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Items: 28


C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.

Dufour A, Bellac CL, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour SJ, Overall CM.

Nat Commun. 2018 Jun 20;9(1):2416. doi: 10.1038/s41467-018-04717-4.


A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function.

Jerlström Hultqvist J, Warsi O, Söderholm A, Knopp M, Eckhard U, Vorontsov E, Selmer M, Andersson DI.

Nat Ecol Evol. 2018 Aug;2(8):1321-1330. doi: 10.1038/s41559-018-0568-5. Epub 2018 May 28.


Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.

Tharmarajah G, Eckhard U, Jain F, Marino G, Prudova A, Urtatiz O, Fuchs H, de Angelis MH, Overall CM, Van Raamsdonk CD.

Pigment Cell Melanoma Res. 2018 Nov;31(6):693-707. doi: 10.1111/pcmr.12711. Epub 2018 Jun 5.


TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.

King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev SY, Schjoldager KT, Overall CM, Wandall HH.

J Biol Chem. 2018 May 18;293(20):7629-7644. doi: 10.1074/jbc.RA118.001978. Epub 2018 Mar 28.


Proteolytic Cleavage-Mechanisms, Function, and "Omic" Approaches for a Near-Ubiquitous Posttranslational Modification.

Klein T, Eckhard U, Dufour A, Solis N, Overall CM.

Chem Rev. 2018 Feb 14;118(3):1137-1168. doi: 10.1021/acs.chemrev.7b00120. Epub 2017 Dec 21. Review.


The Human Odontoblast Cell Layer and Dental Pulp Proteomes and N-Terminomes.

Abbey SR, Eckhard U, Solis N, Marino G, Matthew I, Overall CM.

J Dent Res. 2018 Mar;97(3):338-346. doi: 10.1177/0022034517736054. Epub 2017 Oct 16.


Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella.

Eckhard U, Bandukwala H, Mansfield MJ, Marino G, Cheng J, Wallace I, Holyoak T, Charles TC, Austin J, Overall CM, Doxey AC.

Nat Commun. 2017 Sep 12;8(1):521. doi: 10.1038/s41467-017-00599-0.


TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.


Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).

Butler GS, Connor AR, Sounni NE, Eckhard U, Morrison CJ, Noël A, Overall CM.

Matrix Biol. 2017 May;59:23-38. doi: 10.1016/j.matbio.2016.07.006. Epub 2016 Jul 26.


Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.


TAILS N-terminomic and proteomic datasets of healthy human dental pulp.

Eckhard U, Marino G, Abbey SR, Matthew I, Overall CM.

Data Brief. 2015 Oct 16;5:542-8. doi: 10.1016/j.dib.2015.10.003. eCollection 2015 Dec.


Positional proteomics in the era of the human proteome project on the doorstep of precision medicine.

Eckhard U, Marino G, Butler GS, Overall CM.

Biochimie. 2016 Mar;122:110-8. doi: 10.1016/j.biochi.2015.10.018. Epub 2015 Nov 14. Review.


Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25.


The Human Dental Pulp Proteome and N-Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues.

Eckhard U, Marino G, Abbey SR, Tharmarajah G, Matthew I, Overall CM.

J Proteome Res. 2015 Sep 4;14(9):3568-82. doi: 10.1021/acs.jproteome.5b00579. Epub 2015 Aug 14.


Protein Termini and Their Modifications Revealed by Positional Proteomics.

Marino G, Eckhard U, Overall CM.

ACS Chem Biol. 2015 Aug 21;10(8):1754-64. doi: 10.1021/acschembio.5b00189. Epub 2015 Jul 6. Review.


LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.

Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM.

Nat Methods. 2015 Jan;12(1):55-8. doi: 10.1038/nmeth.3177. Epub 2014 Nov 24.


TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage.

Prudova A, Serrano K, Eckhard U, Fortelny N, Devine DV, Overall CM.

Blood. 2014 Dec 18;124(26):e49-60. doi: 10.1182/blood-2014-04-569640. Epub 2014 Oct 20.


Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries.

Barré O, Dufour A, Eckhard U, Kappelhoff R, Béliveau F, Leduc R, Overall CM.

PLoS One. 2014 Sep 11;9(9):e105984. doi: 10.1371/journal.pone.0105984. eCollection 2014.


Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity.

Marino G, Huesgen PF, Eckhard U, Overall CM, Schröder WP, Funk C.

Biochem J. 2014 Jan 15;457(2):335-46. doi: 10.1042/BJ20130196.


Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.

Eckhard U, Huesgen PF, Brandstetter H, Overall CM.

J Proteomics. 2014 Apr 4;100:102-14. doi: 10.1016/j.jprot.2013.10.004. Epub 2013 Oct 11.


Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T.

Eckhard U, Schönauer E, Brandstetter H.

J Biol Chem. 2013 Jul 12;288(28):20184-94. doi: 10.1074/jbc.M112.448548. Epub 2013 May 23.


Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation.

auf dem Keller U, Prudova A, Eckhard U, Fingleton B, Overall CM.

Sci Signal. 2013 Jan 15;6(258):rs2. doi: 10.1126/scisignal.2003512.


Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen bet v 1.

Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H.

J Mol Biol. 2012 Sep 7;422(1):109-23. doi: 10.1016/j.jmb.2012.05.016. Epub 2012 May 23.


Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis.

Eckhard U, Schönauer E, Nüss D, Brandstetter H.

Nat Struct Mol Biol. 2011 Sep 25;18(10):1109-14. doi: 10.1038/nsmb.2127.


Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment.

Eckhard U, Brandstetter H.

Biol Chem. 2011 Nov;392(11):1039-45. doi: 10.1515/BC.2011.099. Epub 2011 Aug 28.


A universal strategy for high-yield production of soluble and functional clostridial collagenases in E. coli.

Ducka P, Eckhard U, Schönauer E, Kofler S, Gottschalk G, Brandstetter H, Nüss D.

Appl Microbiol Biotechnol. 2009 Jul;83(6):1055-65. doi: 10.1007/s00253-009-1953-4. Epub 2009 Mar 31.


Biochemical characterization of the catalytic domains of three different Clostridial collagenases.

Eckhard U, Schönauer E, Ducka P, Briza P, Nüss D, Brandstetter H.

Biol Chem. 2009 Jan;390(1):11-8. doi: 10.1515/BC.2009.004.


Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum.

Eckhard U, Nüss D, Ducka P, Schönauer E, Brandstetter H.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):419-21. doi: 10.1107/S1744309108010476. Epub 2008 Apr 24.

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