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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.

Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A.

Nat Biotechnol. 2019 Aug;37(8):884-894. doi: 10.1038/s41587-019-0205-0. Epub 2019 Aug 2.


Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.

Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott R, Wang Y, Shaffer SA, Kiebish MA, DiFiglia M, Aronin N, Khvorova A.

iScience. 2019 Jun 28;16:230-241. doi: 10.1016/j.isci.2019.05.029. Epub 2019 May 27.


The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.

Biscans A, Coles A, Echeverria D, Khvorova A.

J Control Release. 2019 May 28;302:116-125. doi: 10.1016/j.jconrel.2019.03.028. Epub 2019 Mar 30.


Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.

Biscans A, Coles A, Haraszti R, Echeverria D, Hassler M, Osborn M, Khvorova A.

Nucleic Acids Res. 2019 Feb 20;47(3):1082-1096. doi: 10.1093/nar/gky1239.


Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.

Osborn MF, Coles AH, Biscans A, Haraszti RA, Roux L, Davis S, Ly S, Echeverria D, Hassler MR, Godinho BMDC, Nikan M, Khvorova A.

Nucleic Acids Res. 2019 Feb 20;47(3):1070-1081. doi: 10.1093/nar/gky1232.


RNAi modulation of placental sFLT1 for the treatment of preeclampsia.

Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho BMDC, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A.

Nat Biotechnol. 2018 Nov 19. doi: 10.1038/nbt.4297. [Epub ahead of print]


Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.

Didiot MC, Ferguson CM, Ly S, Coles AH, Smith AO, Bicknell AA, Hall LM, Sapp E, Echeverria D, Pai AA, DiFiglia M, Moore MJ, Hayward LJ, Aronin N, Khvorova A.

Cell Rep. 2018 Sep 4;24(10):2553-2560.e5. doi: 10.1016/j.celrep.2018.07.106.


Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.

Godinho BMDC, Henninger N, Bouley J, Alterman JF, Haraszti RA, Gilbert JW, Sapp E, Coles AH, Biscans A, Nikan M, Echeverria D, DiFiglia M, Aronin N, Khvorova A.

Mol Ther. 2018 Nov 7;26(11):2580-2591. doi: 10.1016/j.ymthe.2018.08.005. Epub 2018 Aug 8.


Is pulse oximetry helpful for the early detection of critical congenital heart disease at high altitude?

González-Andrade F, Echeverría D, López V, Arellano M.

Congenit Heart Dis. 2018 Nov;13(6):911-918. doi: 10.1111/chd.12654. Epub 2018 Aug 10.


Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.

Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ.

Nat Commun. 2018 Jul 6;9(1):2641. doi: 10.1038/s41467-018-05073-z.


Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.

Haraszti RA, Miller R, Didiot MC, Biscans A, Alterman JF, Hassler MR, Roux L, Echeverria D, Sapp E, DiFiglia M, Aronin N, Khvorova A.

Mol Ther. 2018 Aug 1;26(8):1973-1982. doi: 10.1016/j.ymthe.2018.05.024. Epub 2018 Jun 21.


Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo.

Sharma VK, Osborn MF, Hassler MR, Echeverria D, Ly S, Ulashchik EA, Martynenko-Makaev YV, Shmanai VV, Zatsepin TS, Khvorova A, Watts JK.

Bioconjug Chem. 2018 Jul 18;29(7):2478-2488. doi: 10.1021/acs.bioconjchem.8b00365. Epub 2018 Jul 2.


Correction: Rates and risk factors for human cutaneous anthrax in the country of Georgia: National surveillance data, 2008-2015.

Kasradze A, Echeverria D, Zakhashvili K, Bautista C, Heyer N, Imnadze P, Mirtskhulava V.

PLoS One. 2018 May 2;13(5):e0196958. doi: 10.1371/journal.pone.0196958. eCollection 2018.


Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.

Biscans A, Haraszti RA, Echeverria D, Miller R, Didiot MC, Nikan M, Roux L, Aronin N, Khvorova A.

Mol Ther. 2018 Jun 6;26(6):1520-1528. doi: 10.1016/j.ymthe.2018.03.019. Epub 2018 Apr 4.


Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.

Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A.

Mol Cancer Ther. 2018 Jun;17(6):1251-1258. doi: 10.1158/1535-7163.MCT-17-1144. Epub 2018 Apr 13.


Genetic Architecture of Dietary Fiber and Oligosaccharide Content in a Middle American Panel of Edible Dry Bean.

Moghaddam SM, Brick MA, Echeverria D, Thompson HJ, Brick LA, Lee R, Mamidi S, McClean PE.

Plant Genome. 2018 Mar;11(1). doi: 10.3835/plantgenome2017.08.0074.


Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.

Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A.

Nucleic Acids Res. 2018 Mar 16;46(5):2185-2196. doi: 10.1093/nar/gky037.


Rates and risk factors for human cutaneous anthrax in the country of Georgia: National surveillance data, 2008-2015.

Kasradze A, Echeverria D, Zakhashvili K, Bautista C, Heyer N, Imnadze P, Mirtskhulava V.

PLoS One. 2018 Feb 7;13(2):e0192031. doi: 10.1371/journal.pone.0192031. eCollection 2018. Erratum in: PLoS One. 2018 May 2;13(5):e0196958.


Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.

Godinho BMDC, Gilbert JW, Haraszti RA, Coles AH, Biscans A, Roux L, Nikan M, Echeverria D, Hassler M, Khvorova A.

Nucleic Acid Ther. 2017 Dec;27(6):323-334. doi: 10.1089/nat.2017.0690. Epub 2017 Oct 12.


Quantitative evaluation of arteriovenous malformation hemodynamic changes after endovascular treatment using parametric color coding: A case series study.

Rivera R, Sordo JG, Echeverria D, Badilla L, Pinto C, Merino-Osorio C.

Interv Neuroradiol. 2017 Dec;23(6):650-655. doi: 10.1177/1591019917721867. Epub 2017 Aug 1.


5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.

Haraszti RA, Roux L, Coles AH, Turanov AA, Alterman JF, Echeverria D, Godinho BMDC, Aronin N, Khvorova A.

Nucleic Acids Res. 2017 Jul 27;45(13):7581-7592. doi: 10.1093/nar/gkx507.


Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

Nikan M, Osborn MF, Coles AH, Biscans A, Godinho BMDC, Haraszti RA, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A.

Bioconjug Chem. 2017 Jun 21;28(6):1758-1766. doi: 10.1021/acs.bioconjchem.7b00226. Epub 2017 May 10.


Visualization of self-delivering hydrophobically modified siRNA cellular internalization.

Ly S, Navaroli DM, Didiot MC, Cardia J, Pandarinathan L, Alterman JF, Fogarty K, Standley C, Lifshitz LM, Bellve KD, Prot M, Echeverria D, Corvera S, Khvorova A.

Nucleic Acids Res. 2017 Jan 9;45(1):15-25. doi: 10.1093/nar/gkw1005. Epub 2016 Nov 28.


Solvent neurotoxicity in vehicle collision repair workers in New Zealand.

Keer S, Glass B, Prezant B, McLean D, Pearce N, Harding E, Echeverria D, McGlothlin J, Babbage DR, Douwes J.

Neurotoxicology. 2016 Dec;57:223-229. doi: 10.1016/j.neuro.2016.10.005. Epub 2016 Oct 11.


Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.

Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BM, Chase K, Sapp E, Ly S, Alterman JF, Hassler MR, Echeverria D, Raj L, Morrissey DV, DiFiglia M, Aronin N, Khvorova A.

Mol Ther. 2016 Oct;24(10):1836-1847. doi: 10.1038/mt.2016.126. Epub 2016 Jun 27.


Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.

Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A.

Mol Ther Nucleic Acids. 2016 Aug 9;5(8):e344. doi: 10.1038/mtna.2016.50.


Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat.

Zhu Z, Jiang W, Thompson MD, Echeverria D, McGinley JN, Thompson HJ.

Cancer Prev Res (Phila). 2015 Jun;8(6):518-27. doi: 10.1158/1940-6207.CAPR-14-0121. Epub 2015 Mar 24.


Significant tacrolimus and dronedarone interaction in a kidney transplant recipient.

Marin-Casino M, Pérez-Sáez MJ, Crespo M, Echeverría D, Mir M, Pascual J.

Transplantation. 2014 Aug 27;98(4):e33-4. doi: 10.1097/TP.0000000000000280. No abstract available.


Unusual origin of the left ophthalmic artery from the basilar trunk.

Rivera R, Choi IS, Sordo JG, Giacaman P, Badilla L, Bravo E, Echeverria D.

Surg Radiol Anat. 2015 May;37(4):399-401. doi: 10.1007/s00276-014-1327-1. Epub 2014 Jul 4.


Adaptation of the AOAC 2011.25 integrated total dietary fiber assay to determine the dietary fiber and oligosaccharide content of dry edible beans.

Kleintop AE, Echeverria D, Brick LA, Thompson HJ, Brick MA.

J Agric Food Chem. 2013 Oct 9;61(40):9719-26. doi: 10.1021/jf403018k. Epub 2013 Sep 30.


Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children.

Woods JS, Heyer NJ, Echeverria D, Russo JE, Martin MD, Bernardo MF, Luis HS, Vaz L, Farin FM.

Neurotoxicol Teratol. 2012 Sep-Oct;34(5):513-21. doi: 10.1016/ Epub 2012 Jul 2.


Disordered porphyrin metabolism: a potential biological marker for autism risk assessment.

Heyer NJ, Echeverria D, Woods JS.

Autism Res. 2012 Apr;5(2):84-92. doi: 10.1002/aur.236. Epub 2012 Feb 1.


Inter-rater reliability of assessed prenatal maternal occupational exposures to solvents, polycyclic aromatic hydrocarbons, and heavy metals.

Rocheleau CM, Lawson CC, Waters MA, Hein MJ, Stewart PA, Correa A, Echeverria D, Reefhuis J.

J Occup Environ Hyg. 2011 Dec;8(12):718-28. doi: 10.1080/15459624.2011.627293.


Does caring for a spouse with dementia promote cognitive decline? A hypothesis and proposed mechanisms.

Vitaliano PP, Murphy M, Young HM, Echeverria D, Borson S.

J Am Geriatr Soc. 2011 May;59(5):900-8. doi: 10.1111/j.1532-5415.2011.03368.x. Review.


Image-based analysis of primary human neutrophil chemotaxis in an automated direct-viewing assay.

Meyvantsson I, Vu E, Lamers C, Echeverria D, Worzella T, Echeverria V, Skoien A, Hayes S.

J Immunol Methods. 2011 Nov 30;374(1-2):70-7. doi: 10.1016/j.jim.2010.12.017. Epub 2011 Jan 5.


Urinary porphyrin excretion in neurotypical and autistic children.

Woods JS, Armel SE, Fulton DI, Allen J, Wessels K, Simmonds PL, Granpeesheh D, Mumper E, Bradstreet JJ, Echeverria D, Heyer NJ, Rooney JP.

Environ Health Perspect. 2010 Oct;118(10):1450-7. doi: 10.1289/ehp.0901713. Epub 2010 Jun 24.


The association between serotonin transporter gene promotor polymorphism (5-HTTLPR) and elemental mercury exposure on mood and behavior in humans.

Echeverria D, Woods JS, Heyer NJ, Martin MD, Rohlman DS, Farin FM, Li T.

J Toxicol Environ Health A. 2010;73(15):1003-20. doi: 10.1080/15287390903566591.


Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia Children's Dental Amalgam Trial.

Woods JS, Martin MD, Leroux BG, DeRouen TA, Bernardo MF, Luis HS, Leitão JG, Simmonds PL, Echeverria D, Rue TC.

J Toxicol Environ Health A. 2009;72(14):891-6. doi: 10.1080/15287390902959557.


Depressed mood mediates decline in cognitive processing speed in caregivers.

Vitaliano PP, Zhang J, Young HM, Caswell LW, Scanlan JM, Echeverria D.

Gerontologist. 2009 Feb;49(1):12-22. doi: 10.1093/geront/gnp004. Epub 2009 Mar 18.


Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood.

Heyer NJ, Echeverria D, Martin MD, Farin FM, Woods JS.

J Toxicol Environ Health A. 2009;72(9):599-609. doi: 10.1080/15287390802706405.


Approaches to psychiatric assessment in epidemiological studies of children.

McClellan J, Bresnahan MA, Echeverria D, Knox SS, Susser E.

J Epidemiol Community Health. 2009 Jan;63 Suppl 1:i4-14. doi: 10.1136/jech.2007.070789.


Assessing social-emotional development in children from a longitudinal perspective.

Denham SA, Wyatt TM, Bassett HH, Echeverria D, Knox SS.

J Epidemiol Community Health. 2009 Jan;63 Suppl 1:i37-52. doi: 10.1136/jech.2007.070797.


Proposed motor development assessment protocol for epidemiological studies in children.

Rosenbaum PL, Missiuna C, Echeverria D, Knox SS.

J Epidemiol Community Health. 2009 Jan;63 Suppl 1:i27-36. doi: 10.1136/jech.2007.070896.


Assessment of neuropsychological trajectories in longitudinal population-based studies of children.

White RF, Campbell R, Echeverria D, Knox SS, Janulewicz P.

J Epidemiol Community Health. 2009 Jan;63 Suppl 1:i15-26. doi: 10.1136/jech.2007.071530.


The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure.

Heyer NJ, Echeverria D, Farin FM, Woods JS.

J Toxicol Environ Health A. 2008;71(19):1318-26. doi: 10.1080/15287390802240850.


Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks.

Aguilar MB, Luna-Ramírez KS, Echeverría D, Falcón A, Olivera BM, Heimer de la Cotera EP, Maillo M.

Peptides. 2008 Feb;29(2):186-95. doi: 10.1016/j.peptides.2007.09.022. Epub 2007 Dec 5.


Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry.

Serdar B, Tornero-Velez R, Echeverria D, Nylander-French LA, Kupper LL, Rappaport SM.

Occup Environ Med. 2006 Oct;63(10):707-12. Epub 2006 Jun 6.


The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans.

Echeverria D, Woods JS, Heyer NJ, Rohlman D, Farin FM, Li T, Garabedian CE.

Neurotoxicol Teratol. 2006 Jan-Feb;28(1):39-48. Epub 2005 Dec 15.


Caregiving and gingival symptom reports: psychophysiologic mediators.

Vitaliano PP, Persson R, Kiyak A, Saini H, Echeverria D.

Psychosom Med. 2005 Nov-Dec;67(6):930-8.


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