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Items: 1 to 50 of 111

1.

Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.

Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG.

J Clin Invest. 2019 Mar 26;130:2357-2373. doi: 10.1172/JCI124218.

2.

Targeting Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor 2 (HER2) Expressing Bladder Cancer Using Combination Photoimmunotherapy (PIT).

Siddiqui MR, Railkar R, Sanford T, Crooks DR, Eckhaus MA, Haines D, Choyke PL, Kobayashi H, Agarwal PK.

Sci Rep. 2019 Feb 14;9(1):2084. doi: 10.1038/s41598-019-38575-x.

3.

Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice.

Kim KS, Zhang DL, Kovtunovych G, Ghosh MC, Ollivierre H, Eckhaus MA, Rouault TA.

Blood Adv. 2018 Oct 23;2(20):2732-2743. doi: 10.1182/bloodadvances.2018019737.

4.

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI, Laurence A, Bogyo M, Watts C, Shevach EM, Amarnath S.

Immunity. 2018 Aug 21;49(2):247-263.e7. doi: 10.1016/j.immuni.2018.05.006. Epub 2018 Jul 24.

PMID:
30054205
5.

Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia.

Ghosh MC, Zhang DL, Ollivierre H, Eckhaus MA, Rouault TA.

J Clin Invest. 2018 Apr 2;128(4):1317-1325. doi: 10.1172/JCI97684. Epub 2018 Feb 26.

6.

In vivo kinetics and nonradioactive imaging of rapidly proliferating cells in graft-versus-host disease.

Buxbaum NP, Farthing DE, Maglakelidze N, Lizak M, Merkle H, Carpenter AC, Oliver BU, Kapoor V, Castro E, Swan GA, Dos Santos LM, Bouladoux NJ, Bare CV, Flomerfelt FA, Eckhaus MA, Telford WG, Belkaid Y, Bosselut RJ, Gress RE.

JCI Insight. 2017 Jun 15;2(12). pii: 92851. doi: 10.1172/jci.insight.92851. eCollection 2017 Jun 15.

7.

Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease.

Amarnath S, Laurence A, Zhu N, Cunha R, Eckhaus MA, Taylor S, Foley JE, Ghosh M, Felizardo TC, Fowler DH.

Haematologica. 2017 Aug;102(8):1446-1456. doi: 10.3324/haematol.2016.155879. Epub 2017 May 4.

8.

Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity.

Ahuja M, Schwartz DM, Tandon M, Son A, Zeng M, Swaim W, Eckhaus M, Hoffman V, Cui Y, Xiao B, Worley PF, Muallem S.

Cell Metab. 2017 Mar 7;25(3):635-646. doi: 10.1016/j.cmet.2017.02.007.

9.

Transcatheter Myocardial Needle Chemoablation During Real-Time Magnetic Resonance Imaging: A New Approach to Ablation Therapy for Rhythm Disorders.

Rogers T, Mahapatra S, Kim S, Eckhaus MA, Schenke WH, Mazal JR, Campbell-Washburn A, Sonmez M, Faranesh AZ, Ratnayaka K, Lederman RJ.

Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003926. doi: 10.1161/CIRCEP.115.003926.

10.

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft.

Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson Iii RN, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, Horvath KA.

Nat Commun. 2016 Apr 5;7:11138. doi: 10.1038/ncomms11138.

11.

Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV.

Park S, Ahuja M, Kim MS, Brailoiu GC, Jha A, Zeng M, Baydyuk M, Wu LG, Wassif CA, Porter FD, Zerfas PM, Eckhaus MA, Brailoiu E, Shin DM, Muallem S.

EMBO Rep. 2016 Feb;17(2):266-78. doi: 10.15252/embr.201541542. Epub 2015 Dec 18.

12.

Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis.

Sionov E, Mayer-Barber KD, Chang YC, Kauffman KD, Eckhaus MA, Salazar AM, Barber DL, Kwon-Chung KJ.

PLoS Pathog. 2015 Aug 7;11(8):e1005040. doi: 10.1371/journal.ppat.1005040. eCollection 2015 Aug.

13.

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

Losada L, Sugui JA, Eckhaus MA, Chang YC, Mounaud S, Figat A, Joardar V, Pakala SB, Pakala S, Venepally P, Fedorova N, Nierman WC, Kwon-Chung KJ.

PLoS Pathog. 2015 Apr 24;11(4):e1004834. doi: 10.1371/journal.ppat.1004834. eCollection 2015 Apr.

14.

Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.

Amarnath S, Foley JE, Farthing DE, Gress RE, Laurence A, Eckhaus MA, Métais JY, Rose JJ, Hakim FT, Felizardo TC, Cheng AV, Robey PG, Stroncek DE, Sabatino M, Battiwalla M, Ito S, Fowler DH, Barrett AJ.

Stem Cells. 2015 Apr;33(4):1200-12. doi: 10.1002/stem.1934.

15.

Molecular biology, pathogenesis and pathology of mumps virus.

Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP.

J Pathol. 2015 Jan;235(2):242-52. doi: 10.1002/path.4445. Review.

16.

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.

Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y.

J Exp Med. 2014 Sep 22;211(10):2061-74. doi: 10.1084/jem.20132494. Epub 2014 Aug 25.

17.

Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging.

Springer DA, Allen M, Hoffman V, Brinster L, Starost MF, Bryant M, Eckhaus M.

Pathobiol Aging Age Relat Dis. 2014 Aug 1;4. doi: 10.3402/pba.v4.24932. eCollection 2014.

18.

Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice.

Kovtunovych G, Ghosh MC, Ollivierre W, Weitzel RP, Eckhaus MA, Tisdale JF, Yachie A, Rouault TA.

Blood. 2014 Aug 28;124(9):1522-30. doi: 10.1182/blood-2014-02-554162. Epub 2014 Jun 24.

19.

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.

20.

One-year heterotopic cardiac xenograft survival in a pig to baboon model.

Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Reimann KA, Klymiuk N, Wolf E, Ayares D, Horvath KA.

Am J Transplant. 2014 Feb;14(2):488-9. doi: 10.1111/ajt.12562. Epub 2013 Dec 11. No abstract available.

21.

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.

Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Dabkowski NL, Belli AJ, Reimann KA, Ayares D, Horvath KA.

Xenotransplantation. 2014 Jan-Feb;21(1):35-45. doi: 10.1111/xen.12066. Epub 2013 Oct 29.

22.

Safety and tolerability of a live oral Salmonella typhimurium vaccine candidate in SIV-infected nonhuman primates.

Ault A, Tennant SM, Gorres JP, Eckhaus M, Sandler NG, Roque A, Livio S, Bao S, Foulds KE, Kao SF, Roederer M, Schmidlein P, Boyd MA, Pasetti MF, Douek DC, Estes JD, Nabel GJ, Levine MM, Rao SS.

Vaccine. 2013 Dec 2;31(49):5879-88. doi: 10.1016/j.vaccine.2013.09.041. Epub 2013 Oct 5.

PMID:
24099872
23.

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA.

Cell Metab. 2013 Feb 5;17(2):271-81. doi: 10.1016/j.cmet.2012.12.016.

24.

Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility.

Halabi M, Ratnayaka K, Faranesh AZ, Hansen MS, Barbash IM, Eckhaus MA, Wilson JR, Chen MY, Slack MC, Kocaturk O, Schenke WH, Wright VJ, Lederman RJ.

J Cardiovasc Magn Reson. 2013 Jan 18;15:10. doi: 10.1186/1532-429X-15-10.

25.

BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation.

Métais JY, Winkler T, Geyer JT, Calado RT, Aplan PD, Eckhaus MA, Dunbar CE.

PLoS One. 2012;7(10):e48267. doi: 10.1371/journal.pone.0048267. Epub 2012 Oct 30.

26.

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

Laurence A, Amarnath S, Mariotti J, Kim YC, Foley J, Eckhaus M, O'Shea JJ, Fowler DH.

Immunity. 2012 Aug 24;37(2):209-22. doi: 10.1016/j.immuni.2012.05.027.

27.

IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.

Roffê E, Rothfuchs AG, Santiago HC, Marino AP, Ribeiro-Gomes FL, Eckhaus M, Antonelli LR, Murphy PM.

J Immunol. 2012 Jan 15;188(2):649-60. doi: 10.4049/jimmunol.1003845. Epub 2011 Dec 12.

28.

Anthrax edema toxin impairs clearance in mice.

Sastalla I, Tang S, Crown D, Liu S, Eckhaus MA, Hewlett IK, Leppla SH, Moayeri M.

Infect Immun. 2012 Feb;80(2):529-38. doi: 10.1128/IAI.05947-11. Epub 2011 Nov 21.

29.

B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

Mohiuddin MM, Corcoran PC, Singh AK, Azimzadeh A, Hoyt RF Jr, Thomas ML, Eckhaus MA, Seavey C, Ayares D, Pierson RN 3rd, Horvath KA.

Am J Transplant. 2012 Mar;12(3):763-71. doi: 10.1111/j.1600-6143.2011.03846.x. Epub 2011 Nov 9.

30.

Retro-orbital injections in mice.

Yardeni T, Eckhaus M, Morris HD, Huizing M, Hoogstraten-Miller S.

Lab Anim (NY). 2011 May;40(5):155-60. doi: 10.1038/laban0511-155.

31.

Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy.

Chatterjee R, Bhattacharya P, Gavrilova O, Glass K, Moitra J, Myakishev M, Pack S, Jou W, Feigenbaum L, Eckhaus M, Vinson C.

J Mol Endocrinol. 2011 Apr 15;46(3):175-92. doi: 10.1530/JME-10-0172. Print 2011 Jun.

32.

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.

Moayeri M, Crown D, Newman ZL, Okugawa S, Eckhaus M, Cataisson C, Liu S, Sastalla I, Leppla SH.

PLoS Pathog. 2010 Dec 9;6(12):e1001222. doi: 10.1371/journal.ppat.1001222.

33.

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function.

Okugawa S, Moayeri M, Eckhaus MA, Crown D, Miller-Randolph S, Liu S, Akira S, Leppla SH.

Infect Immun. 2011 Jan;79(1):118-24. doi: 10.1128/IAI.00963-10. Epub 2010 Oct 25.

34.

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution.

Kovtunovych G, Eckhaus MA, Ghosh MC, Ollivierre-Wilson H, Rouault TA.

Blood. 2010 Dec 23;116(26):6054-62. doi: 10.1182/blood-2010-03-272138. Epub 2010 Sep 15.

35.

Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model.

Corcoran PC, Horvath KA, Singh AK, Hoyt RF Jr, Thomas ML 3rd, Eckhaus MA, Mohiuddin MM.

Transplant Proc. 2010 Jul-Aug;42(6):2149-51. doi: 10.1016/j.transproceed.2010.05.116.

36.

Amelanotic melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus).

Zerfas PM, Brinster LR, Starost MF, Burkholder TH, Raffeld M, Eckhaus MA.

Vet Pathol. 2010 Sep;47(5):977-81. doi: 10.1177/0300985810369898. Epub 2010 May 11.

PMID:
20460451
37.

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.

Amarnath S, Flomerfelt FA, Costanzo CM, Foley JE, Mariotti J, Konecki DM, Gangopadhyay A, Eckhaus M, Wong S, Levine BL, June CH, Fowler DH.

Autophagy. 2010 May;6(4):523-41. doi: 10.4161/auto.6.4.11811. Epub 2010 May 16.

38.

Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

Zheng C, Voutetakis A, Metzger M, Afione S, Cotrim AP, Eckhaus MA, Rivera VM, Clackson T, Chiorini JA, Donahue RE, Dunbar CE, Baum BJ.

Oral Dis. 2010 Apr;16(3):269-77. doi: 10.1111/j.1601-0825.2009.01631.x.

39.

Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques.

Nishimura Y, Shingai M, Willey R, Sadjadpour R, Lee WR, Brown CR, Brenchley JM, Buckler-White A, Petros R, Eckhaus M, Hoffman V, Igarashi T, Martin MA.

J Virol. 2010 May;84(9):4769-81. doi: 10.1128/JVI.02279-09. Epub 2010 Feb 10.

40.

Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.

Hall BE, Zheng C, Swaim WD, Cho A, Nagineni CN, Eckhaus MA, Flanders KC, Ambudkar IS, Baum BJ, Kulkarni AB.

Lab Invest. 2010 Apr;90(4):543-55. doi: 10.1038/labinvest.2010.5. Epub 2010 Feb 8.

41.

AAV5-mediated gene transfer to the parotid glands of non-human primates.

Voutetakis A, Zheng C, Cotrim AP, Mineshiba F, Afione S, Roescher N, Swaim WD, Metzger M, Eckhaus MA, Donahue RE, Dunbar CE, Chiorini JA, Baum BJ.

Gene Ther. 2010 Jan;17(1):50-60. doi: 10.1038/gt.2009.123. Epub 2009 Sep 17.

42.

GNAS haploinsufficiency leads to subcutaneous tumor formation with collagen and elastin deposition and calcification.

Sakamoto A, Weinstein LS, Plagge A, Eckhaus M, Kelsey G.

Endocr Res. 2009;34(1-2):1-9. doi: 10.1080/07435800902841280.

43.

Lymphocytes with aberrant expression of Fas or Fas ligand attenuate immune bone marrow failure in a mouse model.

Omokaro SO, Desierto MJ, Eckhaus MA, Ellison FM, Chen J, Young NS.

J Immunol. 2009 Mar 15;182(6):3414-22. doi: 10.4049/jimmunol.0801430.

44.

Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.

Foley JE, Mariotti J, Ryan K, Eckhaus M, Fowler DH.

Biol Blood Marrow Transplant. 2008 Sep;14(9):959-972. doi: 10.1016/j.bbmt.2008.06.007.

45.

Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition.

Narver HL, Kong L, Burnett BG, Choe DW, Bosch-Marcé M, Taye AA, Eckhaus MA, Sumner CJ.

Ann Neurol. 2008 Oct;64(4):465-70. doi: 10.1002/ana.21449.

PMID:
18661558
46.

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice.

Chen J, Ellison FM, Keyvanfar K, Omokaro SO, Desierto MJ, Eckhaus MA, Young NS.

Exp Hematol. 2008 Oct;36(10):1236-43. doi: 10.1016/j.exphem.2008.04.012. Epub 2008 Jun 17.

47.

Peripheral edema with hypoalbuminemia in a nonhuman primate infected with simian-human immunodeficiency virus: a case report.

Clarke CL, Eckhaus MA, Zerfas PM, Elkins WR.

J Am Assoc Lab Anim Sci. 2008 Jan;47(1):42-8.

48.

Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax.

Sheleg SV, Peloponese JM, Chi YH, Li Y, Eckhaus M, Jeang KT.

J Virol. 2007 Aug;81(15):7894-901. Epub 2007 May 16.

49.

Minor antigen h60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells.

Chen J, Ellison FM, Eckhaus MA, Smith AL, Keyvanfar K, Calado RT, Young NS.

J Immunol. 2007 Apr 1;178(7):4159-68.

50.

Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.

Voutetakis A, Zheng C, Mineshiba F, Cotrim AP, Goldsmith CM, Schmidt M, Afione S, Roescher N, Metzger M, Eckhaus MA, Chiorini JA, Dunbar CE, Donahue RE, Baum BJ.

Hum Gene Ther. 2007 Feb;18(2):142-50.

PMID:
17328682

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