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Erratum to: Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.

Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LAD, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH.

J Inherit Metab Dis. 2016 Sep;39(5):757. doi: 10.1007/s10545-016-9944-y. No abstract available.


Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.

Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X.

Basic Res Cardiol. 2016 Jan;111(1):4. doi: 10.1007/s00395-015-0523-4. Epub 2015 Nov 26.


Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.

Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LA, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH.

J Inherit Metab Dis. 2015 Nov;38(6):1029-39. doi: 10.1007/s10545-015-9843-7. Epub 2015 Apr 15. Erratum in: J Inherit Metab Dis. 2016 Sep;39(5):757.


Understanding the apothecaries within: the necessity of a systematic approach for defining the chemical output of the human microbiome.

Beebe K, Sampey B, Watkins SM, Milburn M, Eckhart AD.

Clin Transl Sci. 2014 Feb;7(1):74-81. doi: 10.1111/cts.12131. Epub 2014 Jan 14. Review.


Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle.

Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart AD, Penn RB.

FASEB J. 2014 Feb;28(2):956-65. doi: 10.1096/fj.13-240226. Epub 2013 Oct 16.


Metabolomics as a key integrator for "omic" advancement of personalized medicine and future therapies.

Eckhart AD, Beebe K, Milburn M.

Clin Transl Sci. 2012 Jun;5(3):285-8. doi: 10.1111/j.1752-8062.2011.00388.x. Review.


S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes.

Brinks H, Rohde D, Voelkers M, Qiu G, Pleger ST, Herzog N, Rabinowitz J, Ruhparwar A, Silvestry S, Lerchenmüller C, Mather PJ, Eckhart AD, Katus HA, Carrel T, Koch WJ, Most P.

J Am Coll Cardiol. 2011 Aug 23;58(9):966-73. doi: 10.1016/j.jacc.2011.03.054.


Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.

Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR.

J Mol Cell Cardiol. 2011 Mar;50(3):460-70. doi: 10.1016/j.yjmcc.2010.11.012. Epub 2010 Nov 25.


The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.

Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, Wegner FV, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P.

Circ Res. 2011 Jan 7;108(1):27-39. doi: 10.1161/CIRCRESAHA.110.225201. Epub 2010 Nov 24.


Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: restoration by intravascular human β₂-adrenoceptor gene transfer and role of NFκB and CREB transcription factors.

Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou RH, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G.

Br J Pharmacol. 2011 Feb;162(3):712-21. doi: 10.1111/j.1476-5381.2010.01078.x.


Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.

Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ.

Circ Res. 2010 Oct 29;107(9):1140-9. doi: 10.1161/CIRCRESAHA.110.221010. Epub 2010 Sep 2.


Mineralocorticoid receptors, corticosteroids and the heart: where do we stand?

Eckhart AD.

J Hypertens. 2010 May;28(5):889-91. doi: 10.1097/HJH.0b013e3283378698. No abstract available.


Regulation of GPCR signaling in hypertension.

Brinks HL, Eckhart AD.

Biochim Biophys Acta. 2010 Dec;1802(12):1268-75. doi: 10.1016/j.bbadis.2010.01.005. Epub 2010 Jan 11. Review.


[Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration].

Ma YB, Li BY, Gao HQ, Yao M, Koch WJ, Eckhart AD, Zhou RH.

Zhonghua Bing Li Xue Za Zhi. 2009 Jan;38(1):50-4. Chinese.


G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans.

Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B, Eckhart AD.

Hypertension. 2009 Jul;54(1):71-6. doi: 10.1161/HYPERTENSIONAHA.108.125955. Epub 2009 Jun 1.


Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5.

Zhou RH, Pesant S, Cohn HI, Soltys S, Koch WJ, Eckhart AD.

Clin Transl Sci. 2009 Feb;2(1):57-61. doi: 10.1111/j.1752-8062.2008.00058.x.


Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure.

Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD.

J Mol Cell Cardiol. 2009 Jan;46(1):100-7. doi: 10.1016/j.yjmcc.2008.09.708. Epub 2008 Sep 30.


Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.

Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn GW 2nd, Eckhart AD.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1695-704. doi: 10.1152/ajpheart.00564.2008. Epub 2008 Aug 22.


Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

Martini JS, Raake P, Vinge LE, DeGeorge BR Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62. doi: 10.1073/pnas.0803153105. Epub 2008 Aug 18. Erratum in: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17206. DeGeorge, Brent Jr [corrected to DeGeorge, Brent R Jr].


G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ.

Circ Res. 2008 Aug 15;103(4):413-22. doi: 10.1161/CIRCRESAHA.107.168336. Epub 2008 Jul 17.


GPCR signalling in hypertension: role of GRKs.

Harris DM, Cohn HI, Pesant S, Eckhart AD.

Clin Sci (Lond). 2008 Aug;115(3):79-89. doi: 10.1042/CS20070442. Review.


Simultaneous administration of insulin-like growth factor-1 and darbepoetin alfa protects the rat myocardium against myocardial infarction and enhances angiogenesis.

Boucher M, Pesant S, Lei YH, Nanton N, Most P, Eckhart AD, Koch WJ, Gao E.

Clin Transl Sci. 2008 May;1(1):13-20. doi: 10.1111/j.1752-8062.2008.00008.x.


Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells.

Ohtsu H, Higuchi S, Shirai H, Eguchi K, Suzuki H, Hinoki A, Brailoiu E, Eckhart AD, Frank GD, Eguchi S.

Endocrinology. 2008 Jul;149(7):3569-75. doi: 10.1210/en.2007-1694. Epub 2008 Mar 20.


Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.

DeGeorge BR Jr, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ.

Circulation. 2008 Mar 18;117(11):1378-87. doi: 10.1161/CIRCULATIONAHA.107.752618. Epub 2008 Mar 3.


Endothelial S100A1 modulates vascular function via nitric oxide.

Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M, Heierhorst J, Øie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P.

Circ Res. 2008 Apr 11;102(7):786-94. doi: 10.1161/CIRCRESAHA.108.172031. Epub 2008 Feb 21.


Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells.

Mahadev K, Wu X, Donnelly S, Ouedraogo R, Eckhart AD, Goldstein BJ.

Cardiovasc Res. 2008 May 1;78(2):376-84. doi: 10.1093/cvr/cvn034. Epub 2008 Feb 10.


Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension.

Harris DM, Cohn HI, Pesant S, Zhou RH, Eckhart AD.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3072-9. Epub 2007 Sep 14.


Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.

Giangrande PH, Zhang J, Tanner A, Eckhart AD, Rempel RE, Andrechek ER, Layzer JM, Keys JR, Hagen PO, Nevins JR, Koch WJ, Sullenger BA.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12988-93. Epub 2007 Jul 25.


Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.

Pleger ST, Most P, Boucher M, Soltys S, Chuprun JK, Pleger W, Gao E, Dasgupta A, Rengo G, Remppis A, Katus HA, Eckhart AD, Rabinowitz JE, Koch WJ.

Circulation. 2007 May 15;115(19):2506-15. Epub 2007 Apr 30.


Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart.

Gao E, Boucher M, Chuprun JK, Zhou RH, Eckhart AD, Koch WJ.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H60-8. Epub 2007 Mar 23.


Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.

Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ.

Nat Med. 2007 Mar;13(3):315-23. Epub 2007 Feb 18.


Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

Most P, Seifert H, Gao E, Funakoshi H, Völkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ.

Circulation. 2006 Sep 19;114(12):1258-68. Epub 2006 Sep 4.


Galphaq and its Aktions.

Harris DM, Eckhart AD, Koch WJ.

J Mol Cell Cardiol. 2006 May;40(5):589-92. Epub 2006 Apr 21. No abstract available.


S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.

Pleger ST, Remppis A, Heidt B, Völkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Müller OJ, Eckhart AD, Katus HA, Koch WJ, Most P.

Mol Ther. 2005 Dec;12(6):1120-9. Epub 2005 Sep 15.


Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling.

Keys JR, Zhou RH, Harris DM, Druckman CA, Eckhart AD.

Circulation. 2005 Aug 23;112(8):1145-53. Epub 2005 Aug 15.


G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.

Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S.

J Biol Chem. 2005 Jul 15;280(28):26592-9. Epub 2005 May 19.


Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

Most P, Pleger ST, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ.

J Clin Invest. 2004 Dec;114(11):1550-63.


Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts.

Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ.

J Thorac Cardiovasc Surg. 2002 Dec;124(6):1149-56.


Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation.

Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ.

Eur J Cardiothorac Surg. 2002 Nov;22(5):733-7.


Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature.

Keys JR, Greene EA, Koch WJ, Eckhart AD.

Hypertension. 2002 Nov;40(5):660-6.


Myocardial gene transfer and overexpression of beta2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts.

Tevaearai HT, Eckhart AD, Walton GB, Keys JR, Wilson K, Koch WJ.

Circulation. 2002 Jul 2;106(1):124-9.


Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.

Eckhart AD, Fentzke RC, Lepore J, Lang R, Lin H, Lefkowitz RJ, Koch WJ, Leiden JM.

J Mol Cell Cardiol. 2002 Jun;34(6):669-77.


Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure.

Tevaearai HT, Eckhart AD, Koch WJ.

Minerva Cardioangiol. 2001 Dec;49(6):389-94. Review.


Beta-Adrenergic gene therapy for cardiovascular disease.

Eckhart AD, Koch WJ.

Curr Control Trials Cardiovasc Med. 2000;1(3):131-134.

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