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Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization.

Vivas-Ruiz DE, Sandoval GA, Gonzalez-Kozlova E, Zarria-Romero J, Lazo F, Rodríguez E, Magalhães HPB, Chávez-Olortegui C, Oliveira LS, Alvarenga VG, Urra FA, Toledo J, Yarlequé A, Eble JA, Sanchez EF.

Int J Biol Macromol. 2020 Mar 10;153:779-795. doi: 10.1016/j.ijbiomac.2020.03.055. [Epub ahead of print]


Extracellular Redox Regulation of α7β Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch.

Bergerhausen L, Grosche J, Meißner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Mörgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA.

Antioxidants (Basel). 2020 Mar 10;9(3). pii: E227. doi: 10.3390/antiox9030227.


Neuropilin: Handyman and Power Broker in the Tumor Microenvironment.

Niland S, Eble JA.

Adv Exp Med Biol. 2020;1223:31-67. doi: 10.1007/978-3-030-35582-1_3. Review.


Low dose Btk inhibitors selectively block platelet activation by CLEC-2.

Nicolson PLR, Nock SH, Hinds J, Garcia-Quintanilla L, Smith CW, Campos J, Brill A, Pike JA, Khan AO, Poulter NS, Kavanagh DM, Watson S, Watson CN, Clifford H, Huissoon AP, Pollitt AY, Eble JA, Pratt G, Watson SP, Hughes CE.

Haematologica. 2020 Jan 16. pii: haematol.2019.218545. doi: 10.3324/haematol.2019.218545. [Epub ahead of print]


A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade.

Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Morán LA, Lacerenza S, Pinto-Llorente R, Eble JA, de Los Ríos V, Domínguez E, Loza MI, Casal JI, Carrascal M, Abián J, García A.

Thromb Haemost. 2020 Feb;120(2):262-276. doi: 10.1055/s-0039-3400295. Epub 2020 Jan 4.


From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks.

Martins Lima A, Martins Cavaco AC, Fraga-Silva RA, Eble JA, Stergiopulos N.

Thromb Haemost. 2019 Nov;119(11):1720-1739. doi: 10.1055/s-0039-1695770. Epub 2019 Sep 29.


Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function.

Oliveira LS, Estevão-Costa MI, Alvarenga VG, Vivas-Ruiz DE, Yarleque A, Lima AM, Cavaco A, Eble JA, Sanchez EF.

Molecules. 2019 Sep 26;24(19). pii: E3489. doi: 10.3390/molecules24193489.


What Is the Fuss about Integrins and the Tumor Microenvironment?

Eble JA, Gullberg D.

Cancers (Basel). 2019 Sep 3;11(9). pii: E1296. doi: 10.3390/cancers11091296.


TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists.

Kostyak JC, Mauri BR, Dangelmaier C, Patel A, Zhou Y, Eble JA, Tsygankov AY, McKenzie SE, Kunapuli SP.

TH Open. 2018 Dec 5;2(4):e411-e419. doi: 10.1055/s-0038-1676358. eCollection 2018 Oct.


The extracellular matrix in tumor progression and metastasis.

Eble JA, Niland S.

Clin Exp Metastasis. 2019 Jun;36(3):171-198. doi: 10.1007/s10585-019-09966-1. Epub 2019 Apr 11. Review.


Comparison of the GPVI inhibitors losartan and honokiol.

Onselaer MB, Nagy M, Pallini C, Pike JA, Perrella G, Quintanilla LG, Eble JA, Poulter NS, Heemskerk JWM, Watson SP.

Platelets. 2020;31(2):187-197. doi: 10.1080/09537104.2019.1585526. Epub 2019 Mar 8.


Structurally Robust and Functionally Highly Versatile-C-Type Lectin (-Related) Proteins in Snake Venoms.

Eble JA.

Toxins (Basel). 2019 Mar 1;11(3). pii: E136. doi: 10.3390/toxins11030136. Review.


ELMO1 deficiency enhances platelet function.

Patel A, Kostyak J, Dangelmaier C, Badolia R, Bhavanasi D, Aslan JE, Merali S, Kim S, Eble JA, Goldfinger L, Kunapuli S.

Blood Adv. 2019 Feb 26;3(4):575-587. doi: 10.1182/bloodadvances.2018016444.


Neuropilins in the Context of Tumor Vasculature.

Niland S, Eble JA.

Int J Mol Sci. 2019 Feb 1;20(3). pii: E639. doi: 10.3390/ijms20030639. Review.


Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.

Kardeby C, Fälker K, Haining EJ, Criel M, Lindkvist M, Barroso R, Påhlsson P, Ljungberg LU, Tengdelius M, Rainger GE, Watson S, Eble JA, Hoylaerts MF, Emsley J, Konradsson P, Watson SP, Sun Y, Grenegård M.

Blood Adv. 2019 Feb 12;3(3):275-287. doi: 10.1182/bloodadvances.2018024950.


Signals of the Neuropilin-1-MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells.

Rezaei M, Martins Cavaco AC, Seebach J, Niland S, Zimmermann J, Hanschmann EM, Hallmann R, Schillers H, Eble JA.

J Immunol. 2019 Mar 1;202(5):1559-1572. doi: 10.4049/jimmunol.1801346. Epub 2019 Jan 28.


Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation.

Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Eble JA, Carrascal M, Abián J, García Á.

J Proteomics. 2019 Mar 20;195:88-97. doi: 10.1016/j.jprot.2019.01.014. Epub 2019 Jan 22.


The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells.

Cavaco ACM, Rezaei M, Caliandro MF, Lima AM, Stehling M, Dhayat SA, Haier J, Brakebusch C, Eble JA.

Cancers (Basel). 2018 Dec 21;11(1). pii: E14. doi: 10.3390/cancers11010014.


Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application.

Estevão-Costa MI, Sanz-Soler R, Johanningmeier B, Eble JA.

Int J Biochem Cell Biol. 2018 Nov;104:94-113. doi: 10.1016/j.biocel.2018.09.011. Epub 2018 Sep 24. Review.


C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.

de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB.

J Cell Sci. 2018 Oct 2;131(19). pii: jcs214551. doi: 10.1242/jcs.214551.


Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijpers MJE, Heemskerk JWM, Eble JA, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Jarvis GE, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA.

Blood. 2018 Sep 27;132(13):1399-1412. doi: 10.1182/blood-2017-08-802769. Epub 2018 Jun 13.


Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.

Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith CW, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Eble JA, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA.

Blood. 2018 Sep 27;132(13):1413-1425. doi: 10.1182/blood-2017-10-802975. Epub 2018 Jun 11.


Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models.

Niland S, Komljenovic D, Macas J, Bracht T, Bäuerle T, Liebner S, Eble JA.

Oncotarget. 2018 Apr 27;9(32):22406-22422. doi: 10.18632/oncotarget.25032. eCollection 2018 Apr 27.


Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia.

Hardy AT, Palma-Barqueros V, Watson SK, Malcor JD, Eble JA, Gardiner EE, Blanco JE, Guijarro-Campillo R, Delgado JL, Lozano ML, Teruel-Montoya R, Vicente V, Watson SP, Rivera J, Ferrer-Marín F.

Thromb Haemost. 2018 Jun;118(6):1009-1020. doi: 10.1055/s-0038-1646924. Epub 2018 Apr 25.


More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts.

Grosche J, Meißner J, Eble JA.

Mol Aspects Med. 2018 Oct;63:30-46. doi: 10.1016/j.mam.2018.03.005. Epub 2018 Apr 6. Review.


The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine α2β1 integrin-dependent platelet activation.

Lima AM, Wegner SV, Martins Cavaco AC, Estevão-Costa MI, Sanz-Soler R, Niland S, Nosov G, Klingauf J, Spatz JP, Eble JA.

Biomaterials. 2018 Jun;167:107-120. doi: 10.1016/j.biomaterials.2018.03.028. Epub 2018 Mar 16.


Direct Fibrinolytic Snake Venom Metalloproteinases Affecting Hemostasis: Structural, Biochemical Features and Therapeutic Potential.

Sanchez EF, Flores-Ortiz RJ, Alvarenga VG, Eble JA.

Toxins (Basel). 2017 Dec 5;9(12). pii: E392. doi: 10.3390/toxins9120392. Review.


Collateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy.

Cavaco A, Rezaei M, Niland S, Eble JA.

Int J Mol Sci. 2017 Nov 7;18(11). pii: E2355. doi: 10.3390/ijms18112355. Review.


Correction: Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively.

Eble JA, McDougall M, Orriss GL, Niland S, Johanningmeier B, Pohlentz G, Meier M, Karrasch S, Estevão-Costa MI, Lima AM, Stetefeld J.

PLoS Biol. 2017 Sep 6;15(9):e1002613. doi: 10.1371/journal.pbio.1002613. eCollection 2017 Sep.


CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B.

Blood. 2017 Nov 16;130(20):2224-2228. doi: 10.1182/blood-2017-03-771907. Epub 2017 Aug 23.


Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets.

Badolia R, Inamdar V, Manne BK, Dangelmaier C, Eble JA, Kunapuli SP.

J Biol Chem. 2017 Sep 1;292(35):14516-14531. doi: 10.1074/jbc.M117.791012. Epub 2017 Jul 13.


Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively.

Eble JA, McDougall M, Orriss GL, Niland S, Johanningmeier B, Pohlentz G, Meier M, Karrasch S, Estevão-Costa MI, Martins Lima A, Stetefeld J.

PLoS Biol. 2017 Jul 13;15(7):e2001492. doi: 10.1371/journal.pbio.2001492. eCollection 2017 Jul. Erratum in: PLoS Biol. 2017 Sep 6;15(9):e1002613.


Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides.

Delierneux C, Donis N, Servais L, Wéra O, Lecut C, Vandereyken M, Musumeci L, Rahmouni S, Schneider J, Eble JA, Lancellotti P, Oury C.

J Thromb Haemost. 2017 May;15(5):983-997. doi: 10.1111/jth.13669. Epub 2017 Apr 13.


The binding capacity of α1β1-, α2β1- and α10β1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils.

Woltersdorf C, Bonk M, Leitinger B, Huhtala M, Käpylä J, Heino J, Gil Girol C, Niland S, Eble JA, Bruckner P, Dreier R, Hansen U.

Matrix Biol. 2017 Nov;63:91-105. doi: 10.1016/j.matbio.2017.02.001. Epub 2017 Feb 10.


Role of Integrins α1β1 and α2β1 in Wound and Tumor Angiogenesis in Mice.

Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B.

Am J Pathol. 2016 Nov;186(11):3011-3027. doi: 10.1016/j.ajpath.2016.06.021. Epub 2016 Sep 14.


Data for a direct fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (barnett(,)s pitviper) snake venom with anti-thrombotic effect.

Sanchez EF, Richardson M, Gremski LH, Veiga SS, Yarleque A, Niland S, Lima AM, Estevao-Costa MI, Eble JA.

Data Brief. 2016 Apr 30;7:1609-13. doi: 10.1016/j.dib.2016.04.054. eCollection 2016 Jun.


Regal phylogeography: Range-wide survey of the marine angelfish Pygoplites diacanthus reveals evolutionary partitions between the Red Sea, Indian Ocean, and Pacific Ocean.

Coleman RR, Eble JA, DiBattista JD, Rocha LA, Randall JE, Berumen ML, Bowen BW.

Mol Phylogenet Evol. 2016 Jul;100:243-253. doi: 10.1016/j.ympev.2016.04.005. Epub 2016 Apr 8.


Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A.

Pelillo C, Mollica H, Eble JA, Grosche J, Herzog L, Codan B, Sava G, Bergamo A.

J Inorg Biochem. 2016 Jul;160:225-35. doi: 10.1016/j.jinorgbio.2016.02.025. Epub 2016 Feb 27.


A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (Barnett´s pitviper) snake venom with anti-platelet properties.

Sanchez EF, Richardson M, Gremski LH, Veiga SS, Yarleque A, Niland S, Lima AM, Estevao-Costa MI, Eble JA.

Biochim Biophys Acta. 2016 Mar;1860(3):542-56. doi: 10.1016/j.bbagen.2015.12.021. Epub 2015 Dec 23.


Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration.

Rabiej VK, Pflanzner T, Wagner T, Goetze K, Storck SE, Eble JA, Weggen S, Mueller-Klieser W, Pietrzik CU.

Exp Cell Res. 2016 Jan 1;340(1):102-15. doi: 10.1016/j.yexcr.2015.11.020. Epub 2015 Nov 22.


Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices.

Baldo C, Lopes DS, Faquim-Mauro EL, Jacysyn JF, Niland S, Eble JA, Clissa PB, Moura-da-Silva AM.

Toxicon. 2015 Dec 15;108:240-8. doi: 10.1016/j.toxicon.2015.10.016. Epub 2015 Oct 31.


Ground-Dwelling Arthropod Communities of a Sky Island Mountain Range in Southeastern Arizona, USA: Obtaining a Baseline for Assessing the Effects of Climate Change.

Meyer WM 3rd, Eble JA, Franklin K, McManus RB, Brantley SL, Henkel J, Marek PE, Hall WE, Olson CA, McInroy R, Bernal Loaiza EM, Brusca RC, Moore W.

PLoS One. 2015 Sep 2;10(9):e0135210. doi: 10.1371/journal.pone.0135210. eCollection 2015.


Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.

Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M, Kunapuli SP.

J Biol Chem. 2015 May 1;290(18):11557-68. doi: 10.1074/jbc.M114.629527. Epub 2015 Mar 12.


Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.

Awwad K, Hu J, Shi L, Mangels N, Abdel Malik R, Zippel N, Fisslthaler B, Eble JA, Pfeilschifter J, Popp R, Fleming I.

Cardiovasc Res. 2015 May 1;106(2):284-94. doi: 10.1093/cvr/cvv098. Epub 2015 Mar 5.


Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity.

Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P.

Drug Des Devel Ther. 2015 Jan 5;9:291-304. doi: 10.2147/DDDT.S72844. eCollection 2015.


Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.

Musumeci L, Kuijpers MJ, Gilio K, Hego A, Théâtre E, Maurissen L, Vandereyken M, Diogo CV, Lecut C, Guilmain W, Bobkova EV, Eble JA, Dahl R, Drion P, Rascon J, Mostofi Y, Yuan H, Sergienko E, Chung TD, Thiry M, Senis Y, Moutschen M, Mustelin T, Lancellotti P, Heemskerk JW, Tautz L, Oury C, Rahmouni S.

Circulation. 2015 Feb 17;131(7):656-68. doi: 10.1161/CIRCULATIONAHA.114.010186. Epub 2014 Dec 17.


Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity.

Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P.

J Pharmacol Exp Ther. 2014 Sep;350(3):506-19. doi: 10.1124/jpet.114.214643. Epub 2014 Jun 17.


Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels.

Schesny MK, Monaghan M, Bindermann AH, Freund D, Seifert M, Eble JA, Vogel S, Gawaz MP, Hinderer S, Schenke-Layland K.

Biomaterials. 2014 Aug;35(25):7180-7. doi: 10.1016/j.biomaterials.2014.04.116. Epub 2014 May 27.

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