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Items: 1 to 50 of 55

1.

Disease Resistance Genetics and Genomics in Octoploid Strawberry.

Barbey C, Lee S, Verma S, Bird KA, Yocca AE, Edger PP, Knapp SJ, Whitaker VM, Folta KM.

G3 (Bethesda). 2019 Aug 16. pii: g3.400597.2019. doi: 10.1534/g3.119.400597. [Epub ahead of print]

2.

Author Correction: Origin and evolution of the octoploid strawberry genome.

Edger PP, Poorten TJ, VanBuren R, Hardigan MA, Colle M, McKain MR, Smith RD, Teresi SJ, Nelson ADL, Wai CM, Alger EI, Bird KA, Yocca AE, Pumplin N, Ou S, Ben-Zvi G, Brodt A, Baruch K, Swale T, Shiue L, Acharya CB, Cole GS, Mower JP, Childs KL, Jiang N, Lyons E, Freeling M, Puzey JR, Knapp SJ.

Nat Genet. 2019 Apr;51(4):765. doi: 10.1038/s41588-019-0380-4.

PMID:
30842601
3.

Origin and evolution of the octoploid strawberry genome.

Edger PP, Poorten TJ, VanBuren R, Hardigan MA, Colle M, McKain MR, Smith RD, Teresi SJ, Nelson ADL, Wai CM, Alger EI, Bird KA, Yocca AE, Pumplin N, Ou S, Ben-Zvi G, Brodt A, Baruch K, Swale T, Shiue L, Acharya CB, Cole GS, Mower JP, Childs KL, Jiang N, Lyons E, Freeling M, Puzey JR, Knapp SJ.

Nat Genet. 2019 Mar;51(3):541-547. doi: 10.1038/s41588-019-0356-4. Epub 2019 Feb 25. Erratum in: Nat Genet. 2019 Apr;51(4):765.

PMID:
30804557
4.

A galling insect activates plant reproductive programs during gall development.

Schultz JC, Edger PP, Body MJA, Appel HM.

Sci Rep. 2019 Feb 12;9(1):1833. doi: 10.1038/s41598-018-38475-6.

5.

Haplotype-phased genome and evolution of phytonutrient pathways of tetraploid blueberry.

Colle M, Leisner CP, Wai CM, Ou S, Bird KA, Wang J, Wisecaver JH, Yocca AE, Alger EI, Tang H, Xiong Z, Callow P, Ben-Zvi G, Brodt A, Baruch K, Swale T, Shiue L, Song GQ, Childs KL, Schilmiller A, Vorsa N, Buell CR, VanBuren R, Jiang N, Edger PP.

Gigascience. 2019 Mar 1;8(3). pii: giz012. doi: 10.1093/gigascience/giz012.

6.

Usability of reference-free transcriptome assemblies for detection of differential expression: a case study on Aethionema arabicum dimorphic seeds.

Wilhelmsson PKI, Chandler JO, Fernandez-Pozo N, Graeber K, Ullrich KK, Arshad W, Khan S, Hofberger JA, Buchta K, Edger PP, Pires JC, Schranz ME, Leubner-Metzger G, Rensing SA.

BMC Genomics. 2019 Jan 30;20(1):95. doi: 10.1186/s12864-019-5452-4.

7.

Domestication of Temperate and Coastal Hybrids with Distinct Ancestral Gene Selection in Octoploid Strawberry.

Hardigan MA, Poorten TJ, Acharya CB, Cole GS, Hummer KE, Bassil N, Edger PP, Knapp SJ.

Plant Genome. 2018 Nov;11(3). doi: 10.3835/plantgenome2018.07.0049.

8.

A near complete, chromosome-scale assembly of the black raspberry (Rubus occidentalis) genome.

VanBuren R, Wai CM, Colle M, Wang J, Sullivan S, Bushakra JM, Liachko I, Vining KJ, Dossett M, Finn CE, Jibran R, Chagné D, Childs K, Edger PP, Mockler TC, Bassil NV.

Gigascience. 2018 Aug 1;7(8). doi: 10.1093/gigascience/giy094.

9.

The causes and consequences of subgenome dominance in hybrids and recent polyploids.

Bird KA, VanBuren R, Puzey JR, Edger PP.

New Phytol. 2018 Oct;220(1):87-93. doi: 10.1111/nph.15256. Epub 2018 Jun 8. Review.

PMID:
29882360
10.

Subgenome assignment in allopolyploids: challenges and future directions.

Edger PP, McKain MR, Bird KA, VanBuren R.

Curr Opin Plant Biol. 2018 Apr;42:76-80. doi: 10.1016/j.pbi.2018.03.006. Epub 2018 Apr 9. Review.

PMID:
29649616
11.

Patterns of Population Variation in Two Paleopolyploid Eudicot Lineages Suggest That Dosage-Based Selection on Homeologs Is Long-Lived.

Hao Y, Washburn JD, Rosenthal J, Nielsen B, Lyons E, Edger PP, Pires JC, Conant GC.

Genome Biol Evol. 2018 Mar 1;10(3):999-1011. doi: 10.1093/gbe/evy061.

12.

Genome-Wide Association Mapping Uncovers Fw1, a Dominant Gene Conferring Resistance to Fusarium Wilt in Strawberry.

Pincot DDA, Poorten TJ, Hardigan MA, Harshman JM, Acharya CB, Cole GS, Gordon TR, Stueven M, Edger PP, Knapp SJ.

G3 (Bethesda). 2018 May 4;8(5):1817-1828. doi: 10.1534/g3.118.200129.

13.

Preferential retention of genes from one parental genome after polyploidy illustrates the nature and scope of the genomic conflicts induced by hybridization.

Emery M, Willis MMS, Hao Y, Barry K, Oakgrove K, Peng Y, Schmutz J, Lyons E, Pires JC, Edger PP, Conant GC.

PLoS Genet. 2018 Mar 28;14(3):e1007267. doi: 10.1371/journal.pgen.1007267. eCollection 2018 Mar.

14.

Brassicales phylogeny inferred from 72 plastid genes: A reanalysis of the phylogenetic localization of two paleopolyploid events and origin of novel chemical defenses.

Edger PP, Hall JC, Harkess A, Tang M, Coombs J, Mohammadin S, Schranz ME, Xiong Z, Leebens-Mack J, Meyers BC, Sytsma KJ, Koch MA, Al-Shehbaz IA, Pires JC.

Am J Bot. 2018 Mar;105(3):463-469. doi: 10.1002/ajb2.1040. Epub 2018 Mar 25.

15.

Chromosome-scale scaffolding of the black raspberry (Rubus occidentalis L.) genome based on chromatin interaction data.

Jibran R, Dzierzon H, Bassil N, Bushakra JM, Edger PP, Sullivan S, Finn CE, Dossett M, Vining KJ, VanBuren R, Mockler TC, Liachko I, Davies KM, Foster TM, Chagné D.

Hortic Res. 2018 Feb 7;5:8. doi: 10.1038/s41438-017-0013-y. eCollection 2018.

16.

Transcriptome-wide comparison of selenium hyperaccumulator and nonaccumulator Stanleya species provides new insight into key processes mediating the hyperaccumulation syndrome.

Wang J, Cappa JJ, Harris JP, Edger PP, Zhou W, Pires JC, Adair M, Unruh SA, Simmons MP, Schiavon M, Pilon-Smits EAH.

Plant Biotechnol J. 2018 Feb 7. doi: 10.1111/pbi.12897. [Epub ahead of print]

17.

Single-molecule sequencing and optical mapping yields an improved genome of woodland strawberry (Fragaria vesca) with chromosome-scale contiguity.

Edger PP, VanBuren R, Colle M, Poorten TJ, Wai CM, Niederhuth CE, Alger EI, Ou S, Acharya CB, Wang J, Callow P, McKain MR, Shi J, Collier C, Xiong Z, Mower JP, Slovin JP, Hytönen T, Jiang N, Childs KL, Knapp SJ.

Gigascience. 2018 Feb 1;7(2):1-7. doi: 10.1093/gigascience/gix124.

18.

Molecular Resources from Transcriptomes in the Brassicaceae Family.

Lopez L, Wolf EM, Pires JC, Edger PP, Koch MA.

Front Plant Sci. 2017 Aug 29;8:1488. doi: 10.3389/fpls.2017.01488. eCollection 2017.

19.

Subgenome Dominance in an Interspecific Hybrid, Synthetic Allopolyploid, and a 140-Year-Old Naturally Established Neo-Allopolyploid Monkeyflower.

Edger PP, Smith R, McKain MR, Cooley AM, Vallejo-Marin M, Yuan Y, Bewick AJ, Ji L, Platts AE, Bowman MJ, Childs KL, Washburn JD, Schmitz RJ, Smith GD, Pires JC, Puzey JR.

Plant Cell. 2017 Sep;29(9):2150-2167. doi: 10.1105/tpc.17.00010. Epub 2017 Aug 16.

20.

Anatolian origins and diversification of Aethionema, the sister lineage of the core Brassicaceae.

Mohammadin S, Peterse K, van de Kerke SJ, Chatrou LW, Dönmez AA, Mummenhoff K, Pires JC, Edger PP, Al-Shehbaz IA, Schranz ME.

Am J Bot. 2017 Jul;104(7):1042-1054. doi: 10.3732/ajb.1700091.

21.

Seed desiccation mechanisms co-opted for vegetative desiccation in the resurrection grass Oropetium thomaeum.

VanBuren R, Wai CM, Zhang Q, Song X, Edger PP, Bryant D, Michael TP, Mockler TC, Bartels D.

Plant Cell Environ. 2017 Oct;40(10):2292-2306. doi: 10.1111/pce.13027.

PMID:
28730594
22.

Temporal and spatial transcriptomic and microRNA dynamics of CAM photosynthesis in pineapple.

Wai CM, VanBuren R, Zhang J, Huang L, Miao W, Edger PP, Yim WC, Priest HD, Meyers BC, Mockler T, Smith JAC, Cushman JC, Ming R.

Plant J. 2017 Oct;92(1):19-30. doi: 10.1111/tpj.13630. Epub 2017 Aug 21.

23.

Insights into the Evolution of Hydroxyproline-Rich Glycoproteins from 1000 Plant Transcriptomes.

Johnson KL, Cassin AM, Lonsdale A, Wong GK, Soltis DE, Miles NW, Melkonian M, Melkonian B, Deyholos MK, Leebens-Mack J, Rothfels CJ, Stevenson DW, Graham SW, Wang X, Wu S, Pires JC, Edger PP, Carpenter EJ, Bacic A, Doblin MS, Schultz CJ.

Plant Physiol. 2017 Jun;174(2):904-921. doi: 10.1104/pp.17.00295. Epub 2017 Apr 26.

24.

A Whole-Transcriptome Approach to Evaluating Reference Genes for Quantitative Gene Expression Studies: A Case Study in Mimulus.

Stanton KA, Edger PP, Puzey JR, Kinser T, Cheng P, Vernon DM, Forsthoefel NR, Cooley AM.

G3 (Bethesda). 2017 Apr 3;7(4):1085-1095. doi: 10.1534/g3.116.038075.

25.

The pangenome of an agronomically important crop plant Brassica oleracea.

Golicz AA, Bayer PE, Barker GC, Edger PP, Kim H, Martinez PA, Chan CK, Severn-Ellis A, McCombie WR, Parkin IA, Paterson AH, Pires JC, Sharpe AG, Tang H, Teakle GR, Town CD, Batley J, Edwards D.

Nat Commun. 2016 Nov 11;7:13390. doi: 10.1038/ncomms13390.

26.

The Evolution of HD2 Proteins in Green Plants.

Bourque S, Jeandroz S, Grandperret V, Lehotai N, Aimé S, Soltis DE, Miles NW, Melkonian M, Deyholos MK, Leebens-Mack JH, Chase MW, Rothfels CJ, Stevenson DW, Graham SW, Wang X, Wu S, Pires JC, Edger PP, Yan Z, Xie Y, Carpenter EJ, Wong GKS, Wendehenne D, Nicolas-Francès V.

Trends Plant Sci. 2016 Dec;21(12):1008-1016. doi: 10.1016/j.tplants.2016.10.001. Epub 2016 Oct 24. Review.

PMID:
27789157
27.

PYK10 myrosinase reveals a functional coordination between endoplasmic reticulum bodies and glucosinolates in Arabidopsis thaliana.

Nakano RT, Piślewska-Bednarek M, Yamada K, Edger PP, Miyahara M, Kondo M, Böttcher C, Mori M, Nishimura M, Schulze-Lefert P, Hara-Nishimura I, Bednarek P.

Plant J. 2017 Jan;89(2):204-220. doi: 10.1111/tpj.13377. Epub 2016 Dec 19.

28.

Evolutionary relationships in Panicoid grasses based on plastome phylogenomics (Panicoideae; Poaceae).

Burke SV, Wysocki WP, Zuloaga FO, Craine JM, Pires JC, Edger PP, Mayfield-Jones D, Clark LG, Kelchner SA, Duvall MR.

BMC Plant Biol. 2016 Jun 18;16(1):140. doi: 10.1186/s12870-016-0823-3.

29.

Diversity of ABC transporter genes across the plant kingdom and their potential utility in biotechnology.

Lane TS, Rempe CS, Davitt J, Staton ME, Peng Y, Soltis DE, Melkonian M, Deyholos M, Leebens-Mack JH, Chase M, Rothfels CJ, Stevenson D, Graham SW, Yu J, Liu T, Pires JC, Edger PP, Zhang Y, Xie Y, Zhu Y, Carpenter E, Wong GK, Stewart CN Jr.

BMC Biotechnol. 2016 May 31;16(1):47. doi: 10.1186/s12896-016-0277-6.

30.

The genome of black raspberry (Rubus occidentalis).

VanBuren R, Bryant D, Bushakra JM, Vining KJ, Edger PP, Rowley ER, Priest HD, Michael TP, Lyons E, Filichkin SA, Dossett M, Finn CE, Bassil NV, Mockler TC.

Plant J. 2016 Sep;87(6):535-47. doi: 10.1111/tpj.13215. Epub 2016 Jul 20.

31.

Functional network analysis of genes differentially expressed during xylogenesis in soc1ful woody Arabidopsis plants.

Davin N, Edger PP, Hefer CA, Mizrachi E, Schuetz M, Smets E, Myburg AA, Douglas CJ, Schranz ME, Lens F.

Plant J. 2016 Jun;86(5):376-90. doi: 10.1111/tpj.13157.

32.

Selecting Superior De Novo Transcriptome Assemblies: Lessons Learned by Leveraging the Best Plant Genome.

Honaas LA, Wafula EK, Wickett NJ, Der JP, Zhang Y, Edger PP, Altman NS, Pires JC, Leebens-Mack JH, dePamphilis CW.

PLoS One. 2016 Jan 5;11(1):e0146062. doi: 10.1371/journal.pone.0146062. eCollection 2016.

33.

Single-molecule sequencing of the desiccation-tolerant grass Oropetium thomaeum.

VanBuren R, Bryant D, Edger PP, Tang H, Burgess D, Challabathula D, Spittle K, Hall R, Gu J, Lyons E, Freeling M, Bartels D, Ten Hallers B, Hastie A, Michael TP, Mockler TC.

Nature. 2015 Nov 26;527(7579):508-11. doi: 10.1038/nature15714. Epub 2015 Nov 11.

PMID:
26560029
34.

The pineapple genome and the evolution of CAM photosynthesis.

Ming R, VanBuren R, Wai CM, Tang H, Schatz MC, Bowers JE, Lyons E, Wang ML, Chen J, Biggers E, Zhang J, Huang L, Zhang L, Miao W, Zhang J, Ye Z, Miao C, Lin Z, Wang H, Zhou H, Yim WC, Priest HD, Zheng C, Woodhouse M, Edger PP, Guyot R, Guo HB, Guo H, Zheng G, Singh R, Sharma A, Min X, Zheng Y, Lee H, Gurtowski J, Sedlazeck FJ, Harkess A, McKain MR, Liao Z, Fang J, Liu J, Zhang X, Zhang Q, Hu W, Qin Y, Wang K, Chen LY, Shirley N, Lin YR, Liu LY, Hernandez AG, Wright CL, Bulone V, Tuskan GA, Heath K, Zee F, Moore PH, Sunkar R, Leebens-Mack JH, Mockler T, Bennetzen JL, Freeling M, Sankoff D, Paterson AH, Zhu X, Yang X, Smith JA, Cushman JC, Paull RE, Yu Q.

Nat Genet. 2015 Dec;47(12):1435-42. doi: 10.1038/ng.3435. Epub 2015 Nov 2.

35.

Resolution of Brassicaceae Phylogeny Using Nuclear Genes Uncovers Nested Radiations and Supports Convergent Morphological Evolution.

Huang CH, Sun R, Hu Y, Zeng L, Zhang N, Cai L, Zhang Q, Koch MA, Al-Shehbaz I, Edger PP, Pires JC, Tan DY, Zhong Y, Ma H.

Mol Biol Evol. 2016 Feb;33(2):394-412. doi: 10.1093/molbev/msv226. Epub 2015 Oct 29.

36.

Positionally-conserved but sequence-diverged: identification of long non-coding RNAs in the Brassicaceae and Cleomaceae.

Mohammadin S, Edger PP, Pires JC, Schranz ME.

BMC Plant Biol. 2015 Sep 11;15:217. doi: 10.1186/s12870-015-0603-5.

37.

Resolving deep relationships of PACMAD grasses: a phylogenomic approach.

Cotton JL, Wysocki WP, Clark LG, Kelchner SA, Pires JC, Edger PP, Mayfield-Jones D, Duvall MR.

BMC Plant Biol. 2015 Jul 11;15:178. doi: 10.1186/s12870-015-0563-9.

38.

The butterfly plant arms-race escalated by gene and genome duplications.

Edger PP, Heidel-Fischer HM, Bekaert M, Rota J, Glöckner G, Platts AE, Heckel DG, Der JP, Wafula EK, Tang M, Hofberger JA, Smithson A, Hall JC, Blanchette M, Bureau TE, Wright SI, dePamphilis CW, Eric Schranz M, Barker MS, Conant GC, Wahlberg N, Vogel H, Pires JC, Wheat CW.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8362-6. doi: 10.1073/pnas.1503926112. Epub 2015 Jun 22.

39.

Plastid phylogenomics of the cool-season grass subfamily: clarification of relationships among early-diverging tribes.

Saarela JM, Wysocki WP, Barrett CF, Soreng RJ, Davis JI, Clark LG, Kelchner SA, Pires JC, Edger PP, Mayfield DR, Duvall MR.

AoB Plants. 2015 May 4;7. pii: plv046. doi: 10.1093/aobpla/plv046.

40.

Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells.

Augustin MM, Ruzicka DR, Shukla AK, Augustin JM, Starks CM, O'Neil-Johnson M, McKain MR, Evans BS, Barrett MD, Smithson A, Wong GK, Deyholos MK, Edger PP, Pires JC, Leebens-Mack JH, Mann DA, Kutchan TM.

Plant J. 2015 Jun;82(6):991-1003. doi: 10.1111/tpj.12871.

41.

Origin of a novel regulatory module by duplication and degeneration of an ancient plant transcription factor.

Floyd SK, Ryan JG, Conway SJ, Brenner E, Burris KP, Burris JN, Chen T, Edger PP, Graham SW, Leebens-Mack JH, Pires JC, Rothfels CJ, Sigel EM, Stevenson DW, Neal Stewart C Jr, Wong GK, Bowman JL.

Mol Phylogenet Evol. 2014 Dec;81:159-73. doi: 10.1016/j.ympev.2014.06.017. Epub 2014 Sep 27.

42.

Plant genetics. Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome.

Chalhoub B, Denoeud F, Liu S, Parkin IA, Tang H, Wang X, Chiquet J, Belcram H, Tong C, Samans B, Corréa M, Da Silva C, Just J, Falentin C, Koh CS, Le Clainche I, Bernard M, Bento P, Noel B, Labadie K, Alberti A, Charles M, Arnaud D, Guo H, Daviaud C, Alamery S, Jabbari K, Zhao M, Edger PP, Chelaifa H, Tack D, Lassalle G, Mestiri I, Schnel N, Le Paslier MC, Fan G, Renault V, Bayer PE, Golicz AA, Manoli S, Lee TH, Thi VH, Chalabi S, Hu Q, Fan C, Tollenaere R, Lu Y, Battail C, Shen J, Sidebottom CH, Wang X, Canaguier A, Chauveau A, Bérard A, Deniot G, Guan M, Liu Z, Sun F, Lim YP, Lyons E, Town CD, Bancroft I, Wang X, Meng J, Ma J, Pires JC, King GJ, Brunel D, Delourme R, Renard M, Aury JM, Adams KL, Batley J, Snowdon RJ, Tost J, Edwards D, Zhou Y, Hua W, Sharpe AG, Paterson AH, Guan C, Wincker P.

Science. 2014 Aug 22;345(6199):950-3. doi: 10.1126/science.1253435. Epub 2014 Aug 21.

43.

Polyploid evolution of the Brassicaceae during the Cenozoic era.

Kagale S, Robinson SJ, Nixon J, Xiao R, Huebert T, Condie J, Kessler D, Clarke WE, Edger PP, Links MG, Sharpe AG, Parkin IA.

Plant Cell. 2014 Jul;26(7):2777-91. doi: 10.1105/tpc.114.126391. Epub 2014 Jul 17.

44.

Comparative phylogenomics uncovers the impact of symbiotic associations on host genome evolution.

Delaux PM, Varala K, Edger PP, Coruzzi GM, Pires JC, Ané JM.

PLoS Genet. 2014 Jul 17;10(7):e1004487. doi: 10.1371/journal.pgen.1004487. eCollection 2014 Jul.

45.

Secondary structure analyses of the nuclear rRNA internal transcribed spacers and assessment of its phylogenetic utility across the Brassicaceae (mustards).

Edger PP, Tang M, Bird KA, Mayfield DR, Conant G, Mummenhoff K, Koch MA, Pires JC.

PLoS One. 2014 Jul 1;9(7):e101341. doi: 10.1371/journal.pone.0101341. eCollection 2014.

46.

Comparative analysis of 11 Brassicales mitochondrial genomes and the mitochondrial transcriptome of Brassica oleracea.

Grewe F, Edger PP, Keren I, Sultan L, Pires JC, Ostersetzer-Biran O, Mower JP.

Mitochondrion. 2014 Nov;19 Pt B:135-43. doi: 10.1016/j.mito.2014.05.008. Epub 2014 Jun 4.

PMID:
24907441
47.

Whole genome and tandem duplicate retention facilitated glucosinolate pathway diversification in the mustard family.

Hofberger JA, Lyons E, Edger PP, Chris Pires J, Eric Schranz M.

Genome Biol Evol. 2013;5(11):2155-73. doi: 10.1093/gbe/evt162.

48.

An atlas of over 90,000 conserved noncoding sequences provides insight into crucifer regulatory regions.

Haudry A, Platts AE, Vello E, Hoen DR, Leclercq M, Williamson RJ, Forczek E, Joly-Lopez Z, Steffen JG, Hazzouri KM, Dewar K, Stinchcombe JR, Schoen DJ, Wang X, Schmutz J, Town CD, Edger PP, Pires JC, Schumaker KS, Jarvis DE, Mandáková T, Lysak MA, van den Bergh E, Schranz ME, Harrison PM, Moses AM, Bureau TE, Wright SI, Blanchette M.

Nat Genet. 2013 Aug;45(8):891-8. doi: 10.1038/ng.2684. Epub 2013 Jun 30.

PMID:
23817568
49.

Watching the grin fade: tracing the effects of polyploidy on different evolutionary time scales.

Mayfield-Jones D, Washburn JD, Arias T, Edger PP, Pires JC, Conant GC.

Semin Cell Dev Biol. 2013 Apr;24(4):320-31. doi: 10.1016/j.semcdb.2013.02.002. Epub 2013 Mar 1. Review.

PMID:
23466286
50.

Evaluating methods for isolating total RNA and predicting the success of sequencing phylogenetically diverse plant transcriptomes.

Johnson MT, Carpenter EJ, Tian Z, Bruskiewich R, Burris JN, Carrigan CT, Chase MW, Clarke ND, Covshoff S, Depamphilis CW, Edger PP, Goh F, Graham S, Greiner S, Hibberd JM, Jordon-Thaden I, Kutchan TM, Leebens-Mack J, Melkonian M, Miles N, Myburg H, Patterson J, Pires JC, Ralph P, Rolf M, Sage RF, Soltis D, Soltis P, Stevenson D, Stewart CN Jr, Surek B, Thomsen CJ, Villarreal JC, Wu X, Zhang Y, Deyholos MK, Wong GK.

PLoS One. 2012;7(11):e50226. doi: 10.1371/journal.pone.0050226. Epub 2012 Nov 21.

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