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Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair.

Jahid S, Sun J, Gelincik O, Blecua P, Edelmann W, Kucherlapati R, Zhou K, Jasin M, Gümüş ZH, Lipkin SM.

Oncotarget. 2017 May 10;8(42):71574-71586. doi: 10.18632/oncotarget.17776. eCollection 2017 Sep 22.


EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.

Chen CC, Avdievich E, Zhang Y, Zhang Y, Wei K, Lee K, Edelmann W, Jasin M, LaRocque JR.

DNA Repair (Amst). 2017 Sep;57:98-106. doi: 10.1016/j.dnarep.2017.07.003. Epub 2017 Jul 10.


The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.

Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T.

Stem Cells. 2017 Jun;35(6):1614-1623. doi: 10.1002/stem.2604. Epub 2017 Apr 15.


A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Zhang Y, Fox JT, Park YU, Elliott G, Rai G, Cai M, Sakamuru S, Huang R, Xia M, Lee K, Jeon MH, Mathew BP, Park HD, Edelmann W, Park CY, Hong SY, Maloney D, Myung K.

Cancer Res. 2016 Jul 15;76(14):4183-91. doi: 10.1158/0008-5472.CAN-15-2974. Epub 2016 Jun 4.


MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.

Eso Y, Takai A, Matsumoto T, Inuzuka T, Horie T, Ono K, Uemoto S, Lee K, Edelmann W, Chiba T, Marusawa H.

Cancer Res. 2016 Aug 1;76(15):4383-93. doi: 10.1158/0008-5472.CAN-15-2926. Epub 2016 Jun 3.


Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.

He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A.

Development. 2016 Jun 1;143(11):1937-47. doi: 10.1242/dev.135285.


Genomic Landscape of Colorectal Mucosa and Adenomas.

Borras E, San Lucas FA, Chang K, Zhou R, Masand G, Fowler J, Mork ME, You YN, Taggart MW, McAllister F, Jones DA, Davies GE, Edelmann W, Ehli EA, Lynch PM, Hawk ET, Capella G, Scheet P, Vilar E.

Cancer Prev Res (Phila). 2016 Jun;9(6):417-27. doi: 10.1158/1940-6207.CAPR-16-0081. Epub 2016 May 24.


Mouse models of DNA mismatch repair in cancer research.

Lee K, Tosti E, Edelmann W.

DNA Repair (Amst). 2016 Feb;38:140-6. doi: 10.1016/j.dnarep.2015.11.015. Epub 2015 Dec 4. Review.


Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

Will B, Vogler TO, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Neriah DB, Roth M, van Oers J, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U.

Nat Med. 2015 Oct;21(10):1172-81. doi: 10.1038/nm.3936. Epub 2015 Sep 7.


EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.

Rein K, Yanez DA, Terré B, Palenzuela L, Aivio S, Wei K, Edelmann W, Stark JM, Stracker TH.

Nucleic Acids Res. 2015 Sep 3;43(15):7371-87. doi: 10.1093/nar/gkv691. Epub 2015 Jul 8.


Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.

Chen HJ, Sun J, Huang Z, Hou H Jr, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümüş ZH, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin SM.

Nat Biotechnol. 2015 Jun;33(6):656-60. doi: 10.1038/nbt.3239. Epub 2015 May 25.


Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.

Kortüm B, Campregher C, Lang M, Khare V, Pinter M, Evstatiev R, Schmid G, Mittlböck M, Scharl T, Kucherlapati MH, Edelmann W, Gasche C.

Gut. 2015 Dec;64(12):1905-12. doi: 10.1136/gutjnl-2014-307663. Epub 2014 Nov 26.


Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.

Tosti E, Katakowski JA, Schaetzlein S, Kim HS, Ryan CJ, Shales M, Roguev A, Krogan NJ, Palliser D, Keogh MC, Edelmann W.

Genome Med. 2014 Sep 17;6(9):68. doi: 10.1186/s13073-014-0068-4. eCollection 2014.


Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.

Woerner SM, Tosti E, Yuan YP, Kloor M, Bork P, Edelmann W, Gebert J.

Mol Carcinog. 2015 Nov;54(11):1376-86. doi: 10.1002/mc.22213. Epub 2014 Sep 11.


Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Surendra A, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TMS, Edelmann W, Guttman DS, Philpott DJ, Martin A.

Cell. 2014 Jul 17;158(2):288-299. doi: 10.1016/j.cell.2014.04.051. Erratum in: Cell. 2014 Oct 9;159(2):456.


Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.

Kim HS, Mukhopadhyay R, Rothbart SB, Silva AC, Vanoosthuyse V, Radovani E, Kislinger T, Roguev A, Ryan CJ, Xu J, Jahari H, Hardwick KG, Greenblatt JF, Krogan NJ, Fillingham JS, Strahl BD, Bouhassira EE, Edelmann W, Keogh MC.

Cell Rep. 2014 Mar 13;6(5):892-905. doi: 10.1016/j.celrep.2014.01.029. Epub 2014 Feb 22.


A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC.

Cancer Discov. 2014 May;4(5):592-605. doi: 10.1158/2159-8290.CD-13-0907. Epub 2014 Feb 20.


Seamless Ligation Cloning Extract (SLiCE) cloning method.

Zhang Y, Werling U, Edelmann W.

Methods Mol Biol. 2014;1116:235-44. doi: 10.1007/978-1-62703-764-8_16.


The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair.

van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W.

Oncogene. 2014 Jul 24;33(30):3939-46. doi: 10.1038/onc.2013.365. Epub 2013 Sep 9.


Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.

Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9. doi: 10.1073/pnas.1308512110. Epub 2013 Jun 10.


Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression.

Ene AC, Park S, Edelmann W, Taketo T.

Dev Biol. 2013 May 1;377(1):213-23. doi: 10.1016/j.ydbio.2013.01.027. Epub 2013 Feb 4.


Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.

Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM Jr, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF.

J Exp Med. 2013 Jan 14;210(1):115-23. doi: 10.1084/jem.20121975. Epub 2012 Dec 17.


Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.

Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, Edelmann W, Gümüs ZH, Shen X, Lipkin S.

J Clin Invest. 2012 Sep;122(9):3184-96. doi: 10.1172/JCI62110. Epub 2012 Aug 6.


AIDing antibody diversity by error-prone mismatch repair.

Chahwan R, Edelmann W, Scharff MD, Roa S.

Semin Immunol. 2012 Aug;24(4):293-300. doi: 10.1016/j.smim.2012.05.005. Epub 2012 Jun 14. Review.


Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ.

Mol Cell. 2012 Jun 8;46(5):691-704. doi: 10.1016/j.molcel.2012.05.028.


The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.

Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S.

J Exp Med. 2012 Apr 9;209(4):671-8. doi: 10.1084/jem.20111531. Epub 2012 Mar 26.


Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer.

Itano O, Fan K, Yang K, Suzuki K, Quimby F, Dong Z, Jin B, Edelmann W, Lipkin M.

Nutr Cancer. 2012 Apr;64(3):401-8. doi: 10.1080/01635581.2012.660672. Epub 2012 Mar 22.


SLiCE: a novel bacterial cell extract-based DNA cloning method.

Zhang Y, Werling U, Edelmann W.

Nucleic Acids Res. 2012 Apr;40(8):e55. doi: 10.1093/nar/gkr1288. Epub 2012 Jan 12.


Mismatch-mediated error prone repair at the immunoglobulin genes.

Chahwan R, Edelmann W, Scharff MD, Roa S.

Biomed Pharmacother. 2011 Dec;65(8):529-36. doi: 10.1016/j.biopha.2011.09.001. Epub 2011 Oct 24. Review.


Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.

McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R.

Cancer Prev Res (Phila). 2011 May;4(5):684-93. doi: 10.1158/1940-6207.CAPR-10-0319. Epub 2011 Mar 24.


Msh6 protects mature B cells from lymphoma by preserving genomic stability.

Peled JU, Sellers RS, Iglesias-Ussel MD, Shin DM, Montagna C, Zhao C, Li Z, Edelmann W, Morse HC 3rd, Scharff MD.

Am J Pathol. 2010 Nov;177(5):2597-608. doi: 10.2353/ajpath.2010.100234. Epub 2010 Oct 7.


Conditional inactivation of MLH1 in thymic and naive T-cells in mice leads to a limited incidence of lymphoblastic T-cell lymphomas.

Reiss C, Haneke T, Völker HU, Spahn M, Rosenwald A, Edelmann W, Kneitz B.

Leuk Lymphoma. 2010 Oct;51(10):1875-86. doi: 10.3109/10428194.2010.510360.


Genes essential for cell viability that are linked to tumor suppressor genes play a role in cancer susceptibility.

Wang Y, Huang B, Edelmann L, Kolodner RD, Edelmann W.

Cell Cycle. 2010 Aug 15;9(16):3144-5. doi: 10.4161/cc.9.16.12951. Epub 2010 Aug 9. No abstract available.


PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

van Oers JM, Roa S, Werling U, Liu Y, Genschel J, Hou H Jr, Sellers RS, Modrich P, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13384-9. doi: 10.1073/pnas.1008589107. Epub 2010 Jul 12.


MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.

Roa S, Li Z, Peled JU, Zhao C, Edelmann W, Scharff MD.

PLoS One. 2010 Jun 17;5(6):e11182. doi: 10.1371/journal.pone.0011182.


Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.

Wang Y, Zhang W, Edelmann L, Kolodner RD, Kucherlapati R, Edelmann W.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5511-5. doi: 10.1073/pnas.1001223107. Epub 2010 Mar 8.


An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.

Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H Jr, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W.

Gastroenterology. 2010 Mar;138(3):993-1002.e1. doi: 10.1053/j.gastro.2009.11.009. Epub 2009 Nov 18.


Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas.

Nepal RM, Tong L, Kolaj B, Edelmann W, Martin A.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18698-703. doi: 10.1073/pnas.0905965106. Epub 2009 Oct 16.


Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.

Itano O, Yang K, Fan K, Kurihara N, Shinozaki H, Abe S, Jin B, Gravaghi C, Edelmann W, Augenlicht L, Kopelovich L, Kucherlapati R, Lamprecht S, Lipkin M.

Carcinogenesis. 2009 Nov;30(11):1923-6. doi: 10.1093/carcin/bgp200. Epub 2009 Sep 15.


MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.

Tomé S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G.

PLoS Genet. 2009 May;5(5):e1000482. doi: 10.1371/journal.pgen.1000482. Epub 2009 May 15.


A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.

Kadyrov FA, Genschel J, Fang Y, Penland E, Edelmann W, Modrich P.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8495-500. doi: 10.1073/pnas.0903654106. Epub 2009 May 6.


Involvement of Exo1b in DNA damage-induced apoptosis.

Bolderson E, Richard DJ, Edelmann W, Khanna KK.

Nucleic Acids Res. 2009 Jun;37(10):3452-63. doi: 10.1093/nar/gkp194. Epub 2009 Apr 1.


Mouse models of colon cancer.

Taketo MM, Edelmann W.

Gastroenterology. 2009 Mar;136(3):780-98. Review.


Perforin-mediated suppression of B-cell lymphoma.

Bolitho P, Street SE, Westwood JA, Edelmann W, Macgregor D, Waring P, Murray WK, Godfrey DI, Trapani JA, Johnstone RW, Smyth MJ.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2723-8. doi: 10.1073/pnas.0809008106. Epub 2009 Feb 5.


O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.

Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):576-81. doi: 10.1073/pnas.0811991106. Epub 2009 Jan 5.


Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

Guikema JE, Schrader CE, Leus NG, Ucher A, Linehan EK, Werling U, Edelmann W, Stavnezer J.

J Immunol. 2008 Dec 15;181(12):8450-9.


Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.

Dragileva E, Hendricks A, Teed A, Gillis T, Lopez ET, Friedberg EC, Kucherlapati R, Edelmann W, Lunetta KL, MacDonald ME, Wheeler VC.

Neurobiol Dis. 2009 Jan;33(1):37-47. doi: 10.1016/j.nbd.2008.09.014. Epub 2008 Sep 30.


Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16248-53. doi: 10.1073/pnas.0808182105. Epub 2008 Oct 14.


Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice.

Eude-Le Parco I, Gendronneau G, Dang T, Delacour D, Thijssen VL, Edelmann W, Peuchmaur M, Poirier F.

Glycobiology. 2009 Jan;19(1):68-75. doi: 10.1093/glycob/cwn105. Epub 2008 Oct 10.


Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

Yang K, Kurihara N, Fan K, Newmark H, Rigas B, Bancroft L, Corner G, Livote E, Lesser M, Edelmann W, Velcich A, Lipkin M, Augenlicht L.

Cancer Res. 2008 Oct 1;68(19):7803-10. doi: 10.1158/0008-5472.CAN-08-1209.

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