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Items: 1 to 50 of 116

1.

Differential Effects of Silibinin A on Mitochondrial Function in Neuronal PC12 and HepG2 Liver Cells.

Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP.

Oxid Med Cell Longev. 2019 Nov 23;2019:1652609. doi: 10.1155/2019/1652609. eCollection 2019.

2.

Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity of C. elegans.

Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP.

Oxid Med Cell Longev. 2019 Nov 15;2019:6840540. doi: 10.1155/2019/6840540. eCollection 2019.

3.

Malnutrition in Paediatrics: Stationary Screening & Follow-up.

Werner D, Zimmer KP, Eckert GP, Laffolie J.

Klin Padiatr. 2020 Jan;232(1):20-28. doi: 10.1055/a-1003-6933. Epub 2019 Sep 30.

PMID:
31569262
4.

Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria.

Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP.

Nutrients. 2019 Aug 13;11(8). pii: E1886. doi: 10.3390/nu11081886.

5.

Metabolic Fate and Distribution of 2´-Fucosyllactose: Direct Influence on Gut Microbial Activity but not on Brain.

Kuntz S, Kunz C, Borsch C, Vazquez E, Buck R, Reutzel M, Eckert GP, Rudloff S.

Mol Nutr Food Res. 2019 May 24:e1900035. doi: 10.1002/mnfr.201900035. [Epub ahead of print]

6.

Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice.

Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP.

Oxid Med Cell Longev. 2018 Oct 30;2018:4070935. doi: 10.1155/2018/4070935. eCollection 2018.

7.

Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer's Disease.

Eckert SH, Gaca J, Kolesova N, Friedland K, Eckert GP, Muller WE.

Aging Dis. 2018 Aug 1;9(4):729-744. doi: 10.14336/AD.2017.1014. eCollection 2018 Aug. Review.

8.

Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain.

Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J, Eckert GP.

Biol Sex Differ. 2018 Jul 25;9(1):34. doi: 10.1186/s13293-018-0193-7.

9.

Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer's Disease.

Stockburger C, Eckert S, Eckert GP, Friedland K, Müller WE.

J Alzheimers Dis. 2018;64(s1):S455-S467. doi: 10.3233/JAD-179915. Review.

PMID:
29504539
10.

MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease.

Pohland M, Pellowska M, Asseburg H, Hagl S, Reutzel M, Joppe A, Berressem D, Eckert SH, Wurglics M, Schubert-Zsilavecz M, Eckert GP.

Alzheimers Res Ther. 2018 Feb 13;10(1):18. doi: 10.1186/s13195-018-0342-6.

11.

Peptidomimetics That Inhibit and Partially Reverse the Aggregation of Aβ1-42.

Stark T, Lieblein T, Pohland M, Kalden E, Freund P, Zangl R, Grewal R, Heilemann M, Eckert GP, Morgner N, Göbel MW.

Biochemistry. 2017 Sep 12;56(36):4840-4849. doi: 10.1021/acs.biochem.7b00223. Epub 2017 Aug 25.

PMID:
28841311
12.

A diet rich in omega-3 fatty acids enhances expression of soluble epoxide hydrolase in murine brain.

Ostermann AI, Reutzel M, Hartung N, Franke N, Kutzner L, Schoenfeld K, Weylandt KH, Eckert GP, Schebb NH.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:79-87. doi: 10.1016/j.prostaglandins.2017.06.001. Epub 2017 Jun 3.

PMID:
28583889
13.

Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer's disease.

Müller WE, Eckert A, Eckert GP, Fink H, Friedland K, Gauthier S, Hoerr R, Ihl R, Kasper S, Möller HJ.

World J Biol Psychiatry. 2019 Mar;20(3):173-189. doi: 10.1080/15622975.2017.1308552. Epub 2017 May 2. Review.

PMID:
28460580
14.

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice.

Koch K, Berressem D, Konietzka J, Thinnes A, Eckert GP, Klein J.

J Am Heart Assoc. 2017 Apr 5;6(4). pii: e005556. doi: 10.1161/JAHA.117.005556.

15.

Intravenous Treatment with a Long-Chain Omega-3 Lipid Emulsion Provides Neuroprotection in a Murine Model of Ischemic Stroke - A Pilot Study.

Berressem D, Koch K, Franke N, Klein J, Eckert GP.

PLoS One. 2016 Nov 30;11(11):e0167329. doi: 10.1371/journal.pone.0167329. eCollection 2016.

16.

Effects of Grape Skin Extract on Age-Related Mitochondrial Dysfunction, Memory and Life Span in C57BL/6J Mice.

Asseburg H, Schäfer C, Müller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP.

Neuromolecular Med. 2016 Sep;18(3):378-95. doi: 10.1007/s12017-016-8428-4. Epub 2016 Jul 25.

PMID:
27455862
17.

Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice.

Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP.

Neuromolecular Med. 2016 Sep;18(3):347-63. doi: 10.1007/s12017-016-8420-z. Epub 2016 Jun 27.

PMID:
27350374
18.

Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway.

Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL.

J Neuroinflammation. 2016 Jun 14;13(1):148. doi: 10.1186/s12974-016-0615-6.

19.

Pharmacology: The Pharmacodynamics of Nutrients and Nutrient Interactions in Biological Functions.

Mohajeri MH, Eckert GP, Pauly JR, Butt CM.

Biomed Res Int. 2015;2015:974572. doi: 10.1155/2015/974572. Epub 2015 Dec 22. No abstract available.

20.

MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease.

Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP.

Neurochem Res. 2016 Feb;41(1-2):231-42. doi: 10.1007/s11064-015-1765-0. Epub 2015 Dec 31.

PMID:
26721513
21.

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP.

Brain. 2015 Dec;138(Pt 12):3632-53. doi: 10.1093/brain/awv290. Epub 2015 Oct 21.

PMID:
26490331
22.

Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components.

Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP.

Molecules. 2015 Sep 11;20(9):16524-39. doi: 10.3390/molecules200916524.

23.

Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability.

Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP.

Neurochem Int. 2015 Oct;89:234-42. doi: 10.1016/j.neuint.2015.07.026. Epub 2015 Aug 5.

PMID:
26254982
24.

Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice.

Hagl S, Berressem D, Grewal R, Sus N, Frank J, Eckert GP.

Nutr Neurosci. 2016;19(1):1-10. doi: 10.1179/1476830515Y.0000000040. Epub 2015 Aug 4.

PMID:
26241203
25.

¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.

Doert A, Pilatus U, Zanella F, Müller WE, Eckert GP.

J Neural Transm (Vienna). 2015 Apr;122(4):541-50. doi: 10.1007/s00702-015-1387-3. Epub 2015 Mar 6.

PMID:
25742870
26.

Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.

Afshordel S, Kern B, Clasohm J, König H, Priester M, Weissenberger J, Kögel D, Eckert GP.

Pharmacol Res. 2015 Jan;91:69-77. doi: 10.1016/j.phrs.2014.11.006. Epub 2014 Dec 8.

PMID:
25497898
27.

Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity.

Pellowska M, Stein C, Pohland M, Merk D, Klein J, Eckert GP, Schubert-Zsilavecz M, Wurglics M.

J Pharm Biomed Anal. 2015 Jan;102:417-24. doi: 10.1016/j.jpba.2014.10.001. Epub 2014 Oct 13.

PMID:
25459941
28.

Geranylgeranyl pyrophosphate is crucial for neuronal survival but has no special role in Purkinje cell degeneration in Niemann Pick type C1 disease.

Marschalek N, Albert F, Afshordel S, Meske V, Eckert GP, Ohm TG.

J Neurochem. 2015 Apr;133(1):153-61. doi: 10.1111/jnc.12959. Epub 2015 Feb 5.

29.

Mitochondrial dysfunction: cause and consequence of Alzheimer's disease.

Friedland-Leuner K, Stockburger C, Denzer I, Eckert GP, Müller WE.

Prog Mol Biol Transl Sci. 2014;127:183-210. doi: 10.1016/B978-0-12-394625-6.00007-6. Review.

PMID:
25149218
30.

Rice bran extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer's disease.

Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP.

J Alzheimers Dis. 2015;43(3):927-38. doi: 10.3233/JAD-132084.

PMID:
25125472
31.

Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging--impact of Bcl-2 and NPD-1 like metabolites.

Afshordel S, Hagl S, Werner D, Röhner N, Kögel D, Bazan NG, Eckert GP.

Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:23-31. doi: 10.1016/j.plefa.2014.05.008. Epub 2014 Jun 9.

PMID:
24972878
32.

Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin.

Chin D, Hagl S, Hoehn A, Huebbe P, Pallauf K, Grune T, Frank J, Eckert GP, Rimbach G.

Genes Nutr. 2014 May;9(3):397. doi: 10.1007/s12263-014-0397-3. Epub 2014 Mar 27.

33.

Mitochondrial membrane fluidity is consistently increased in different models of Huntington disease: restorative effects of olesoxime.

Eckmann J, Clemens LE, Eckert SH, Hagl S, Yu-Taeger L, Bordet T, Pruss RM, Muller WE, Leuner K, Nguyen HP, Eckert GP.

Mol Neurobiol. 2014 Aug;50(1):107-18. doi: 10.1007/s12035-014-8663-3. Epub 2014 Mar 18.

PMID:
24633813
34.

Cellular membrane fluidity in amyloid precursor protein processing.

Yang X, Sun GY, Eckert GP, Lee JC.

Mol Neurobiol. 2014 Aug;50(1):119-29. doi: 10.1007/s12035-014-8652-6. Epub 2014 Feb 20. Review.

35.

Statins and neuroprotection: basic pharmacology needed.

Wood WG, Mΰller WE, Eckert GP.

Mol Neurobiol. 2014 Aug;50(1):214-20. doi: 10.1007/s12035-014-8647-3. Epub 2014 Jan 29. Review.

PMID:
24474514
36.

Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain.

Afshordel S, Wood WG, Igbavboa U, Muller WE, Eckert GP.

J Neurochem. 2014 May;129(4):732-42. doi: 10.1111/jnc.12654. Epub 2014 Feb 7.

37.

Curcumin Micelles Improve Mitochondrial Function in a Mouse Model of Alzheimer's Disease.

Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP.

J Prev Alzheimers Dis. 2014;1(2):80-83. doi: 10.14283/jpad.2014.2.

PMID:
29255835
38.

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.

Wood WG, Li L, Müller WE, Eckert GP.

J Neurochem. 2014 May;129(4):559-72. doi: 10.1111/jnc.12637. Epub 2014 Jan 2. Review.

39.
40.

Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function.

Schwarzkopf TM, Hagl S, Eckert GP, Klein J.

Pharmazie. 2013 Jul;68(7):584-9.

PMID:
23923641
41.

Rice bran extract protects from mitochondrial dysfunction in guinea pig brains.

Hagl S, Kocher A, Schiborr C, Eckert SH, Ciobanu I, Birringer M, El-Askary H, Helal A, Khayyal MT, Frank J, Muller WE, Eckert GP.

Pharmacol Res. 2013 Oct;76:17-27. doi: 10.1016/j.phrs.2013.06.008. Epub 2013 Jul 1.

PMID:
23827162
42.

Statins, Bcl-2, and apoptosis: cell death or cell protection?

Wood WG, Igbavboa U, Muller WE, Eckert GP.

Mol Neurobiol. 2013 Oct;48(2):308-14. doi: 10.1007/s12035-013-8496-5. Epub 2013 Jul 3. Review.

43.

The senescence-accelerated mouse-prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals.

Schiborr C, Schwamm D, Kocher A, Rimbach G, Eckert GP, Frank J.

Pharmacol Res. 2013 Aug;74:113-20. doi: 10.1016/j.phrs.2013.06.004. Epub 2013 Jun 17.

PMID:
23792082
44.

Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8.

Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Müller WE, Rimbach G, Frank J.

Neurochem Int. 2013 Apr;62(5):595-602. doi: 10.1016/j.neuint.2013.02.014. Epub 2013 Feb 17.

PMID:
23422877
45.

Atorvastatin requires geranylgeranyl transferase-I and Rac1 activation to exert neuronal protection and induce plasticity.

Posada-Duque RA, Velasquez-Carvajal D, Eckert GP, Cardona-Gomez GP.

Neurochem Int. 2013 Mar;62(4):433-45. doi: 10.1016/j.neuint.2013.01.026. Epub 2013 Feb 11.

PMID:
23411415
47.

Alterations of brain membranes in schizophrenia: impact of phospholipase A(2).

Schaeffer EL, Gattaz WF, Eckert GP.

Curr Top Med Chem. 2012;12(21):2314-23. Review.

PMID:
23279172
48.

Alzheimer's disease: new perspectives on therapeutic targets and pathways. Foreword.

Müller WE, Eckert GP, Sun GY, Wood WG.

Mol Neurobiol. 2012 Aug;46(1):1-2. doi: 10.1007/s12035-012-8306-5. No abstract available.

PMID:
22829142
49.

Mitochondria: mitochondrial membranes in brain ageing and neurodegeneration.

Eckmann J, Eckert SH, Leuner K, Muller WE, Eckert GP.

Int J Biochem Cell Biol. 2013 Jan;45(1):76-80. doi: 10.1016/j.biocel.2012.06.009. Epub 2012 Jun 26.

PMID:
22743330
50.

Omega-3 fatty acids in neurodegenerative diseases: focus on mitochondria.

Eckert GP, Lipka U, Muller WE.

Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):105-14. doi: 10.1016/j.plefa.2012.05.006. Epub 2012 Jun 22. Review.

PMID:
22727983

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