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Items: 1 to 50 of 89

1.

Multifunctional Alleles: A novel method for the generation of "All-In-One" null and conditional alleles.

Pefanis E, Schoenherr C, Persaud T, Zhang Y, Golubov J, Wang B, Skokos D, Zambrowicz B, Murphy AJ, Economides AN.

Methods. 2019 Apr 27. pii: S1046-2023(18)30365-7. doi: 10.1016/j.ymeth.2019.04.013. [Epub ahead of print]

2.

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression.

Sebastian A, Chang JC, Mendez ME, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG.

Int J Mol Sci. 2018 Sep 7;19(9). pii: E2657. doi: 10.3390/ijms19092657.

3.

Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury.

Stumm J, Vallecillo-García P, Vom Hofe-Schneider S, Ollitrault D, Schrewe H, Economides AN, Marazzi G, Sassoon DA, Stricker S.

Stem Cell Res. 2018 Oct;32:8-16. doi: 10.1016/j.scr.2018.08.010. Epub 2018 Aug 10.

4.

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

Yu J, Zanotti S, Schilling L, Schoenherr C, Economides AN, Sanjay A, Canalis E.

Am J Pathol. 2018 Jun;188(6):1430-1446. doi: 10.1016/j.ajpath.2018.02.010. Epub 2018 Mar 12.

5.

Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization.

Malik Z, Alexiou M, Hallgrimsson B, Economides AN, Luder HU, Graf D.

J Dent Res. 2018 Jul;97(7):835-843. doi: 10.1177/0022034518758044. Epub 2018 Feb 28.

PMID:
29489425
6.

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.

Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG.

J Bone Miner Res. 2018 Jun;33(6):1105-1113. doi: 10.1002/jbmr.3397. Epub 2018 Apr 2.

7.

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

Souma T, Thomson BR, Heinen S, Carota IA, Yamaguchi S, Onay T, Liu P, Ghosh AK, Li C, Eremina V, Hong YK, Economides AN, Vestweber D, Peters KG, Jin J, Quaggin SE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1298-1303. doi: 10.1073/pnas.1714446115. Epub 2018 Jan 22.

8.

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

Sebastian A, Hum NR, Murugesh DK, Hatsell S, Economides AN, Loots GG.

PLoS One. 2017 Nov 27;12(11):e0188264. doi: 10.1371/journal.pone.0188264. eCollection 2017.

9.

MAPPIN: a method for annotating, predicting pathogenicity and mode of inheritance for nonsynonymous variants.

Gosalia N, Economides AN, Dewey FE, Balasubramanian S.

Nucleic Acids Res. 2017 Oct 13;45(18):10393-10402. doi: 10.1093/nar/gkx730.

10.

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent.

Upadhyay J, Xie L, Huang L, Das N, Stewart RC, Lyon MC, Palmer K, Rajamani S, Graul C, Lobo M, Wellman TJ, Soares EJ, Silva MD, Hesterman J, Wang L, Wen X, Qian X, Nannuru K, Idone V, Murphy AJ, Economides AN, Hatsell SJ.

J Bone Miner Res. 2017 Dec;32(12):2489-2499. doi: 10.1002/jbmr.3235. Epub 2017 Sep 22.

11.

The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.

Alessi Wolken DM, Idone V, Hatsell SJ, Yu PB, Economides AN.

Bone. 2018 Apr;109:210-217. doi: 10.1016/j.bone.2017.06.011. Epub 2017 Jun 16. Review.

12.

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome.

Zanotti S, Yu J, Sanjay A, Schilling L, Schoenherr C, Economides AN, Canalis E.

J Biol Chem. 2017 Jul 21;292(29):12232-12244. doi: 10.1074/jbc.M117.786129. Epub 2017 Jun 7.

13.

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB.

Sci Transl Med. 2016 Nov 23;8(366):366ra163.

14.

Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.

Collette NM, Yee CS, Hum NR, Murugesh DK, Christiansen BA, Xie L, Economides AN, Manilay JO, Robling AG, Loots GG.

Bone. 2016 Jul;88:20-30. doi: 10.1016/j.bone.2016.04.005. Epub 2016 Apr 19.

15.

Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.

Chang JC, Sebastian A, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG.

J Orthop Res. 2017 Mar;35(3):474-485. doi: 10.1002/jor.23263. Epub 2016 May 10.

16.

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.

Chakkalakal SA, Uchibe K, Convente MR, Zhang D, Economides AN, Kaplan FS, Pacifici M, Iwamoto M, Shore EM.

J Bone Miner Res. 2016 Sep;31(9):1666-75. doi: 10.1002/jbmr.2820. Epub 2016 Mar 12.

17.

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis.

Takaori K, Nakamura J, Yamamoto S, Nakata H, Sato Y, Takase M, Nameta M, Yamamoto T, Economides AN, Kohno K, Haga H, Sharma K, Yanagita M.

J Am Soc Nephrol. 2016 Aug;27(8):2393-406. doi: 10.1681/ASN.2015060647. Epub 2015 Dec 23.

18.

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.

Katsifa A, Kaffe E, Nikolaidou-Katsaridou N, Economides AN, Newbigging S, McKerlie C, Aidinis V.

PLoS One. 2015 Nov 16;10(11):e0143083. doi: 10.1371/journal.pone.0143083. eCollection 2015.

19.

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, Schoenherr CJ, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides AN.

Sci Transl Med. 2015 Sep 2;7(303):303ra137. doi: 10.1126/scitranslmed.aac4358.

20.

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

Pefanis E, Wang J, Rothschild G, Lim J, Kazadi D, Sun J, Federation A, Chao J, Elliott O, Liu ZP, Economides AN, Bradner JE, Rabadan R, Basu U.

Cell. 2015 May 7;161(4):774-89. doi: 10.1016/j.cell.2015.04.034.

21.

Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.

Yee CS, Xie L, Hatsell S, Hum N, Murugesh D, Economides AN, Loots GG, Collette NM.

Bone. 2016 Jan;82:122-34. doi: 10.1016/j.bone.2015.04.048. Epub 2015 May 5.

22.

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age.

Abula K, Muneta T, Miyatake K, Yamada J, Matsukura Y, Inoue M, Sekiya I, Graf D, Economides AN, Rosen V, Tsuji K.

FEBS Lett. 2015 May 8;589(11):1240-8. doi: 10.1016/j.febslet.2015.04.004. Epub 2015 Apr 15.

23.

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.

Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ.

FASEB J. 2015 Jul;29(7):2702-11. doi: 10.1096/fj.14-265496. Epub 2015 Mar 10.

24.

microTSS: accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs.

Georgakilas G, Vlachos IS, Paraskevopoulou MD, Yang P, Zhang Y, Economides AN, Hatzigeorgiou AG.

Nat Commun. 2014 Dec 10;5:5700. doi: 10.1038/ncomms6700.

PMID:
25492647
25.

Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development.

Mandalos N, Rhinn M, Granchi Z, Karampelas I, Mitsiadis T, Economides AN, Dollé P, Remboutsika E.

Front Physiol. 2014 Sep 12;5:345. doi: 10.3389/fphys.2014.00345. eCollection 2014.

26.

A lymphatic defect causes ocular hypertension and glaucoma in mice.

Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE.

J Clin Invest. 2014 Oct;124(10):4320-4. doi: 10.1172/JCI77162. Epub 2014 Sep 9.

27.

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts.

Krevvata M, Silva BC, Manavalan JS, Galan-Diez M, Kode A, Matthews BG, Park D, Zhang CA, Galili N, Nickolas TL, Dempster DW, Dougall W, Teruya-Feldstein J, Economides AN, Kalajzic I, Raza A, Berman E, Mukherjee S, Bhagat G, Kousteni S.

Blood. 2014 Oct 30;124(18):2834-46. doi: 10.1182/blood-2013-07-517219. Epub 2014 Aug 18.

28.

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.

Pefanis E, Wang J, Rothschild G, Lim J, Chao J, Rabadan R, Economides AN, Basu U.

Nature. 2014 Oct 16;514(7522):389-93. doi: 10.1038/nature13580. Epub 2014 Aug 6.

29.

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.

Kiso H, Takahashi K, Saito K, Togo Y, Tsukamoto H, Huang B, Sugai M, Shimizu A, Tabata Y, Economides AN, Slavkin HC, Bessho K.

PLoS One. 2014 May 9;9(5):e96938. doi: 10.1371/journal.pone.0096938. eCollection 2014.

30.

Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.

Yamada S, Nakamura J, Asada M, Takase M, Matsusaka T, Iguchi T, Yamada R, Tanaka M, Higashi AY, Okuda T, Asada N, Fukatsu A, Kawachi H, Graf D, Muso E, Kita T, Kimura T, Pastan I, Economides AN, Yanagita M.

PLoS One. 2014 Feb 25;9(2):e89135. doi: 10.1371/journal.pone.0089135. eCollection 2014.

31.

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG.

Dev Biol. 2013 Nov 1;383(1):90-105. doi: 10.1016/j.ydbio.2013.08.015. Epub 2013 Aug 29.

32.

Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth.

Tomita M, Asada M, Asada N, Nakamura J, Oguchi A, Higashi AY, Endo S, Robertson E, Kimura T, Kita T, Economides AN, Kreidberg J, Yanagita M.

PLoS One. 2013 Aug 26;8(8):e73554. doi: 10.1371/journal.pone.0073554. eCollection 2013.

33.

Conditionals by inversion provide a universal method for the generation of conditional alleles.

Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W, Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L, Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA, Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ, Yancopoulos GD.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88. doi: 10.1073/pnas.1217812110. Epub 2013 Aug 5.

34.

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA.

Cell Stem Cell. 2013 Jun 6;12(6):787-99. doi: 10.1016/j.stem.2013.04.014.

35.

Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

Mandalos N, Saridaki M, Harper JL, Kotsoni A, Yang P, Economides AN, Remboutsika E.

PLoS One. 2012;7(9):e45768. doi: 10.1371/journal.pone.0045768. Epub 2012 Sep 27.

36.

Targeted deletion of Sost distal enhancer increases bone formation and bone mass.

Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14092-7. doi: 10.1073/pnas.1207188109. Epub 2012 Aug 10.

37.

Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function.

Henley KD, Gooding KA, Economides AN, Gannon M.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E752-61. doi: 10.1152/ajpendo.00531.2011. Epub 2012 Jul 24.

38.

Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF.

Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA.

Gene Ther. 2012 May;19(5):483-93. doi: 10.1038/gt.2011.114. Epub 2011 Sep 15. Erratum in: Gene Ther. 2012 May;19(5):582.

39.

Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells.

Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15242-7. doi: 10.1073/pnas.1100072108. Epub 2011 Aug 29.

40.

Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice.

Myers M, Tripurani SK, Middlebrook B, Economides AN, Canalis E, Pangas SA.

Biol Reprod. 2011 Dec;85(6):1175-82. doi: 10.1095/biolreprod.111.091728. Epub 2011 Aug 10.

41.

Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism.

Yoshikawa Y, Kode A, Xu L, Mosialou I, Silva BC, Ferron M, Clemens TL, Economides AN, Kousteni S.

J Bone Miner Res. 2011 Sep;26(9):2012-25. doi: 10.1002/jbmr.417.

42.

Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.

Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y.

Dev Cell. 2011 Feb 15;20(2):163-76. doi: 10.1016/j.devcel.2011.01.001.

43.

Cooperative activity of noggin and gremlin 1 in axial skeleton development.

Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM.

Development. 2011 Mar;138(5):1005-14. doi: 10.1242/dev.051938.

44.

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12. doi: 10.1073/pnas.1019761108. Epub 2011 Jan 31.

45.

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

Grumolato L, Liu G, Mong P, Mudbhary R, Biswas R, Arroyave R, Vijayakumar S, Economides AN, Aaronson SA.

Genes Dev. 2010 Nov 15;24(22):2517-30. doi: 10.1101/gad.1957710.

46.

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.

Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Löwik CW, ten Dijke P.

J Biol Chem. 2010 Dec 31;285(53):41614-26. doi: 10.1074/jbc.M110.153890. Epub 2010 Oct 15.

47.

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region.

Witte F, Chan D, Economides AN, Mundlos S, Stricker S.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14211-6. doi: 10.1073/pnas.1009314107. Epub 2010 Jul 26.

48.

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice.

Canalis E, Zanotti S, Beamer WG, Economides AN, Smerdel-Ramoya A.

Endocrinology. 2010 Aug;151(8):3490-501. doi: 10.1210/en.2010-0145. Epub 2010 Jun 9.

49.

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M.

J Clin Invest. 2010 Mar;120(3):768-77. doi: 10.1172/JCI39569. Epub 2010 Feb 8.

50.

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis.

Canalis E, Smerdel-Ramoya A, Durant D, Economides AN, Beamer WG, Zanotti S.

Endocrinology. 2010 Jan;151(1):221-33. doi: 10.1210/en.2009-0574. Epub 2009 Nov 24.

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