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Items: 1 to 50 of 67

1.

Generation of two induced pluripotent stem cell lines from skin fibroblasts of sisters carrying a c.1094C>A variation in the SCN10A gene potentially associated with small fiber neuropathy.

Klein T, Klug K, Henkel L, Kwok CK, Edenhofer F, Klopocki E, Kurth I, Üçeyler N.

Stem Cell Res. 2019 Mar;35:101396. doi: 10.1016/j.scr.2019.101396. Epub 2019 Feb 2.

2.

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.

Thier MC, Hommerding O, Panten J, Pinna R, García-González D, Berger T, Wörsdörfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A.

Cell Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015. Epub 2018 Dec 20.

PMID:
30581079
3.

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium.

Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plötz S, Farrell M, Trautmann U, Kraus C, Ekici AB, Asadollahi R, Regensburger M, Günther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A.

Sci Rep. 2018 Nov 21;8(1):17201. doi: 10.1038/s41598-018-35506-0.

4.

Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells.

Mekala SR, Wörsdörfer P, Bauer J, Stoll O, Wagner N, Reeh L, Loew K, Eckner G, Kwok CK, Wischmeyer E, Dickinson ME, Schulze H, Stegner D, Benndorf RA, Edenhofer F, Pfeiffer V, Kuerten S, Frantz S, Ergün S.

Circ Res. 2018 Aug 31;123(6):686-699. doi: 10.1161/CIRCRESAHA.117.312526.

PMID:
30355234
5.

Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay.

Nose N, Werner RA, Ueda Y, Günther K, Lapa C, Javadi MS, Fukushima K, Edenhofer F, Higuchi T.

Int J Cardiol. 2018 Oct 15;269:229-234. doi: 10.1016/j.ijcard.2018.06.089. Epub 2018 Jun 21.

7.

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH.

Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105.

8.

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok CK, Leonardi T, Booty LM, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Donegà M, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C, Pluchino S.

Cell Stem Cell. 2018 Mar 1;22(3):355-368.e13. doi: 10.1016/j.stem.2018.01.020. Epub 2018 Feb 22.

9.

Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3.

Jansch C, Günther K, Waider J, Ziegler GC, Forero A, Kollert S, Svirin E, Pühringer D, Kwok CK, Ullmann R, Maierhofer A, Flunkert J, Haaf T, Edenhofer F, Lesch KP.

Stem Cell Res. 2018 Apr;28:136-140. doi: 10.1016/j.scr.2018.02.005. Epub 2018 Feb 13.

10.

BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.

Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C.

J Neurosci. 2018 Feb 14;38(7):1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018. Epub 2018 Jan 10.

11.

A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

Dobeš J, Edenhofer F, Vobořil M, Brabec T, Dobešová M, Čepková A, Klein L, Rajewsky K, Filipp D.

Eur J Immunol. 2018 Mar;48(3):546-548. doi: 10.1002/eji.201747267. Epub 2017 Dec 27.

12.

Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain.

Forero A, Rivero O, Wäldchen S, Ku HP, Kiser DP, Gärtner Y, Pennington LS, Waider J, Gaspar P, Jansch C, Edenhofer F, Resink TJ, Blum R, Sauer M, Lesch KP.

Front Cell Neurosci. 2017 Sep 26;11:307. doi: 10.3389/fncel.2017.00307. eCollection 2017.

13.

Scalable stirred suspension culture for the generation of billions of human induced pluripotent stem cells using single-use bioreactors.

Kwok CK, Ueda Y, Kadari A, Günther K, Ergün S, Heron A, Schnitzler AC, Rook M, Edenhofer F.

J Tissue Eng Regen Med. 2018 Feb;12(2):e1076-e1087. doi: 10.1002/term.2435. Epub 2017 Oct 2.

PMID:
28382727
14.

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells.

Appelt-Menzel A, Cubukova A, Günther K, Edenhofer F, Piontek J, Krause G, Stüber T, Walles H, Neuhaus W, Metzger M.

Stem Cell Reports. 2017 Apr 11;8(4):894-906. doi: 10.1016/j.stemcr.2017.02.021. Epub 2017 Mar 23.

15.

Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies.

Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K.

Stem Cells. 2017 Apr;35(4):859-871. doi: 10.1002/stem.2545. Epub 2016 Dec 20.

16.

The vascular adventitia: An endogenous, omnipresent source of stem cells in the body.

Wörsdörfer P, Mekala SR, Bauer J, Edenhofer F, Kuerten S, Ergün S.

Pharmacol Ther. 2017 Mar;171:13-29. doi: 10.1016/j.pharmthera.2016.07.017. Epub 2016 Aug 3. Review.

PMID:
27498405
17.

Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.

Safina D, Schlitt F, Romeo R, Pflanzner T, Pietrzik CU, Narayanaswami V, Edenhofer F, Faissner A.

Glia. 2016 Aug;64(8):1363-80. doi: 10.1002/glia.23009. Epub 2016 Jun 3.

18.

Model Testing of PluriTest with Next-Generation Sequencing Data.

Schulze M, Hoja S, Winner B, Winkler J, Edenhofer F, Riemenschneider MJ.

Stem Cells Dev. 2016 Apr 1;25(7):569-71. doi: 10.1089/scd.2015.0266. Epub 2016 Mar 15. No abstract available.

PMID:
26978076
19.

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A.

Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033.

20.

Nanog induces suppression of senescence through downregulation of p27KIP1 expression.

Münst B, Thier MC, Winnemöller D, Helfen M, Thummer RP, Edenhofer F.

J Cell Sci. 2016 Mar 1;129(5):912-20. doi: 10.1242/jcs.167932. Epub 2016 Jan 21.

21.

Partial Dedifferentiation of Murine Radial Glia-Type Neural Stem Cells by Brn2 and c-Myc Yields Early Neuroepithelial Progenitors.

Bung R, Wörsdörfer P, Thier MC, Lemke K, Gebhardt M, Edenhofer F.

J Mol Biol. 2016 Apr 10;428(7):1476-83. doi: 10.1016/j.jmb.2015.10.028. Epub 2015 Nov 10.

PMID:
26555748
22.

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells.

Meyer S, Wörsdörfer P, Günther K, Thier M, Edenhofer F.

J Vis Exp. 2015 Jul 29;(101):e52831. doi: 10.3791/52831.

23.

Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system.

Mohr M, Tosun S, Arnold WH, Edenhofer F, Zänker KS, Dittmar T.

Cell Mol Life Sci. 2015 Oct;72(19):3769-82. doi: 10.1007/s00018-015-1910-6. Epub 2015 Apr 22.

PMID:
25900663
24.

Characterization of a novel cell penetrating peptide derived from human Oct4.

Harreither E, Rydberg HA, Amand HL, Jadhav V, Fliedl L, Benda C, Esteban MA, Pei D, Borth N, Grillari-Voglauer R, Hommerding O, Edenhofer F, Nordén B, Grillari J.

Cell Regen (Lond). 2014 Jan 31;3(1):2. doi: 10.1186/2045-9769-3-2. eCollection 2014.

25.

Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.

Kadari A, Mekala S, Wagner N, Malan D, Köth J, Doll K, Stappert L, Eckert D, Peitz M, Matthes J, Sasse P, Herzig S, Brüstle O, Ergün S, Edenhofer F.

Stem Cell Rev Rep. 2015 Aug;11(4):560-9. doi: 10.1007/s12015-014-9564-6.

26.

Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells.

Kadari A, Lu M, Li M, Sekaran T, Thummer RP, Guyette N, Chu V, Edenhofer F.

Stem Cell Res Ther. 2014 Apr 8;5(2):47. doi: 10.1186/scrt435.

27.

Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.

Peitz M, Münst B, Thummer RP, Helfen M, Edenhofer F.

Stem Cell Res. 2014 May;12(3):680-9. doi: 10.1016/j.scr.2014.02.006. Epub 2014 Mar 5.

28.

Roadmap to cellular reprogramming--manipulating transcriptional networks with DNA, RNA, proteins and small molecules.

Wörsdörfer P, Thier M, Kadari A, Edenhofer F.

Curr Mol Med. 2013 Jun;13(5):868-78. Review.

PMID:
23642067
29.

A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.

Hennen E, Safina D, Haussmann U, Wörsdörfer P, Edenhofer F, Poetsch A, Faissner A.

J Biol Chem. 2013 Jun 7;288(23):16538-45. doi: 10.1074/jbc.M112.419812. Epub 2013 Apr 24.

30.

Automated selection and harvesting of pluripotent stem cell colonies.

Haupt S, Grützner J, Thier MC, Kallweit T, Rath BH, Laufenberg I, Forgber M, Eberhardt J, Edenhofer F, Brüstle O.

Biotechnol Appl Biochem. 2012 Mar-Apr;59(2):77-87. doi: 10.1002/bab.1014.

PMID:
23586788
31.

A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells.

Zhang R, Mjoseng HK, Hoeve MA, Bauer NG, Pells S, Besseling R, Velugotla S, Tourniaire G, Kishen RE, Tsenkina Y, Armit C, Duffy CR, Helfen M, Edenhofer F, de Sousa PA, Bradley M.

Nat Commun. 2013;4:1335. doi: 10.1038/ncomms2341.

32.

MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells.

Kim BM, Thier MC, Oh S, Sherwood R, Kanellopoulou C, Edenhofer F, Choi MY.

PLoS One. 2012;7(6):e39239. doi: 10.1371/journal.pone.0039239. Epub 2012 Jun 21.

33.

Cellular reprogramming employing recombinant sox2 protein.

Thier M, Münst B, Mielke S, Edenhofer F.

Stem Cells Int. 2012;2012:549846. doi: 10.1155/2012/549846. Epub 2012 May 29.

34.

Direct conversion of fibroblasts into stably expandable neural stem cells.

Thier M, Wörsdörfer P, Lakes YB, Gorris R, Herms S, Opitz T, Seiferling D, Quandel T, Hoffmann P, Nöthen MM, Brüstle O, Edenhofer F.

Cell Stem Cell. 2012 Apr 6;10(4):473-9. doi: 10.1016/j.stem.2012.03.003. Epub 2012 Mar 22.

35.

Non-genetic modulation of Notch activity by artificial delivery of Notch intracellular domain into neural stem cells.

Haupt S, Borghese L, Brüstle O, Edenhofer F.

Stem Cell Rev Rep. 2012 Sep;8(3):672-84.

PMID:
22290418
36.

Genetic engineering of mammalian cells by direct delivery of FLP recombinase protein.

Patsch C, Kesseler D, Edenhofer F.

Methods. 2011 Apr;53(4):386-93. doi: 10.1016/j.ymeth.2010.12.018. Epub 2010 Dec 23.

PMID:
21185381
37.

Sox2 is essential for formation of trophectoderm in the preimplantation embryo.

Keramari M, Razavi J, Ingman KA, Patsch C, Edenhofer F, Ward CM, Kimber SJ.

PLoS One. 2010 Nov 12;5(11):e13952. doi: 10.1371/journal.pone.0013952.

38.

Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage.

Kiss E, Popovic ZV, Bedke J, Adams J, Bonrouhi M, Babelova A, Schmidt C, Edenhofer F, Zschiedrich I, Domhan S, Abdollahi A, Schäfer L, Gretz N, Porubsky S, Gröne HJ.

Am J Pathol. 2010 May;176(5):2150-62. doi: 10.2353/ajpath.2010.090370. Epub 2010 Apr 2.

39.

Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction.

Stock K, Nolden L, Edenhofer F, Quandel T, Brüstle O.

Cell Mol Life Sci. 2010 Jul;67(14):2439-49. doi: 10.1007/s00018-010-0347-1. Epub 2010 Mar 30.

40.

Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells.

Patsch C, Peitz M, Otte DM, Kesseler D, Jungverdorben J, Wunderlich FT, Brüstle O, Zimmer A, Edenhofer F.

Stem Cells. 2010 May;28(5):894-902. doi: 10.1002/stem.417.

41.

Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo.

Borghese L, Dolezalova D, Opitz T, Haupt S, Leinhaas A, Steinfarz B, Koch P, Edenhofer F, Hampl A, Brüstle O.

Stem Cells. 2010 May;28(5):955-64. doi: 10.1002/stem.408.

42.

Exploring refined conditions for reprogramming cells by recombinant Oct4 protein.

Thier M, Münst B, Edenhofer F.

Int J Dev Biol. 2010;54(11-12):1713-21. doi: 10.1387/ijdb.103193mt.

43.

Engineering cell-permeable protein.

Münst B, Patsch C, Edenhofer F.

J Vis Exp. 2009 Dec 28;(34). pii: 1627. doi: 10.3791/1627.

44.

Monodispersity of recombinant Cre recombinase correlates with its effectiveness in vivo.

Capasso P, Aliprandi M, Ossolengo G, Edenhofer F, de Marco A.

BMC Biotechnol. 2009 Sep 11;9:80. doi: 10.1186/1472-6750-9-80.

45.

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice.

Anastassiadis K, Fu J, Patsch C, Hu S, Weidlich S, Duerschke K, Buchholz F, Edenhofer F, Stewart AF.

Dis Model Mech. 2009 Sep-Oct;2(9-10):508-15. doi: 10.1242/dmm.003087. Epub 2009 Aug 19.

46.

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.

Lienenklaus S, Cornitescu M, Zietara N, Łyszkiewicz M, Gekara N, Jabłónska J, Edenhofer F, Rajewsky K, Bruder D, Hafner M, Staeheli P, Weiss S.

J Immunol. 2009 Sep 1;183(5):3229-36. doi: 10.4049/jimmunol.0804277. Epub 2009 Aug 10.

47.

Deciphering the stem cell machinery as a basis for understanding the molecular mechanism underlying reprogramming.

Bosnali M, Münst B, Thier M, Edenhofer F.

Cell Mol Life Sci. 2009 Nov;66(21):3403-20. doi: 10.1007/s00018-009-0095-2. Epub 2009 Aug 7. Review.

48.

Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1.

Klotz L, Hucke S, Thimm D, Classen S, Gaarz A, Schultze J, Edenhofer F, Kurts C, Klockgether T, Limmer A, Knolle P, Burgdorf S.

J Immunol. 2009 Jul 1;183(1):129-36. doi: 10.4049/jimmunol.0804260. Epub 2009 Jun 17.

49.
50.

Generation of transducible versions of transcription factors Oct4 and Sox2.

Bosnali M, Edenhofer F.

Biol Chem. 2008 Jul;389(7):851-61. doi: 10.1515/BC.2008.106.

PMID:
18681826

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