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Items: 1 to 50 of 73

1.

Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976. No abstract available.

PMID:
29748370
2.

Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy.

Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD.

J Med Chem. 2018 May 10;61(9):4271. doi: 10.1021/acs.jmedchem.8b00582. Epub 2018 Apr 27. No abstract available.

3.

Commercial scale production of RvD4 opens the resolving door to new research.

Edin ML, Zeldin DC.

J Leukoc Biol. 2018 Mar 30. doi: 10.1002/JLB.3CE0118-032R. [Epub ahead of print] No abstract available.

PMID:
29603390
4.

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.

Edin ML, Hamedani BG, Gruzdev A, Graves JP, Lih FB, Arbes SJ 3rd, Singh R, Orjuela Leon AC, Bradbury JA, DeGraff LM, Hoopes SL, Arand M, Zeldin DC.

J Biol Chem. 2018 Mar 2;293(9):3281-3292. doi: 10.1074/jbc.RA117.000298. Epub 2018 Jan 3.

PMID:
29298899
5.

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.

6.

Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.

Hagar JA, Edin ML, Lih FB, Thurlow LR, Koller BH, Cairns BA, Zeldin DC, Miao EA.

J Immunol. 2017 Nov 15;199(10):3634-3643. doi: 10.4049/jimmunol.1700820. Epub 2017 Oct 16.

PMID:
29038248
7.

Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Ledent C, Tilley SL, Nayeem MA.

Prostaglandins Other Lipid Mediat. 2017 Jul;131:83-95. doi: 10.1016/j.prostaglandins.2017.09.001. Epub 2017 Sep 7.

PMID:
28890385
8.

Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7545-E7553. doi: 10.1073/pnas.1620898114. Epub 2017 Aug 21.

9.

Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Edin ML, Zeldin DC.

Drug Metab Dispos. 2017 Jul;45(7):807-816. doi: 10.1124/dmd.117.075697. Epub 2017 Apr 27.

10.

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

Hoopes SL, Gruzdev A, Edin ML, Graves JP, Bradbury JA, Flake GP, Lih FB, DeGraff LM, Zeldin DC.

PLoS One. 2017 Apr 6;12(4):e0175348. doi: 10.1371/journal.pone.0175348. eCollection 2017.

11.

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Mar 22;12(3):e0174137. doi: 10.1371/journal.pone.0174137. eCollection 2017.

12.

Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease.

Jerschow E, Edin ML, Pelletier T, Abuzeid WM, Akbar NA, Gibber M, Fried M, Lih FB, Gruzdev A, Bradbury JA, Han W, Hudes G, Keskin T, Schuster VL, Spivack S, Zeldin DC, Rosenstreich D.

J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):998-1007.e2. doi: 10.1016/j.jaip.2016.11.021. Epub 2017 Jan 31.

13.

Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Jan 5;12(1):e0169584. doi: 10.1371/journal.pone.0169584. eCollection 2017.

14.

Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis.

Gong Y, Shao Z, Fu Z, Edin ML, Sun Y, Liegl RG, Wang Z, Liu CH, Burnim SB, Meng SS, Lih FB, SanGiovanni JP, Zeldin DC, Hellström A, Smith LEH.

EBioMedicine. 2016 Nov;13:201-211. doi: 10.1016/j.ebiom.2016.09.025. Epub 2016 Sep 30.

15.

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2016 Dec;30(12):4256-4266. Epub 2016 Sep 15.

16.

Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Nayeem MA.

PLoS One. 2016 Sep 1;11(9):e0162147. doi: 10.1371/journal.pone.0162147. eCollection 2016.

17.

Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Nayeem MA.

Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R676-R688. doi: 10.1152/ajpregu.00237.2016. Epub 2016 Aug 3.

18.

Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.

Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1919-27. doi: 10.1161/ATVBAHA.116.307558. Epub 2016 Jul 14.

19.

Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L.

Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul.

20.

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

Wells MA, Vendrov KC, Edin ML, Ferslew BC, Zha W, Nguyen BK, Church RJ, Lih FB, DeGraff LM, Brouwer KL, Barritt AS 4th, Zeldin DC, Lee CR.

Prostaglandins Other Lipid Mediat. 2016 Sep;125:19-29. doi: 10.1016/j.prostaglandins.2016.07.002. Epub 2016 Jul 9.

21.

CYP450-derived oxylipins mediate inflammatory resolution.

Gilroy DW, Edin ML, De Maeyer RP, Bystrom J, Newson J, Lih FB, Stables M, Zeldin DC, Bishop-Bailey D.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3240-9. doi: 10.1073/pnas.1521453113. Epub 2016 May 25.

22.

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.

Jia J, Davis CM, Zhang W, Edin ML, Jouihan S, Jia T, Bradbury JA, Graves JP, DeGraff LM, Lee CR, Ronnekleiv O, Wang R, Xu Y, Zeldin DC, Alkayed NJ.

Exp Neurol. 2016 May;279:75-85. doi: 10.1016/j.expneurol.2016.02.016. Epub 2016 Feb 20.

23.

Oviductal estrogen receptor α signaling prevents protease-mediated embryo death.

Winuthayanon W, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih FB, Hewitt SC, Korach KS, Williams CJ.

Elife. 2015 Dec 1;4:e10453. doi: 10.7554/eLife.10453.

24.

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.

Oni-Orisan A, Edin ML, Lee JA, Wells MA, Christensen ES, Vendrov KC, Lih FB, Tomer KB, Bai X, Taylor JM, Stouffer GA, Zeldin DC, Lee CR.

J Lipid Res. 2016 Jan;57(1):109-19. doi: 10.1194/jlr.M061697. Epub 2015 Nov 10.

25.

Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis.

Cheng J, Dackor RT, Bradbury JA, Li H, DeGraff LM, Hong LK, King D, Lih FB, Gruzdev A, Edin ML, Travlos GS, Flake GP, Tomer KB, Zeldin DC.

FASEB J. 2016 Jan;30(1):160-73. doi: 10.1096/fj.14-268458. Epub 2015 Sep 22.

26.

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065. Epub 2015 Jul 16.

27.

Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins.

Thomson S, Edin ML, Lih FB, Davies M, Yaqoob MM, Hammock BD, Gilroy D, Zeldin DC, Bishop-Bailey D.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):774-80. doi: 10.1016/j.bbrc.2015.06.012. Epub 2015 Jun 15.

28.

Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Li H, House JS, Hoopes SL, Edin ML, Zeldin DC.

Drug Metab Dispos. 2015 Aug;43(8):1169-80. doi: 10.1124/dmd.115.064139. Epub 2015 May 20.

29.

Vascular actions of 20-HETE.

Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC.

Prostaglandins Other Lipid Mediat. 2015 Jul;120:9-16. doi: 10.1016/j.prostaglandins.2015.03.002. Epub 2015 Mar 23. Review.

30.

CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.

Chen G, Xu R, Zhang S, Wang Y, Wang P, Edin ML, Zeldin DC, Wang DW.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E97-E110. doi: 10.1152/ajpendo.00366.2014. Epub 2014 Nov 11.

31.

The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.

Schuck RN, Zha W, Edin ML, Gruzdev A, Vendrov KC, Miller TM, Xu Z, Lih FB, DeGraff LM, Tomer KB, Jones HM, Makowski L, Huang L, Poloyac SM, Zeldin DC, Lee CR.

PLoS One. 2014 Oct 13;9(10):e110162. doi: 10.1371/journal.pone.0110162. eCollection 2014.

32.

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.

Zha W, Edin ML, Vendrov KC, Schuck RN, Lih FB, Jat JL, Bradbury JA, DeGraff LM, Hua K, Tomer KB, Falck JR, Zeldin DC, Lee CR.

J Lipid Res. 2014 Oct;55(10):2124-36. doi: 10.1194/jlr.M053199. Epub 2014 Aug 11.

33.

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.

Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD.

J Med Chem. 2014 Aug 28;57(16):7016-30. doi: 10.1021/jm500694p. Epub 2014 Aug 11. Erratum in: J Med Chem. 2018 May 10;61(9):4271.

34.

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

Cheng J, Edin ML, Hoopes SL, Li H, Bradbury JA, Graves JP, DeGraff LM, Lih FB, Garcia V, Shaik JS, Tomer KB, Flake GP, Falck JR, Lee CR, Poloyac SM, Schwartzman ML, Zeldin DC.

FASEB J. 2014 Jul;28(7):2915-31. doi: 10.1096/fj.13-241927. Epub 2014 Mar 25.

35.

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells.

Askari AA, Thomson S, Edin ML, Lih FB, Zeldin DC, Bishop-Bailey D.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):633-7. doi: 10.1016/j.bbrc.2014.03.020. Epub 2014 Mar 13.

36.

Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.

Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE.

Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):581-6. doi: 10.1161/ATVBAHA.113.302927. Epub 2014 Jan 23.

37.

CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.

Wang X, Ni L, Yang L, Duan Q, Chen C, Edin ML, Zeldin DC, Wang DW.

Mol Pharmacol. 2014 Jan;85(1):105-15. doi: 10.1124/mol.113.087122. Epub 2013 Oct 21.

38.

Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis: a role for CYP2J2 deficiency in the pathogenesis of Crohn's disease?

Bystrom J, Thomson SJ, Johansson J, Edin ML, Zeldin DC, Gilroy DW, Smith AM, Bishop-Bailey D.

PLoS One. 2013 Sep 13;8(9):e75107. doi: 10.1371/journal.pone.0075107. eCollection 2013.

39.

Epoxyeicosanoids promote organ and tissue regeneration.

Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13528-33. doi: 10.1073/pnas.1311565110. Epub 2013 Jul 29.

40.

Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.

Klett EL, Chen S, Edin ML, Li LO, Ilkayeva O, Zeldin DC, Newgard CB, Coleman RA.

J Biol Chem. 2013 Jul 26;288(30):21618-29. doi: 10.1074/jbc.M113.481077. Epub 2013 Jun 13.

41.

Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes.

Sayers BC, Taylor AJ, Glista-Baker EE, Shipley-Phillips JK, Dackor RT, Edin ML, Lih FB, Tomer KB, Zeldin DC, Langenbach R, Bonner JC.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):525-35. doi: 10.1165/rcmb.2013-0019OC.

42.

Role of endothelial soluble epoxide hydrolase in cerebrovascular function and ischemic injury.

Zhang W, Davis CM, Edin ML, Lee CR, Zeldin DC, Alkayed NJ.

PLoS One. 2013 Apr 9;8(4):e61244. doi: 10.1371/journal.pone.0061244. Print 2013.

43.

Roles of the epoxygenase CYP2J2 in the endothelium.

Askari A, Thomson SJ, Edin ML, Zeldin DC, Bishop-Bailey D.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:56-63. doi: 10.1016/j.prostaglandins.2013.02.003. Epub 2013 Mar 6. Review.

44.

Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patients.

Schuck RN, Theken KN, Edin ML, Caughey M, Bass A, Ellis K, Tran B, Steele S, Simmons BP, Lih FB, Tomer KB, Wu MC, Hinderliter AL, Stouffer GA, Zeldin DC, Lee CR.

Atherosclerosis. 2013 Apr;227(2):442-8. doi: 10.1016/j.atherosclerosis.2013.01.034. Epub 2013 Feb 5.

45.

Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB.

Li H, Edin ML, Bradbury JA, Graves JP, DeGraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, Garantziotis S, Jetten AM, Zeldin DC.

Am J Respir Crit Care Med. 2013 Apr 15;187(8):812-22. doi: 10.1164/rccm.201211-2073OC.

46.

Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily.

Graves JP, Edin ML, Bradbury JA, Gruzdev A, Cheng J, Lih FB, Masinde TA, Qu W, Clayton NP, Morrison JP, Tomer KB, Zeldin DC.

Drug Metab Dispos. 2013 Apr;41(4):763-73. doi: 10.1124/dmd.112.049429. Epub 2013 Jan 11.

47.

Regulation of T helper cell subsets by cyclooxygenases and their metabolites.

Li H, Edin ML, Gruzdev A, Cheng J, Bradbury JA, Graves JP, DeGraff LM, Zeldin DC.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:74-83. doi: 10.1016/j.prostaglandins.2012.11.002. Epub 2012 Nov 28. Review.

48.

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.

Li R, Xu X, Chen C, Yu X, Edin ML, Degraff LM, Lee CR, Zeldin DC, Wang DW.

Prostaglandins Other Lipid Mediat. 2012 Dec;99(3-4):68-78. doi: 10.1016/j.prostaglandins.2012.09.004. Epub 2012 Oct 2.

49.

Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice.

Oni-Orisan A, Deng Y, Schuck RN, Theken KN, Edin ML, Lih FB, Molnar K, DeGraff L, Tomer KB, Zeldin DC, Lee CR.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:67-73. doi: 10.1016/j.prostaglandins.2012.09.003. Epub 2012 Sep 19.

50.

Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice.

Chaudhary KR, Zordoky BN, Edin ML, Alsaleh N, El-Kadi AO, Zeldin DC, Seubert JM.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:8-17. doi: 10.1016/j.prostaglandins.2012.08.001. Epub 2012 Aug 16.

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