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Items: 35

1.

An enhanced CRISPR repressor for targeted mammalian gene regulation.

Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM.

Nat Methods. 2018 Aug;15(8):611-616. doi: 10.1038/s41592-018-0048-5. Epub 2018 Jul 16.

2.

Programming Morphogenesis through Systems and Synthetic Biology.

Velazquez JJ, Su E, Cahan P, Ebrahimkhani MR.

Trends Biotechnol. 2018 Apr;36(4):415-429. doi: 10.1016/j.tibtech.2017.11.003. Epub 2017 Dec 8. Review.

PMID:
29229492
3.

Engineered CRISPR Systems for Next Generation Gene Therapies.

Pineda M, Moghadam F, Ebrahimkhani MR, Kiani S.

ACS Synth Biol. 2017 Sep 15;6(9):1614-1626. doi: 10.1021/acssynbio.7b00011. Epub 2017 Jun 7. Review.

PMID:
28558198
4.

A New Positive Feedback Circuit in the Fibrosis-Cancer Axis for Male Livers.

Ebrahimkhani MR.

Cell Mol Gastroenterol Hepatol. 2017 Mar 15;3(3):301-302. doi: 10.1016/j.jcmgh.2017.02.007. eCollection 2017 May. No abstract available.

5.

TLR4-Dependent Secretion by Hepatic Stellate Cells of the Neutrophil-Chemoattractant CXCL1 Mediates Liver Response to Gut Microbiota.

Bigorgne AE, John B, Ebrahimkhani MR, Shimizu-Albergine M, Campbell JS, Crispe IN.

PLoS One. 2016 Mar 22;11(3):e0151063. doi: 10.1371/journal.pone.0151063. eCollection 2016.

6.

Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.

Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R.

Nat Commun. 2016 Jan 6;7:10243. doi: 10.1038/ncomms10243.

7.

Isolation of Non-parenchymal Cells from the Mouse Liver.

Mohar I, Brempelis KJ, Murray SA, Ebrahimkhani MR, Crispe IN.

Methods Mol Biol. 2015;1325:3-17. doi: 10.1007/978-1-4939-2815-6_1.

PMID:
26450375
8.

Cas9 gRNA engineering for genome editing, activation and repression.

Kiani S, Chavez A, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, Church G.

Nat Methods. 2015 Nov;12(11):1051-4. doi: 10.1038/nmeth.3580. Epub 2015 Sep 7.

9.

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.

Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29.

10.

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4878-86. doi: 10.1073/pnas.1413582111. Epub 2014 Oct 27.

11.

CRISPR transcriptional repression devices and layered circuits in mammalian cells.

Kiani S, Beal J, Ebrahimkhani MR, Huh J, Hall RN, Xie Z, Li Y, Weiss R.

Nat Methods. 2014 Jul;11(7):723-6. doi: 10.1038/nmeth.2969. Epub 2014 May 5.

12.

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.

Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT.

Drug Discov Today. 2014 Jun;19(6):754-62. doi: 10.1016/j.drudis.2014.04.017. Epub 2014 May 2. Review.

13.

Bioreactor technologies to support liver function in vitro.

Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG.

Adv Drug Deliv Rev. 2014 Apr;69-70:132-57. doi: 10.1016/j.addr.2014.02.011. Epub 2014 Mar 5. Review.

14.

All-human microphysical model of metastasis therapy.

Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, Wells A, Young C.

Stem Cell Res Ther. 2013;4 Suppl 1:S11. doi: 10.1186/scrt372. Epub 2013 Dec 20. Review.

15.

Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffré F, Maroteaux L, Mann DA.

Nat Med. 2011 Nov 27;17(12):1668-73. doi: 10.1038/nm.2490.

16.

Cross-presentation of antigen by diverse subsets of murine liver cells.

Ebrahimkhani MR, Mohar I, Crispe IN.

Hepatology. 2011 Oct;54(4):1379-87. doi: 10.1002/hep.24508.

17.

The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation.

Gieling RG, Elsharkawy AM, Caamaño JH, Cowie DE, Wright MC, Ebrahimkhani MR, Burt AD, Mann J, Raychaudhuri P, Liou HC, Oakley F, Mann DA.

Hepatology. 2010 Mar;51(3):922-31. doi: 10.1002/hep.23385.

PMID:
20058312
18.

Galactosylated LDL nanoparticles: a novel targeting delivery system to deliver antigen to macrophages and enhance antigen specific T cell responses.

Wu F, Wuensch SA, Azadniv M, Ebrahimkhani MR, Crispe IN.

Mol Pharm. 2009 Sep-Oct;6(5):1506-17. doi: 10.1021/mp900081y.

19.

Nitric oxide metabolites as biomarkers for follow-up after chronic rhinosinusitis surgery.

Deroee AF, Naraghi M, Sontou AF, Ebrahimkhani MR, Dehpour AR.

Am J Rhinol Allergy. 2009 Mar-Apr;23(2):159-61. doi: 10.2500/ajra.2009.23.3289.

PMID:
19401041
20.

Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis.

Ebrahimkhani MR, Moezi L, Kiani S, Merat S, Dehpour AR.

Dig Dis Sci. 2008 Nov;53(11):3007-11. doi: 10.1007/s10620-008-0261-7. Epub 2008 May 9.

PMID:
18465246
21.

Wound healing and local neuroendocrine regulation in the injured liver.

Ebrahimkhani MR, Elsharkawy AM, Mann DA.

Expert Rev Mol Med. 2008 Apr 29;10:e11. doi: 10.1017/S146239940800063X. Review.

PMID:
18442446
22.

Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis.

Kiani S, Ebrahimkhani MR, Shariftabrizi A, Doratotaj B, Payabvash S, Riazi K, Dehghani M, Honar H, Karoon A, Amanlou M, Tavangar SM, Dehpour AR.

J Gastroenterol Hepatol. 2007 Mar;22(3):406-13.

PMID:
17295775
23.

Metalloprotein-dependent decomposition of S-nitrosothiols: studies on the stabilization and measurement of S-nitrosothiols in tissues.

Mani AR, Ebrahimkhani MR, Ippolito S, Ollosson R, Moore KP.

Free Radic Biol Med. 2006 May 1;40(9):1654-63. Epub 2006 Jan 26.

PMID:
16632125
24.

Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats.

Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR.

Gut. 2006 Nov;55(11):1606-16. Epub 2006 Mar 16.

25.

Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine.

Shariftabrizi A, Nifli AP, Ansari M, Saadat F, Ebrahimkhani MR, Alizadeh N, Nasseh A, Alexaki VI, Dehpour AR, Castanas E, Khorramizadeh MR.

Eur J Pharmacol. 2006 Jan 13;530(1-2):33-9. Epub 2005 Dec 28.

PMID:
16386243
26.

Effect of morphine on ischemia-reperfusion injury: experimental study in testicular torsion rat model.

Salmasi AH, Beheshtian A, Payabvash S, Demehri S, Ebrahimkhani MR, Karimzadegan M, Bahadori M, Pasalar P, Dehpour AR.

Urology. 2005 Dec;66(6):1338-42.

PMID:
16360480
27.

Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis.

Ebrahimkhani MR, Mani AR, Moore K.

Gut. 2005 Dec;54(12):1668-71. Epub 2005 Sep 20. Review.

28.

Concomitant reduction of matrix metalloproteinase-2 secretion and intracellular reactive oxygen species following anti-sense inhibition of telomerase activity in PC-3 prostate carcinoma cells.

Shariftabrizi A, Khorramizadeh MR, Saadat F, Alimoghadam K, Safavifar F, Ebrahimkhani MR.

Mol Cell Biochem. 2005 May;273(1-2):109-16.

PMID:
16013445
29.

The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors.

Riazi K, Honar H, Homayoun H, Rashidi N, Kiani S, Ebrahimkhani MR, Noorian AR, Ghaffari K, Jannati A, Dehpour AR.

Epilepsy Res. 2005 Jun;65(1-2):33-40.

PMID:
15975766
30.

Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis.

Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR.

Life Sci. 2005 Apr 8;76(21):2497-512.

PMID:
15763080
31.

Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures.

Honar H, Riazi K, Homayoun H, Sadeghipour H, Rashidi N, Ebrahimkhani MR, Mirazi N, Dehpour AR.

Neuroscience. 2004;129(3):733-42.

PMID:
15541894
32.

Lithium inhibits the modulatory effects of morphine on susceptibility to pentylenetetrazole-induced clonic seizure in mice: involvement of a nitric oxide pathway.

Honar H, Riazi K, Homayoun H, Demehri S, Dehghani M, Vafaie K, Ebrahimkhani MR, Rashidi N, Gaskari SA, Dehpour AR.

Brain Res. 2004 Dec 10;1029(1):48-55.

PMID:
15533315
33.

Obstructive cholestasis alters intestinal transit in mice: role of opioid system.

Ghaffari K, Savadkuhi ST, Honar H, Riazi K, Shafaroodi H, Moezi L, Ebrahimkhani MR, Tahmasebi MS, Dehpour AR.

Life Sci. 2004 Dec 10;76(4):397-406.

PMID:
15530502
34.

Time-dependent reduction of acetylcholine-induced relaxation in corpus cavernosum of cholestatic rats: role of nitric oxide and cyclooxygenase pathway.

Dehghani M, Sadeghipour H, Shafaroodi H, Honar H, Riazi K, Ebrahimkhani MR, Hajrasouliha AR, Tavakoli S, Dehpour AR.

Eur J Pharmacol. 2004 Aug 2;496(1-3):181-7.

PMID:
15288589
35.

Potentiation of anandamide effects in mesenteric beds isolated from bile duct-ligated rats: role of nitric oxide.

Moezi L, Rezayat M, Samini M, Shafaroodi H, Mehr SE, Ebrahimkhani MR, Dehpour AR.

Eur J Pharmacol. 2004 Feb 13;486(1):53-9.

PMID:
14751408

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