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Items: 1 to 50 of 103

1.

Dual role of laminin‑511 in regulating melanocyte migration and differentiation.

Üstün Y, Reibetanz M, Brachvogel B, Nischt R, Eckes B, Zigrino P, Krieg T.

Matrix Biol. 2019 Jul;80:59-71. doi: 10.1016/j.matbio.2018.09.006. Epub 2018 Sep 29.

PMID:
30273664
2.

Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program.

Do NN, Willenborg S, Eckes B, Jüngst C, Sengle G, Zaucke F, Eming SA.

J Immunol. 2018 Jul 15;201(2):663-674. doi: 10.4049/jimmunol.1701791. Epub 2018 Jun 13.

3.

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts.

Schulz JN, Plomann M, Sengle G, Gullberg D, Krieg T, Eckes B.

Matrix Biol. 2018 Aug;68-69:522-532. doi: 10.1016/j.matbio.2018.01.025. Epub 2018 Feb 12. Review.

PMID:
29408278
4.

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B.

Autophagy. 2018;14(3):465-486. doi: 10.1080/15548627.2017.1422850. Epub 2018 Mar 11.

5.

Pathophysiological Mechanisms in Sclerosing Skin Diseases.

Eckes B, Wang F, Moinzadeh P, Hunzelmann N, Krieg T.

Front Med (Lausanne). 2017 Aug 18;4:120. doi: 10.3389/fmed.2017.00120. eCollection 2017. Review.

6.

Cell-Populated Collagen Lattice Models.

Eckes B, Wang F, Rittié L, Scherr G, Zigrino P.

Methods Mol Biol. 2017;1627:223-233. doi: 10.1007/978-1-4939-7113-8_15.

PMID:
28836205
7.

Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis.

Schiller HB, Mayr CH, Leuschner G, Strunz M, Staab-Weijnitz C, Preisendörfer S, Eckes B, Moinzadeh P, Krieg T, Schwartz DA, Hatz RA, Behr J, Mann M, Eickelberg O.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1298-1310. doi: 10.1164/rccm.201611-2263OC.

PMID:
28654764
8.

Role of Integrins α1β1 and α2β1 in Wound and Tumor Angiogenesis in Mice.

Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B.

Am J Pathol. 2016 Nov;186(11):3011-3027. doi: 10.1016/j.ajpath.2016.06.021. Epub 2016 Sep 14.

PMID:
27639165
9.

Tissue fibrosis: a pathomechanistically unresolved challenge and scary clinical problem.

Eckes B, Eming SA.

Exp Dermatol. 2017 Feb;26(2):135-136. doi: 10.1111/exd.13165. No abstract available.

PMID:
27513440
10.

Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.

Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bösing H, Eckes B, Nieswandt B, Schulze H.

J Cell Sci. 2016 Sep 15;129(18):3473-84. doi: 10.1242/jcs.187971. Epub 2016 Aug 5.

11.

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.

Fleger-Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R.

Matrix Biol. 2016 Dec;56:42-56. doi: 10.1016/j.matbio.2016.05.002. Epub 2016 May 25.

PMID:
27234308
12.

Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication.

Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L.

Matrix Biol. 2016 Dec;56:24-41. doi: 10.1016/j.matbio.2016.05.001. Epub 2016 May 24.

PMID:
27234307
13.

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin.

Zigrino P, Brinckmann J, Niehoff A, Lu Y, Giebeler N, Eckes B, Kadler KE, Mauch C.

J Invest Dermatol. 2016 Aug;136(8):1575-1583. doi: 10.1016/j.jid.2016.03.036. Epub 2016 Apr 9.

14.

Thy-1/β3 Integrin Interaction-Induced Apoptosis of Dermal Fibroblasts Is Mediated by Up-Regulation of FasL Expression.

Schmidt M, Gutknecht D, Anastassiadis K, Eckes B, Anderegg U, Saalbach A.

J Invest Dermatol. 2016 Feb;136(2):526-529. doi: 10.1016/j.jid.2015.10.063. Epub 2015 Nov 18. No abstract available.

15.

COMP-assisted collagen secretion--a novel intracellular function required for fibrosis.

Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B.

J Cell Sci. 2016 Feb 15;129(4):706-16. doi: 10.1242/jcs.180216. Epub 2016 Jan 8.

16.

Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1.

Schmidt M, Gutknecht D, Simon JC, Schulz JN, Eckes B, Anderegg U, Saalbach A.

J Invest Dermatol. 2015 Jul;135(7):1893-1902. doi: 10.1038/jid.2015.86. Epub 2015 Mar 4.

17.

Reduced granulation tissue and wound strength in the absence of α11β1 integrin.

Schulz JN, Zeltz C, Sørensen IW, Barczyk M, Carracedo S, Hallinger R, Niehoff A, Eckes B, Gullberg D.

J Invest Dermatol. 2015 May;135(5):1435-1444. doi: 10.1038/jid.2015.24. Epub 2015 Jan 29.

18.

Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice.

Peters AS, Brunner G, Krieg T, Eckes B.

Arch Dermatol Res. 2015 Mar;307(2):191-7. doi: 10.1007/s00403-014-1514-2. Epub 2014 Oct 28.

PMID:
25348252
19.

Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing.

Lettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R.

PLoS One. 2014 Aug 26;9(8):e105686. doi: 10.1371/journal.pone.0105686. eCollection 2014.

20.

Molecular and cellular basis of scleroderma.

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T.

J Mol Med (Berl). 2014 Sep;92(9):913-24. doi: 10.1007/s00109-014-1190-x. Epub 2014 Jul 18. Review.

PMID:
25030650
21.

Role of integrin signalling through integrin-linked kinase in skin physiology and pathology.

Eckes B, Krieg T, Wickström SA.

Exp Dermatol. 2014 Jul;23(7):453-6. doi: 10.1111/exd.12429.

PMID:
24773528
22.

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice.

Rubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O.

Matrix Biol. 2014 Feb;34:13-21. doi: 10.1016/j.matbio.2014.01.006. Epub 2014 Jan 27.

PMID:
24480069
23.

Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis.

Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA.

J Invest Dermatol. 2014 Jul;134(7):2005-2015. doi: 10.1038/jid.2014.12. Epub 2014 Jan 9.

24.

CD49b-dependent establishment of T helper cell memory.

Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T.

Immunol Cell Biol. 2013 Sep;91(8):524-31. doi: 10.1038/icb.2013.36. Epub 2013 Jul 30.

PMID:
23897120
25.

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B.

J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

26.

Systemic sclerosis with multiple nodules: characterization of the extracellular matrix.

Moinzadeh P, Agarwal P, Bloch W, Orteu C, Hunzelmann N, Eckes B, Krieg T.

Arch Dermatol Res. 2013 Sep;305(7):645-52. doi: 10.1007/s00403-013-1383-0. Epub 2013 Jul 9.

PMID:
23836353
27.

Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice.

Stange R, Kronenberg D, Timmen M, Everding J, Hidding H, Eckes B, Hansen U, Holtkamp M, Karst U, Pap T, Raschke MJ.

Bone. 2013 Sep;56(1):48-54. doi: 10.1016/j.bone.2013.05.003. Epub 2013 May 13.

PMID:
23680479
28.

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.

Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA.

EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23.

29.

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies.

Agarwal P, Schulz JN, Blumbach K, Andreasson K, Heinegård D, Paulsson M, Mauch C, Eming SA, Eckes B, Krieg T.

Matrix Biol. 2013 Aug 8;32(6):325-31. doi: 10.1016/j.matbio.2013.02.010. Epub 2013 Mar 15.

PMID:
23507196
30.

Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.

Stegemann A, Sindrilaru A, Eckes B, del Rey A, Heinick A, Schulte JS, Müller FU, Grando SA, Fiebich BL, Scharffetter-Kochanek K, Luger TA, Böhm M.

Arthritis Rheum. 2013 Mar;65(3):792-804. doi: 10.1002/art.37809.

31.

PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair.

Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, Mauch C, Eckes B, Ulus H, Lund FE, Rappl G, Abken H, Paulsson M, Brachvogel B.

PLoS One. 2013;8(1):e53262. doi: 10.1371/journal.pone.0053262. Epub 2013 Jan 4.

32.

The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis.

Jungmann O, Nikolovska K, Stock C, Schulz JN, Eckes B, Riethmüller C, Owens RT, Iozzo RV, Seidler DG.

PLoS One. 2012;7(12):e50809. doi: 10.1371/journal.pone.0050809. Epub 2012 Dec 3.

33.

Cyclic mechanical stress downregulates endothelin-1 and its responsive genes independently of TGFβ1 in dermal fibroblasts.

Peters AS, Brunner G, Blumbach K, Abraham DJ, Krieg T, Eckes B.

Exp Dermatol. 2012 Oct;21(10):765-70. doi: 10.1111/exd.12010.

PMID:
23078398
34.

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.

Agarwal P, Zwolanek D, Keene DR, Schulz JN, Blumbach K, Heinegård D, Zaucke F, Paulsson M, Krieg T, Koch M, Eckes B.

J Biol Chem. 2012 Jun 29;287(27):22549-59. doi: 10.1074/jbc.M111.335935. Epub 2012 May 9.

35.

Inhibition of integrin α2β1 ameliorates glomerular injury.

Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A.

J Am Soc Nephrol. 2012 Jun;23(6):1027-38. doi: 10.1681/ASN.2011040367. Epub 2012 Mar 22.

36.

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels.

Blumbach K, Niehoff A, Belgardt BF, Ehlen HW, Schmitz M, Hallinger R, Schulz JN, Brüning JC, Krieg T, Schubert M, Gullberg D, Eckes B.

J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

37.

The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.

Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, Eichinger L, Noegel AA.

Nucleus. 2012 Mar 1;3(2):172-86. doi: 10.4161/nucl.19090. Epub 2012 Mar 1.

38.

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.

Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb-Pap A, Joosten LA, van den Berg WB, Kollias G, Eckes B, Pap T.

Arthritis Rheum. 2012 May;64(5):1359-68. doi: 10.1002/art.33487.

39.

Biomarkers for skin involvement and fibrotic activity in scleroderma.

Moinzadeh P, Denton CP, Abraham D, Ong V, Hunzelmann N, Eckes B, Krieg T.

J Eur Acad Dermatol Venereol. 2012 Mar;26(3):267-76. doi: 10.1111/j.1468-3083.2011.04206.x. Epub 2011 Aug 8. Review.

PMID:
21819452
40.

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis.

Veit G, Zwolanek D, Eckes B, Niland S, Käpylä J, Zweers MC, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M.

J Biol Chem. 2011 Aug 5;286(31):27804-13. doi: 10.1074/jbc.M111.220046. Epub 2011 Jun 7.

41.

Biofunctionalization of a generic collagenous triple helix with the α2β1 integrin binding site allows molecular force measurements.

Niland S, Westerhausen C, Schneider SW, Eckes B, Schneider MF, Eble JA.

Int J Biochem Cell Biol. 2011 May;43(5):721-31. doi: 10.1016/j.biocel.2011.01.013. Epub 2011 Jan 22.

PMID:
21262375
42.

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity.

Blumbach K, Zweers MC, Brunner G, Peters AS, Schmitz M, Schulz JN, Schild A, Denton CP, Sakai T, Fässler R, Krieg T, Eckes B.

J Cell Sci. 2010 Nov 15;123(Pt 22):3872-83. doi: 10.1242/jcs.063024. Epub 2010 Oct 27.

43.

Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.

Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A.

J Cell Sci. 2010 Nov 1;123(Pt 21):3674-82. doi: 10.1242/jcs.070672. Epub 2010 Oct 12.

44.

Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney.

Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Müller GA, Gross O.

Fibrogenesis Tissue Repair. 2010 Sep 22;3:19. doi: 10.1186/1755-1536-3-19.

45.

Cell-matrix interactions in dermal repair and scarring.

Eckes B, Nischt R, Krieg T.

Fibrogenesis Tissue Repair. 2010 Mar 11;3:4. doi: 10.1186/1755-1536-3-4.

46.

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation.

Carracedo S, Lu N, Popova SN, Jonsson R, Eckes B, Gullberg D.

J Biol Chem. 2010 Apr 2;285(14):10434-45. doi: 10.1074/jbc.M109.078766. Epub 2010 Feb 2.

47.

A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy.

Nissinen L, Pentikäinen OT, Jouppila A, Käpylä J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamäki A, Heino J.

Thromb Haemost. 2010 Feb;103(2):387-97. doi: 10.1160/TH09-06-0358. Epub 2009 Dec 1.

PMID:
20126829
48.

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV.

Blood. 2009 Nov 26;114(23):4897-906. doi: 10.1182/blood-2009-02-207134. Epub 2009 Sep 29.

49.

alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma?

Kokot A, Sindrilaru A, Schiller M, Sunderkötter C, Kerkhoff C, Eckes B, Scharffetter-Kochanek K, Luger TA, Böhm M.

Arthritis Rheum. 2009 Feb;60(2):592-603. doi: 10.1002/art.24228.

50.

Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.

Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP.

Am J Pathol. 2008 Nov;173(5):1577-88. doi: 10.2353/ajpath.2008.080042. Epub 2008 Oct 2.

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