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Items: 28


Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.

Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR.

Gastroenterology. 2019 Nov;157(5):1323-1337. doi: 10.1053/j.gastro.2019.07.058. Epub 2019 Aug 8.


Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine.

Jia L, Edelblum KL.

J Vis Exp. 2019 Jun 24;(148). doi: 10.3791/59853.


Intestinal Epithelial Interference in Cryptospordium Infection: Type III Interferon Confers Protection Against Protozoan Parasites.

Edelblum KL.

Cell Mol Gastroenterol Hepatol. 2019;8(1):149-150. doi: 10.1016/j.jcmgh.2019.04.003. Epub 2019 Apr 25. No abstract available.


Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability.

Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR.

J Clin Invest. 2019 Feb 1;129(2):902-914. doi: 10.1172/JCI98554. Epub 2019 Jan 22.


B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.

Chen F, Wu W, Jin L, Millman A, Palma M, El-Naccache DW, Lothstein KE, Dong C, Edelblum KL, Gause WC.

Cell Rep. 2018 Dec 4;25(10):2775-2783.e3. doi: 10.1016/j.celrep.2018.11.038.


Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.

Hu MD, Ethridge AD, Lipstein R, Kumar S, Wang Y, Jabri B, Turner JR, Edelblum KL.

J Immunol. 2018 Jul 15;201(2):747-756. doi: 10.4049/jimmunol.1701603. Epub 2018 Jun 8.


Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.

Hu MD, Jia L, Edelblum KL.

Curr Pathobiol Rep. 2018 Mar;6(1):35-46. Epub 2018 Jan 15.


Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.

Pearce SC, Al-Jawadi A, Kishida K, Yu S, Hu M, Fritzky LF, Edelblum KL, Gao N, Ferraris RP.

BMC Biol. 2018 Feb 1;16(1):19. doi: 10.1186/s12915-018-0481-z.


Sentinels at the frontline: the role of intraepithelial lymphocytes in inflammatory bowel disease.

Hu MD, Edelblum KL.

Curr Pharmacol Rep. 2017 Dec;3(6):321-334. doi: 10.1007/s40495-017-0105-2. Epub 2017 Aug 22.


Location Matters in Defining T Cell-mediated Immunity in Response to Salmonella Typhi Vaccination.

Edelblum KL.

Cell Mol Gastroenterol Hepatol. 2017 Sep 18;4(3):439-440. doi: 10.1016/j.jcmgh.2017.09.003. eCollection 2017 Nov. No abstract available.


The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability.

Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR.

Cell Mol Gastroenterol Hepatol. 2017 Jun 10;4(2):285-297. doi: 10.1016/j.jcmgh.2017.06.001. eCollection 2017 Sep.


Dissecting the Requirement for Secondary Lymphoid Organs in Peripheral Regulatory T-Cell Development.

Edelblum KL.

Cell Mol Gastroenterol Hepatol. 2016 Mar 19;2(3):253-254. doi: 10.1016/j.jcmgh.2016.02.004. eCollection 2016 May. No abstract available.


γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice.

Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR.

Gastroenterology. 2015 Jun;148(7):1417-26. doi: 10.1053/j.gastro.2015.02.053. Epub 2015 Mar 4.


Calamari and science: dinner on the marina with a Nobel laureate.

Edelblum KL, Bradley J, Banek C.

Physiologist. 2014 Sep;57(5):206. No abstract available.


Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease.

Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR.

Sci Transl Med. 2014 Jul 2;6(243):243ra87. doi: 10.1126/scitranslmed.3008941.


Young Investigator Perspectives. Networking and service through professional societies.

Edelblum KL.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G359-60. doi: 10.1152/ajpgi.00448.2013. Epub 2013 Dec 31. No abstract available.


Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig.

Chen J, Yin H, Xu J, Wang Q, Edelblum KL, Sciammas R, Chong AS.

Am J Transplant. 2013 Sep;13(9):2280-92. doi: 10.1111/ajt.12350. Epub 2013 Jul 15.


Dynamic migration of γδ intraepithelial lymphocytes requires occludin.

Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7097-102. doi: 10.1073/pnas.1112519109. Epub 2012 Apr 17.


TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells.

Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G220-9. doi: 10.1152/ajpgi.00383.2010. Epub 2011 May 12.


The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding.

Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ.

Gastroenterology. 2011 Apr;140(4):1208-1218.e1-2. doi: 10.1053/j.gastro.2011.01.004. Epub 2011 Jan 13.


KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.

Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB.

Exp Cell Res. 2011 Feb 15;317(4):452-63. doi: 10.1016/j.yexcr.2010.11.018. Epub 2010 Dec 7.


The tight junction in inflammatory disease: communication breakdown.

Edelblum KL, Turner JR.

Curr Opin Pharmacol. 2009 Dec;9(6):715-20. doi: 10.1016/j.coph.2009.06.022. Epub 2009 Jul 24. Review.


The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF.

Frey MR, Edelblum KL, Mullane MT, Liang D, Polk DB.

Gastroenterology. 2009 Jan;136(1):217-26. doi: 10.1053/j.gastro.2008.09.023. Epub 2008 Sep 25.


TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB.

Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB.

J Biol Chem. 2008 Oct 24;283(43):29485-94. doi: 10.1074/jbc.M801269200. Epub 2008 Aug 18.


Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.

Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB.

Gastroenterology. 2008 Aug;135(2):539-51. doi: 10.1053/j.gastro.2008.04.025. Epub 2008 Apr 30.


Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism.

McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G285-93. doi: 10.1152/ajpgi.00425.2007. Epub 2008 May 8.


p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.

Frey MR, Dise RS, Edelblum KL, Polk DB.

EMBO J. 2006 Dec 13;25(24):5683-92. Epub 2006 Nov 30.


Regulation of apoptosis during homeostasis and disease in the intestinal epithelium.

Edelblum KL, Yan F, Yamaoka T, Polk DB.

Inflamm Bowel Dis. 2006 May;12(5):413-24. Review.


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