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Items: 26


In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: it is the time to combine.

Vidalin O, Muslmani M, Estienne C, Echchakir H, Abina AM.

Curr Opin Pharmacol. 2009 Oct;9(5):669-76. doi: 10.1016/j.coph.2009.06.017. Epub 2009 Jul 29. Review.


Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway.

El Hage F, Stroobant V, Vergnon I, Baurain JF, Echchakir H, Lazar V, Chouaib S, Coulie PG, Mami-Chouaib F.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10119-24. doi: 10.1073/pnas.0802753105. Epub 2008 Jul 14.


CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome.

Poszepczynska-Guigné E, Schiavon V, D'Incan M, Echchakir H, Musette P, Ortonne N, Boumsell L, Moretta A, Bensussan A, Bagot M.

J Invest Dermatol. 2004 Mar;122(3):820-3.


Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma.

Dorothée G, Echchakir H, Le Maux Chansac B, Vergnon I, El Hage F, Moretta A, Bensussan A, Chouaib S, Mami-Chouaib F.

Oncogene. 2003 Oct 16;22(46):7192-8.


A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation.

Dangles-Marie V, Richon S, El-Behi M, Echchakir H, Dorothée G, Thiery J, Validire P, Vergnon I, Menez J, Ladjimi M, Chouaib S, Bellet D, Mami-Chouaib F.

Cancer Res. 2003 Jul 1;63(13):3682-7.


Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function.

Thiery J, Dorothée G, Haddada H, Echchakir H, Richon C, Stancou R, Vergnon I, Benard J, Mami-Chouaib F, Chouaib S.

J Immunol. 2003 Jun 15;170(12):5919-26.


Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients.

Griscelli F, Opolon P, Saulnier P, Mami-Chouaib F, Gautier E, Echchakir H, Angevin E, Le Chevalier T, Bataille V, Squiban P, Tursz T, Escudier B.

Gene Ther. 2003 Mar;10(5):386-95.


Isolation of a CD8alphaalpha+ CD4- tumour T-cell clone with cytotoxic activity from a CD4+ CD8- cutaneous T-cell lymphoma.

Nikolova M, Echchakir H, Wechsler J, Boumsell L, Bensussan A, Bagot M.

Br J Dermatol. 2003 Jan;148(1):24-9.


Antitumor cytotoxic T-lymphocyte response in human lung carcinoma: identification of a tumor-associated antigen.

Mami-Chouaib F, Echchakir H, Dorothée G, Vergnon I, Chouaib S.

Immunol Rev. 2002 Oct;188:114-21. Review.


Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution.

Echchakir H, Dorothée G, Vergnon I, Menez J, Chouaib S, Mami-Chouaib F.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9358-63. Epub 2002 Jul 1.


Role of p53 in the sensitization of tumor cells to apoptotic cell death.

Thiery J, Echchakir H, Dorothée G, Ameyar-Zazoua M, Haddada H, Mami-Chouaib F, Chouaib S.

Mol Immunol. 2002 May;38(12-13):977-80.


[Technological advances in immuno-oncology: from fundamental concepts to patient immunological monitoring].

Chouaib S, Echchakir H, Angevin E, Guerra N, Kosmatopoulos K, Caignard A, Lim A, Baron V, Ferradini L, Mami-Chouaib F.

Bull Cancer. 2001 Aug;88(8):733-40. Review. French.


Erythrodermic cutaneous T-cell lymphoma with disseminated pustulosis. Production of high levels of interleukin-8 by tumour cells.

Poszepczynska E, Martinvalet D, Bouloc A, Echchakir H, Wechsler J, Bécherel PA, Boumsell L, Bensussan A, Bagot M.

Br J Dermatol. 2001 May;144(5):1073-9.


A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma.

Echchakir H, Mami-Chouaib F, Vergnon I, Baurain JF, Karanikas V, Chouaib S, Coulie PG.

Cancer Res. 2001 May 15;61(10):4078-83.


Role of Fas and granule exocytosis pathways in tumor-infiltrating T lymphocyte-induced apoptosis of autologous human lung-carcinoma cells.

Dorothee G, Ameyar M, Bettaieb A, Vergnon I, Echchakir H, Bouziane M, Chouaib S, Mami-Chouaib F.

Int J Cancer. 2001 Mar 15;91(6):772-7.


Functional inhibitory receptors expressed by a cutaneous T cell lymphoma-specific cytolytic clonal T cell population.

Bagot M, Martinvalet D, Echchakir H, Chabanette-Schirm F, Boumsell L, Bensussan A.

J Invest Dermatol. 2000 Dec;115(6):994-9. Erratum in: J Invest Dermatol 2002 Jul;119(1):206. Martinvallet D [corrected to Martinvalet D].


Functional characterization of an IL-7-dependent CD4(+)CD8alphaalpha(+) Th3-type malignant cell line derived from a patient with a cutaneous T-cell lymphoma.

Poszepczynska E, Bagot M, Echchakir H, Martinvalet D, Ramez M, Charue D, Boumsell L, Bensussan A.

Blood. 2000 Aug 1;96(3):1056-63.


Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis.

Echchakir H, Bagot M, Dorothée G, Martinvalet D, Le Gouvello S, Boumsell L, Chouaib S, Bensussan A, Mami-Chouaib F.

J Invest Dermatol. 2000 Jul;115(1):74-80.


Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas.

Guerra N, Guillard M, Angevin E, Echchakir H, Escudier B, Moretta A, Chouaib S, Caignard A.

Blood. 2000 May 1;95(9):2883-9.


Evidence for in situ expansion of diverse antitumor-specific cytotoxic T lymphocyte clones in a human large cell carcinoma of the lung.

Echchakir H, Vergnon I, Dorothée G, Grunenwald D, Chouaib S, Mami-Chouaib F.

Int Immunol. 2000 Apr;12(4):537-46.


Analysis of T-cell-receptor beta-chain-gene usage in peripheral-blood and tumor-infiltrating lymphocytes from human non-small-cell lung carcinomas.

Echchakir H, Asselin-Paturel C, Dorothee G, Vergnon I, Grunenwald D, Chouaib S, Mami-Chouaib F.

Int J Cancer. 1999 Apr 12;81(2):205-13.


Quantitative analysis of Th1, Th2 and TGF-beta1 cytokine expression in tumor, TIL and PBL of non-small cell lung cancer patients.

Asselin-Paturel C, Echchakir H, Carayol G, Gay F, Opolon P, Grunenwald D, Chouaib S, Mami-Chouaib F.

Int J Cancer. 1998 Jul 3;77(1):7-12.


Isolation of tumor-specific cytotoxic CD4+ and CD4+CD8dim+ T-cell clones infiltrating a cutaneous T-cell lymphoma.

Bagot M, Echchakir H, Mami-Chouaib F, Delfau-Larue MH, Charue D, Bernheim A, Chouaib S, Boumsell L, Bensussan A.

Blood. 1998 Jun 1;91(11):4331-41.


Characterization of proliferative responses and cytokine mRNA profiles induced by Vespula venom in patients with severe reactions to wasp stings.

Bonay M, Echchakir H, Lecossier D, Lainé P, Herman D, Hance AJ, Soler P, Tazi A.

Clin Exp Immunol. 1997 Aug;109(2):342-50.

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