Sort by
Items per page

Send to

Choose Destination

Search results

Items: 16


Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt.

Gauld S, Jacquet S, Gauvin D, Wallace C, Wang Y, McCarthy R, Goess C, Leys L, Huang S, Su Z, Edelmayer R, Wetter J, Salte K, McGaraughty S, Argiriadi M, Honore P, Luccarini JM, Bressac D, Desino K, Breinlinger E, Cusack K, Potin D, Kort M, Masson P.

J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046. doi: 10.1124/jpet.119.258046. [Epub ahead of print]


Characterization of psoriasiform dermatitis induced by systemic injection of interleukin-23 minicircles in mice.

Leys L, Wang Y, Paulsboe S, Edelmayer R, Salte K, Wetter J, Namovic M, Phillips L, Dunstan R, Gauvin D, Donnelly-Roberts D, Su Z, Honore P, McGaraughty S.

J Dermatol. 2019 Jun;46(6):482-497. doi: 10.1111/1346-8138.14899. Epub 2019 May 7.


Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses.

Slivka PF, Hsieh CL, Lipovsky A, Pratt SD, Locklear J, Namovic MT, McDonald HA, Wetter J, Edelmayer R, Hu M, Murphy E, Domanus M, Lu C, Duggan R, King J, Scott VE, Donnelly-Roberts D, Slavin A, Gopalakrishnan S, Chung N, Goedken ER.

ACS Chem Biol. 2019 May 17;14(5):857-872. doi: 10.1021/acschembio.8b00260. Epub 2019 Apr 15.


Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation.

Wang Y, Edelmayer R, Wetter J, Salte K, Gauvin D, Leys L, Paulsboe S, Su Z, Weinberg I, Namovic M, Gauld SB, Honore P, Scott VE, McGaraughty S.

Sci Rep. 2019 Mar 29;9(1):5310. doi: 10.1038/s41598-019-41655-7.


IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis.

Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorović V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE.

Exp Dermatol. 2019 Feb;28(2):113-120. doi: 10.1111/exd.13841. Epub 2018 Dec 21.


Mechanistic and pharmacological assessment of murine IL-23 mediated psoriasiform dermatitis; implications for drug discovery.

Gauld SB, Gauvin D, Olson L, Leys L, Paulsboe S, Liu Z, Edelmayer RM, Wetter J, Salte K, Wang Y, Huang S, Honore P, McGaraughty S.

J Dermatol Sci. 2018 Oct;92(1):45-53. doi: 10.1016/j.jdermsci.2018.08.001. Epub 2018 Aug 7.


Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain.

Brederson JD, Chu KL, Xu J, Nikkel AL, Markosyan S, Jarvis MF, Edelmayer R, Bitner RS, McGaraughty S.

J Orthop Res. 2018 Feb 11. doi: 10.1002/jor.23869. [Epub ahead of print]


Biochemical and pharmacological assessment of MAP-kinase signaling along pain pathways in experimental rodent models: a potential tool for the discovery of novel antinociceptive therapeutics.

Edelmayer RM, Brederson JD, Jarvis MF, Bitner RS.

Biochem Pharmacol. 2014 Feb 1;87(3):390-8. doi: 10.1016/j.bcp.2013.11.019. Epub 2013 Dec 1. Review.


pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators.

Yan J, Wei X, Bischoff C, Edelmayer RM, Dussor G.

Headache. 2013 Sep;53(8):1250-61. doi: 10.1111/head.12152. Epub 2013 Jun 28.


Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.

Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G.

Pain. 2012 Sep;153(9):1949-58. doi: 10.1016/j.pain.2012.06.012. Epub 2012 Jul 17.


Receptor specificity defines algogenic properties of propofol and fospropofol.

Patwardhan A, Edelmayer R, Annabi E, Price T, Malan P, Dussor G.

Anesth Analg. 2012 Oct;115(4):837-40. Epub 2012 May 14.


An experimental model of headache-related pain.

Edelmayer RM, Ossipov MH, Porreca F.

Methods Mol Biol. 2012;851:109-20. doi: 10.1007/978-1-61779-561-9_7.


Activation of TRPV4 on dural afferents produces headache-related behavior in a preclinical rat model.

Wei X, Edelmayer RM, Yan J, Dussor G.

Cephalalgia. 2011 Dec;31(16):1595-600. doi: 10.1177/0333102411427600. Epub 2011 Nov 2.


Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats.

Fioravanti B, Kasasbeh A, Edelmayer R, Skinner DP Jr, Hartings JA, Burklund RD, De Felice M, French ED, Dussor GO, Dodick DW, Porreca F, Vanderah TW.

Cephalalgia. 2011 Jul;31(10):1090-100. doi: 10.1177/0333102411410609. Epub 2011 Jun 23.


Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache.

Yan J, Edelmayer RM, Wei X, De Felice M, Porreca F, Dussor G.

Pain. 2011 Jan;152(1):106-13. doi: 10.1016/j.pain.2010.09.036. Epub 2010 Oct 23.


Medullary pain facilitating neurons mediate allodynia in headache-related pain.

Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F.

Ann Neurol. 2009 Feb;65(2):184-93. doi: 10.1002/ana.21537.

Supplemental Content

Loading ...
Support Center