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An explorative vs. traditional practical course: how to inspire scientific thinking in medical students.

Eckel J, Zavaritskaya O, Schüttpelz-Brauns K, Schubert R.

Adv Physiol Educ. 2019 Sep 1;43(3):350-354. doi: 10.1152/advan.00120.2018.


Myokines in metabolic homeostasis and diabetes.

Eckel J.

Diabetologia. 2019 Sep;62(9):1523-1528. doi: 10.1007/s00125-019-4927-9. Epub 2019 Jul 1. Review.


Adipokines and inflammatory markers in elderly subjects with high risk of type 2 diabetes and cardiovascular disease.

Saukkonen T, Mutt SJ, Jokelainen J, Saukkonen AM, Raza GS, Karhu T, Härkönen P, Eckel J, Herzig KH, Rajala U, Keinänen-Kiukaanniemi S.

Sci Rep. 2018 Aug 24;8(1):12816. doi: 10.1038/s41598-018-31144-8.


Heat Shock Protein 60 in Obesity: Effect of Bariatric Surgery and its Relation to Inflammation and Cardiovascular Risk.

Sell H, Poitou C, Habich C, Bouillot JL, Eckel J, Clément K.

Obesity (Silver Spring). 2017 Dec;25(12):2108-2114. doi: 10.1002/oby.22014. Epub 2017 Oct 11.


Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1α Pathway.

Görgens SW, Benninghoff T, Eckardt K, Springer C, Chadt A, Melior A, Wefers J, Cramer A, Jensen J, Birkeland KI, Drevon CA, Al-Hasani H, Eckel J.

Diabetes. 2017 Nov;66(11):2800-2807. doi: 10.2337/db16-1488. Epub 2017 Aug 15.


The inventory as a core element in the further development of the science curriculum in the Mannheim Reformed Curriculum of Medicine.

Eckel J, Schüttpelz-Brauns K, Miethke T, Rolletschek A, Fritz HM.

GMS J Med Educ. 2017 May 15;34(2):Doc22. doi: 10.3205/zma001099. eCollection 2017.


LAPS Insulin115: A novel ultra-long-acting basal insulin with a unique action profile.

Wronkowitz N, Hartmann T, Görgens SW, Dietze-Schroeder D, Indrakusuma I, Choi IY, Park SH, Lee YM, Kwon SC, Kang Y, Hompesch M, Eckel J.

Diabetes Obes Metab. 2017 Dec;19(12):1722-1731. doi: 10.1111/dom.13006. Epub 2017 Jul 13.


Protease-Activated Receptor 2 Promotes Pro-Atherogenic Effects through Transactivation of the VEGF Receptor 2 in Human Vascular Smooth Muscle Cells.

Indrakusuma I, Romacho T, Eckel J.

Front Pharmacol. 2017 Jan 4;7:497. doi: 10.3389/fphar.2016.00497. eCollection 2016.


Electrical pulse stimulation of cultured skeletal muscle cells as a model for in vitro exercise - possibilities and limitations.

Nikolić N, Görgens SW, Thoresen GH, Aas V, Eckel J, Eckardt K.

Acta Physiol (Oxf). 2017 Jul;220(3):310-331. doi: 10.1111/apha.12830. Epub 2016 Nov 30. Review.


Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function.

Hartmann T, Overhagen S, Ouwens DM, Raschke S, Wohlfart P, Tennagels N, Wronkowitz N, Eckel J.

Cardiovasc Diabetol. 2016 Jul 15;15:96. doi: 10.1186/s12933-016-0410-9.


Eicosapentaenoic acid and arachidonic acid differentially regulate adipogenesis, acquisition of a brite phenotype and mitochondrial function in primary human adipocytes.

Fleckenstein-Elsen M, Dinnies D, Jelenik T, Roden M, Romacho T, Eckel J.

Mol Nutr Food Res. 2016 Sep;60(9):2065-75. doi: 10.1002/mnfr.201500892. Epub 2016 Jun 9.


Soluble dipeptidyl peptidase-4 induces microvascular endothelial dysfunction through proteinase-activated receptor-2 and thromboxane A2 release.

Romacho T, Vallejo S, Villalobos LA, Wronkowitz N, Indrakusuma I, Sell H, Eckel J, Sánchez-Ferrer CF, Peiró C.

J Hypertens. 2016 May;34(5):869-76. doi: 10.1097/HJH.0000000000000886.


Reduced DPP4 activity improves insulin signaling in primary human adipocytes.

Röhrborn D, Brückner J, Sell H, Eckel J.

Biochem Biophys Res Commun. 2016 Mar 11;471(3):348-54. doi: 10.1016/j.bbrc.2016.02.019. Epub 2016 Feb 10.


Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.

Schering L, Hoene M, Kanzleiter T, Jähnert M, Wimmers K, Klaus S, Eckel J, Weigert C, Schürmann A, Maak S, Jonas W, Sell H.

Arch Physiol Biochem. 2015;121(5):194-205. doi: 10.3109/13813455.2015.1092044. Epub 2015 Nov 24.


Exercise and Regulation of Adipokine and Myokine Production.

Görgens SW, Eckardt K, Jensen J, Drevon CA, Eckel J.

Prog Mol Biol Transl Sci. 2015;135:313-36. doi: 10.1016/bs.pmbts.2015.07.002. Epub 2015 Jul 31. Review.


Novel Mediators of Adipose Tissue and Muscle Crosstalk.

Indrakusuma I, Sell H, Eckel J.

Curr Obes Rep. 2015 Dec;4(4):411-7. doi: 10.1007/s13679-015-0174-7. Review.


The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation.

Görgens SW, Hjorth M, Eckardt K, Wichert S, Norheim F, Holen T, Lee S, Langleite T, Birkeland KI, Stadheim HK, Kolnes KJ, Tangen DS, Kolnes AJ, Jensen J, Drevon CA, Eckel J.

Acta Physiol (Oxf). 2016 Mar;216(3):330-45. doi: 10.1111/apha.12579. Epub 2015 Sep 8.


DPP4 in Diabetes.

Röhrborn D, Wronkowitz N, Eckel J.

Front Immunol. 2015 Jul 27;6:386. doi: 10.3389/fimmu.2015.00386. eCollection 2015. Review.


Adipokines enhance oleic acid-induced proliferation of vascular smooth muscle cells by inducing CD36 expression.

Schlich R, Lamers D, Eckel J, Sell H.

Arch Physiol Biochem. 2015;121(3):81-7. doi: 10.3109/13813455.2015.1045520. Epub 2015 Jul 1.


Nutritional ingredients modulate adipokine secretion and inflammation in human primary adipocytes.

Romacho T, Glosse P, Richter I, Elsen M, Schoemaker MH, van Tol EA, Eckel J.

Nutrients. 2015 Jan 26;7(2):865-86. doi: 10.3390/nu7020865.


Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells.

Röhrborn D, Eckel J, Sell H.

FEBS Lett. 2014 Nov 3;588(21):3870-7. doi: 10.1016/j.febslet.2014.08.029. Epub 2014 Sep 12.


Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383.

Elsen M, Raschke S, Sommerfeld M, Gassenhuber H, Eckel J.

Diabetes. 2014 Sep;63(9):e16. doi: 10.2337/db14-0776. No abstract available.


A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.

Hall G, Gbadegesin RA, Lavin P, Wu G, Liu Y, Oh EC, Wang L, Spurney RF, Eckel J, Lindsey T, Homstad A, Malone AF, Phelan PJ, Shaw A, Howell DN, Conlon PJ, Katsanis N, Winn MP.

J Am Soc Nephrol. 2015 Apr;26(4):831-43. doi: 10.1681/ASN.2013101053. Epub 2014 Aug 21.


Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

Pasternak L, Meltzer-Mats E, Babai-Shani G, Cohen G, Viskind O, Eckel J, Cerasi E, Sasson S, Gruzman A.

Chem Commun (Camb). 2014 Oct 4;50(76):11222-5. doi: 10.1039/c4cc03310h.


The myokine decorin is regulated by contraction and involved in muscle hypertrophy.

Kanzleiter T, Rath M, Görgens SW, Jensen J, Tangen DS, Kolnes AJ, Kolnes KJ, Lee S, Eckel J, Schürmann A, Eckardt K.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):1089-94. doi: 10.1016/j.bbrc.2014.06.123. Epub 2014 Jul 1.


Adipose tissue dysfunction and inflammation in cardiovascular disease.

Wronkowitz N, Romacho T, Sell H, Eckel J.

Front Horm Res. 2014;43:79-92. doi: 10.1159/000360560. Epub 2014 Jun 10. Review.


Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2.

Wronkowitz N, Görgens SW, Romacho T, Villalobos LA, Sánchez-Ferrer CF, Peiró C, Sell H, Eckel J.

Biochim Biophys Acta. 2014 Sep;1842(9):1613-21. doi: 10.1016/j.bbadis.2014.06.004. Epub 2014 Jun 11.


Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany.

Müller MJ, Baracos V, Bosy-Westphal A, Dulloo AG, Eckel J, Fearon KC, Hall KD, Pietrobelli A, Sørensen TI, Speakman J, Trayhurn P, Visser M, Heymsfield SB.

Obes Rev. 2014 Aug;15(8):640-56. doi: 10.1111/obr.12187. Epub 2014 May 18. Review.


Browning of white fat: does irisin play a role in humans?

Elsen M, Raschke S, Eckel J.

J Endocrinol. 2014 Jul;222(1):R25-38. doi: 10.1530/JOE-14-0189. Epub 2014 Apr 29. Review.


Myokines in insulin resistance and type 2 diabetes.

Eckardt K, Görgens SW, Raschke S, Eckel J.

Diabetologia. 2014 Jun;57(6):1087-99. doi: 10.1007/s00125-014-3224-x. Epub 2014 Mar 28. Review.


Chitinase-3-like protein 1 protects skeletal muscle from TNFα-induced inflammation and insulin resistance.

Görgens SW, Eckardt K, Elsen M, Tennagels N, Eckel J.

Biochem J. 2014 May 1;459(3):479-88. doi: 10.1042/BJ20131151.


Adipose tissue and its role in organ crosstalk.

Romacho T, Elsen M, Röhrborn D, Eckel J.

Acta Physiol (Oxf). 2014 Apr;210(4):733-53. doi: 10.1111/apha.12246. Epub 2014 Feb 25. Review.


Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells.

Lipert B, Wegrzyn P, Sell H, Eckel J, Winiarski M, Budzynski A, Matlok M, Kotlinowski J, Ramage L, Malecki M, Wilk W, Mitus J, Jura J.

Biochim Biophys Acta. 2014 Apr;1843(4):780-8. doi: 10.1016/j.bbamcr.2014.01.001. Epub 2014 Jan 10.


Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.

Blumensatt M, Wronkowitz N, Wiza C, Cramer A, Mueller H, Rabelink MJ, Hoeben RC, Eckel J, Sell H, Ouwens DM.

Biochim Biophys Acta. 2014 Feb;1842(2):275-83. doi: 10.1016/j.bbadis.2013.12.001. Epub 2013 Dec 9.


BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells.

Elsen M, Raschke S, Tennagels N, Schwahn U, Jelenik T, Roden M, Romacho T, Eckel J.

Am J Physiol Cell Physiol. 2014 Mar 1;306(5):C431-40. doi: 10.1152/ajpcell.00290.2013. Epub 2013 Nov 27.


Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro.

Sell H, Blüher M, Klöting N, Schlich R, Willems M, Ruppe F, Knoefel WT, Dietrich A, Fielding BA, Arner P, Frayn KN, Eckel J.

Diabetes Care. 2013 Dec;36(12):4083-90. doi: 10.2337/dc13-0496. Epub 2013 Oct 15.


Evidence against a beneficial effect of irisin in humans.

Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisløff U, Tjønna AE, Raastad T, Hallén J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J.

PLoS One. 2013 Sep 11;8(9):e73680. doi: 10.1371/journal.pone.0073680. eCollection 2013.


Secretome profiling of primary human skeletal muscle cells.

Hartwig S, Raschke S, Knebel B, Scheler M, Irmler M, Passlack W, Muller S, Hanisch FG, Franz T, Li X, Dicken HD, Eckardt K, Beckers J, de Angelis MH, Weigert C, Häring HU, Al-Hasani H, Ouwens DM, Eckel J, Kotzka J, Lehr S.

Biochim Biophys Acta. 2014 May;1844(5):1011-7. doi: 10.1016/j.bbapap.2013.08.004. Epub 2013 Aug 27.


VEGF in the crosstalk between human adipocytes and smooth muscle cells: depot-specific release from visceral and perivascular adipose tissue.

Schlich R, Willems M, Greulich S, Ruppe F, Knoefel WT, Ouwens DM, Maxhera B, Lichtenberg A, Eckel J, Sell H.

Mediators Inflamm. 2013;2013:982458. doi: 10.1155/2013/982458. Epub 2013 Jul 9.


Adipo-myokines: two sides of the same coin--mediators of inflammation and mediators of exercise.

Raschke S, Eckel J.

Mediators Inflamm. 2013;2013:320724. doi: 10.1155/2013/320724. Epub 2013 Jun 3. Review.


[Use of standardized patients in the psycho-social subjects of medical studies--applicability of standardized patients in postgraduate psychotherapy training curricula?].

Eckel J, Merod R, Vogel H, Neuderth S.

Psychother Psychosom Med Psychol. 2014 Jan;64(1):5-11. doi: 10.1055/s-0033-1347210. Epub 2013 Jun 21. German.


Adipose tissue-related proteins locally associated with resolution of inflammation in obese mice.

Jilkova ZM, Hensler M, Medrikova D, Janovska P, Horakova O, Rossmeisl M, Flachs P, Sell H, Eckel J, Kopecky J.

Int J Obes (Lond). 2014 Feb;38(2):216-23. doi: 10.1038/ijo.2013.108. Epub 2013 Jun 12.


Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

Meltzer-Mats E, Babai-Shani G, Pasternak L, Uritsky N, Getter T, Viskind O, Eckel J, Cerasi E, Senderowitz H, Sasson S, Gruzman A.

J Med Chem. 2013 Jul 11;56(13):5335-50. doi: 10.1021/jm4001488. Epub 2013 Jun 26.


"Browning" of adipose tissue--regulation and therapeutic perspectives.

Peschechera A, Eckel J.

Arch Physiol Biochem. 2013 Oct;119(4):151-60. doi: 10.3109/13813455.2013.796995. Epub 2013 May 30. Review.


Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells.

Raschke S, Eckardt K, Bjørklund Holven K, Jensen J, Eckel J.

PLoS One. 2013 Apr 24;8(4):e62008. doi: 10.1371/journal.pone.0062008. Print 2013.


Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies.

Greulich S, Chen WJ, Maxhera B, Rijzewijk LJ, van der Meer RW, Jonker JT, Mueller H, de Wiza DH, Floerke RR, Smiris K, Lamb HJ, de Roos A, Bax JJ, Romijn JA, Smit JW, Akhyari P, Lichtenberg A, Eckel J, Diamant M, Ouwens DM.

PLoS One. 2013;8(3):e59697. doi: 10.1371/journal.pone.0059697. Epub 2013 Mar 29.


Regulation of follistatin-like protein 1 expression and secretion in primary human skeletal muscle cells.

Görgens SW, Raschke S, Holven KB, Jensen J, Eckardt K, Eckel J.

Arch Physiol Biochem. 2013 May;119(2):75-80. doi: 10.3109/13813455.2013.768270. Epub 2013 Feb 19.


Deletion of CD73 promotes dyslipidemia and intramyocellular lipid accumulation in muscle of mice.

Burghoff S, Flögel U, Bongardt S, Burkart V, Sell H, Tucci S, Ikels K, Eberhard D, Kern M, Klöting N, Eckel J, Schrader J.

Arch Physiol Biochem. 2013 May;119(2):39-51. doi: 10.3109/13813455.2012.755547. Epub 2013 Feb 11.


Prolonged fasting and the effects on biomarkers of inflammation and on adipokines in healthy lean men.

van Herpen NA, Sell H, Eckel J, Schrauwen P, Mensink RP.

Horm Metab Res. 2013 May;45(5):378-82. doi: 10.1055/s-0032-1330015. Epub 2012 Dec 12.


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