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Items: 36


Functionalization of CD36 cardiovascular disease and expression associated variants by interdisciplinary high throughput analysis.

Madan N, Ghazi AR, Kong X, Chen ES, Shaw CA, Edelstein LC.

PLoS Genet. 2019 Jul 25;15(7):e1008287. doi: 10.1371/journal.pgen.1008287. eCollection 2019 Jul.


Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells.

Goldfinger LE, Edelstein LC.

J Thromb Haemost. 2019 Jul;17(7):1014-1017. doi: 10.1111/jth.14442. No abstract available.


Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood.

Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE Jr, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF.

Haematologica. 2019 Oct;104(10):2075-2083. doi: 10.3324/haematol.2018.204685. Epub 2019 Feb 7.


Identification of the Regulatory Elements and Target Genes of Megakaryopoietic Transcription Factor MEF2C.

Kong X, Ma L, Chen E, Shaw CA, Edelstein LC.

Thromb Haemost. 2019 May;119(5):716-725. doi: 10.1055/s-0039-1678694. Epub 2019 Feb 7.


miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway.

Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray PF.

J Thromb Haemost. 2019 Mar;17(3):511-524. doi: 10.1111/jth.14382. Epub 2019 Feb 25.


The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.

Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF.

J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22.


Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.

Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF.

Blood Cells Mol Dis. 2018 Sep;72:37-43. doi: 10.1016/j.bcmd.2018.07.004. Epub 2018 Jul 21.


Design tools for MPRA experiments.

Ghazi AR, Chen ES, Henke DM, Madan N, Edelstein LC, Shaw CA.

Bioinformatics. 2018 Aug 1;34(15):2682-2683. doi: 10.1093/bioinformatics/bty150.


Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.

Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1632-1643. doi: 10.1161/ATVBAHA.118.311112. Epub 2018 May 10.


Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.

Michael JV, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, Hoffman NE, Rajan S, Tomar D, Madesh M, Nieman MT, Yu J, Edelstein LC, Rowley JW, Weyrich AS, Goldfinger LE.

Blood. 2017 Aug 3;130(5):567-580. doi: 10.1182/blood-2016-11-751099. Epub 2017 May 12.


Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.

Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC.

Thromb Haemost. 2017 May 3;117(5):962-970. doi: 10.1160/TH16-09-0692. Epub 2017 Mar 2.


The role of platelet microvesicles in intercellular communication.

Edelstein LC.

Platelets. 2017 May;28(3):222-227. doi: 10.1080/09537104.2016.1257114. Epub 2016 Dec 8. Review.


TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice.

Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2315-2323. Epub 2016 Oct 20.


Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2.

Simon LM, Chen ES, Edelstein LC, Kong X, Bhatlekar S, Rigoutsos I, Bray PF, Shaw CA.

Am J Hum Genet. 2016 May 5;98(5):883-897. doi: 10.1016/j.ajhg.2016.03.007. Epub 2016 Apr 28.


MicroRNAs in Platelet Physiology and Function.

Lindsay CR, Edelstein LC.

Semin Thromb Hemost. 2016 Apr;42(3):215-22. doi: 10.1055/s-0035-1570077. Epub 2016 Mar 7. Review.


Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.

Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE.

Blood. 2015 Dec 24;126(26):2871-81. doi: 10.1182/blood-2015-02-631135. Epub 2015 Oct 29.


Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.

Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF.

Blood. 2014 Nov 27;124(23):3450-8. doi: 10.1182/blood-2014-04-572479. Epub 2014 Oct 7.


Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis.

Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2644-50. doi: 10.1161/ATVBAHA.114.304249. Epub 2014 Oct 2.


MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression.

Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF.

PLoS One. 2014 Jul 16;9(7):e102259. doi: 10.1371/journal.pone.0102259. eCollection 2014.


Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics.

Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF.

Blood. 2014 Apr 17;123(16):e37-45. doi: 10.1182/blood-2013-12-544692. Epub 2014 Feb 12.


Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.

Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong JF, Shaw C, Bray PF.

Nat Med. 2013 Dec;19(12):1609-16. doi: 10.1038/nm.3385. Epub 2013 Nov 10.


MicroRNAs in platelet production and activation.

Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF.

J Thromb Haemost. 2013 Jun;11 Suppl 1:340-50. doi: 10.1111/jth.12214. Review.


The complex transcriptional landscape of the anucleate human platelet.

Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I.

BMC Genomics. 2013 Jan 16;14:1. doi: 10.1186/1471-2164-14-1.


Small RNAs as potential platelet therapeutics.

Edelstein LC, Bray PF.

Handb Exp Pharmacol. 2012;(210):435-45. doi: 10.1007/978-3-642-29423-5_17. Review.


Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.

Edelstein LC, Luna EJ, Gibson IB, Bray M, Jin Y, Kondkar A, Nagalla S, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Stolla M, Kong X, Fang Z, Bergmeier W, Shaw C, Leal SM, Bray PF.

Circulation. 2012 Jun 5;125(22):2762-71. doi: 10.1161/CIRCULATIONAHA.112.091462. Epub 2012 May 1.


High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.

Micheva-Viteva S, Kobayashi Y, Edelstein LC, Pacchia AL, Lee HL, Graci JD, Breslin J, Phelan BD, Miller LK, Colacino JM, Gu Z, Ron Y, Peltz SW, Dougherty JP.

J Biol Chem. 2011 Jun 17;286(24):21083-91. doi: 10.1074/jbc.M110.195537. Epub 2011 Apr 15.


Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity.

Nagalla S, Shaw C, Kong X, Kondkar AA, Edelstein LC, Ma L, Chen J, McKnight GS, López JA, Yang L, Jin Y, Bray MS, Leal SM, Dong JF, Bray PF.

Blood. 2011 May 12;117(19):5189-97. doi: 10.1182/blood-2010-09-299719. Epub 2011 Mar 17.


MicroRNAs in platelet production and activation.

Edelstein LC, Bray PF.

Blood. 2011 May 19;117(20):5289-96. doi: 10.1182/blood-2011-01-292011. Epub 2011 Mar 1. Review.


Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma.

Edelstein LC, Micheva-Viteva S, Phelan BD, Dougherty JP.

AIDS Res Hum Retroviruses. 2009 Sep;25(9):883-7. doi: 10.1089/aid.2008.0294.


The SCAN domain family of zinc finger transcription factors.

Edelstein LC, Collins T.

Gene. 2005 Oct 10;359:1-17. Review.


Chromatin modification and the endothelial-specific activation of the E-selectin gene.

Edelstein LC, Pan A, Collins T.

J Biol Chem. 2005 Mar 25;280(12):11192-202. Epub 2005 Jan 25.


Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor.

D'Souza BN, Edelstein LC, Pegman PM, Smith SM, Loughran ST, Clarke A, Mehl A, Rowe M, Gélinas C, Walls D.

J Virol. 2004 Feb;78(4):1800-16.


NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1.

Edelstein LC, Lagos L, Simmons M, Tirumalai H, Gélinas C.

Mol Cell Biol. 2003 Apr;23(8):2749-61.


Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells.

Suh J, Payvandi F, Edelstein LC, Amenta PS, Zong WX, Gélinas C, Rabson AB.

Prostate. 2002 Aug 1;52(3):183-200.


The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

Chen C, Edelstein LC, Gélinas C.

Mol Cell Biol. 2000 Apr;20(8):2687-95.


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