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MicroRNA-17 acts as a tumor chemosensitizer by targeting JAB1/CSN5 in triple-negative breast cancer.

Wang S, Oh DY, Leventaki V, Drakos E, Zhang R, Sahin AA, Resetkova E, Edgerton ME, Wu W, Claret FX.

Cancer Lett. 2019 Aug 29;465:12-23. doi: 10.1016/j.canlet.2019.08.016. [Epub ahead of print]


Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins.

McCall AD, Pathirana RU, Prabhakar A, Cullen PJ, Edgerton M.

NPJ Biofilms Microbiomes. 2019 Aug 23;5:21. doi: 10.1038/s41522-019-0094-5. eCollection 2019.


Filamentous Non-albicans Candida Species Adhere to Candida albicans and Benefit From Dual Biofilm Growth.

Pathirana RU, McCall AD, Norris HL, Edgerton M.

Front Microbiol. 2019 May 31;10:1188. doi: 10.3389/fmicb.2019.01188. eCollection 2019.


Aggregate Filamentous Growth Responses in Yeast.

Chow J, Dionne HM, Prabhakar A, Mehrotra A, Somboonthum J, Gonzalez B, Edgerton M, Cullen PJ.

mSphere. 2019 Mar 6;4(2). pii: e00702-18. doi: 10.1128/mSphere.00702-18.


Iron Chelator Deferasirox Reduces Candida albicans Invasion of Oral Epithelial Cells and Infection Levels in Murine Oropharyngeal Candidiasis.

Puri S, Kumar R, Rojas IG, Salvatori O, Edgerton M.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02152-18. doi: 10.1128/AAC.02152-18. Print 2019 Apr.


Real-time Imaging and Quantification of Fungal Biofilm Development Using a Two-Phase Recirculating Flow System.

McCall AD, Edgerton M.

J Vis Exp. 2018 Oct 18;(140). doi: 10.3791/58457.


Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies.

McCall AD, Kumar R, Edgerton M.

PLoS Pathog. 2018 Sep 25;14(9):e1007316. doi: 10.1371/journal.ppat.1007316. eCollection 2018 Sep.


Candida albicans Ras1 Inactivation Increases Resistance to Phagosomal Killing by Human Neutrophils.

Salvatori O, Pathirana RU, Kay JG, Edgerton M.

Infect Immun. 2018 Nov 20;86(12). pii: e00685-18. doi: 10.1128/IAI.00685-18. Print 2018 Dec.


Management of Snakebites in the Upper Extremity.

Edgerton MT, Koepplinger ME.

J Hand Surg Am. 2019 Feb;44(2):137-142. doi: 10.1016/j.jhsa.2018.06.016. Epub 2018 Jul 26. Review.


Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K.

Microb Cell. 2018 Jun 14;5(7):300-326. doi: 10.15698/mic2018.07.638. Review.


Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels.

Norris HL, Friedman J, Chen Z, Puri S, Wilding G, Edgerton M.

J Oral Microbiol. 2018 Mar 13;10(1):1447216. doi: 10.1080/20002297.2018.1447216. eCollection 2018.


Real-Time Approach to Flow Cell Imaging of Candida albicans Biofilm Development.

McCall A, Edgerton M.

J Fungi (Basel). 2017 Mar 6;3(1). pii: E13. doi: 10.3390/jof3010013.


Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing.

Casasent AK, Schalck A, Gao R, Sei E, Long A, Pangburn W, Casasent T, Meric-Bernstam F, Edgerton ME, Navin NE.

Cell. 2018 Jan 11;172(1-2):205-217.e12. doi: 10.1016/j.cell.2017.12.007. Epub 2018 Jan 4.


Fluconazole-Resistant Candida auris Is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses.

Pathirana RU, Friedman J, Norris HL, Salvatori O, McCall AD, Kay J, Edgerton M.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01872-17. doi: 10.1128/AAC.01872-17. Print 2018 Feb.


An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses.

Hampe IAI, Friedman J, Edgerton M, Morschhäuser J.

PLoS Pathog. 2017 Sep 27;13(9):e1006655. doi: 10.1371/journal.ppat.1006655. eCollection 2017 Sep.


DCIS Margins and Breast Conservation: MD Anderson Cancer Center Multidisciplinary Practice Guidelines and Outcomes.

Kuerer HM, Smith BD, Chavez-MacGregor M, Albarracin C, Barcenas CH, Santiago L, Edgerton ME, Rauch GM, Giordano SH, Sahin A, Krishnamurthy S, Woodward W, Tripathy D, Yang WT, Hunt KK.

J Cancer. 2017 Aug 22;8(14):2653-2662. doi: 10.7150/jca.20871. eCollection 2017. Review.


A Novel All-Inside Arthroscopic Technique for Radial-Sided Triangular Fibrocartilage Complex Tears: A Case Report and Review of Literature.

Edgerton MT, Kollmorgen RC.

Hand (N Y). 2017 Sep;12(5):NP166-NP169. doi: 10.1177/1558944717715138. Epub 2017 Jun 23. Review.


Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition.

Kumar R, Breindel C, Saraswat D, Cullen PJ, Edgerton M.

Sci Rep. 2017 Jun 6;7(1):2908. doi: 10.1038/s41598-017-03082-4.


Structural Characterization of Histatin 5-Spermidine Conjugates: A Combined Experimental and Theoretical Study.

Jephthah S, Henriques J, Cragnell C, Puri S, Edgerton M, Skepö M.

J Chem Inf Model. 2017 Jun 26;57(6):1330-1341. doi: 10.1021/acs.jcim.7b00150. Epub 2017 Jun 6.


Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens.

Du H, Puri S, McCall A, Norris HL, Russo T, Edgerton M.

Front Cell Infect Microbiol. 2017 Feb 15;7:41. doi: 10.3389/fcimb.2017.00041. eCollection 2017.


Genome evolution in ductal carcinoma in situ: invasion of the clones.

Casasent AK, Edgerton M, Navin NE.

J Pathol. 2017 Jan;241(2):208-218. doi: 10.1002/path.4840. Epub 2016 Nov 27. Review.


Unmasking fungal pathogens by studying MAPK-dependent cell wall regulation in Candida albicans.

Cullen PJ, Edgerton M.

Virulence. 2016 Jul 3;7(5):502-5. doi: 10.1080/21505594.2016.1177695. Epub 2016 Apr 18. No abstract available.


Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis.

Tati S, Davidow P, McCall A, Hwang-Wong E, Rojas IG, Cormack B, Edgerton M.

PLoS Pathog. 2016 Mar 30;12(3):e1005522. doi: 10.1371/journal.ppat.1005522. eCollection 2016 Mar.


2013 HIPAA Changes Provide Opportunities and Challenges for Researchers: Perspectives from a Cancer Center.

Freedman RS, Cantor SB, Merriman KW, Edgerton ME.

Clin Cancer Res. 2016 Feb 1;22(3):533-9. doi: 10.1158/1078-0432.CCR-15-2155.


Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans.

Saraswat D, Kumar R, Pande T, Edgerton M, Cullen PJ.

Mol Microbiol. 2016 May;100(3):425-41. doi: 10.1111/mmi.13326. Epub 2016 Feb 10.


Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases.

Salvatori O, Puri S, Tati S, Edgerton M.

J Dent Res. 2016 Apr;95(4):365-71. doi: 10.1177/0022034515625222. Epub 2016 Jan 8. Review.


Candida albicans Shed Msb2 and Host Mucins Affect the Candidacidal Activity of Salivary Hst 5.

Puri S, Friedman J, Saraswat D, Kumar R, Li R, Ruszaj D, Edgerton M.

Pathogens. 2015 Oct 30;4(4):752-63. doi: 10.3390/pathogens4040752.


Candida albicans Cek1 mitogen-activated protein kinase signaling enhances fungicidal activity of salivary histatin 5.

Li R, Puri S, Tati S, Cullen PJ, Edgerton M.

Antimicrob Agents Chemother. 2015;59(6):3460-8. doi: 10.1128/AAC.00214-15. Epub 2015 Mar 30.


Iron binding modulates candidacidal properties of salivary histatin 5.

Puri S, Li R, Ruszaj D, Tati S, Edgerton M.

J Dent Res. 2015 Jan;94(1):201-8. doi: 10.1177/0022034514556709. Epub 2014 Nov 3.


The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes.

Han L, Yuan Y, Zheng S, Yang Y, Li J, Edgerton ME, Diao L, Xu Y, Verhaak RGW, Liang H.

Nat Commun. 2014 Jul 7;5:3963. doi: 10.1038/ncomms4963.


How does it kill?: understanding the candidacidal mechanism of salivary histatin 5.

Puri S, Edgerton M.

Eukaryot Cell. 2014 Aug;13(8):958-64. doi: 10.1128/EC.00095-14. Epub 2014 Jun 20. Review.


Iron-responsive chromatin remodelling and MAPK signalling enhance adhesion in Candida albicans.

Puri S, Lai WK, Rizzo JM, Buck MJ, Edgerton M.

Mol Microbiol. 2014 Jul;93(2):291-305. doi: 10.1111/mmi.12659. Epub 2014 Jun 15.


Saliva-microbe interactions and salivary gland dysfunction.

Baker OJ, Edgerton M, Kramer JM, Ruhl S.

Adv Dent Res. 2014 May;26(1):7-14. doi: 10.1177/0022034514526239. Review.


Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis.

Tati S, Li R, Puri S, Kumar R, Davidow P, Edgerton M.

Antimicrob Agents Chemother. 2014;58(2):756-66. doi: 10.1128/AAC.01851-13. Epub 2013 Nov 18.


Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31.

Tati S, Jang WS, Li R, Kumar R, Puri S, Edgerton M.

PLoS One. 2013 Apr 22;8(4):e61480. doi: 10.1371/journal.pone.0061480. Print 2013.


Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity.

Li R, Kumar R, Tati S, Puri S, Edgerton M.

Antimicrob Agents Chemother. 2013 Apr;57(4):1832-9. doi: 10.1128/AAC.02295-12. Epub 2013 Feb 4.


Challenges of the information age: the impact of false discovery on pathway identification.

Rog CJ, Chekuri SC, Edgerton ME.

BMC Res Notes. 2012 Nov 21;5:647. doi: 10.1186/1756-0500-5-647.


Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.

Puri S, Kumar R, Chadha S, Tati S, Conti HR, Hube B, Cullen PJ, Edgerton M.

PLoS One. 2012;7(11):e46020. doi: 10.1371/journal.pone.0046020. Epub 2012 Nov 6. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/13ef5e14-c192-4bb2-af91-886024500b4b.


Transgenic insect resistance traits increase corn yield and yield stability.

Edgerton MD, Fridgen J, Anderson JR Jr, Ahlgrim J, Criswell M, Dhungana P, Gocken T, Li Z, Mariappan S, Pilcher CD, Rosielle A, Stark SB.

Nat Biotechnol. 2012 Jun 7;30(6):493-6. doi: 10.1038/nbt.2259. No abstract available.


Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression.

Macklin P, Edgerton ME, Thompson AM, Cristini V.

J Theor Biol. 2012 May 21;301:122-40. doi: 10.1016/j.jtbi.2012.02.002. Epub 2012 Feb 9.


Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins.

Kumar R, Chadha S, Saraswat D, Bajwa JS, Li RA, Conti HR, Edgerton M.

J Biol Chem. 2011 Dec 23;286(51):43748-58. doi: 10.1074/jbc.M111.311175. Epub 2011 Oct 27.


Metastatic neuroendocrine tumour in the breast: a potential mimic of in-situ and invasive mammary carcinoma.

Perry KD, Reynolds C, Rosen DG, Edgerton ME, T Albarracin C, Gilcrease MZ, Sahin AA, Abraham SC, Wu Y.

Histopathology. 2011 Oct;59(4):619-30. doi: 10.1111/j.1365-2559.2011.03940.x.


A novel, patient-specific mathematical pathology approach for assessment of surgical volume: application to ductal carcinoma in situ of the breast.

Edgerton ME, Chuang YL, Macklin P, Yang W, Bearer EL, Cristini V.

Anal Cell Pathol (Amst). 2011;34(5):247-63. doi: 10.3233/ACP-2011-0019.


Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer.

Thompson PA, Brewster AM, Kim-Anh D, Baladandayuthapani V, Broom BM, Edgerton ME, Hahn KM, Murray JL, Sahin A, Tsavachidis S, Wang Y, Zhang L, Hortobagyi GN, Mills GB, Bondy ML.

PLoS One. 2011;6(8):e23543. doi: 10.1371/journal.pone.0023543. Epub 2011 Aug 12.


Copy number imbalances between screen- and symptom-detected breast cancers and impact on disease-free survival.

Brewster AM, Thompson P, Sahin AA, Do K, Edgerton M, Murray JL, Tsavachidis S, Zhou R, Liu Y, Zhang L, Mills G, Bondy M.

Cancer Prev Res (Phila). 2011 Oct;4(10):1609-16. doi: 10.1158/1940-6207.CAPR-10-0361. Epub 2011 Jul 27.


Multiplicity: an organizing principle for cancers and somatic mutations.

Frey LJ, Piccolo SR, Edgerton ME.

BMC Med Genomics. 2011 Jun 29;4:52. doi: 10.1186/1755-8794-4-52.


CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model.

Pandiyan P, Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL, Lenardo MJ.

Immunity. 2011 Mar 25;34(3):422-34. doi: 10.1016/j.immuni.2011.03.002.


New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome.

Conti HR, Baker O, Freeman AF, Jang WS, Holland SM, Li RA, Edgerton M, Gaffen SL.

Mucosal Immunol. 2011 Jul;4(4):448-55. doi: 10.1038/mi.2011.5. Epub 2011 Feb 23.


Host cell invasion and virulence mediated by Candida albicans Ssa1.

Sun JN, Solis NV, Phan QT, Bajwa JS, Kashleva H, Thompson A, Liu Y, Dongari-Bagtzoglou A, Edgerton M, Filler SG.

PLoS Pathog. 2010 Nov 11;6(11):e1001181. doi: 10.1371/journal.ppat.1001181.

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