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Items: 18


The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.

Rohlfing AE, Eckenroth BE, Forster ER, Kevorkian Y, Donnelly ML, Benito de la Puebla H, Doublié S, Shen A.

PLoS Genet. 2019 Jul 5;15(7):e1008224. doi: 10.1371/journal.pgen.1008224. eCollection 2019 Jul.


Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain.

Gay JC, Eckenroth BE, Evans CM, Langini C, Carlson S, Lloyd JT, Caflisch A, Glass KC.

Proteins. 2019 Feb;87(2):157-167. doi: 10.1002/prot.25636. Epub 2018 Dec 27.


I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity.

Liptak C, Mahmoud MM, Eckenroth BE, Moreno MV, East K, Alnajjar KS, Huang J, Towle-Weicksel JB, Doublié S, Loria JP, Sweasy JB.

Nucleic Acids Res. 2018 Nov 16;46(20):10740-10756. doi: 10.1093/nar/gky825.


Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.

Mahmoud MM, Schechter A, Alnajjar KS, Huang J, Towle-Weicksel J, Eckenroth BE, Doublié S, Sweasy JB.

Biochemistry. 2017 Oct 17;56(41):5550-5559. doi: 10.1021/acs.biochem.7b00869. Epub 2017 Oct 2.


Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

Eckenroth BE, Towle-Weicksel JB, Nemec AA, Murphy DL, Sweasy JB, Doublié S.

Biochemistry. 2017 May 9;56(18):2363-2371. doi: 10.1021/acs.biochem.6b01287. Epub 2017 Apr 21.


Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.

Piret J, Goyette N, Eckenroth BE, Drouot E, Götte M, Boivin G.

J Virol. 2015 Apr;89(8):4636-44. doi: 10.1128/JVI.03360-14. Epub 2015 Feb 11.


Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.

Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, Glass KC.

FEBS Lett. 2014 Nov 3;588(21):3844-54. doi: 10.1016/j.febslet.2014.09.028. Epub 2014 Sep 30.


Crystal structure of DNA polymerase β with DNA containing the base lesion spiroiminodihydantoin in a templating position.

Eckenroth BE, Fleming AM, Sweasy JB, Burrows CJ, Doublié S.

Biochemistry. 2014 Apr 8;53(13):2075-7. doi: 10.1021/bi500270e. Epub 2014 Mar 26.


The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection.

Eckenroth BE, Towle-Weicksel JB, Sweasy JB, Doublié S.

J Biol Chem. 2013 Nov 29;288(48):34850-60. doi: 10.1074/jbc.M113.510891. Epub 2013 Oct 16.


Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases.

Prakash A, Eckenroth BE, Averill AM, Imamura K, Wallace SS, Doublié S.

DNA Repair (Amst). 2013 Dec;12(12):1062-71. doi: 10.1016/j.dnarep.2013.09.004. Epub 2013 Oct 10.


Structural studies of a bacterial tRNA(HIS) guanylyltransferase (Thg1)-like protein, with nucleotide in the activation and nucleotidyl transfer sites.

Hyde SJ, Rao BS, Eckenroth BE, Jackman JE, Doublié S.

PLoS One. 2013 Jul 3;8(7):e67465. doi: 10.1371/journal.pone.0067465. Print 2013.


Structural and functional analysis of the CspB protease required for Clostridium spore germination.

Adams CM, Eckenroth BE, Putnam EE, Doublié S, Shen A.

PLoS Pathog. 2013 Feb;9(2):e1003165. doi: 10.1371/journal.ppat.1003165. Epub 2013 Feb 7.


How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.

Eckenroth BE, Steere AN, Chasteen ND, Everse SJ, Mason AB.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13089-94. doi: 10.1073/pnas.1105786108. Epub 2011 Jul 25.


tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.

Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublié S.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20305-10. doi: 10.1073/pnas.1010436107. Epub 2010 Nov 8.


The structure and evolution of the murine inhibitor of carbonic anhydrase: a member of the transferrin superfamily.

Eckenroth BE, Mason AB, McDevitt ME, Lambert LA, Everse SJ.

Protein Sci. 2010 Sep;19(9):1616-26. doi: 10.1002/pro.439.


Selenium in thioredoxin reductase: a mechanistic perspective.

Lacey BM, Eckenroth BE, Flemer S, Hondal RJ.

Biochemistry. 2008 Dec 2;47(48):12810-21. doi: 10.1021/bi800951f.


Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis.

Eckenroth BE, Lacey BM, Lothrop AP, Harris KM, Hondal RJ.

Biochemistry. 2007 Aug 21;46(33):9472-83. Epub 2007 Jul 28.


Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases.

Eckenroth BE, Rould MA, Hondal RJ, Everse SJ.

Biochemistry. 2007 Apr 24;46(16):4694-705. Epub 2007 Mar 27.

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