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Prophylaxis of mitochondrial dysfunction caused by cellular decompression from hyperbaric exposure.

Ranganathan A, Owiredu S, Jang DH, Eckmann DM.

Mitochondrion. 2020 Feb 8;52:8-19. doi: 10.1016/j.mito.2020.02.002. [Epub ahead of print]


Nanoparticle transport phenomena in confined flows.

Radhakrishnan R, Farokhirad S, Eckmann DM, Ayyaswamy PS.

Adv Heat Transf. 2019;51:55-129. doi: 10.1016/bs.aiht.2019.08.002. Epub 2019 Oct 4.


Cross-linker-Modulated Nanogel Flexibility Correlates with Tunable Targeting to a Sterically Impeded Endothelial Marker.

Myerson JW, McPherson O, DeFrates KG, Towslee JH, Marcos-Contreras OA, Shuvaev VV, Braender B, Composto RJ, Muzykantov VR, Eckmann DM.

ACS Nano. 2019 Oct 22;13(10):11409-11421. doi: 10.1021/acsnano.9b04789. Epub 2019 Oct 10.


Nanofluid Dynamics of Flexible Polymeric Nanoparticles Under Wall Confinement.

Farokhirad S, Ramakrishnan N, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

J Heat Transfer. 2019 May;141(5):0524011-524016. doi: 10.1115/1.4043014. Epub 2019 Mar 27.


Stiffness can mediate balance between hydrodynamic forces and avidity to impact the targeting of flexible polymeric nanoparticles in flow.

Farokhirad S, Ranganathan A, Myerson J, Muzykantov VR, Ayyaswamy PS, Eckmann DM, Radhakrishnan R.

Nanoscale. 2019 Apr 4;11(14):6916-6928. doi: 10.1039/c8nr09594a.


Rheology of colloidal suspensions in confined flow: Treatment of hydrodynamic interactions in particle-based simulations inspired by dynamical density functional theory.

Jabeen Z, Yu HY, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

Phys Rev E. 2018 Oct;98(4). pii: 042602. doi: 10.1103/PhysRevE.98.042602. Epub 2018 Oct 9.


Acute decompression following simulated dive conditions alters mitochondrial respiration and motility.

Jang DH, Owiredu S, Ranganathan A, Eckmann DM.

Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C699-C705. doi: 10.1152/ajpcell.00243.2018. Epub 2018 Aug 15.


Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles.

Myerson JW, Braender B, Mcpherson O, Glassman PM, Kiseleva RY, Shuvaev VV, Marcos-Contreras O, Grady ME, Lee HS, Greineder CF, Stan RV, Composto RJ, Eckmann DM, Muzykantov VR.

Adv Mater. 2018 Aug;30(32):e1802373. doi: 10.1002/adma.201802373. Epub 2018 Jun 28.


Alterations in Mitochondrial Function in Blood Cells Obtained From Patients With Sepsis Presenting to an Emergency Department.

Jang DH, Orloski CJ, Owiredu S, Shofer FS, Greenwood JC, Eckmann DM.

Shock. 2019 May;51(5):580-584. doi: 10.1097/SHK.0000000000001208.


Translational Application of Measuring Mitochondrial Functions in Blood Cells Obtained from Patients with Acute Poisoning.

Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM.

J Med Toxicol. 2018 Jun;14(2):144-151. doi: 10.1007/s13181-018-0656-6. Epub 2018 Mar 13.


Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen.

Jang DH, Khatri UG, Shortal BP, Kelly M, Hardy K, Lambert DS, Eckmann DM.

Intensive Care Med Exp. 2018 Jan 30;6(1):4. doi: 10.1186/s40635-018-0169-2.


Mitochondrial networking in human blood cells with application in acute care illnesses.

Jang DH, Greenwood JC, Owiredu S, Ranganathan A, Eckmann DM.

Mitochondrion. 2019 Jan;44:27-34. doi: 10.1016/j.mito.2017.12.009. Epub 2017 Dec 21.


Excess area dependent scaling behavior of nano-sized membrane tethers.

Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R.

Phys Biol. 2018 Jan 11;15(2):026002. doi: 10.1088/1478-3975/aa9905.


Motion of a nano-spheroid in a cylindrical vessel flow: Brownian and hydrodynamic interactions.

Ramakrishnan N, Wang Y, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

J Fluid Mech. 2017 Jun 25;821:117-152. doi: 10.1017/jfm.2017.182. Epub 2017 May 18.


Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes.

Jang DH, Seeger SC, Grady ME, Shofer FS, Eckmann DM.

Biol Open. 2017 Dec 15;6(12):1831-1839. doi: 10.1242/bio.029009.


Fluorescence Microscopy Imaging Calibration for Quantifying Nanocarrier Binding to Cells During Shear Flow Exposure.

Ranganathan A, Campo J, Myerson J, Shuvaev V, Zern B, Muzykantov V, Eckmann DM.

J Biomed Nanotechnol. 2017 Jun;13(6):737-745. doi: 10.1166/jbn.2017.2392.


Microstructure of Flow-Driven Suspension of Hardspheres in Cylindrical Confinement: A Dynamical Density Functional Theory and Monte Carlo Study.

Yu HY, Jabeen Z, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

Langmuir. 2017 Oct 24;33(42):11332-11344. doi: 10.1021/acs.langmuir.7b01860. Epub 2017 Sep 1.


Mitochondrial DNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics.

Kandel J, Picard M, Wallace DC, Eckmann DM.

J R Soc Interface. 2017 Jun;14(131). pii: 20170071. doi: 10.1098/rsif.2017.0071.


A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells.

Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM.

Clin Toxicol (Phila). 2017 Jul;55(6):579-584. doi: 10.1080/15563650.2017.1288912. Epub 2017 Feb 16.


Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy.

Barel O, Malicdan MCV, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, Ganelin E, Barshack I, Polak-Charcon S, Nass D, Marek-Yagel D, Amariglio N, Shalva N, Vilboux T, Ferreira C, Pode-Shakked B, Heimer G, Hoffmann C, Yardeni T, Nissenkorn A, Avivi C, Eyal E, Kol N, Glick Saar E, Wallace DC, Gahl WA, Rechavi G, Schrader M, Eckmann DM, Anikster Y.

Brain. 2017 Mar 1;140(3):568-581. doi: 10.1093/brain/awx002. Erratum in: Brain. 2018 Apr 1;141(4):e34.


Competitive Adsorption of Polyelectrolytes onto and into Pellicle-Coated Hydroxyapatite Investigated by QCM-D and Force Spectroscopy.

Lee HS, Myers C, Zaidel L, Nalam PC, Caporizzo MA, A Daep C, Eckmann DM, Masters JG, Composto RJ.

ACS Appl Mater Interfaces. 2017 Apr 19;9(15):13079-13091. doi: 10.1021/acsami.7b02774. Epub 2017 Apr 5.


Nanomechanics of pH-Responsive, Drug-Loaded, Bilayered Polymer Grafts.

Nalam PC, Lee HS, Bhatt N, Carpick RW, Eckmann DM, Composto RJ.

ACS Appl Mater Interfaces. 2017 Apr 19;9(15):12936-12948. doi: 10.1021/acsami.6b14116. Epub 2017 Apr 7.


Intracellular nanoparticle dynamics affected by cytoskeletal integrity.

Grady ME, Parrish E, Caporizzo MA, Seeger SC, Composto RJ, Eckmann DM.

Soft Matter. 2017 Mar 1;13(9):1873-1880. doi: 10.1039/c6sm02464e.


Effect of wall-mediated hydrodynamic fluctuations on the kinetics of a Brownian nanoparticle.

Yu HY, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

Proc Math Phys Eng Sci. 2016 Dec;472(2196):20160397. doi: 10.1098/rspa.2016.0397.


Computational Models for Nanoscale Fluid Dynamics and Transport Inspired by Nonequilibrium Thermodynamics.

Radhakrishnan R, Yu HY, Eckmann DM, Ayyaswamy PS.

J Heat Transfer. 2017 Mar;139(3):0330011-330019. doi: 10.1115/1.4035006. Epub 2016 Nov 22.


Nanoparticle stochastic motion in the inertial regime and hydrodynamic interactions close to a cylindrical wall.

Vitoshkin H, Yu HY, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

Phys Rev Fluids. 2016;1. pii: 054104. Epub 2016 Sep 28.


Mitochondrial respiration is sensitive to cytoarchitectural breakdown.

Kandel J, Angelin AA, Wallace DC, Eckmann DM.

Integr Biol (Camb). 2016 Nov 7;8(11):1170-1182.


Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning.

Jang DH, Greenwood JC, Spyres MB, Eckmann DM.

J Intensive Care Med. 2017 Jan;32(1):86-94. Epub 2016 Jul 21.


Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors.

Ramakrishnan N, Tourdot RW, Eckmann DM, Ayyaswamy PS, Muzykantov VR, Radhakrishnan R.

R Soc Open Sci. 2016 Jun 29;3(6):160260. doi: 10.1098/rsos.160260. eCollection 2016 Jun.


Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.

Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA.

Ann Biomed Eng. 2016 Sep;44(9):2642-60. doi: 10.1007/s10439-016-1628-0. Epub 2016 May 2.


Multiscale Modeling in the Clinic: Drug Design and Development.

Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM.

Ann Biomed Eng. 2016 Sep;44(9):2591-610. doi: 10.1007/s10439-016-1563-0. Epub 2016 Feb 17. Review.


Cell elasticity with altered cytoskeletal architectures across multiple cell types.

Grady ME, Composto RJ, Eckmann DM.

J Mech Behav Biomed Mater. 2016 Aug;61:197-207. doi: 10.1016/j.jmbbm.2016.01.022. Epub 2016 Feb 1.


Strain-rate Dependence of Elastic Modulus Reveals Silver Nanoparticle Induced Cytotoxicity.

Caporizzo MA, Roco CM, Ferrer MC, Grady ME, Parrish E, Eckmann DM, Composto RJ.

Nanobiomedicine (Rij). 2015;2. pii: 9. Epub 2015 Sep 2.


Non-affinity factors modulating vascular targeting of nano- and microcarriers.

Myerson JW, Anselmo AC, Liu Y, Mitragotri S, Eckmann DM, Muzykantov VR.

Adv Drug Deliv Rev. 2016 Apr 1;99(Pt A):97-112. doi: 10.1016/j.addr.2015.10.011. Epub 2015 Oct 24. Review.


Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement.

Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR.

ACS Nano. 2015 Jul 28;9(7):6785-93. doi: 10.1021/nn505672x. Epub 2015 Jul 13.


Hydrodynamic interactions of deformable polymeric nanocarriers and the effect of crosslinking.

Sarkar A, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

Soft Matter. 2015 Aug 7;11(29):5955-69. doi: 10.1039/c5sm00669d.


Composite generalized Langevin equation for Brownian motion in different hydrodynamic and adhesion regimes.

Yu HY, Eckmann DM, Ayyaswamy PS, Radhakrishnan R.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 May;91(5):052303. Epub 2015 May 12.


Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR.

J Control Release. 2015 Jul 28;210:39-47. doi: 10.1016/j.jconrel.2015.05.006. Epub 2015 May 9.


Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity.

Kandel J, Chou P, Eckmann DM.

Biotechnol Bioeng. 2015 Jul;112(7):1395-405. doi: 10.1002/bit.25563. Epub 2015 Mar 13.


Targeted release of tobramycin from a pH-responsive grafted bilayer challenged with S. aureus.

Lee HS, Dastgheyb SS, Hickok NJ, Eckmann DM, Composto RJ.

Biomacromolecules. 2015 Feb 9;16(2):650-9. doi: 10.1021/bm501751v. Epub 2015 Jan 27.


Nanogel Carrier Design for Targeted Drug Delivery.

Eckmann DM, Composto RJ, Tsourkas A, Muzykantov VR.

J Mater Chem B. 2014 Dec 14;2(46):8085-8097.


Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation.

Ferrer MC, Shuvaev VV, Zern BJ, Composto RJ, Muzykantov VR, Eckmann DM.

PLoS One. 2014 Jul 14;9(7):e102329. doi: 10.1371/journal.pone.0102329. eCollection 2014.


Modelling of Binding Free Energy of Targeted Nanocarriers to Cell Surface.

Liu J, Ayyaswamy PS, Eckmann DM, Radhakrishnan R.

Heat Mass Transf. 2014 Mar 1;50(3):315-321.


Chemically grafted fibronectin for use in QCM-D cell studies.

Kandel J, Lee HS, Sobolewski P, Tomczyk N, Composto RJ, Eckmann DM 2nd.

Biosens Bioelectron. 2014 Aug 15;58:249-257. doi: 10.1016/j.bios.2014.02.053. Epub 2014 Feb 28.


Gold nanorod linking to control plasmonic properties in solution and polymer nanocomposites.

Ferrier RC Jr, Lee HS, Hore MJ, Caporizzo M, Eckmann DM, Composto RJ.

Langmuir. 2014 Feb 25;30(7):1906-14. doi: 10.1021/la404588w. Epub 2014 Feb 13.


Designing nanogel carriers for antibacterial applications.

Coll Ferrer MC, Dastgheyb S, Hickok NJ, Eckmann DM, Composto RJ.

Acta Biomater. 2014 May;10(5):2105-11. doi: 10.1016/j.actbio.2014.01.009. Epub 2014 Jan 13.


Hemocompatibility of Chitosan/poly(acrylic acid) Grafted Polyurethane Tubing.

Lee HS, Tomczyk N, Kandel J, Composto RJ, Eckmann DM.

J Mater Chem B. 2013 Dec 14;1(46). doi: 10.1039/C3TB21218A.


Photo-activated porphyrin in combination with antibiotics: therapies against Staphylococci.

Dastgheyb SS, Eckmann DM, Composto RJ, Hickok NJ.

J Photochem Photobiol B. 2013 Dec 5;129:27-35. doi: 10.1016/j.jphotobiol.2013.09.006. Epub 2013 Oct 4.


Pefluorocarbon inhibition of bubble induced Ca2+ transients in an in vitro model of vascular gas embolism.

Klinger AL, Kandel J, Pichette B, Eckmann DM.

Exp Biol Med (Maywood). 2014 Jan;239(1):116-22. doi: 10.1177/1535370213506434. Epub 2013 Oct 16.


Hemocompatibility and biocompatibility of antibacterial biomimetic hybrid films.

Coll Ferrer MC, Eckmann UN, Composto RJ, Eckmann DM.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):703-12. doi: 10.1016/j.taap.2013.07.023. Epub 2013 Aug 7.

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