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INtervention for Cognitive Reserve Enhancement in delaying the onset of Alzheimer's Symptomatic Expression (INCREASE), a randomized controlled trial: rationale, study design, and protocol.

Moga DC, Beech BF, Abner EL, Schmitt FA, El Khouli RH, Martinez AI, Eckmann L, Huffmyer M, George R, Jicha GA.

Trials. 2019 Dec 30;20(1):806. doi: 10.1186/s13063-019-3993-0.


Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases.

Solaymani-Mohammadi S, Eckmann L, Singer SM.

Front Cell Infect Microbiol. 2019 Dec 4;9:401. doi: 10.3389/fcimb.2019.00401. eCollection 2019. Review.


Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.

Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B.

Nature. 2019 Nov;575(7783):505-511. doi: 10.1038/s41586-019-1742-x. Epub 2019 Nov 13.


β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells.

Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH.

Cell Mol Gastroenterol Hepatol. 2019 Nov 9. pii: S2352-345X(19)30148-1. doi: 10.1016/j.jcmgh.2019.10.012. [Epub ahead of print]


20S Proteasome as a Drug Target in Trichomonas vaginalis.

O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L.

Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e00448-19. doi: 10.1128/AAC.00448-19. Print 2019 Nov.


Evaluation of Peroxides and Chlorine Oxides as Disinfectants for Chemical Sterilization of Gnotobiotic Rodent Isolators.

Moody LV, Miyamoto Y, Ang J, Richter PJ, Eckmann L.

J Am Assoc Lab Anim Sci. 2019 Sep 1;58(5):558-568. doi: 10.30802/AALAS-JAALAS-18-000130. Epub 2019 Jul 18.


Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases?

Dulai PS, Singh S, Vande Casteele N, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ.

Clin Gastroenterol Hepatol. 2019 Dec;17(13):2634-2643. doi: 10.1016/j.cgh.2019.04.040. Epub 2019 Apr 19. Review.


Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia.

Davids BJ, Liu CM, Hanson EM, Le CHY, Ang J, Hanevik K, Fischer M, Radunovic M, Langeland N, Ferella M, Svärd SG, Ghassemian M, Miyamoto Y, Eckmann L.

Infect Immun. 2019 May 21;87(6). pii: e00219-19. doi: 10.1128/IAI.00219-19. Print 2019 Jun.


Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut.

Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V.

Front Immunol. 2018 Sep 11;9:2082. doi: 10.3389/fimmu.2018.02082. eCollection 2018. Review.


Validation of Babesia proteasome as a drug target.

Jalovecka M, Hartmann D, Miyamoto Y, Eckmann L, Hajdusek O, O'Donoghue AJ, Sojka D.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):394-402. doi: 10.1016/j.ijpddr.2018.08.001. Epub 2018 Aug 7.


Patient awareness, willingness, and barriers to point-of-care hepatitis C screening in community pharmacy.

Brewer A, Hanna C, Eckmann L, Schadler A, Divine H.

J Am Pharm Assoc (2003). 2018 Jul - Aug;58(4S):S69-S72.e1. doi: 10.1016/j.japh.2018.04.031.


Giardia Infection of the Small Intestine Induces Chronic Colitis in Genetically Susceptible Hosts.

Dann SM, Le CHY, Hanson EM, Ross MC, Eckmann L.

J Immunol. 2018 Jul 15;201(2):548-559. doi: 10.4049/jimmunol.1700824. Epub 2018 Jun 13.


Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease.

Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J.

Inflamm Bowel Dis. 2018 Oct 12;24(11):2366-2376. doi: 10.1093/ibd/izy214.


Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera.

Das S, Angsantikul P, Le C, Bao D, Miyamoto Y, Gao W, Zhang L, Eckmann L.

PLoS Negl Trop Dis. 2018 Feb 22;12(2):e0006266. doi: 10.1371/journal.pntd.0006266. eCollection 2018 Feb.


Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study.

Westera L, van Viegen T, Jeyarajah J, Azad A, Bilsborough J, van den Brink GR, Cremer J, Danese S, D'Haens G, Eckmann L, Faubion W, Filice M, Korf H, McGovern D, Panes J, Salas A, Sandborn WJ, Silverberg MS, Smith MI, Vermeire S, Vetrano S, Shackelton LM, Stitt L, Jairath V, Levesque BG, Spencer DM, Feagan BG, Vande Casteele N.

Clin Transl Gastroenterol. 2017 Nov 2;8(11):e126. doi: 10.1038/ctg.2017.52.


ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection.

Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S.

J Infect Dis. 2017 Dec 19;216(12):1655-1666. doi: 10.1093/infdis/jix528.


Quality of Life and Medication Adherence of Independently Living Older Adults Enrolled in a Pharmacist-Based Medication Management Program.

Harlow C, Hanna C, Eckmann L, Gokun Y, Zanjani F, Blumenschein K, Divine H.

Pharmacy (Basel). 2017 Apr 6;5(2). pii: E20. doi: 10.3390/pharmacy5020020.


Therapy for Clostridium difficile infection - any news beyond Metronidazole and Vancomycin?

Manthey CF, Eckmann L, Fuhrmann V.

Expert Rev Clin Pharmacol. 2017 Nov;10(11):1239-1250. doi: 10.1080/17512433.2017.1362978. Epub 2017 Aug 11. Review.


Optimizing medication appropriateness in older adults: a randomized clinical interventional trial to decrease anticholinergic burden.

Moga DC, Abner EL, Rigsby DN, Eckmann L, Huffmyer M, Murphy RR, Coy BB, Jicha GA.

Alzheimers Res Ther. 2017 May 23;9(1):36. doi: 10.1186/s13195-017-0263-9.


Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.

Kim WJ, Korthals KA, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02397-16. doi: 10.1128/AAC.02397-16. Print 2017 Jun.


Gut-liver axis at the frontier of host-microbial interactions.

Brandl K, Kumar V, Eckmann L.

Am J Physiol Gastrointest Liver Physiol. 2017 May 1;312(5):G413-G419. doi: 10.1152/ajpgi.00361.2016. Epub 2017 Feb 23. Review.


Visualizing the enteric nervous system using genetically engineered double reporter mice: Comparison with immunofluorescence.

Jiang Y, Dong H, Eckmann L, Hanson EM, Ihn KC, Mittal RK.

PLoS One. 2017 Feb 3;12(2):e0171239. doi: 10.1371/journal.pone.0171239. eCollection 2017.


Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo.

Hopper M, Yun JF, Zhou B, Le C, Kehoe K, Le R, Hill R, Jongeward G, Debnath A, Zhang L, Miyamoto Y, Eckmann L, Land KM, Wrischnik LA.

Int J Antimicrob Agents. 2016 Dec;48(6):690-694. doi: 10.1016/j.ijantimicag.2016.09.020. Epub 2016 Nov 2.


Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis.

Babaei Z, Malihi N, Zia-Ali N, Sharifi I, Mohammadi MA, Kagnoff MF, Eckmann L, Singer SM, Solaymani-Mohammadi S.

Microbes Infect. 2016 Nov;18(11):687-695. doi: 10.1016/j.micinf.2016.06.009. Epub 2016 Jul 8.


Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes.

Wang Z, Mascarenhas N, Eckmann L, Miyamoto Y, Sun X, Kawakami T, Di Nardo A.

J Allergy Clin Immunol. 2017 Apr;139(4):1205-1216.e6. doi: 10.1016/j.jaci.2016.09.019. Epub 2016 Oct 14.


TLR3 signaling is downregulated by a MAVS isoform in epithelial cells.

Lakhdari O, McAllister CS, Wang M, Minev I, Prince LS, Eckmann L, Kagnoff MF.

Cell Immunol. 2016 Dec;310:205-210. doi: 10.1016/j.cellimm.2016.08.010. Epub 2016 Aug 24.


Microbiota and Alcoholic Liver Disease.

Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B.

Alcohol Clin Exp Res. 2016 Aug;40(8):1791-2. doi: 10.1111/acer.13129. Epub 2016 Jul 1. No abstract available.


A Bioadhesive Nanoparticle-Hydrogel Hybrid System for Localized Antimicrobial Drug Delivery.

Zhang Y, Zhang J, Chen M, Gong H, Thamphiwatana S, Eckmann L, Gao W, Zhang L.

ACS Appl Mater Interfaces. 2016 Jul 20;8(28):18367-74. doi: 10.1021/acsami.6b04858. Epub 2016 Jul 11.


Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis.

Jarrad AM, Debnath A, Miyamoto Y, Hansford KA, Pelingon R, Butler MS, Bains T, Karoli T, Blaskovich MA, Eckmann L, Cooper MA.

Eur J Med Chem. 2016 Sep 14;120:353-62. doi: 10.1016/j.ejmech.2016.04.064. Epub 2016 Apr 27.


ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome.

Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB.

Cell Mol Gastroenterol Hepatol. 2015 Apr 1;1(3):311-324.


Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids.

Rouch JD, Scott A, Lei NY, Solorzano-Vargas RS, Wang J, Hanson EM, Kobayashi M, Lewis M, Stelzner MG, Dunn JC, Eckmann L, Martín MG.

PLoS One. 2016 Jan 28;11(1):e0148216. doi: 10.1371/journal.pone.0148216. eCollection 2016.


Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia.

den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE.

PLoS Pathog. 2016 Jan 13;12(1):e1005382. doi: 10.1371/journal.ppat.1005382. eCollection 2016 Jan.


Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia.

Miyamoto Y, Eckmann L.

Front Microbiol. 2015 Nov 19;6:1208. doi: 10.3389/fmicb.2015.01208. eCollection 2015. Review.


Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury.

Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B.

Alcohol Clin Exp Res. 2015 Dec;39(12):2313-23. doi: 10.1111/acer.12900. Epub 2015 Nov 11.


Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer.

Bauer J, Ozden O, Akagi N, Carroll T, Principe DR, Staudacher JJ, Spehlmann ME, Eckmann L, Grippo PJ, Jung B.

Mol Cancer. 2015 Oct 24;14:182. doi: 10.1186/s12943-015-0456-4.


Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules.

Solaymani-Mohammadi S, Lakhdari O, Minev I, Shenouda S, Frey BF, Billeskov R, Singer SM, Berzofsky JA, Eckmann L, Kagnoff MF.

J Leukoc Biol. 2016 Mar;99(3):475-82. doi: 10.1189/jlb.4A0115-003RR. Epub 2015 Oct 14.


Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis.

Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS.

J Clin Invest. 2015 Sep;125(9):3606-18. doi: 10.1172/JCI81423. Epub 2015 Aug 17.


Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites.

Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA.

Eur J Med Chem. 2015 Aug 28;101:96-102. doi: 10.1016/j.ejmech.2015.06.019. Epub 2015 Jun 18.


IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia.

Dann SM, Manthey CF, Le C, Miyamoto Y, Gima L, Abrahim A, Cao AT, Hanson EM, Kolls JK, Raz E, Cong Y, Eckmann L.

Exp Parasitol. 2015 Sep;156:68-78. doi: 10.1016/j.exppara.2015.06.003. Epub 2015 Jun 9.


IgG "detoxes" the intestinal mucosa.

Eckmann L, Stappenbeck TS.

Cell Host Microbe. 2015 May 13;17(5):538-9. doi: 10.1016/j.chom.2015.05.001.


Martin F. Kagnoff, MD: 1941-2014.

Barrett KE, Eckmann L, Carethers JM.

Mucosal Immunol. 2015 May;8(3):441-3. doi: 10.1038/mi.2015.8. No abstract available.


Martin F. Kagnoff, MD, January 19, 1941--November 16, 2014.

Eckmann L, Barrett KE, Carethers JM.

Gastroenterology. 2015 Mar;148(3):457-8. doi: 10.1053/j.gastro.2015.01.028. Epub 2015 Jan 22. No abstract available.


Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT.

Inflamm Bowel Dis. 2015 Feb;21(2):323-30. doi: 10.1097/MIB.0000000000000264.


Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice.

Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B.

FASEB J. 2015 Mar;29(3):1043-55. doi: 10.1096/fj.14-259515. Epub 2014 Dec 2.


Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.

de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E.

J Clin Invest. 2014 Sep;124(9):3793-806. doi: 10.1172/JCI72340. Epub 2014 Aug 1.


Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT.

Aliment Pharmacol Ther. 2014 Sep;40(5):477-85. doi: 10.1111/apt.12862. Epub 2014 Jul 13.


Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions.

Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang JY, Eckmann L.

Am J Physiol Cell Physiol. 2014 Jul 15;307(2):C180-9. doi: 10.1152/ajpcell.00013.2014. Epub 2014 May 21.


Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.

Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH.

Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12.


Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice.

Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ.

Inflamm Bowel Dis. 2014 Apr;20(4):712-22. doi: 10.1097/MIB.0000000000000010.


Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium.

Dann SM, Le C, Choudhury BK, Liu H, Saldarriaga O, Hanson EM, Cong Y, Eckmann L.

Infect Immun. 2014 May;82(5):1949-58. doi: 10.1128/IAI.00066-14. Epub 2014 Feb 24.

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