biosci. 2015 Mar 19;2:9. doi: 10.3389/fmolb.2015.00009. eCollection 2015.

16.

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.

Warthaka M, Adelmann CH, Kaoud TS, Edupuganti R, Yan C, Johnson WH Jr, Ferguson S, Tavares CD, Pence LJ, Anslyn EV, Ren P, Tsai KY, Dalby KN.

ACS Med Chem Lett. 2014 Oct 17;6(1):47-52. doi: 10.1021/ml500198b. eCollection 2015 Jan 8.

17.

Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers.

Jo HH, Edupuganti R, You L, Dalby KN, Anslyn EV.

Chem Sci. 2015 Jan 1;6(1):158-164.

18.

Reversible covalent inhibition of eEF-2K by carbonitriles.

Devkota AK, Edupuganti R, Yan C, Shi Y, Jose J, Wang Q, Kaoud TS, Cho EJ, Ren P, Dalby KN.

Chembiochem. 2014 Nov 3;15(16):2435-42. doi: 10.1002/cbic.201402321. Epub 2014 Sep 15.

19.

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

Edupuganti R, Wang Q, Tavares CD, Chitjian CA, Bachman JL, Ren P, Anslyn EV, Dalby KN.

Bioorg Med Chem. 2014 Sep 1;22(17):4910-6. doi: 10.1016/j.bmc.2014.06.050. Epub 2014 Jun 30.

20.

Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.

Barman S, You L, Chen R, Codrea V, Kago G, Edupuganti R, Robertus J, Krug RM, Anslyn EV.

Eur J Med Chem. 2014 Jan;71:81-90. doi: 10.1016/j.ejmech.2013.10.063. Epub 2013 Nov 7.

21.

High-throughput screens for eEF-2 kinase.

Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN.

J Biomol Screen. 2014 Mar;19(3):445-52. doi: 10.1177/1087057113505204. Epub 2013 Sep 27.

PMID:
24078616
22.

Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics.

Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, Sender M, Choudhary A, DeBrosse C, Ross CW 3rd, Carroll P, Raines RT.

J Org Chem. 2012 Jun 15;77(12):5331-44. doi: 10.1021/jo300700a. Epub 2012 May 25.

23.

Synthesis and applications of masked oxo-sulfinamides in asymmetric synthesis.

Edupuganti R, Davis FA.

Org Biomol Chem. 2012 Jul 14;10(26):5021-31. doi: 10.1039/c2ob25345c. Epub 2012 May 11.

PMID:
22576951
24.

Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines.

Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, Zdilla MJ, DeBrosse C, Cannon KC, Ross CW 3rd, Choudhary A, Shoulders MD, Raines RT.

J Org Chem. 2011 May 20;76(10):3626-34. doi: 10.1021/jo200117p. Epub 2011 Apr 18.

25.

Asymmetric total synthesis of (S)-(+)-cocaine and the first synthesis of cocaine C-1 analogs from N-sulfinyl β-amino ester ketals.

Davis FA, Theddu N, Edupuganti R.

Org Lett. 2010 Sep 17;12(18):4118-21. doi: 10.1021/ol1017118.

PMID:
20731370
26.

Asymmetric synthesis of substituted homotropinones from N-sulfinyl beta-amino ketone ketals. (-)-Euphococcinine and (-)-adaline.

Davis FA, Edupuganti R.

Org Lett. 2010 Feb 19;12(4):848-51. doi: 10.1021/ol902910w.

PMID:
20092270
27.

5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: a nucleophilic displacement route.

Krow GR, Edupuganti R, Gandla D, Choudhary A, Lin G, Sonnet PE, DeBrosse C, Ross CW 3rd, Cannon KC, Raines RT.

J Org Chem. 2009 Nov 6;74(21):8232-42. doi: 10.1021/jo901725k.

28.

Conformational preferences of substrates for human prolyl 4-hydroxylase.

Gorres KL, Edupuganti R, Krow GR, Raines RT.

Biochemistry. 2008 Sep 9;47(36):9447-55. doi: 10.1021/bi8009373. Epub 2008 Aug 15.

29.

The relationship between left ventricular shape and QT interval dispersion.

Harjai KJ, Samal A, Shah M, Edupuganti R, Nunez E, Pandian NG.

Echocardiography. 2002 Nov;19(8):641-4.

PMID:
12487632
30.

The Tei index: a new prognostic index for patients with symptomatic heart failure.

Harjai KJ, Scott L, Vivekananthan K, Nunez E, Edupuganti R.

J Am Soc Echocardiogr. 2002 Sep;15(9):864-8.

PMID:
12221401
31.

Does left ventricular shape influence clinical outcome in heart failure?

Harjai KJ, Edupuganti R, Nunez E, Turgut T, Scott L, Pandian NG.

Clin Cardiol. 2000 Nov;23(11):813-9.

32.

Acute coronary occlusion and in-stent thrombosis in a patient with essential thrombocythemia.

Turgut T, Harjai KJ, Edupuganti R, Cole J, Jenkins JS, Ramee SR, Collins TJ.

Cathet Cardiovasc Diagn. 1998 Dec;45(4):428-33.

PMID:
9863754

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