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Items: 40


Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.

Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D.

Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3.


PGE2 Augments Inflammasome Activation and M1 Polarization in Macrophages Infected With Salmonella Typhimurium and Yersinia enterocolitica.

Sheppe AEF, Kummari E, Walker A, Richards A, Hui WW, Lee JH, Mangum L, Borazjani A, Ross MK, Edelmann MJ.

Front Microbiol. 2018 Oct 31;9:2447. doi: 10.3389/fmicb.2018.02447. eCollection 2018.


Proteome-wide lysine acetylation identification in developing rice (Oryza sativa) seeds and protein co-modification by acetylation, succinylation, ubiquitination, and phosphorylation.

Meng X, Lv Y, Mujahid H, Edelmann MJ, Zhao H, Peng X, Peng Z.

Biochim Biophys Acta Proteins Proteom. 2018 Mar;1866(3):451-463. doi: 10.1016/j.bbapap.2017.12.001. Epub 2017 Dec 5.


Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity.

Lee JH, Hou X, Kummari E, Borazjani A, Edelmann MJ, Ross MK.

Mol Cell Biochem. 2018 Jul;444(1-2):125-141. doi: 10.1007/s11010-017-3237-0. Epub 2017 Dec 1.


Salmonella enterica Serovar Typhimurium Alters the Extracellular Proteome of Macrophages and Leads to the Production of Proinflammatory Exosomes.

Hui WW, Hercik K, Belsare S, Alugubelly N, Clapp B, Rinaldi C, Edelmann MJ.

Infect Immun. 2018 Jan 22;86(2). pii: e00386-17. doi: 10.1128/IAI.00386-17. Print 2018 Feb.


Use of focused ultrasonication in activity-based profiling of deubiquitinating enzymes in tissue.

Nanduri B, Shack LA, Rai AN, Epperson WB, Baumgartner W, Schmidt TB, Edelmann MJ.

Anal Biochem. 2016 Dec 15;515:9-13. doi: 10.1016/j.ab.2016.09.016. Epub 2016 Sep 20.


Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

Lopez-Castejon G, Edelmann MJ.

Mediators Inflamm. 2016;2016:3481371. doi: 10.1155/2016/3481371. Epub 2016 Aug 14. Review.


The Effect of Oxygen on Bile Resistance in Listeria monocytogenes.

Wright ML, Pendarvis K, Nanduri B, Edelmann MJ, Jenkins HN, Reddy JS, Wilson JG, Ding X, Broadway PR, Ammari MG, Paul O, Roberts B, Donaldson JR.

J Proteomics Bioinform. 2016 Apr;9(4):107-119. Epub 2016 Apr 5.


Analysis of differentially expressed proteins in Yersinia enterocolitica-infected HeLa cells.

Alugubelly N, Hercik K, Kibler P, Nanduri B, Edelmann MJ.

Biochim Biophys Acta. 2016 May;1864(5):562-9. doi: 10.1016/j.bbapap.2016.02.004. Epub 2016 Feb 5.


Correction: Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.

Kummari E, Alugubelly N, Hsu CY, Dong B, Nanduri B, Edelmann MJ.

PLoS One. 2015 Sep 15;10(9):e0138635. doi: 10.1371/journal.pone.0138635. eCollection 2015. No abstract available.


Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.

Kummari E, Alugubelly N, Hsu CY, Dong B, Nanduri B, Edelmann MJ.

PLoS One. 2015 Aug 12;10(8):e0135531. doi: 10.1371/journal.pone.0135531. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138635.


Ubiquitination as an efficient molecular strategy employed in salmonella infection.

Narayanan LA, Edelmann MJ.

Front Immunol. 2014 Nov 25;5:558. doi: 10.3389/fimmu.2014.00558. eCollection 2014. Review.


SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles.

Edelmann MJ, Shack LA, Naske CD, Walters KB, Nanduri B.

PLoS One. 2014 Dec 3;9(12):e114390. doi: 10.1371/journal.pone.0114390. eCollection 2014.


Global analysis of lysine acetylation suggests the involvement of protein acetylation in diverse biological processes in rice (Oryza sativa).

Nallamilli BR, Edelmann MJ, Zhong X, Tan F, Mujahid H, Zhang J, Nanduri B, Peng Z.

PLoS One. 2014 Feb 20;9(2):e89283. doi: 10.1371/journal.pone.0089283. eCollection 2014.


Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.

Glinka T, Alter J, Braunstein I, Tzach L, Wei Sheng C, Geifman S, Edelmann MJ, Kessler BM, Stanhill A.

Biochem J. 2014 Jan 15;457(2):253-61. doi: 10.1042/BJ20130710.


Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes.

Hipp MM, Shepherd D, Gileadi U, Aichinger MC, Kessler BM, Edelmann MJ, Essalmani R, Seidah NG, Reis e Sousa C, Cerundolo V.

Immunity. 2013 Oct 17;39(4):711-21. doi: 10.1016/j.immuni.2013.09.004.


Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme.

Wang R, Borazjani A, Matthews AT, Mangum LC, Edelmann MJ, Ross MK.

Biochemistry. 2013 Oct 29;52(43):7559-74. doi: 10.1021/bi401138s. Epub 2013 Oct 18.


Deubiquitinating enzymes as promising drug targets for infectious diseases.

Nanduri B, Suvarnapunya AE, Venkatesan M, Edelmann MJ.

Curr Pharm Des. 2013;19(18):3234-47. Review.


Strong cation exchange chromatography in analysis of posttranslational modifications: innovations and perspectives.

Edelmann MJ.

J Biomed Biotechnol. 2011;2011:936508. doi: 10.1155/2011/936508. Epub 2011 Nov 17. Review.


Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.

Edelmann MJ, Nicholson B, Kessler BM.

Expert Rev Mol Med. 2011 Nov 17;13:e35. doi: 10.1017/S1462399411002031. Review.


E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.

David Y, Ternette N, Edelmann MJ, Ziv T, Gayer B, Sertchook R, Dadon Y, Kessler BM, Navon A.

J Biol Chem. 2011 Dec 23;286(51):44104-15. doi: 10.1074/jbc.M111.234559. Epub 2011 Sep 30.


Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.

Meisenberg C, Tait PS, Dianova II, Wright K, Edelmann MJ, Ternette N, Tasaki T, Kessler BM, Parsons JL, Kwon YT, Dianov GL.

Nucleic Acids Res. 2012 Jan;40(2):701-11. doi: 10.1093/nar/gkr744. Epub 2011 Sep 20.


Catabolism of 4-hydroxy-2-trans-nonenal by THP1 monocytes/macrophages and inactivation of carboxylesterases by this lipid electrophile.

Borazjani A, Edelmann MJ, Hardin KL, Herring KL, Allen Crow J, Ross MK.

Chem Biol Interact. 2011 Oct 15;194(1):1-12. doi: 10.1016/j.cbi.2011.08.007. Epub 2011 Aug 22.


Dia2 controls transcription by mediating assembly of the RSC complex.

Andress EJ, Holic R, Edelmann MJ, Kessler BM, Yu VP.

PLoS One. 2011;6(6):e21172. doi: 10.1371/journal.pone.0021172. Epub 2011 Jun 20.


PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.

Kessler BM, Edelmann MJ.

Cell Biochem Biophys. 2011 Jun;60(1-2):21-38. doi: 10.1007/s12013-011-9176-6. Review.


USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.

Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL.

Mol Cell. 2011 Mar 4;41(5):609-15. doi: 10.1016/j.molcel.2011.02.016.


Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.

Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ, Ratcliffe PJ.

J Biol Chem. 2011 Apr 15;286(15):13041-51. doi: 10.1074/jbc.M110.211110. Epub 2011 Feb 18.


Tyrosine dephosphorylation is required for Bak activation in apoptosis.

Fox JL, Ismail F, Azad A, Ternette N, Leverrier S, Edelmann MJ, Kessler BM, Leigh IM, Jackson S, Storey A.

EMBO J. 2010 Nov 17;29(22):3853-68. doi: 10.1038/emboj.2010.244. Epub 2010 Oct 19.


Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.

Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B.

J Biol Chem. 2010 Dec 17;285(51):39597-608. doi: 10.1074/jbc.M110.129718. Epub 2010 Oct 12.


Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.

Edelmann MJ, Kramer HB, Altun M, Kessler BM.

FEBS J. 2010 Jun;277(11):2515-30. doi: 10.1111/j.1742-4658.2010.07665.x.


Cks1 activates transcription by binding to the ubiquitylated proteasome.

Holic R, Kukalev A, Lane S, Andress EJ, Lau I, Yu CW, Edelmann MJ, Kessler BM, Yu VP.

Mol Cell Biol. 2010 Aug;30(15):3894-901. doi: 10.1128/MCB.00655-09. Epub 2010 Jun 1.


Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM.

Mol Cell. 2010 Mar 12;37(5):607-19. doi: 10.1016/j.molcel.2010.01.035.


Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.

Parsons JL, Tait PS, Finch D, Dianova II, Edelmann MJ, Khoronenkova SV, Kessler BM, Sharma RA, McKenna WG, Dianov GL.

EMBO J. 2009 Oct 21;28(20):3207-15. doi: 10.1038/emboj.2009.243. Epub 2009 Aug 27.


Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake.

Ahmed M, Neville MJ, Edelmann MJ, Kessler BM, Karpe F.

Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.


Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.

Sobott F, Watt SJ, Smith J, Edelmann MJ, Kramer HB, Kessler BM.

J Am Soc Mass Spectrom. 2009 Sep;20(9):1652-9. doi: 10.1016/j.jasms.2009.04.023. Epub 2009 May 18.


Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.

Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ.

Angew Chem Int Ed Engl. 2008;47(48):9322-5. doi: 10.1002/anie.200803906. No abstract available.


Structural basis and specificity of human otubain 1-mediated deubiquitination.

Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM.

Biochem J. 2009 Mar 1;418(2):379-90. doi: 10.1042/BJ20081318.


Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells.

Emaduddin M, Edelmann MJ, Kessler BM, Feller SM.

Cell Commun Signal. 2008 Oct 9;6:7. doi: 10.1186/1478-811X-6-7.


Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles.

Edelmann MJ, Kessler BM.

Biochim Biophys Acta. 2008 Dec;1782(12):809-16. doi: 10.1016/j.bbadis.2008.08.010. Epub 2008 Sep 10. Review.


Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach.

Xu D, Suenaga N, Edelmann MJ, Fridman R, Muschel RJ, Kessler BM.

Mol Cell Proteomics. 2008 Nov;7(11):2215-28. doi: 10.1074/mcp.M800095-MCP200. Epub 2008 Jul 2.

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