Sort by
Items per page

Send to

Choose Destination

Search results

Items: 46


Designer Sinorhizobium meliloti strains and multi-functional vectors enable direct inter-kingdom DNA transfer.

Brumwell SL, MacLeod MR, Huang T, Cochrane RR, Meaney RS, Zamani M, Matysiakiewicz O, Dan KN, Janakirama P, Edgell DR, Charles TC, Finan TM, Karas BJ.

PLoS One. 2019 Jun 17;14(6):e0206781. doi: 10.1371/journal.pone.0206781. eCollection 2019. Erratum in: PLoS One. 2019 Jul 9;14(7):e0219562.


Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases.

McMurrough TA, Brown CM, Zhang K, Hausner G, Junop MS, Gloor GB, Edgell DR.

Nucleic Acids Res. 2018 Dec 14;46(22):11990-12007. doi: 10.1093/nar/gky976.


mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.

Pereira CV, Bacman SR, Arguello T, Zekonyte U, Williams SL, Edgell DR, Moraes CT.

EMBO Mol Med. 2018 Sep;10(9). pii: e8084. doi: 10.15252/emmm.201708084.


Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE.

PLoS Genet. 2018 Jan 22;14(1):e1007159. doi: 10.1371/journal.pgen.1007159. eCollection 2018 Jan.


An Expanded Plasmid-Based Genetic Toolbox Enables Cas9 Genome Editing and Stable Maintenance of Synthetic Pathways in Phaeodactylum tricornutum.

Slattery SS, Diamond A, Wang H, Therrien JA, Lant JT, Jazey T, Lee K, Klassen Z, Desgagné-Penix I, Karas BJ, Edgell DR.

ACS Synth Biol. 2018 Feb 16;7(2):328-338. doi: 10.1021/acssynbio.7b00191. Epub 2018 Jan 8.


Applications of Alternative Nucleases in the Age of CRISPR/Cas9.

Guha TK, Edgell DR.

Int J Mol Sci. 2017 Nov 29;18(12). pii: E2565. doi: 10.3390/ijms18122565. Review.


Evolutionary and biogeographical implications of degraded LAGLIDADG endonuclease functionality and group I intron occurrence in stony corals (Scleractinia) and mushroom corals (Corallimorpharia).

Celis JS, Edgell DR, Stelbrink B, Wibberg D, Hauffe T, Blom J, Kalinowski J, Wilke T.

PLoS One. 2017 Mar 9;12(3):e0173734. doi: 10.1371/journal.pone.0173734. eCollection 2017.


Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.

Wolfs JM, Hamilton TA, Lant JT, Laforet M, Zhang J, Salemi LM, Gloor GB, Schild-Poulter C, Edgell DR.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14988-14993. doi: 10.1073/pnas.1616343114. Epub 2016 Dec 12.


Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference.

Roy AC, Wilson GG, Edgell DR.

Nucleic Acids Res. 2016 Sep 6;44(15):7350-9. doi: 10.1093/nar/gkw614. Epub 2016 Jul 7.


MegaTevs: single-chain dual nucleases for efficient gene disruption.

Wolfs JM, DaSilva M, Meister SE, Wang X, Schild-Poulter C, Edgell DR.

Nucleic Acids Res. 2014 Jul;42(13):8816-29. doi: 10.1093/nar/gku573. Epub 2014 Jul 10.


Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.

McMurrough TA, Dickson RJ, Thibert SM, Gloor GB, Edgell DR.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2376-83. doi: 10.1073/pnas.1322352111. Epub 2014 May 27.


Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis.

Fernandes AD, Reid JN, Macklaim JM, McMurrough TA, Edgell DR, Gloor GB.

Microbiome. 2014 May 5;2:15. doi: 10.1186/2049-2618-2-15. eCollection 2014.


The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs.

Kleinstiver BP, Wang L, Wolfs JM, Kolaczyk T, McDowell B, Wang X, Schild-Poulter C, Bogdanove AJ, Edgell DR.

G3 (Bethesda). 2014 Apr 16;4(6):1155-65. doi: 10.1534/g3.114.011445.


Bacterial group I introns: mobile RNA catalysts.

Hausner G, Hafez M, Edgell DR.

Mob DNA. 2014 Mar 10;5(1):8. doi: 10.1186/1759-8753-5-8.


Rapid screening of endonuclease target site preference using a modified bacterial two-plasmid selection.

Wolfs JM, Kleinstiver BP, Edgell DR.

Methods Mol Biol. 2014;1123:97-104. doi: 10.1007/978-1-62703-968-0_8.


The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA.

Kleinstiver BP, Wolfs JM, Edgell DR.

Nucleic Acids Res. 2013 May 1;41(10):5413-27. doi: 10.1093/nar/gkt186. Epub 2013 Apr 4.


Monomeric site-specific nucleases for genome editing.

Kleinstiver BP, Wolfs JM, Kolaczyk T, Roberts AK, Hu SX, Edgell DR.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8061-6. doi: 10.1073/pnas.1117984109. Epub 2012 May 7.


Divalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.

Kleinstiver BP, Bérubé-Janzen W, Fernandes AD, Edgell DR.

PLoS One. 2011;6(8):e23804. doi: 10.1371/journal.pone.0023804. Epub 2011 Aug 22.


Tapping natural reservoirs of homing endonucleases for targeted gene modification.

Takeuchi R, Lambert AR, Mak AN, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13077-82. doi: 10.1073/pnas.1107719108. Epub 2011 Jul 22.


Learning to live together: mutualism between self-splicing introns and their hosts.

Edgell DR, Chalamcharla VR, Belfort M.

BMC Biol. 2011 Apr 11;9:22. doi: 10.1186/1741-7007-9-22. Review.


Estimating the evidence of selection and the reliability of inference in unigenic evolution.

Fernandes AD, Kleinstiver BP, Edgell DR, Wahl LM, Gloor GB.

Algorithms Mol Biol. 2010 Nov 8;5:35. doi: 10.1186/1748-7188-5-35.


Mobile DNA elements in T4 and related phages.

Edgell DR, Gibb EA, Belfort M.

Virol J. 2010 Oct 28;7:290. doi: 10.1186/1743-422X-7-290. Review.


Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element.

Crona M, Moffatt C, Friedrich NC, Hofer A, Sjöberg BM, Edgell DR.

Nucleic Acids Res. 2011 Mar;39(4):1381-9. doi: 10.1093/nar/gkq924. Epub 2010 Oct 23.


Subunit and small-molecule interaction of ribonucleotide reductases via surface plasmon resonance biosensor analyses.

Crona M, Furrer E, Torrents E, Edgell DR, Sjöberg BM.

Protein Eng Des Sel. 2010 Aug;23(8):633-41. doi: 10.1093/protein/gzq035. Epub 2010 Jun 9.


Better late than early: delayed translation of intron-encoded endonuclease I-TevI is required for efficient splicing of its host group I intron.

Gibb EA, Edgell DR.

Mol Microbiol. 2010 Oct;78(1):35-46. doi: 10.1111/j.1365-2958.2010.07216.x. Epub 2010 May 19.


A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.

Kleinstiver BP, Fernandes AD, Gloor GB, Edgell DR.

Nucleic Acids Res. 2010 Apr;38(7):2411-27. doi: 10.1093/nar/gkp1223. Epub 2010 Jan 8.


Phage T4 mobE promotes trans homing of the defunct homing endonuclease I-TevIII.

Wilson GW, Edgell DR.

Nucleic Acids Res. 2009 Nov;37(21):7110-23. doi: 10.1093/nar/gkp769.


Genes within genes: multiple LAGLIDADG homing endonucleases target the ribosomal protein S3 gene encoded within an rnl group I intron of Ophiostoma and related taxa.

Sethuraman J, Majer A, Friedrich NC, Edgell DR, Hausner G.

Mol Biol Evol. 2009 Oct;26(10):2299-315. doi: 10.1093/molbev/msp145. Epub 2009 Jul 13.


Selfish DNA: homing endonucleases find a home.

Edgell DR.

Curr Biol. 2009 Feb 10;19(3):R115-7. doi: 10.1016/j.cub.2008.12.019. Review.


An RNA hairpin sequesters the ribosome binding site of the homing endonuclease mobE gene.

Gibb EA, Edgell DR.

J Bacteriol. 2009 Apr;191(7):2409-13. doi: 10.1128/JB.01751-08. Epub 2009 Jan 30.


Strand-specific contacts and divalent metal ion regulate double-strand break formation by the GIY-YIG homing endonuclease I-BmoI.

Carter JM, Friedrich NC, Kleinstiver B, Edgell DR.

J Mol Biol. 2007 Nov 23;374(2):306-21. Epub 2007 Sep 16.


Insertion of a homing endonuclease creates a genes-in-pieces ribonucleotide reductase that retains function.

Friedrich NC, Torrents E, Gibb EA, Sahlin M, Sjöberg BM, Edgell DR.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6176-81. Epub 2007 Mar 29.


Distance determination by GIY-YIG intron endonucleases: discrimination between repression and cleavage functions.

Liu Q, Derbyshire V, Belfort M, Edgell DR.

Nucleic Acids Res. 2006 Mar 31;34(6):1755-64. Print 2006.


FhuD1, a ferric hydroxamate-binding lipoprotein in Staphylococcus aureus: a case of gene duplication and lateral transfer.

Sebulsky MT, Speziali CD, Shilton BH, Edgell DR, Heinrichs DE.

J Biol Chem. 2004 Dec 17;279(51):53152-9. Epub 2004 Oct 8.


Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor.

Edgell DR, Derbyshire V, Van Roey P, LaBonne S, Stanger MJ, Li Z, Boyd TM, Shub DA, Belfort M.

Nat Struct Mol Biol. 2004 Oct;11(10):936-44. Epub 2004 Sep 7.


SegG endonuclease promotes marker exclusion and mediates co-conversion from a distant cleavage site.

Liu Q, Belle A, Shub DA, Belfort M, Edgell DR.

J Mol Biol. 2003 Nov 14;334(1):13-23.


Selfish DNA: new abode for homing endonucleases.

Edgell DR.

Curr Biol. 2002 Apr 16;12(8):R276-8.


Related homing endonucleases I-BmoI and I-TevI use different strategies to cleave homologous recognition sites.

Edgell DR, Shub DA.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7898-903. Epub 2001 Jun 19.


Barriers to intron promiscuity in bacteria.

Edgell DR, Belfort M, Shub DA.

J Bacteriol. 2000 Oct;182(19):5281-9. Review. No abstract available.


Archaea and the origin(s) of DNA replication proteins.

Edgell DR, Doolittle WF.

Cell. 1997 Jun 27;89(7):995-8. Review. No abstract available.


Gene duplications in evolution of archaeal family B DNA polymerases.

Edgell DR, Klenk HP, Doolittle WF.

J Bacteriol. 1997 Apr;179(8):2632-40.


Selfish DNA: the best defense is a good offense.

Edgell DR, Fast NM, Doolittle WF.

Curr Biol. 1996 Apr 1;6(4):385-8. Review.

Supplemental Content

Loading ...
Support Center