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Ultrasound Shear Wave Elastography as a Measure of Porcine Hepatic Disease in Right Heart Dysfunction: A Pilot Study.

Hu JJ, Qureshi MY, Urban MW, Graham R, Yin M, Oommen S, Holst KA, Edgerton S, Vasconcelos L, Nenadic I, Cetta F; Wanek Program Pre-clinical Pipeline.

Ultrasound Med Biol. 2018 Nov;44(11):2393-2399. doi: 10.1016/j.ultrasmedbio.2018.05.027. Epub 2018 Aug 18.


FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation.

Wellberg EA, Kabos P, Gillen AE, Jacobsen BM, Brechbuhl HM, Johnson SJ, Rudolph MC, Edgerton SM, Thor AD, Anderson SM, Elias A, Zhou XK, Iyengar NM, Morrow M, Falcone DJ, El-Hely O, Dannenberg AJ, Sartorius CA, MacLean PS.

JCI Insight. 2018 Jul 26;3(14). pii: 120594. doi: 10.1172/jci.insight.120594. eCollection 2018 Jul 26.


Metformin Targets Glucose Metabolism in Triple Negative Breast Cancer.

Wahdan-Alaswad RS, Edgerton SM, Salem HS, Thor AD.

J Oncol Transl Res. 2018;4(1). pii: 129. doi: 10.4172/2476-2261.1000129. Epub 2018 Mar 21.


Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells.

Lee H, Saini N, Howard EW, Parris AB, Ma Z, Zhao Q, Zhao M, Liu B, Edgerton SM, Thor AD, Yang X.

Sci Rep. 2018 May 1;8(1):6829. doi: 10.1038/s41598-018-25284-0.


Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases.

Contreras-Zárate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM.

Front Oncol. 2017 Nov 2;7:252. doi: 10.3389/fonc.2017.00252. eCollection 2017.


A Pilot Study Investigating Employee Utilization of Corporate Telehealth Services.

Edgerton SS.

Perspect Health Inf Manag. 2017 Oct 1;14(Fall):1g. eCollection 2017 Fall.


Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells.

Zhao M, Howard EW, Parris AB, Guo Z, Zhao Q, Ma Z, Xing Y, Liu B, Edgerton SM, Thor AD, Yang X.

Oncotarget. 2017 Jul 19;8(35):58847-58864. doi: 10.18632/oncotarget.19375. eCollection 2017 Aug 29.


The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer.

Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM.

Horm Cancer. 2017 Dec;8(5-6):269-285. doi: 10.1007/s12672-017-0302-9. Epub 2017 Jul 24.


Ultrasound guided percutaneous common carotid artery access in piglets for intracoronary stem cell infusion.

Anderson JH, Taggart NW, Edgerton SL, Cantero Peral S, Holst KA, Cetta F; Wanek Program Preclinical Pipeline.

Lab Anim. 2018 Feb;52(1):88-92. doi: 10.1177/0023677217719923. Epub 2017 Jul 14.


Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo.

Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS.

Cancer Prev Res (Phila). 2017 Mar;10(3):198-207. doi: 10.1158/1940-6207.CAPR-16-0211-T. Epub 2017 Feb 2.


Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.

Shively SB, Edgerton SL, Iacono D, Purohit DP, Qu BX, Haroutunian V, Davis KL, Diaz-Arrastia R, Perl DP.

Acta Neuropathol. 2017 Mar;133(3):353-366. doi: 10.1007/s00401-016-1649-7. Epub 2016 Nov 24.


Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.

Wahdan-Alaswad R, Harrell JC, Fan Z, Edgerton SM, Liu B, Thor AD.

Cell Cycle. 2016;15(8):1046-59. doi: 10.1080/15384101.2016.1152432.


Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers.

Gari HH, Gearheart CM, Fosmire S, DeGala GD, Fan Z, Torkko KC, Edgerton SM, Lucia MS, Ray R, Thor AD, Porter CC, Lambert JR.

Oncotarget. 2016 Mar 29;7(13):15757-71. doi: 10.18632/oncotarget.7462.


The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells.

Lyu H, Yang XH, Edgerton SM, Thor AD, Wu X, He Z, Liu B.

Oncotarget. 2016 Jan 19;7(3):2921-35. doi: 10.18632/oncotarget.6404.


Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b.

Wahdan-Alaswad RS, Cochrane DR, Spoelstra NS, Howe EN, Edgerton SM, Anderson SM, Thor AD, Richer JK.

Horm Cancer. 2014 Dec;5(6):374-89. doi: 10.1007/s12672-014-0188-8. Epub 2014 Sep 12.


Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling.

Jindal S, Gao D, Bell P, Albrektsen G, Edgerton SM, Ambrosone CB, Thor AD, Borges VF, Schedin P.

Breast Cancer Res. 2014 Mar 28;16(2):R31. doi: 10.1186/bcr3633.


Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide.

Cochrane DR, Bernales S, Jacobsen BM, Cittelly DM, Howe EN, D'Amato NC, Spoelstra NS, Edgerton SM, Jean A, Guerrero J, Gómez F, Medicherla S, Alfaro IE, McCullagh E, Jedlicka P, Torkko KC, Thor AD, Elias AD, Protter AA, Richer JK.

Breast Cancer Res. 2014 Jan 22;16(1):R7. doi: 10.1186/bcr3599.


Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models.

Zhu P, Davis M, Blackwelder AJ, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X.

Cancer Prev Res (Phila). 2014 Feb;7(2):199-210. doi: 10.1158/1940-6207.CAPR-13-0181. Epub 2013 Dec 9.


Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer.

Wang S, Huang J, Lyu H, Cai B, Yang X, Li F, Tan J, Edgerton SM, Thor AD, Lee CK, Liu B.

Breast Cancer Res. 2013;15(5):R101.


Glucose promotes breast cancer aggression and reduces metformin efficacy.

Wahdan-Alaswad R, Fan Z, Edgerton SM, Liu B, Deng XS, Arnadottir SS, Richer JK, Anderson SM, Thor AD.

Cell Cycle. 2013 Dec 15;12(24):3759-69. doi: 10.4161/cc.26641. Epub 2013 Oct 3.


Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer.

Callihan EB, Gao D, Jindal S, Lyons TR, Manthey E, Edgerton S, Urquhart A, Schedin P, Borges VF.

Breast Cancer Res Treat. 2013 Apr;138(2):549-59. doi: 10.1007/s10549-013-2437-x. Epub 2013 Feb 22.


p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.

Tophkhane C, Yang SH, Jiang Y, Ma Z, Subramaniam D, Anant S, Yogosawa S, Sakai T, Liu WG, Edgerton S, Thor A, Yang X.

PLoS One. 2012;7(8):e43564. doi: 10.1371/journal.pone.0043564. Epub 2012 Aug 30.


Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures.

Kabos P, Finlay-Schultz J, Li C, Kline E, Finlayson C, Wisell J, Manuel CA, Edgerton SM, Harrell JC, Elias A, Sartorius CA.

Breast Cancer Res Treat. 2012 Sep;135(2):415-32. doi: 10.1007/s10549-012-2164-8. Epub 2012 Jul 24.


Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

Deng XS, Wang S, Deng A, Liu B, Edgerton SM, Lind SE, Wahdan-Alaswad R, Thor AD.

Cell Cycle. 2012 Jan 15;11(2):367-76. doi: 10.4161/cc.11.2.18813. Epub 2012 Jan 15.


Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

Liu B, Fan Z, Edgerton SM, Yang X, Lind SE, Thor AD.

Cell Cycle. 2011 Sep 1;10(17):2959-66. Epub 2011 Sep 1.


p53 Expression in node-positive breast cancer patients: results from the Cancer and Leukemia Group B 9344 Trial (159905).

Lara JF, Thor AD, Dressler LG, Broadwater G, Bleiweiss IJ, Edgerton S, Cowan D, Goldstein LJ, Martino S, Ingle JN, Henderson IC, Norton L, Winer EP, Hudis CA, Ellis MJ, Berry DA, Hayes DF; Cancer and Leukemia Group B.

Clin Cancer Res. 2011 Aug 1;17(15):5170-8. doi: 10.1158/1078-0432.CCR-11-0484. Epub 2011 Jun 21.


Downregulation of miR-342 is associated with tamoxifen resistant breast tumors.

Cittelly DM, Das PM, Spoelstra NS, Edgerton SM, Richer JK, Thor AD, Jones FE.

Mol Cancer. 2010 Dec 20;9:317. doi: 10.1186/1476-4598-9-317.


Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells.

Das PM, Thor AD, Edgerton SM, Barry SK, Chen DF, Jones FE.

Oncogene. 2010 Sep 16;29(37):5214-9. doi: 10.1038/onc.2010.271. Epub 2010 Jul 5.


Sonographic evaluation of pediatric localized scleroderma: preliminary disease assessment measures.

Li SC, Liebling MS, Ramji FG, Opitz S, Mohanta A, Kornyat T, Zhang S, Dempsey-Robertson M, Hamer C, Edgerton S, Jarrin J, Malone M, Doria AS.

Pediatr Rheumatol Online J. 2010 Apr 27;8:14. doi: 10.1186/1546-0096-8-14.


Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.

Yang X, Yang S, McKimmey C, Liu B, Edgerton SM, Bales W, Archer LT, Thor AD.

Carcinogenesis. 2010 Apr;31(4):695-702. doi: 10.1093/carcin/bgq007. Epub 2010 Jan 12.


Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling.

Liu B, Ordonez-Ercan D, Fan Z, Huang X, Edgerton SM, Yang X, Thor AD.

Mol Cancer Res. 2009 Nov;7(11):1882-92. doi: 10.1158/1541-7786.MCR-08-0509. Epub 2009 Oct 27.


Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients.

Thor AD, Edgerton SM, Jones FE.

Am J Pathol. 2009 Nov;175(5):1802-9. doi: 10.2353/ajpath.2009.090204. Epub 2009 Oct 1.


Metformin induces unique biological and molecular responses in triple negative breast cancer cells.

Liu B, Fan Z, Edgerton SM, Deng XS, Alimova IN, Lind SE, Thor AD.

Cell Cycle. 2009 Jul 1;8(13):2031-40. Epub 2009 Jul 21.


Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.

Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD.

Cell Cycle. 2009 Mar 15;8(6):909-15. Epub 2009 Mar 26.


Prospects for future climate change and the reasons for early action.

Edgerton SA, MacCracken MC, Jacobson MZ, Ayala A, Whitman CE, Trexler MC.

J Air Waste Manag Assoc. 2008 Nov;58(11):1386-400. No abstract available.


Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100.

Schneider BP, Wang M, Radovich M, Sledge GW, Badve S, Thor A, Flockhart DA, Hancock B, Davidson N, Gralow J, Dickler M, Perez EA, Cobleigh M, Shenkier T, Edgerton S, Miller KD; ECOG 2100.

J Clin Oncol. 2008 Oct 1;26(28):4672-8. doi: 10.1200/JCO.2008.16.1612. Erratum in: J Clin Oncol. 2009 Jun 20;27(18):3070.


The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis.

Naresh A, Thor AD, Edgerton SM, Torkko KC, Kumar R, Jones FE.

Cancer Res. 2008 Aug 1;68(15):6387-95. doi: 10.1158/0008-5472.CAN-08-0538.


Prospects for future climate change and the reasons for early action.

Edgerton S.

J Air Waste Manag Assoc. 2008 Jun;58(6):730-4. Review. No abstract available.


Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B.

DiGiovanna MP, Stern DF, Edgerton S, Broadwater G, Dressler LG, Budman DR, Henderson IC, Norton L, Liu ET, Muss HB, Berry DA, Hayes DF, Thor AD.

J Clin Oncol. 2008 May 10;26(14):2364-72. doi: 10.1200/JCO.2007.13.6580. Epub 2008 Apr 7.


HER2 and response to paclitaxel in node-positive breast cancer.

Hayes DF, Thor AD, Dressler LG, Weaver D, Edgerton S, Cowan D, Broadwater G, Goldstein LJ, Martino S, Ingle JN, Henderson IC, Norton L, Winer EP, Hudis CA, Ellis MJ, Berry DA; Cancer and Leukemia Group B (CALGB) Investigators.

N Engl J Med. 2007 Oct 11;357(15):1496-506.


Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells.

Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, Thor AD.

Int J Cancer. 2007 May 1;120(9):1874-82.


Caspase-3 mediated feedback activation of apical caspases in doxorubicin and TNF-alpha induced apoptosis.

Yang S, Thor AD, Edgerton S, Yang X.

Apoptosis. 2006 Nov;11(11):1987-97.


Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.

Kim A, Liu B, Ordonez-Ercan D, Alvarez KM, Jones LD, McKimmey C, Edgerton SM, Yang X, Thor AD.

Breast Cancer Res. 2005;7(5):R708-18. Epub 2005 Jul 6.


Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to radiation therapy.

Yang XH, Edgerton S, Thor AD.

Int J Oncol. 2005 Jun;26(6):1675-80.


Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients.

DiGiovanna MP, Stern DF, Edgerton SM, Whalen SG, Moore D 2nd, Thor AD.

J Clin Oncol. 2005 Feb 20;23(6):1152-60.


Access to communication technologies in a sample of cancer patients: an urban and rural survey.

Abdullah M, Theobald DE, Butler D, Kroenke K, Perkins A, Edgerton S, Dugan WM Jr.

BMC Cancer. 2005 Feb 17;5:18.


Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention.

Liu B, Edgerton S, Yang X, Kim A, Ordonez-Ercan D, Mason T, Alvarez K, McKimmey C, Liu N, Thor A.

Cancer Res. 2005 Feb 1;65(3):879-86.


Perinucleolar compartment prevalence has an independent prognostic value for breast cancer.

Kamath RV, Thor AD, Wang C, Edgerton SM, Slusarczyk A, Leary DJ, Wang J, Wiley EL, Jovanovic B, Wu Q, Nayar R, Kovarik P, Shi F, Huang S.

Cancer Res. 2005 Jan 1;65(1):246-53.


Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice.

Kosanke S, Edgerton SM, Moore D 2nd, Yang X, Mason T, Alvarez K, Jones L, Kim A, Thor AD.

Comp Med. 2004 Jun;54(3):280-7.


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