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Items: 32


Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma.

Eckerdt F, Clymer J, Bell JB, Beauchamp EM, Blyth GT, Goldman S, Platanias LC.

Sci Rep. 2019 Sep 6;9(1):12822. doi: 10.1038/s41598-019-49299-3.


Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma.

Eckerdt F, Bell JB, Beauchamp EM, Clymer J, Blyth GT, Kosciuczuk EM, Ma Q, Chen DZ, Horbinski C, Goldman S, Munshi HG, Hashizume R, Platanias LC.

Mol Cancer Res. 2019 Jun;17(6):1305-1315. doi: 10.1158/1541-7786.MCR-18-1193. Epub 2019 Mar 6.


Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer.

Brisard D, Eckerdt F, Marsh LA, Blyth GT, Jain S, Cristofanilli M, Horiuchi D, Platanias LC.

Oncotarget. 2018 Dec 18;9(99):37305-37318. doi: 10.18632/oncotarget.26468. eCollection 2018 Dec 18.


HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma.

Bell JB, Rink JS, Eckerdt F, Clymer J, Goldman S, Thaxton CS, Platanias LC.

Sci Rep. 2018 Jan 19;8(1):1211. doi: 10.1038/s41598-017-18100-8.


Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation.

Bell JB, Eckerdt F, Dhruv HD, Finlay D, Peng S, Kim S, Kroczynska B, Beauchamp EM, Alley K, Clymer J, Goldman S, Cheng SY, James CD, Nakano I, Horbinski C, Mazar AP, Vuori K, Kumthekar P, Raizer J, Berens ME, Platanias LC.

Mol Cancer Res. 2018 Jan;16(1):32-46. doi: 10.1158/1541-7786.MCR-17-0397. Epub 2017 Oct 17.


Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.

Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC.

Oncogene. 2017 Oct 26;36(43):6006-6019. doi: 10.1038/onc.2017.205. Epub 2017 Jul 3.


MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.

Bell JB, Eckerdt FD, Alley K, Magnusson LP, Hussain H, Bi Y, Arslan AD, Clymer J, Alvarez AA, Goldman S, Cheng SY, Nakano I, Horbinski C, Davuluri RV, James CD, Platanias LC.

Mol Cancer Res. 2016 Oct;14(10):984-993. Epub 2016 Jun 30.


Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo.

Kosciuczuk EM, Saleiro D, Kroczynska B, Beauchamp EM, Eckerdt F, Blyth GT, Abedin SM, Giles FJ, Altman JK, Platanias LC.

Blood. 2016 Jul 21;128(3):410-4. doi: 10.1182/blood-2016-02-698704. Epub 2016 Jun 15.


Targeting BET bromodomain proteins in solid tumors.

Sahai V, Redig AJ, Collier KA, Eckerdt FD, Munshi HG.

Oncotarget. 2016 Aug 16;7(33):53997-54009. doi: 10.18632/oncotarget.9804. Review.


Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.

Iqbal A, Eckerdt F, Bell J, Nakano I, Giles FJ, Cheng SY, Lulla RR, Goldman S, Platanias LC.

Oncotarget. 2016 May 31;7(22):33192-201. doi: 10.18632/oncotarget.8899.


A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids.

Eckerdt F, Alvarez A, Bell J, Arvanitis C, Iqbal A, Arslan AD, Hu B, Cheng SY, Goldman S, Platanias LC.

Biotechniques. 2016 Jan 1;60(1):43-6. doi: 10.2144/000114372. eCollection 2016 Jan.


Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer.

Kumar K, Chow CR, Ebine K, Arslan AD, Kwok B, Bentrem DJ, Eckerdt FD, Platanias LC, Munshi HG.

Mol Cancer Res. 2016 Feb;14(2):216-27. doi: 10.1158/1541-7786.MCR-15-0285. Epub 2015 Nov 25.


Regulation of Greatwall kinase by protein stabilization and nuclear localization.

Yamamoto TM, Wang L, Fisher LA, Eckerdt FD, Peng A.

Cell Cycle. 2014;13(22):3565-75. doi: 10.4161/15384101.2014.962942.


Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells.

Eckerdt F, Beauchamp E, Bell J, Iqbal A, Su B, Fukunaga R, Lulla RR, Goldman S, Platanias LC.

Oncotarget. 2014 Sep 30;5(18):8442-51.


LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.

Eckerdt F, Perez-Neut M, Colamonici OR.

PLoS One. 2014 Jan 27;9(1):e87620. doi: 10.1371/journal.pone.0087620. eCollection 2014.


New insights into malignant cell survival mechanisms in medulloblastoma.

Eckerdt F, Goldman S, Platanias LC.

Cancer Cell Microenviron. 2014;1(6). pii: e374.


Polo-like kinase 1 inhibitors SBE13 and BI 2536 induce different responses in primary cells.

Eckerdt F.

Cell Cycle. 2011 Apr 1;10(7):1031-1030. doi: 10.4161/cc.10.7.15213.


Polo-like kinase 1 inhibitors SBE13 and BI 2536 induce different responses in primary cells.

Eckerdt F.

Cell Cycle. 2011 Apr 1;10(7):1027-8. Epub 2011 Apr 1. No abstract available.


Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation.

Eckerdt F, Yamamoto TM, Lewellyn AL, Maller JL.

Curr Biol. 2011 Mar 8;21(5):428-32. doi: 10.1016/j.cub.2011.01.072. Epub 2011 Feb 25.


Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells.

Eckerdt F.

Cell Cycle. 2010 Mar 1;9(5):862. Epub 2010 Mar 1. No abstract available.


Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding.

Pascreau G, Eckerdt F, Churchill ME, Maller JL.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2932-7. doi: 10.1073/pnas.0914874107. Epub 2010 Jan 26.


Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A.

Eckerdt F, Pascreau G, Phistry M, Lewellyn AL, DePaoli-Roach AA, Maller JL.

Cell Cycle. 2009 Aug;8(15):2413-9. Epub 2009 Aug 22.


Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes.

Pascreau G, Eckerdt F, Lewellyn AL, Prigent C, Maller JL.

J Biol Chem. 2009 Feb 27;284(9):5497-505. doi: 10.1074/jbc.M805959200. Epub 2009 Jan 2.


Kicking off the polo game.

Eckerdt F, Maller JL.

Trends Biochem Sci. 2008 Nov;33(11):511-3. doi: 10.1016/j.tibs.2008.08.004. Epub 2008 Sep 23.


Spindle pole regulation by a discrete Eg5-interacting domain in TPX2.

Eckerdt F, Eyers PA, Lewellyn AL, Prigent C, Maller JL.

Curr Biol. 2008 Apr 8;18(7):519-25. doi: 10.1016/j.cub.2008.02.077. Epub 2008 Mar 27.


Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells.

Eckerdt F, Yuan J, Saxena K, Martin B, Kappel S, Lindenau C, Kramer A, Naumann S, Daum S, Fischer G, Dikic I, Kaufmann M, Strebhardt K.

J Biol Chem. 2005 Nov 4;280(44):36575-83. Epub 2005 Aug 23.


Polo-like kinases and oncogenesis.

Eckerdt F, Yuan J, Strebhardt K.

Oncogene. 2005 Jan 10;24(2):267-76. Review.


Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells.

Yuan J, Yan R, Krämer A, Eckerdt F, Roller M, Kaufmann M, Strebhardt K.

Oncogene. 2004 Jul 29;23(34):5843-52.


Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

Yuan J, Eckerdt F, Bereiter-Hahn J, Kurunci-Csacsko E, Kaufmann M, Strebhardt K.

Oncogene. 2002 Nov 28;21(54):8282-92.


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