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The Effects of Iron in a Rodent Model of Alzheimer Disease.

Griffin IJ, Eckman CB.

J Nutr. 2019 Dec 1;149(12):2079-2080. doi: 10.1093/jn/nxz208. No abstract available.


Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes.

Pacheco-Quinto J, Clausen D, Pérez-González R, Peng H, Meszaros A, Eckman CB, Levy E, Eckman EA.

FASEB J. 2019 Mar;33(3):3758-3771. doi: 10.1096/fj.201801319R. Epub 2018 Nov 27.


Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.

Pacheco-Quinto J, Eckman CB, Eckman EA.

Neurobiol Aging. 2016 Dec;48:83-92. doi: 10.1016/j.neurobiolaging.2016.08.011. Epub 2016 Aug 20.


Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein.

Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K.

PLoS One. 2014 Mar 21;9(3):e91531. doi: 10.1371/journal.pone.0091531. eCollection 2014.


Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.

Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB.

ACS Chem Neurosci. 2012 Nov 21;3(11):941-51. doi: 10.1021/cn3000857. Epub 2012 Aug 28.


Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease.

Pacheco-Quinto J, Herdt A, Eckman CB, Eckman EA.

J Alzheimers Dis. 2013;33 Suppl 1:S101-10. Review.


Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice.

Ohashi N, Hori T, Chen F, Jermanus S, Eckman CB, Nakao A, Uemoto S, Nguyen JH.

World J Gastroenterol. 2012 May 21;18(19):2320-33. doi: 10.3748/wjg.v18.i19.2320.


Hepatic arterial reconstruction for orthotopic liver transplantation in the rat.

Hori T, Gardner LB, Chen F, Baine AM, Hata T, Herdt AR, Uemoto S, Eckman CB, Nguyen JH.

J Surg Res. 2012 Dec;178(2):907-14. doi: 10.1016/j.jss.2012.04.039. Epub 2012 May 9.


Hepatic arterial reconstruction with a short-term patency by using micro T-tube in rat liver transplantation.

Hori T, Uemoto S, Chen F, Baine AM, Gardner LB, Hata T, Herdt AR, Eckman CB, Nguyen JH.

Microsurgery. 2012 Mar;32(3):253-4. doi: 10.1002/micr.21946. Epub 2012 Mar 8. No abstract available.


Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons.

Pugazhenthi S, Wang M, Pham S, Sze CI, Eckman CB.

Mol Neurodegener. 2011 Aug 19;6:60. doi: 10.1186/1750-1326-6-60.


Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failure.

Chen F, Hori T, Ohashi N, Baine AM, Eckman CB, Nguyen JH.

Hepatology. 2011 Apr;53(4):1294-305. doi: 10.1002/hep.24161.


The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.

Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J 3rd, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA.

J Nat Prod. 2011 Jan 28;74(1):38-44. doi: 10.1021/np100572z. Epub 2010 Dec 8.


Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide.

Hori T, Nguyen JH, Zhao X, Ogura Y, Hata T, Yagi S, Chen F, Baine AM, Ohashi N, Eckman CB, Herdt AR, Egawa H, Takada Y, Oike F, Sakamoto S, Kasahara M, Ogawa K, Hata K, Iida T, Yonekawa Y, Sibulesky L, Kuribayashi K, Kato T, Saito K, Wang L, Torii M, Sahara N, Kamo N, Sahara T, Yasutomi M, Uemoto S.

World J Gastroenterol. 2010 Jul 7;16(25):3120-32.


Molecular characterization of mutations that cause globoid cell leukodystrophy and pharmacological rescue using small molecule chemical chaperones.

Lee WC, Kang D, Causevic E, Herdt AR, Eckman EA, Eckman CB.

J Neurosci. 2010 Apr 21;30(16):5489-97. doi: 10.1523/JNEUROSCI.6383-09.2010.


Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation.

Van Kampen JM, Eckman CB.

Neuropharmacology. 2010 May;58(6):921-9. doi: 10.1016/j.neuropharm.2009.12.005. Epub 2009 Dec 22.


Altered expression of zonula occludens-2 precedes increased blood-brain barrier permeability in a murine model of fulminant hepatic failure.

Shimojima N, Eckman CB, McKinney M, Sevlever D, Yamamoto S, Lin W, Dickson DW, Nguyen JH.

J Invest Surg. 2008 May-Jun;21(3):101-8. doi: 10.1080/08941930802043565.


An update on the amyloid hypothesis.

Eckman CB, Eckman EA.

Neurol Clin. 2007 Aug;25(3):669-82, vi. Review.


The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC.

J Neurosci. 2007 Jul 18;27(29):7817-26.


Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling.

Roosterman D, Cottrell GS, Padilla BE, Muller L, Eckman CB, Bunnett NW, Steinhoff M.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11838-43. Epub 2007 Jun 25.


Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. Epub 2007 Jun 15.


Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy.

Lee WC, Tsoi YK, Troendle FJ, DeLucia MW, Ahmed Z, Dicky CA, Dickson DW, Eckman CB.

FASEB J. 2007 Aug;21(10):2520-7. Epub 2007 Apr 2.


The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L.

J Clin Invest. 2007 Mar;117(3):648-58. Epub 2007 Feb 15.


Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB.

Mol Neurodegener. 2006 Jul 26;1:6.


Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

Eckman EA, Adams SK, Troendle FJ, Stodola BA, Kahn MA, Fauq AH, Xiao HD, Bernstein KE, Eckman CB.

J Biol Chem. 2006 Oct 13;281(41):30471-8. Epub 2006 Aug 14.


Cerebrospinal fluid drainage and cranial decompression prolong survival in rats with fulminant hepatic failure.

Yamamoto S, Steers JL, Wharen RE Jr, Eckman CB, Nguyen JH.

Transpl Int. 2006 Aug;19(8):675-82.


Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD).

Lee WC, Tsoi YK, Dickey CA, Delucia MW, Dickson DW, Eckman CB.

Neurobiol Dis. 2006 Aug;23(2):273-80. Epub 2006 Jun 8.


Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides.

Chen F, Eckman EA, Eckman CB.

FASEB J. 2006 Jun;20(8):1269-71. Epub 2006 Apr 24.


Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.

Nguyen JH, Yamamoto S, Steers J, Sevlever D, Lin W, Shimojima N, Castanedes-Casey M, Genco P, Golde T, Richelson E, Dickson D, McKinney M, Eckman CB.

J Hepatol. 2006 Jun;44(6):1105-14. Epub 2005 Nov 7.


Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.

Guénette S, Chang Y, Hiesberger T, Richardson JA, Eckman CB, Eckman EA, Hammer RE, Herz J.

EMBO J. 2006 Jan 25;25(2):420-31. Epub 2006 Jan 12.


Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.

McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, DeLucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T.

Neuron. 2005 Jul 21;47(2):191-199. doi: 10.1016/j.neuron.2005.06.030.


Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy.

Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB.

FASEB J. 2005 Sep;19(11):1549-51. Epub 2005 Jun 29.


Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.

Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L.

Curr Alzheimer Res. 2005 Apr;2(2):231-8.


The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM.

Neuron. 2004 Oct 14;44(2):227-38. Erratum in: Neuron. 2010 Dec 9;68(5):1014.


Estrogen regulates neprilysin activity in rat brain.

Huang J, Guan H, Booze RM, Eckman CB, Hersh LB.

Neurosci Lett. 2004 Aug 26;367(1):85-7.


Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen.

Hunter CL, Bimonte-Nelson HA, Nelson M, Eckman CB, Granholm AC.

Neurobiol Aging. 2004 Aug;25(7):873-84.


Differential expression of cholesterol hydroxylases in Alzheimer's disease.

Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B.

J Biol Chem. 2004 Aug 13;279(33):34674-81. Epub 2004 May 17.


Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.

Am J Pathol. 2004 Apr;164(4):1425-34.


Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.

Chang Y, Tesco G, Jeong WJ, Lindsley L, Eckman EA, Eckman CB, Tanzi RE, Guénette SY.

J Biol Chem. 2003 Dec 19;278(51):51100-7. Epub 2003 Oct 3.


Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats.

Bimonte-Nelson HA, Singleton RS, Nelson ME, Eckman CB, Barber J, Scott TY, Granholm AC.

Exp Neurol. 2003 Jun;181(2):301-12.


Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6221-6. Epub 2003 May 5.


Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.


Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis.

Golde TE, Eckman CB.

Sci STKE. 2003 Mar 4;2003(172):RE4. Review.


Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.

Eckman EA, Watson M, Marlow L, Sambamurti K, Eckman CB.

J Biol Chem. 2003 Jan 24;278(4):2081-4. Epub 2002 Dec 2.


Natural product extracts that reduce accumulation of the Alzheimer's amyloid beta peptide: selective reduction in A beta42.

Yager D, Watson M, Healy B, Eckman EA, Eckman CB.

J Mol Neurosci. 2002 Aug-Oct;19(1-2):129-33.


beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.

McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL.

Brain Res Mol Brain Res. 2001 Dec 16;97(1):103-13.


Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease.

Golde TE, Eckman CB.

Drug Discov Today. 2001 Oct 15;6(20):1049-1055.


The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L.

Nat Neurosci. 2001 Sep;4(9):887-93.


High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta).

Haugabook SJ, Yager DM, Eckman EA, Golde TE, Younkin SG, Eckman CB.

J Neurosci Methods. 2001 Jul 30;108(2):171-9.


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