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Predictors of recurrence, early treatment failure and death from Staphylococcus aureus bacteraemia: Observational analyses within the ARREST trial.

Szubert A, Bailey SL, Cooke GS, Peto T, Llewelyn MJ, Edgeworth JD, Walker AS, Thwaites GE; United Kingdom Clinical Infection Research Group (UKCIRG).

J Infect. 2019 Aug 6. pii: S0163-4453(19)30240-3. doi: 10.1016/j.jinf.2019.08.001. [Epub ahead of print]


Individual- and community-level risk factors for ESBL Enterobacteriaceae colonization identified by universal admission screening in London.

Otter JA, Natale A, Batra R, Tosas Auguet O, Dyakova E, Goldenberg SD, Edgeworth JD.

Clin Microbiol Infect. 2019 Mar 6. pii: S1198-743X(19)30094-1. doi: 10.1016/j.cmi.2019.02.026. [Epub ahead of print]


Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus.

Costa SS, Sobkowiak B, Parreira R, Edgeworth JD, Viveiros M, Clark TG, Couto I.

Front Genet. 2019 Jan 9;9:710. doi: 10.3389/fgene.2018.00710. eCollection 2018.


Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa.

Edgeworth JD, Merante D, Patel S, Young C, Jones P, Vithlani S, Wyncoll D, Roberts P, Jones A, Den Nagata T, Ariyasu M, Livermore DM, Beale R.

Clin Infect Dis. 2019 May 17;68(11):1932-1934. doi: 10.1093/cid/ciy963.


Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT.

Thwaites GE, Scarborough M, Szubert A, Saramago Goncalves P, Soares M, Bostock J, Nsutebu E, Tilley R, Cunningham R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS.

Health Technol Assess. 2018 Oct;22(59):1-148. doi: 10.3310/hta22590.


Tolerance of MRSA ST239-TW to chlorhexidine-based decolonization: Evidence for keratinocyte invasion as a mechanism of biocide evasion.

Marbach H, Vizcay-Barrena G, Memarzadeh K, Otter JA, Pathak S, Allaker RP, Harvey RD, Edgeworth JD.

J Infect. 2019 Feb;78(2):119-126. doi: 10.1016/j.jinf.2018.10.007. Epub 2018 Oct 24.


Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG).

Lancet. 2018 Feb 17;391(10121):668-678. doi: 10.1016/S0140-6736(17)32456-X. Epub 2017 Dec 14.


Intensive care unit (ICU)-acquired bacteraemia and ICU mortality and discharge: addressing time-varying confounding using appropriate methodology.

Pouwels KB, Vansteelandt S, Batra R, Edgeworth JD, Smieszek T, Robotham JV.

J Hosp Infect. 2018 May;99(1):42-47. doi: 10.1016/j.jhin.2017.11.011. Epub 2017 Nov 23.


Frequent Undetected Ward-Based Methicillin-Resistant Staphylococcus aureus Transmission Linked to Patient Sharing Between Hospitals.

Tosas Auguet O, Stabler RA, Betley J, Preston MD, Dhaliwal M, Gaunt M, Ioannou A, Desai N, Karadag T, Batra R, Otter JA, Marbach H, Clark TG, Edgeworth JD.

Clin Infect Dis. 2018 Mar 5;66(6):840-848. doi: 10.1093/cid/cix901.


Will co-trimoxazole resistance rates ever go down? Resistance rates remain high despite decades of reduced co-trimoxazole consumption.

Pouwels KB, Batra R, Patel A, Edgeworth JD, Robotham JV, Smieszek T.

J Glob Antimicrob Resist. 2017 Dec;11:71-74. doi: 10.1016/j.jgar.2017.07.013. Epub 2017 Jul 31.


Identification of a distinctive phenotype for endocarditis-associated clonal complex 22 MRSA isolates with reduced vancomycin susceptibility.

Marbach H, Boakes E, Lynham S, Ward M, Otter JA, Edgeworth JD.

J Med Microbiol. 2017 May;66(5):584-591. doi: 10.1099/jmm.0.000470. Epub 2017 May 15.


Does appropriate empiric antibiotic therapy modify intensive care unit-acquired Enterobacteriaceae bacteraemia mortality and discharge?

Pouwels KB, Van Kleef E, Vansteelandt S, Batra R, Edgeworth JD, Smieszek T, Robotham JV.

J Hosp Infect. 2017 May;96(1):23-28. doi: 10.1016/j.jhin.2017.03.016. Epub 2017 Mar 16.


Efficacy and acceptability of rectal and perineal sampling for identifying gastrointestinal colonization with extended spectrum β-lactamase Enterobacteriaceae.

Dyakova E, Bisnauthsing KN, Querol-Rubiera A, Patel A, Ahanonu C, Tosas Auguet O, Edgeworth JD, Goldenberg SD, Otter JA.

Clin Microbiol Infect. 2017 Aug;23(8):577.e1-577.e3. doi: 10.1016/j.cmi.2017.02.019. Epub 2017 Feb 24.


Comparative analysis of phenol-soluble modulin production and Galleria mellonella killing by community-associated and healthcare-associated meticillin-resistant Staphylococcusaureus strains.

Boakes E, Marbach H, Lynham S, Ward M, Edgeworth JD, Otter JA.

J Med Microbiol. 2016 Dec;65(12):1429-1433. doi: 10.1099/jmm.0.000379. Epub 2016 Oct 26.


Universal hospital admission screening for carbapenemase-producing organisms in a low-prevalence setting.

Otter JA, Dyakova E, Bisnauthsing KN, Querol-Rubiera A, Patel A, Ahanonu C, Tosas Auguet O, Edgeworth JD, Goldenberg SD.

J Antimicrob Chemother. 2016 Dec;71(12):3556-3561. Epub 2016 Aug 11.


Recent emergence of carbapenem-resistant organisms in a low prevalence UK setting in London.

Hughes J, Goldenberg SD, Tosas O, Edgeworth JD, Otter JA.

J Infect Prev. 2016 May;17(3):130-134. doi: 10.1177/1757177415622693. Epub 2015 Dec 14.


Carriage, Clinical Microbiology and Transmission of Staphylococcus aureus.

Aryee A, Edgeworth JD.

Curr Top Microbiol Immunol. 2017;409:1-19. doi: 10.1007/82_2016_5.


Evidence for Community Transmission of Community-Associated but Not Health-Care-Associated Methicillin-Resistant Staphylococcus Aureus Strains Linked to Social and Material Deprivation: Spatial Analysis of Cross-sectional Data.

Tosas Auguet O, Betley JR, Stabler RA, Patel A, Ioannou A, Marbach H, Hearn P, Aryee A, Goldenberg SD, Otter JA, Desai N, Karadag T, Grundy C, Gaunt MW, Cooper BS, Edgeworth JD, Kypraios T.

PLoS Med. 2016 Jan 26;13(1):e1001944. doi: 10.1371/journal.pmed.1001944. eCollection 2016 Jan.


Gram-negative bacteraemia; a multi-centre prospective evaluation of empiric antibiotic therapy and outcome in English acute hospitals.

Fitzpatrick JM, Biswas JS, Edgeworth JD, Islam J, Jenkins N, Judge R, Lavery AJ, Melzer M, Morris-Jones S, Nsutebu EF, Peters J, Pillay DG, Pink F, Price JR, Scarborough M, Thwaites GE, Tilley R, Walker AS, Llewelyn MJ; United Kingdom Clinical Infection Research Group.

Clin Microbiol Infect. 2016 Mar;22(3):244-51. doi: 10.1016/j.cmi.2015.10.034. Epub 2015 Nov 11.


Clonal variation in high- and low-level phenotypic and genotypic mupirocin resistance of MRSA isolates in south-east London.

Hughes J, Stabler R, Gaunt M, Karadag T, Desai N, Betley J, Ioannou A, Aryee A, Hearn P, Marbach H, Patel A, Otter JA, Edgeworth JD, Tosas Auguet O.

J Antimicrob Chemother. 2015 Dec;70(12):3191-9. doi: 10.1093/jac/dkv248. Epub 2015 Aug 27.


A cost benefit analysis of the Luminex xTAG Gastrointestinal Pathogen Panel for detection of infectious gastroenteritis in hospitalised patients.

Goldenberg SD, Bacelar M, Brazier P, Bisnauthsing K, Edgeworth JD.

J Infect. 2015 May;70(5):504-11. doi: 10.1016/j.jinf.2014.11.009. Epub 2014 Nov 29.


Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection.

Otter JA, Vickery K, Walker JT, deLancey Pulcini E, Stoodley P, Goldenberg SD, Salkeld JA, Chewins J, Yezli S, Edgeworth JD.

J Hosp Infect. 2015 Jan;89(1):16-27. doi: 10.1016/j.jhin.2014.09.008. Epub 2014 Oct 2. Review.


The Enigma ML FluAB-RSV assay: a fully automated molecular test for the rapid detection of influenza A, B and respiratory syncytial viruses in respiratory specimens.

Goldenberg SD, Edgeworth JD.

Expert Rev Mol Diagn. 2015 Jan;15(1):23-32. doi: 10.1586/14737159.2015.983477. Epub 2014 Nov 17.


Implications of targeted versus universal admission screening for meticillin-resistant Staphylococcus aureus carriage in a London hospital.

Otter JA, Tosas-Auguet O, Herdman MT, Williams B, Tucker D, Edgeworth JD, French GL.

J Hosp Infect. 2014 Jul;87(3):171-4. doi: 10.1016/j.jhin.2014.04.005. Epub 2014 May 10.


Identification and control of a gentamicin resistant, meticillin susceptible Staphylococcus aureus outbreak on a neonatal unit.

Otter JA, Davies B, Menson E, Klein JL, Watts TL, Kearns AM, Pichon B, Edgeworth JD, French GL.

J Infect Prev. 2014 May;15(3):104-109. doi: 10.1177/1757177413520057. Epub 2014 Feb 11. Review.


Long-term adherence to a 5 day antibiotic course guideline for treatment of intensive care unit (ICU)-associated Gram-negative infections.

Edgeworth JD, Chis Ster I, Wyncoll D, Shankar-Hari M, McKenzie CA.

J Antimicrob Chemother. 2014 Jun;69(6):1688-94. doi: 10.1093/jac/dku038. Epub 2014 Feb 25.


Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies.

Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues.

J Infect. 2014 Mar;68(3):242-51. doi: 10.1016/j.jinf.2013.10.015. Epub 2013 Nov 16. Erratum in: J Infect. 2014 Sep;69(3):306-7.


Clustering of antimicrobial resistance outbreaks across bacterial species in the intensive care unit.

Vlek AL, Cooper BS, Kypraios T, Cox A, Edgeworth JD, Auguet OT.

Clin Infect Dis. 2013 Jul;57(1):65-76. doi: 10.1093/cid/cit192. Epub 2013 Apr 2.


Low prevalence of meticillin-resistant Staphylococcus aureus carriage at hospital admission: implications for risk-factor-based vs universal screening.

Otter JA, Herdman MT, Williams B, Tosas O, Edgeworth JD, French GL.

J Hosp Infect. 2013 Feb;83(2):114-21. doi: 10.1016/j.jhin.2012.10.008. Epub 2013 Jan 10.


Selection for qacA carriage in CC22, but not CC30, methicillin-resistant Staphylococcus aureus bloodstream infection isolates during a successful institutional infection control programme.

Otter JA, Patel A, Cliff PR, Halligan EP, Tosas O, Edgeworth JD.

J Antimicrob Chemother. 2013 May;68(5):992-9. doi: 10.1093/jac/dks500. Epub 2013 Jan 3.


Quantifying type-specific reproduction numbers for nosocomial pathogens: evidence for heightened transmission of an Asian sequence type 239 MRSA clone.

Cooper BS, Kypraios T, Batra R, Wyncoll D, Tosas O, Edgeworth JD.

PLoS Comput Biol. 2012;8(4):e1002454. doi: 10.1371/journal.pcbi.1002454. Epub 2012 Apr 12.


An association between bacterial genotype combined with a high-vancomycin minimum inhibitory concentration and risk of endocarditis in methicillin-resistant Staphylococcus aureus bloodstream infection.

Miller CE, Batra R, Cooper BS, Patel AK, Klein J, Otter JA, Kypraios T, French GL, Tosas O, Edgeworth JD.

Clin Infect Dis. 2012 Mar 1;54(5):591-600. doi: 10.1093/cid/cir858. Epub 2011 Dec 20.


Screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus in intensive care units: cost effectiveness evaluation.

Robotham JV, Graves N, Cookson BD, Barnett AG, Wilson JA, Edgeworth JD, Batra R, Cuthbertson BH, Cooper BS.

BMJ. 2011 Oct 5;343:d5694. doi: 10.1136/bmj.d5694.


Effect of systemic antibiotics and topical chlorhexidine on meticillin-resistant Staphylococcus aureus carriage in intensive care unit patients.

Kypraios T, O'Neill PD, Jones DE, Ware J, Batra R, Edgeworth JD, Cooper BS.

J Hosp Infect. 2011 Nov;79(3):222-6. doi: 10.1016/j.jhin.2011.05.008. Epub 2011 Jul 16.


Clinical management of Staphylococcus aureus bacteraemia.

Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, Kirby A, Tilley R, Török ME, Walker S, Wertheim HF, Wilson P, Llewelyn MJ; UK Clinical Infection Research Group.

Lancet Infect Dis. 2011 Mar;11(3):208-22. doi: 10.1016/S1473-3099(10)70285-1. Review.


IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans.

Barone F, Vossenkamper A, Boursier L, Su W, Watson A, John S, Dunn-Walters DK, Fields P, Wijetilleka S, Edgeworth JD, Spencer J.

Gastroenterology. 2011 Mar;140(3):947-56. doi: 10.1053/j.gastro.2010.12.005. Epub 2010 Dec 11.


Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care.

Edgeworth JD.

J Antimicrob Chemother. 2011 Apr;66 Suppl 2:ii41-7. doi: 10.1093/jac/dkq325. Epub 2010 Sep 18. Review.


Evolution of MRSA during hospital transmission and intercontinental spread.

Harris SR, Feil EJ, Holden MT, Quail MA, Nickerson EK, Chantratita N, Gardete S, Tavares A, Day N, Lindsay JA, Edgeworth JD, de Lencastre H, Parkhill J, Peacock SJ, Bentley SD.

Science. 2010 Jan 22;327(5964):469-74. doi: 10.1126/science.1182395.


Efficacy and limitation of a chlorhexidine-based decolonization strategy in preventing transmission of methicillin-resistant Staphylococcus aureus in an intensive care unit.

Batra R, Cooper BS, Whiteley C, Patel AK, Wyncoll D, Edgeworth JD.

Clin Infect Dis. 2010 Jan 15;50(2):210-7. doi: 10.1086/648717.


Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).

Holden MT, Lindsay JA, Corton C, Quail MA, Cockfield JD, Pathak S, Batra R, Parkhill J, Bentley SD, Edgeworth JD.

J Bacteriol. 2010 Feb;192(3):888-92. doi: 10.1128/JB.01255-09. Epub 2009 Nov 30.


Clinical application of real-time PCR to screening critically ill and emergency-care surgical patients for methicillin-resistant Staphylococcus aureus: a quantitative analytical study.

Herdman MT, Wyncoll D, Halligan E, Cliff PR, French G, Edgeworth JD.

J Clin Microbiol. 2009 Dec;47(12):4102-8. doi: 10.1128/JCM.01332-09. Epub 2009 Oct 21.


Hospitals are dangerous places.

Barnett AG, Graves N, Cooper BS, Batra R, Edgeworth JD.

Med J Aust. 2008 Dec 1-15;189(11-12):672.


Rapid determination of hospital-acquired meticillin-resistant Staphylococcus aureus lineages.

Cockfield JD, Pathak S, Edgeworth JD, Lindsay JA.

J Med Microbiol. 2007 May;56(Pt 5):614-9.


An outbreak in an intensive care unit of a strain of methicillin-resistant Staphylococcus aureus sequence type 239 associated with an increased rate of vascular access device-related bacteremia.

Edgeworth JD, Yadegarfar G, Pathak S, Batra R, Cockfield JD, Wyncoll D, Beale R, Lindsay JA.

Clin Infect Dis. 2007 Feb 15;44(4):493-501. Epub 2007 Jan 16.


Neutrophils in development of multiple organ failure in sepsis.

Brown KA, Brain SD, Pearson JD, Edgeworth JD, Lewis SM, Treacher DF.

Lancet. 2006 Jul 8;368(9530):157-69. Review.


Enhanced surveillance of meticillin-resistant Staphylococcus aureus bacteraemia in a London teaching hospital.

Jeyaratnam D, Edgeworth JD, French GL.

J Hosp Infect. 2006 Aug;63(4):365-73. Epub 2006 Jun 9.


Human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria.

Boursier L, Gordon JN, Thiagamoorthy S, Edgeworth JD, Spencer J.

Gastroenterology. 2005 Jun;128(7):1879-89.


Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.

Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ.

Eur J Immunol. 2002 May;32(5):1464-71.

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